Adenosine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenosine kinase

Gene product:

adenosine kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q2I4_LEIMA

TriTrypDb:

LmjF.34.3600 , LMJLV39_340042200 , LMJSD75_340042500

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q2I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006144	purine nucleobase metabolic process	5	2
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006166	purine ribonucleoside salvage	5	11
GO:0006167	AMP biosynthetic process	8	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009112	nucleobase metabolic process	4	2
GO:0009116	nucleoside metabolic process	4	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009119	ribonucleoside metabolic process	5	11
GO:0009123	nucleoside monophosphate metabolic process	5	11
GO:0009124	nucleoside monophosphate biosynthetic process	6	11
GO:0009126	purine nucleoside monophosphate metabolic process	6	11
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009152	purine ribonucleotide biosynthetic process	7	11
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	11
GO:0009161	ribonucleoside monophosphate metabolic process	6	11
GO:0009163	nucleoside biosynthetic process	5	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	11
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0032261	purine nucleotide salvage	5	11
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0042278	purine nucleoside metabolic process	5	11
GO:0042451	purine nucleoside biosynthetic process	6	11
GO:0042455	ribonucleoside biosynthetic process	6	11
GO:0043094	cellular metabolic compound salvage	3	11
GO:0043101	purine-containing compound salvage	4	11
GO:0043173	nucleotide salvage	4	11
GO:0043174	nucleoside salvage	4	11
GO:0044209	AMP salvage	7	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046033	AMP metabolic process	7	11
GO:0046128	purine ribonucleoside metabolic process	6	11
GO:0046129	purine ribonucleoside biosynthetic process	7	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072522	purine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:0106380	purine ribonucleotide salvage	6	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901657	glycosyl compound metabolic process	4	11
GO:1901659	glycosyl compound biosynthetic process	5	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	11
GO:0004001	adenosine kinase activity	5	11
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	10
GO:0019205	nucleobase-containing compound kinase activity	5	11
GO:0019206	nucleoside kinase activity	6	11
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	262	264	PF00675	0.295
CLV_NRD_NRD_1	373	375	PF00675	0.476
CLV_PCSK_KEX2_1	262	264	PF00082	0.299
CLV_PCSK_KEX2_1	373	375	PF00082	0.476
CLV_PCSK_SKI1_1	108	112	PF00082	0.247
CLV_PCSK_SKI1_1	140	144	PF00082	0.225
DEG_APCC_DBOX_1	139	147	PF00400	0.425
DOC_MAPK_DCC_7	218	228	PF00069	0.493
DOC_PP1_RVXF_1	79	86	PF00149	0.451
DOC_PP2B_LxvP_1	206	209	PF13499	0.425
DOC_PP2B_LxvP_1	48	51	PF13499	0.391
DOC_PP2B_PxIxI_1	208	214	PF00149	0.508
DOC_PP4_FxxP_1	20	23	PF00568	0.311
DOC_USP7_MATH_1	161	165	PF00917	0.458
DOC_USP7_MATH_1	214	218	PF00917	0.507
DOC_USP7_MATH_1	362	366	PF00917	0.551
DOC_WW_Pin1_4	181	186	PF00397	0.425
DOC_WW_Pin1_4	278	283	PF00397	0.364
DOC_WW_Pin1_4	8	13	PF00397	0.606
LIG_14-3-3_CanoR_1	273	277	PF00244	0.507
LIG_APCC_ABBA_1	222	227	PF00400	0.412
LIG_BRCT_BRCA1_1	211	215	PF00533	0.429
LIG_EVH1_1	308	312	PF00568	0.507
LIG_FHA_1	149	155	PF00498	0.523
LIG_FHA_1	157	163	PF00498	0.488
LIG_FHA_1	342	348	PF00498	0.442
LIG_FHA_1	370	376	PF00498	0.475
LIG_FHA_1	377	383	PF00498	0.508
LIG_FHA_1	77	83	PF00498	0.435
LIG_GBD_Chelix_1	329	337	PF00786	0.195
