Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania major

UniProt:

Q4Q2I3_LEIMA

TriTrypDb:

LmjF.34.3610 , LMJLV39_340042300 , LMJSD75_340042600

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	28	30	PF00675	0.345
CLV_NRD_NRD_1	53	55	PF00675	0.347
CLV_NRD_NRD_1	69	71	PF00675	0.356
CLV_PCSK_KEX2_1	28	30	PF00082	0.369
CLV_PCSK_KEX2_1	53	55	PF00082	0.394
CLV_PCSK_SKI1_1	32	36	PF00082	0.336
CLV_PCSK_SKI1_1	53	57	PF00082	0.344
DEG_Nend_UBRbox_4	1	3	PF02207	0.653
DOC_PP2B_PxIxI_1	120	126	PF00149	0.724
DOC_PP4_FxxP_1	35	38	PF00568	0.344
DOC_USP7_MATH_1	127	131	PF00917	0.715
DOC_USP7_MATH_1	38	42	PF00917	0.444
DOC_WW_Pin1_4	14	19	PF00397	0.535
LIG_14-3-3_CanoR_1	29	39	PF00244	0.445
LIG_Actin_WH2_2	58	75	PF00022	0.401
LIG_BRCT_BRCA1_1	142	146	PF00533	0.768
LIG_FHA_1	50	56	PF00498	0.401
LIG_FHA_2	162	168	PF00498	0.704
LIG_FHA_2	5	11	PF00498	0.618
LIG_IBAR_NPY_1	160	162	PF08397	0.728
LIG_LIR_Apic_2	33	38	PF02991	0.314
LIG_LIR_Gen_1	112	123	PF02991	0.638
LIG_MLH1_MIPbox_1	142	146	PF16413	0.768
LIG_Pex14_2	35	39	PF04695	0.344
LIG_SH2_CRK	85	89	PF00017	0.482
LIG_SH2_NCK_1	85	89	PF00017	0.567
LIG_SH2_SRC	110	113	PF00017	0.559
LIG_SH2_STAP1	107	111	PF00017	0.543
LIG_SH2_STAP1	115	119	PF00017	0.545
LIG_SH2_STAP1	162	166	PF00017	0.765
LIG_SH2_STAP1	79	83	PF00017	0.535
LIG_SH2_STAT3	19	22	PF00017	0.525
LIG_SH2_STAT5	110	113	PF00017	0.597
LIG_SH2_STAT5	145	148	PF00017	0.735
LIG_SH2_STAT5	47	50	PF00017	0.344
LIG_TRAF2_1	99	102	PF00917	0.607
LIG_UBA3_1	135	141	PF00899	0.724
MOD_CDC14_SPxK_1	17	20	PF00782	0.515
MOD_CDK_SPxK_1	14	20	PF00069	0.534
MOD_CK2_1	161	167	PF00069	0.684
MOD_CK2_1	37	43	PF00069	0.497
MOD_CK2_1	4	10	PF00069	0.686
MOD_CK2_1	96	102	PF00069	0.647
MOD_GlcNHglycan	102	105	PF01048	0.586
MOD_GlcNHglycan	112	115	PF01048	0.389
MOD_GlcNHglycan	128	132	PF01048	0.587
MOD_GSK3_1	33	40	PF00069	0.440
MOD_GSK3_1	96	103	PF00069	0.613
MOD_NEK2_1	139	144	PF00069	0.669
MOD_NEK2_1	49	54	PF00069	0.368
MOD_NEK2_1	96	101	PF00069	0.594
MOD_NEK2_2	4	9	PF00069	0.607
MOD_PIKK_1	140	146	PF00454	0.691
MOD_Plk_4	22	28	PF00069	0.369
MOD_ProDKin_1	14	20	PF00069	0.534
MOD_SUMO_rev_2	64	72	PF00179	0.444
TRG_ENDOCYTIC_2	115	118	PF00928	0.631
TRG_ER_diArg_1	27	29	PF00400	0.369
TRG_ER_diArg_1	53	55	PF00400	0.392
TRG_NES_CRM1_1	66	80	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT17	Leptomonas seymouri	78%	100%
A0A0S4JIG2	Bodo saltans	52%	100%
A0A1X0PAC2	Trypanosomatidae	60%	100%
A0A3S7X8B7	Leishmania donovani	97%	100%
A4HB79	Leishmania braziliensis	92%	100%
A4IAC7	Leishmania infantum	96%	100%
C9ZLW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B5F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%