Putative phosphatidylinositol 4-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol 4-kinase, putative

Species:

Leishmania major

UniProt:

Q4Q2I5_LEIMA

TriTrypDb:

LmjF.34.3590 , LMJLV39_340042100 , LMJSD75_340042400

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	5
GO:0006644	phospholipid metabolic process	4	5
GO:0006650	glycerophospholipid metabolic process	5	5
GO:0006661	phosphatidylinositol biosynthetic process	6	5
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0007165	signal transduction	2	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	5
GO:0008654	phospholipid biosynthetic process	5	5
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	5
GO:0035556	intracellular signal transduction	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044255	cellular lipid metabolic process	3	5
GO:0045017	glycerolipid biosynthetic process	4	5
GO:0046474	glycerophospholipid biosynthetic process	5	5
GO:0046486	glycerolipid metabolic process	4	5
GO:0046488	phosphatidylinositol metabolic process	6	5
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	5
GO:0048015	phosphatidylinositol-mediated signaling	5	11
GO:0048017	inositol lipid-mediated signaling	4	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11
GO:0071704	organic substance metabolic process	2	5
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004430	1-phosphatidylinositol 4-kinase activity	6	8
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0052742	phosphatidylinositol kinase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.775
CLV_MEL_PAP_1	539	545	PF00089	0.252
CLV_NRD_NRD_1	13	15	PF00675	0.512
CLV_NRD_NRD_1	158	160	PF00675	0.444
CLV_NRD_NRD_1	192	194	PF00675	0.401
CLV_NRD_NRD_1	198	200	PF00675	0.402
CLV_NRD_NRD_1	335	337	PF00675	0.456
CLV_NRD_NRD_1	438	440	PF00675	0.460
CLV_NRD_NRD_1	598	600	PF00675	0.452
CLV_NRD_NRD_1	7	9	PF00675	0.583
CLV_PCSK_FUR_1	596	600	PF00082	0.446
CLV_PCSK_KEX2_1	13	15	PF00082	0.510
CLV_PCSK_KEX2_1	198	200	PF00082	0.429
CLV_PCSK_KEX2_1	598	600	PF00082	0.444
CLV_PCSK_KEX2_1	7	9	PF00082	0.582
CLV_PCSK_SKI1_1	14	18	PF00082	0.499
CLV_PCSK_SKI1_1	414	418	PF00082	0.414
CLV_Separin_Metazoa	147	151	PF03568	0.493
DEG_APCC_DBOX_1	13	21	PF00400	0.521
DEG_APCC_DBOX_1	197	205	PF00400	0.465
DOC_CKS1_1	545	550	PF01111	0.362
DOC_CYCLIN_yClb1_LxF_4	181	187	PF00134	0.507
DOC_MAPK_gen_1	159	166	PF00069	0.414
DOC_MAPK_gen_1	462	471	PF00069	0.308
DOC_MAPK_MEF2A_6	159	166	PF00069	0.436
DOC_MAPK_MEF2A_6	361	369	PF00069	0.327
DOC_MAPK_MEF2A_6	473	482	PF00069	0.381
DOC_PP1_RVXF_1	86	92	PF00149	0.348
DOC_SPAK_OSR1_1	274	278	PF12202	0.556
DOC_USP7_MATH_1	127	131	PF00917	0.646
DOC_USP7_MATH_1	303	307	PF00917	0.662
DOC_USP7_MATH_1	79	83	PF00917	0.378
DOC_WW_Pin1_4	310	315	PF00397	0.517
DOC_WW_Pin1_4	336	341	PF00397	0.544
