PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3336)/Patatin-like phospholipase, putative

Species:

Leishmania major

UniProt:

Q4Q2I2_LEIMA

TriTrypDb:

LmjF.34.3620 , LMJLV39_340042400 , LMJSD75_340042700 , LMJSD75_340042800

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q2I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004806	triglyceride lipase activity	5	11
GO:0016298	lipase activity	4	11
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0052689	carboxylic ester hydrolase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.389
CLV_C14_Caspase3-7	261	265	PF00656	0.409
CLV_C14_Caspase3-7	74	78	PF00656	0.504
CLV_MEL_PAP_1	156	162	PF00089	0.331
CLV_NRD_NRD_1	133	135	PF00675	0.321
CLV_NRD_NRD_1	322	324	PF00675	0.349
CLV_PCSK_FUR_1	266	270	PF00082	0.331
CLV_PCSK_KEX2_1	133	135	PF00082	0.360
CLV_PCSK_KEX2_1	268	270	PF00082	0.292
CLV_PCSK_KEX2_1	322	324	PF00082	0.320
CLV_PCSK_KEX2_1	564	566	PF00082	0.399
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.346
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.399
CLV_PCSK_SKI1_1	175	179	PF00082	0.378
CLV_PCSK_SKI1_1	419	423	PF00082	0.326
CLV_PCSK_SKI1_1	497	501	PF00082	0.415
DEG_APCC_DBOX_1	174	182	PF00400	0.581
DEG_APCC_DBOX_1	434	442	PF00400	0.595
DEG_Nend_UBRbox_2	1	3	PF02207	0.444
DEG_SIAH_1	351	359	PF03145	0.567
DEG_SPOP_SBC_1	358	362	PF00917	0.684
DOC_CYCLIN_yCln2_LP_2	214	217	PF00134	0.330
DOC_MAPK_gen_1	304	313	PF00069	0.478
DOC_MAPK_gen_1	322	329	PF00069	0.493
DOC_MAPK_gen_1	417	426	PF00069	0.588
DOC_MAPK_MEF2A_6	304	313	PF00069	0.534
DOC_MAPK_MEF2A_6	322	331	PF00069	0.433
DOC_PP1_RVXF_1	476	483	PF00149	0.631
DOC_PP2B_LxvP_1	214	217	PF13499	0.315
DOC_PP2B_LxvP_1	309	312	PF13499	0.535
DOC_PP2B_LxvP_1	41	44	PF13499	0.642
DOC_SPAK_OSR1_1	425	429	PF12202	0.565
DOC_USP7_MATH_1	312	316	PF00917	0.534
DOC_USP7_MATH_1	358	362	PF00917	0.730
DOC_USP7_MATH_1	400	404	PF00917	0.658
DOC_USP7_MATH_1	512	516	PF00917	0.556
DOC_USP7_MATH_1	68	72	PF00917	0.540
DOC_USP7_UBL2_3	139	143	PF12436	0.449
DOC_WW_Pin1_4	314	319	PF00397	0.454
DOC_WW_Pin1_4	334	339	PF00397	0.520
DOC_WW_Pin1_4	489	494	PF00397	0.657
DOC_WW_Pin1_4	522	527	PF00397	0.582
LIG_14-3-3_CanoR_1	382	388	PF00244	0.649
LIG_14-3-3_CanoR_1	462	466	PF00244	0.642
LIG_14-3-3_CanoR_1	550	556	PF00244	0.570
LIG_BRCT_BRCA1_1	199	203	PF00533	0.415
LIG_BRCT_BRCA1_1	27	31	PF00533	0.397
LIG_BRCT_BRCA1_1	87	91	PF00533	0.535
LIG_deltaCOP1_diTrp_1	264	270	PF00928	0.506
LIG_deltaCOP1_diTrp_1	459	465	PF00928	0.580
LIG_eIF4E_1	185	191	PF01652	0.464
LIG_FHA_1	140	146	PF00498	0.442
LIG_FHA_1	17	23	PF00498	0.285
LIG_FHA_1	172	178	PF00498	0.573
LIG_FHA_1	186	192	PF00498	0.423
LIG_FHA_1	274	280	PF00498	0.550
LIG_FHA_1	303	309	PF00498	0.464
LIG_FHA_1	372	378	PF00498	0.649
LIG_FHA_1	462	468	PF00498	0.626
LIG_FHA_2	295	301	PF00498	0.466
LIG_FHA_2	334	340	PF00498	0.530