LIG_LIR_Apic_2	307	311	PF02991	0.507
LIG_LIR_Gen_1	101	111	PF02991	0.468
LIG_LIR_Gen_1	238	245	PF02991	0.517
LIG_LIR_Nem_3	101	106	PF02991	0.426
LIG_LIR_Nem_3	238	242	PF02991	0.481
LIG_Pex14_1	244	248	PF04695	0.507
LIG_Pex14_2	328	332	PF04695	0.412
LIG_SH2_CRK	239	243	PF00017	0.507
LIG_SH2_PTP2	210	213	PF00017	0.526
LIG_SH2_SRC	173	176	PF00017	0.507
LIG_SH2_SRC	70	73	PF00017	0.458
LIG_SH2_STAT5	190	193	PF00017	0.523
LIG_SH2_STAT5	210	213	PF00017	0.370
LIG_SH2_STAT5	298	301	PF00017	0.507
LIG_SH2_STAT5	70	73	PF00017	0.458
LIG_SH2_STAT5	94	97	PF00017	0.468
LIG_SH3_1	279	285	PF00018	0.364
LIG_SH3_1	306	312	PF00018	0.507
LIG_SH3_3	218	224	PF00018	0.419
LIG_SH3_3	239	245	PF00018	0.507
LIG_SH3_3	279	285	PF00018	0.405
LIG_SH3_3	306	312	PF00018	0.468
LIG_SUMO_SIM_par_1	150	155	PF11976	0.411
LIG_TRAF2_1	314	317	PF00917	0.500
LIG_TYR_ITIM	237	242	PF00017	0.471
LIG_UBA3_1	56	65	PF00899	0.382
MOD_CDK_SPxK_1	278	284	PF00069	0.364
MOD_CK1_1	109	115	PF00069	0.570
MOD_CK1_1	376	382	PF00069	0.511
MOD_CK1_1	7	13	PF00069	0.545
MOD_CK2_1	161	167	PF00069	0.458
MOD_CK2_1	336	342	PF00069	0.380
MOD_GlcNHglycan	108	111	PF01048	0.370
MOD_GlcNHglycan	163	166	PF01048	0.339
MOD_GlcNHglycan	351	354	PF01048	0.279
MOD_GlcNHglycan	364	367	PF01048	0.446
MOD_GlcNHglycan	375	378	PF01048	0.625
MOD_GSK3_1	148	155	PF00069	0.467
MOD_GSK3_1	336	343	PF00069	0.469
MOD_GSK3_1	369	376	PF00069	0.437
MOD_GSK3_1	4	11	PF00069	0.654
MOD_NEK2_1	152	157	PF00069	0.458
MOD_NEK2_1	178	183	PF00069	0.429
MOD_PKA_1	373	379	PF00069	0.506
MOD_PKA_2	272	278	PF00069	0.507
MOD_PKA_2	373	379	PF00069	0.506
MOD_Plk_1	138	144	PF00069	0.425
MOD_Plk_1	341	347	PF00069	0.442
MOD_Plk_4	13	19	PF00069	0.434
MOD_Plk_4	167	173	PF00069	0.461
MOD_Plk_4	252	258	PF00069	0.550
MOD_Plk_4	294	300	PF00069	0.430
MOD_Plk_4	342	348	PF00069	0.529
MOD_ProDKin_1	181	187	PF00069	0.425
MOD_ProDKin_1	278	284	PF00069	0.364
MOD_ProDKin_1	8	14	PF00069	0.599
MOD_SUMO_rev_2	121	128	PF00179	0.488
MOD_SUMO_rev_2	247	253	PF00179	0.383
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.270
TRG_ENDOCYTIC_2	210	213	PF00928	0.463
TRG_ENDOCYTIC_2	239	242	PF00928	0.471
TRG_ER_diArg_1	284	287	PF00400	0.484
TRG_ER_diArg_1	373	375	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A6	Leptomonas seymouri	72%	100%
A0A0N0P8X0	Leptomonas seymouri	31%	100%
A0A0N1PDV7	Leptomonas seymouri	25%	100%
A0A0S4IRE7	Bodo saltans	34%	100%
A0A0S4JPW2	Bodo saltans	44%	100%
A0A1X0P296	Trypanosomatidae	35%	100%
A0A1X0PBE6	Trypanosomatidae	50%	100%
A0A3S5H7M6	Leishmania donovani	35%	100%
A0A3S7X8F0	Leishmania donovani	95%	100%
A0A422P4V2	Trypanosoma rangeli	38%	100%
A4HB78	Leishmania braziliensis	81%	100%
A4HI44	Leishmania braziliensis	36%	100%
A4I5C0	Leishmania infantum	35%	100%
A4IAC6	Leishmania infantum	95%	100%
C9ZQQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZQQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B0L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B0L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B5E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O49923	Physcomitrium patens	33%	100%
O93919	Schizophyllum commune	33%	100%
P47143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P55262	Cricetulus griseus	36%	100%
P55263	Homo sapiens	34%	100%
P55264	Mus musculus	35%	100%
P78825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q4Q7L5	Leishmania major	35%	100%
Q54MB5	Dictyostelium discoideum	33%	100%
Q55480	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	100%
Q64640	Rattus norvegicus	37%	100%
Q9LZG0	Arabidopsis thaliana	35%	100%
Q9SF85	Arabidopsis thaliana	34%	100%
Q9TVW2	Toxoplasma gondii	33%	100%
V5B941	Trypanosoma cruzi	35%	100%
V5BLW1	Trypanosoma cruzi	47%	96%