DOC_WW_Pin1_4	486	491	PF00397	0.302
DOC_WW_Pin1_4	544	549	PF00397	0.360
LIG_14-3-3_CanoR_1	13	17	PF00244	0.503
LIG_14-3-3_CanoR_1	140	145	PF00244	0.707
LIG_14-3-3_CanoR_1	171	180	PF00244	0.447
LIG_14-3-3_CanoR_1	296	301	PF00244	0.549
LIG_14-3-3_CanoR_1	334	340	PF00244	0.472
LIG_14-3-3_CanoR_1	418	426	PF00244	0.407
LIG_14-3-3_CanoR_1	88	94	PF00244	0.316
LIG_APCC_ABBA_1	164	169	PF00400	0.397
LIG_APCC_ABBA_1	275	280	PF00400	0.361
LIG_APCC_ABBAyCdc20_2	163	169	PF00400	0.394
LIG_APCC_ABBAyCdc20_2	274	280	PF00400	0.367
LIG_BIR_III_2	311	315	PF00653	0.595
LIG_BRCT_BRCA1_1	496	500	PF00533	0.308
LIG_BRCT_BRCA1_1	514	518	PF00533	0.308
LIG_Clathr_ClatBox_1	477	481	PF01394	0.308
LIG_FHA_1	381	387	PF00498	0.308
LIG_FHA_2	139	145	PF00498	0.710
LIG_FHA_2	257	263	PF00498	0.399
LIG_FHA_2	392	398	PF00498	0.381
LIG_FHA_2	45	51	PF00498	0.421
LIG_LIR_Gen_1	372	380	PF02991	0.319
LIG_LIR_Gen_1	481	490	PF02991	0.327
LIG_LIR_Gen_1	515	526	PF02991	0.287
LIG_LIR_Gen_1	597	606	PF02991	0.416
LIG_LIR_Nem_3	372	376	PF02991	0.319
LIG_LIR_Nem_3	420	426	PF02991	0.417
LIG_LIR_Nem_3	481	487	PF02991	0.327
LIG_LIR_Nem_3	515	521	PF02991	0.294
LIG_LIR_Nem_3	577	583	PF02991	0.369
LIG_LIR_Nem_3	597	603	PF02991	0.240
LIG_PCNA_yPIPBox_3	346	355	PF02747	0.487
LIG_Pex14_2	373	377	PF04695	0.308
LIG_Pex14_2	482	486	PF04695	0.381
LIG_Pex14_2	87	91	PF04695	0.360
LIG_Rb_pABgroove_1	35	43	PF01858	0.502
LIG_SH2_CRK	389	393	PF00017	0.341
LIG_SH2_CRK	452	456	PF00017	0.312
LIG_SH2_STAP1	250	254	PF00017	0.467
LIG_SH2_STAP1	41	45	PF00017	0.499
LIG_SH2_STAP1	526	530	PF00017	0.453
LIG_SH2_STAP1	580	584	PF00017	0.461
LIG_SH2_STAT3	457	460	PF00017	0.327
LIG_SH2_STAT5	246	249	PF00017	0.381
LIG_SH2_STAT5	426	429	PF00017	0.449
LIG_SH2_STAT5	457	460	PF00017	0.381
LIG_SH2_STAT5	520	523	PF00017	0.285
LIG_SH3_3	123	129	PF00018	0.584
LIG_SH3_3	283	289	PF00018	0.517
LIG_SH3_3	484	490	PF00018	0.327
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.327
LIG_SUMO_SIM_anti_2	541	547	PF11976	0.370
LIG_SUMO_SIM_par_1	399	407	PF11976	0.414
LIG_TRAF2_1	29	32	PF00917	0.526
LIG_TRAF2_1	47	50	PF00917	0.423
LIG_TYR_ITIM	248	253	PF00017	0.461
LIG_TYR_ITIM	524	529	PF00017	0.420
LIG_UBA3_1	454	462	PF00899	0.362
LIG_Vh1_VBS_1	78	96	PF01044	0.241
LIG_WRC_WIRS_1	22	27	PF05994	0.550
LIG_WRC_WIRS_1	370	375	PF05994	0.415
MOD_CK1_1	130	136	PF00069	0.719
MOD_CK1_1	139	145	PF00069	0.691
MOD_CK1_1	220	226	PF00069	0.486
MOD_CK1_1	409	415	PF00069	0.428
MOD_CK1_1	544	550	PF00069	0.379
MOD_CK2_1	140	146	PF00069	0.731
MOD_CK2_1	228	234	PF00069	0.346
MOD_CK2_1	236	242	PF00069	0.429
MOD_CK2_1	26	32	PF00069	0.445
MOD_CK2_1	296	302	PF00069	0.689
MOD_CK2_1	43	49	PF00069	0.423
MOD_GlcNHglycan	133	136	PF01048	0.753
MOD_GlcNHglycan	220	223	PF01048	0.422
MOD_GlcNHglycan	28	31	PF01048	0.513