LIG_FHA_2	496	502	PF00498	0.734
LIG_FHA_2	59	65	PF00498	0.467
LIG_FHA_2	70	76	PF00498	0.535
LIG_FHA_2	97	103	PF00498	0.535
LIG_GBD_Chelix_1	22	30	PF00786	0.397
LIG_LIR_Apic_2	361	367	PF02991	0.603
LIG_LIR_Gen_1	148	157	PF02991	0.452
LIG_LIR_Gen_1	514	524	PF02991	0.608
LIG_LIR_Nem_3	148	152	PF02991	0.442
LIG_LIR_Nem_3	19	24	PF02991	0.420
LIG_LIR_Nem_3	264	270	PF02991	0.528
LIG_LIR_Nem_3	459	463	PF02991	0.555
LIG_LIR_Nem_3	514	520	PF02991	0.604
LIG_LIR_Nem_3	64	69	PF02991	0.440
LIG_LIR_Nem_3	88	93	PF02991	0.466
LIG_MLH1_MIPbox_1	87	91	PF16413	0.535
LIG_NRBOX	437	443	PF00104	0.592
LIG_Pex14_2	422	426	PF04695	0.573
LIG_PTB_Apo_2	307	314	PF02174	0.460
LIG_SH2_CRK	149	153	PF00017	0.502
LIG_SH2_CRK	27	31	PF00017	0.397
LIG_SH2_CRK	364	368	PF00017	0.603
LIG_SH2_CRK	463	467	PF00017	0.464
LIG_SH2_CRK	485	489	PF00017	0.648
LIG_SH2_CRK	50	54	PF00017	0.530
LIG_SH2_NCK_1	364	368	PF00017	0.579
LIG_SH2_NCK_1	485	489	PF00017	0.648
LIG_SH2_SRC	364	367	PF00017	0.583
LIG_SH2_SRC	390	393	PF00017	0.563
LIG_SH2_STAP1	27	31	PF00017	0.397
LIG_SH2_STAP1	463	467	PF00017	0.560
LIG_SH2_STAP1	485	489	PF00017	0.601
LIG_SH2_STAP1	63	67	PF00017	0.475
LIG_SH2_STAT5	136	139	PF00017	0.466
LIG_SH2_STAT5	21	24	PF00017	0.417
LIG_SH2_STAT5	334	337	PF00017	0.477
LIG_SH2_STAT5	437	440	PF00017	0.608
LIG_SH2_STAT5	463	466	PF00017	0.588
LIG_SH2_STAT5	519	522	PF00017	0.614
LIG_SH2_STAT5	90	93	PF00017	0.535
LIG_SH3_2	318	323	PF14604	0.473
LIG_SH3_3	276	282	PF00018	0.530
LIG_SH3_3	315	321	PF00018	0.473
LIG_SH3_3	408	414	PF00018	0.614
LIG_SUMO_SIM_par_1	101	108	PF11976	0.500
LIG_SUMO_SIM_par_1	281	287	PF11976	0.497
LIG_SUMO_SIM_par_1	39	46	PF11976	0.612
LIG_TRAF2_1	62	65	PF00917	0.504
LIG_TRAF2_1	99	102	PF00917	0.522
LIG_TYR_ITIM	25	30	PF00017	0.397
LIG_TYR_ITIM	407	412	PF00017	0.642
LIG_UBA3_1	115	121	PF00899	0.512
LIG_WRC_WIRS_1	496	501	PF05994	0.686
LIG_WRC_WIRS_1	90	95	PF05994	0.535
MOD_CK1_1	108	114	PF00069	0.550
MOD_CK1_1	148	154	PF00069	0.511
MOD_CK1_1	179	185	PF00069	0.522
MOD_CK1_1	360	366	PF00069	0.683
MOD_CK1_1	430	436	PF00069	0.510
MOD_CK1_1	492	498	PF00069	0.714
MOD_CK1_1	525	531	PF00069	0.644
MOD_CK2_1	247	253	PF00069	0.568
MOD_CK2_1	294	300	PF00069	0.442
MOD_CK2_1	495	501	PF00069	0.720
MOD_CK2_1	58	64	PF00069	0.474
MOD_CK2_1	96	102	PF00069	0.495
MOD_GlcNHglycan	110	113	PF01048	0.311
MOD_GlcNHglycan	199	202	PF01048	0.409
MOD_GlcNHglycan	2	5	PF01048	0.650
MOD_GlcNHglycan	221	224	PF01048	0.397
MOD_GlcNHglycan	314	317	PF01048	0.271
MOD_GlcNHglycan	343	346	PF01048	0.277
MOD_GlcNHglycan	402	405	PF01048	0.450
MOD_GlcNHglycan	444	447	PF01048	0.481
MOD_GSK3_1	137	144	PF00069	0.530
MOD_GSK3_1	233	240	PF00069	0.424
MOD_GSK3_1	243	250	PF00069	0.548
MOD_GSK3_1	258	265	PF00069	0.464
MOD_GSK3_1	378	385	PF00069	0.557
MOD_GSK3_1	395	402	PF00069	0.614
MOD_GSK3_1	491	498	PF00069	0.726
MOD_GSK3_1	81	88	PF00069	0.537