MOD_GlcNHglycan	305	308	PF01048	0.630
MOD_GlcNHglycan	405	409	PF01048	0.353
MOD_GlcNHglycan	496	499	PF01048	0.302
MOD_GlcNHglycan	590	593	PF01048	0.478
MOD_GlcNHglycan	96	99	PF01048	0.463
MOD_GSK3_1	127	134	PF00069	0.667
MOD_GSK3_1	136	143	PF00069	0.687
MOD_GSK3_1	169	176	PF00069	0.425
MOD_GSK3_1	216	223	PF00069	0.522
MOD_GSK3_1	233	240	PF00069	0.458
MOD_GSK3_1	40	47	PF00069	0.481
MOD_GSK3_1	414	421	PF00069	0.419
MOD_GSK3_1	58	65	PF00069	0.324
MOD_GSK3_1	94	101	PF00069	0.448
MOD_N-GLC_1	178	183	PF02516	0.413
MOD_N-GLC_1	228	233	PF02516	0.500
MOD_N-GLC_1	26	31	PF02516	0.545
MOD_N-GLC_1	345	350	PF02516	0.482
MOD_NEK2_1	173	178	PF00069	0.409
MOD_NEK2_1	180	185	PF00069	0.426
MOD_NEK2_1	217	222	PF00069	0.456
MOD_NEK2_1	324	329	PF00069	0.461
MOD_NEK2_1	369	374	PF00069	0.387
MOD_NEK2_1	445	450	PF00069	0.312
MOD_NEK2_1	485	490	PF00069	0.341
MOD_NEK2_1	53	58	PF00069	0.336
MOD_NEK2_1	99	104	PF00069	0.538
MOD_NEK2_2	380	385	PF00069	0.453
MOD_NMyristoyl	1	7	PF02799	0.510
MOD_PIKK_1	500	506	PF00454	0.308
MOD_PK_1	418	424	PF00069	0.347
MOD_PKA_1	414	420	PF00069	0.414
MOD_PKA_2	12	18	PF00069	0.495
MOD_PKA_2	139	145	PF00069	0.707
MOD_PKA_2	330	336	PF00069	0.478
MOD_PKA_2	417	423	PF00069	0.407
MOD_PKA_2	541	547	PF00069	0.254
MOD_Plk_1	152	158	PF00069	0.553
MOD_Plk_1	169	175	PF00069	0.479
MOD_Plk_1	228	234	PF00069	0.425
MOD_Plk_1	345	351	PF00069	0.455
MOD_Plk_1	43	49	PF00069	0.429
MOD_Plk_1	432	438	PF00069	0.420
MOD_Plk_2-3	256	262	PF00069	0.428
MOD_Plk_2-3	406	412	PF00069	0.381
MOD_Plk_2-3	44	50	PF00069	0.465
MOD_Plk_2-3	573	579	PF00069	0.411
MOD_Plk_4	152	158	PF00069	0.607
MOD_Plk_4	233	239	PF00069	0.428
MOD_Plk_4	296	302	PF00069	0.628
MOD_Plk_4	418	424	PF00069	0.362
MOD_Plk_4	432	438	PF00069	0.368
MOD_Plk_4	450	456	PF00069	0.321
MOD_Plk_4	473	479	PF00069	0.453
MOD_Plk_4	541	547	PF00069	0.382
MOD_ProDKin_1	310	316	PF00069	0.504
MOD_ProDKin_1	336	342	PF00069	0.537
MOD_ProDKin_1	486	492	PF00069	0.302
MOD_ProDKin_1	544	550	PF00069	0.360
TRG_DiLeu_BaEn_1	209	214	PF01217	0.498
TRG_ENDOCYTIC_2	250	253	PF00928	0.429
TRG_ENDOCYTIC_2	389	392	PF00928	0.327
TRG_ENDOCYTIC_2	452	455	PF00928	0.295
TRG_ENDOCYTIC_2	520	523	PF00928	0.308
TRG_ENDOCYTIC_2	526	529	PF00928	0.308
TRG_ENDOCYTIC_2	600	603	PF00928	0.422
TRG_ER_diArg_1	197	199	PF00400	0.447
TRG_ER_diArg_1	566	569	PF00400	0.374
TRG_ER_diArg_1	595	598	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J4	Leptomonas seymouri	74%	97%
A0A0S4JIN0	Bodo saltans	47%	100%
A0A1X0PA54	Trypanosomatidae	53%	100%
A0A3S7X8H7	Leishmania donovani	95%	100%
A0A422N5M8	Trypanosoma rangeli	51%	100%
A4HB77	Leishmania braziliensis	85%	100%
A4IAC5	Leishmania infantum	95%	100%
A4QPH2	Homo sapiens	27%	100%
C9ZLW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B5E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%