MOD_N-GLC_1	57	62	PF02516	0.268
MOD_NEK2_1	137	142	PF00069	0.511
MOD_NEK2_1	197	202	PF00069	0.424
MOD_NEK2_1	227	232	PF00069	0.476
MOD_NEK2_1	241	246	PF00069	0.445
MOD_NEK2_1	258	263	PF00069	0.464
MOD_NEK2_1	289	294	PF00069	0.499
MOD_NEK2_1	341	346	PF00069	0.477
MOD_NEK2_1	378	383	PF00069	0.570
MOD_NEK2_1	442	447	PF00069	0.636
MOD_NEK2_1	549	554	PF00069	0.533
MOD_NEK2_1	559	564	PF00069	0.529
MOD_PKA_2	461	467	PF00069	0.642
MOD_PKA_2	549	555	PF00069	0.562
MOD_PKB_1	380	388	PF00069	0.559
MOD_Plk_1	179	185	PF00069	0.547
MOD_Plk_1	294	300	PF00069	0.451
MOD_Plk_1	430	436	PF00069	0.517
MOD_Plk_1	85	91	PF00069	0.535
MOD_Plk_2-3	105	111	PF00069	0.378
MOD_Plk_2-3	247	253	PF00069	0.378
MOD_Plk_4	11	17	PF00069	0.463
MOD_Plk_4	141	147	PF00069	0.477
MOD_Plk_4	148	154	PF00069	0.399
MOD_Plk_4	227	233	PF00069	0.388
MOD_Plk_4	237	243	PF00069	0.514
MOD_Plk_4	373	379	PF00069	0.641
MOD_Plk_4	383	389	PF00069	0.605
MOD_Plk_4	461	467	PF00069	0.517
MOD_Plk_4	512	518	PF00069	0.612
MOD_Plk_4	86	92	PF00069	0.535
MOD_ProDKin_1	314	320	PF00069	0.454
MOD_ProDKin_1	334	340	PF00069	0.520
MOD_ProDKin_1	489	495	PF00069	0.655
MOD_ProDKin_1	522	528	PF00069	0.584
TRG_DiLeu_BaEn_1	253	258	PF01217	0.449
TRG_DiLeu_BaEn_4	101	107	PF01217	0.535
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.535
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.622
TRG_ENDOCYTIC_2	149	152	PF00928	0.478
TRG_ENDOCYTIC_2	27	30	PF00928	0.397
TRG_ENDOCYTIC_2	409	412	PF00928	0.688
TRG_ENDOCYTIC_2	463	466	PF00928	0.547
TRG_ENDOCYTIC_2	485	488	PF00928	0.659
TRG_ENDOCYTIC_2	50	53	PF00928	0.606
TRG_ENDOCYTIC_2	519	522	PF00928	0.619
TRG_ENDOCYTIC_2	90	93	PF00928	0.483
TRG_ER_diArg_1	133	135	PF00400	0.521
TRG_ER_diArg_1	172	175	PF00400	0.601
TRG_ER_diArg_1	321	323	PF00400	0.547
TRG_ER_diArg_1	380	383	PF00400	0.609
TRG_ER_diArg_1	451	454	PF00400	0.661
TRG_NES_CRM1_1	416	431	PF08389	0.514
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P1	Leptomonas seymouri	27%	69%
A0A0N1P9M9	Leptomonas seymouri	59%	99%
A0A0S4JME6	Bodo saltans	29%	100%
A0A1X0PA17	Trypanosomatidae	33%	100%
A0A3Q8INR2	Leishmania donovani	94%	100%
A0A422N5R5	Trypanosoma rangeli	33%	100%
A1CRG6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	28%	80%
A4HB80	Leishmania braziliensis	83%	100%
A4HIE6	Leishmania braziliensis	28%	75%
A4IAC8	Leishmania infantum	94%	100%
A5DIR3	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	79%
A5DUA8	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	26%	70%
E9B5F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	92%
Q5AM72	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	67%
Q6BXC8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	72%
Q9LZA6	Arabidopsis thaliana	24%	69%
Q9M1I6	Arabidopsis thaliana	24%	71%
Q9Y7P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5BW64	Trypanosoma cruzi	34%	100%