Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2I1_LEIMA

TriTrypDb:

LmjF.34.3630 , LMJLV39_340042500 , LMJSD75_340042900

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 14, no: 2
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

Q4Q2I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016787	hydrolase activity	2	14
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	1
GO:0004564	beta-fructofuranosidase activity	5	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.343
CLV_NRD_NRD_1	399	401	PF00675	0.597
CLV_NRD_NRD_1	511	513	PF00675	0.502
CLV_PCSK_FUR_1	509	513	PF00082	0.499
CLV_PCSK_KEX2_1	230	232	PF00082	0.522
CLV_PCSK_KEX2_1	249	251	PF00082	0.395
CLV_PCSK_KEX2_1	511	513	PF00082	0.502
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.542
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.542
CLV_PCSK_PC7_1	226	232	PF00082	0.542
CLV_PCSK_SKI1_1	113	117	PF00082	0.531
CLV_PCSK_SKI1_1	277	281	PF00082	0.554
CLV_PCSK_SKI1_1	292	296	PF00082	0.442
CLV_PCSK_SKI1_1	351	355	PF00082	0.575
CLV_PCSK_SKI1_1	382	386	PF00082	0.537
CLV_PCSK_SKI1_1	44	48	PF00082	0.560
DEG_APCC_DBOX_1	218	226	PF00400	0.286
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DOC_MAPK_gen_1	274	284	PF00069	0.336
DOC_MAPK_gen_1	400	411	PF00069	0.324
DOC_MAPK_MEF2A_6	277	284	PF00069	0.327
DOC_MAPK_MEF2A_6	298	306	PF00069	0.358
DOC_PP2B_LxvP_1	294	297	PF13499	0.352
DOC_USP7_MATH_1	168	172	PF00917	0.344
DOC_USP7_MATH_1	433	437	PF00917	0.442
DOC_USP7_MATH_1	73	77	PF00917	0.341
DOC_USP7_MATH_1	95	99	PF00917	0.358
DOC_WW_Pin1_4	307	312	PF00397	0.274
DOC_WW_Pin1_4	50	55	PF00397	0.264
DOC_WW_Pin1_4	76	81	PF00397	0.322
LIG_14-3-3_CanoR_1	113	118	PF00244	0.331
LIG_14-3-3_CanoR_1	367	373	PF00244	0.349
LIG_14-3-3_CanoR_1	382	387	PF00244	0.347
LIG_14-3-3_CanoR_1	468	476	PF00244	0.668
LIG_14-3-3_CanoR_1	511	515	PF00244	0.742
LIG_BRCT_BRCA1_1	108	112	PF00533	0.335
LIG_BRCT_BRCA1_1	309	313	PF00533	0.360
LIG_BRCT_BRCA1_1	393	397	PF00533	0.301
LIG_deltaCOP1_diTrp_1	376	387	PF00928	0.323
LIG_deltaCOP1_diTrp_1	88	94	PF00928	0.323
LIG_FHA_1	18	24	PF00498	0.574
LIG_FHA_1	242	248	PF00498	0.283
LIG_FHA_1	325	331	PF00498	0.282
LIG_FHA_1	498	504	PF00498	0.768
LIG_FHA_2	144	150	PF00498	0.260
LIG_FHA_2	336	342	PF00498	0.375
LIG_FHA_2	376	382	PF00498	0.336
LIG_FHA_2	69	75	PF00498	0.286
LIG_LIR_Gen_1	244	252	PF02991	0.324
LIG_LIR_Gen_1	266	276	PF02991	0.282
LIG_LIR_Gen_1	377	387	PF02991	0.330
LIG_LIR_Gen_1	473	483	PF02991	0.687
LIG_LIR_LC3C_4	278	282	PF02991	0.286
LIG_LIR_Nem_3	109	115	PF02991	0.297
LIG_LIR_Nem_3	138	143	PF02991	0.319
LIG_LIR_Nem_3	244	248	PF02991	0.310
LIG_LIR_Nem_3	266	272	PF02991	0.247
LIG_LIR_Nem_3	275	279	PF02991	0.237
LIG_LIR_Nem_3	288	294	PF02991	0.230
LIG_LIR_Nem_3	33	39	PF02991	0.298
LIG_LIR_Nem_3	377	383	PF02991	0.308
LIG_NRBOX	190	196	PF00104	0.307
LIG_PDZ_Class_1	510	515	PF00595	0.687
LIG_Pex14_1	261	265	PF04695	0.243
LIG_Pex14_2	324	328	PF04695	0.384
LIG_Pex14_2	383	387	PF04695	0.356
LIG_PTB_Apo_2	172	179	PF02174	0.331
LIG_PTB_Phospho_1	172	178	PF10480	0.331
LIG_SH2_CRK	245	249	PF00017	0.339
LIG_SH2_CRK	269	273	PF00017	0.295
LIG_SH2_CRK	36	40	PF00017	0.260
LIG_SH2_CRK	429	433	PF00017	0.411
LIG_SH2_NCK_1	361	365	PF00017	0.224
LIG_SH2_PTP2	408	411	PF00017	0.349
LIG_SH2_STAP1	179	183	PF00017	0.314
LIG_SH2_STAP1	265	269	PF00017	0.337
LIG_SH2_STAT3	56	59	PF00017	0.260
LIG_SH2_STAT5	140	143	PF00017	0.239
LIG_SH2_STAT5	179	182	PF00017	0.273
LIG_SH2_STAT5	319	322	PF00017	0.268
LIG_SH2_STAT5	337	340	PF00017	0.227
LIG_SH2_STAT5	408	411	PF00017	0.346
LIG_SH2_STAT5	85	88	PF00017	0.314
LIG_SH3_3	199	205	PF00018	0.287
LIG_SH3_3	340	346	PF00018	0.370
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.355
LIG_SUMO_SIM_anti_2	446	453	PF11976	0.323
LIG_SUMO_SIM_par_1	187	193	PF11976	0.239
LIG_SUMO_SIM_par_1	446	453	PF11976	0.354
LIG_SUMO_SIM_par_1	463	469	PF11976	0.570
LIG_TRAF2_1	147	150	PF00917	0.334
LIG_TRAF2_1	490	493	PF00917	0.700
LIG_TRFH_1	429	433	PF08558	0.361
LIG_TYR_ITIM	34	39	PF00017	0.286
MOD_CK1_1	142	148	PF00069	0.276
MOD_CK1_1	203	209	PF00069	0.323
MOD_CK1_1	335	341	PF00069	0.382
MOD_CK1_1	355	361	PF00069	0.366
MOD_CK1_1	436	442	PF00069	0.494
MOD_CK1_1	457	463	PF00069	0.375
MOD_CK1_1	469	475	PF00069	0.612
MOD_CK1_1	487	493	PF00069	0.719
MOD_CK1_1	494	500	PF00069	0.729
MOD_CK1_1	50	56	PF00069	0.264
MOD_CK1_1	76	82	PF00069	0.265
MOD_CK2_1	143	149	PF00069	0.336
MOD_CK2_1	346	352	PF00069	0.375
MOD_CK2_1	410	416	PF00069	0.336
MOD_CK2_1	487	493	PF00069	0.690
MOD_CK2_1	499	505	PF00069	0.702
MOD_GlcNHglycan	126	129	PF01048	0.536
MOD_GlcNHglycan	253	256	PF01048	0.540
MOD_GlcNHglycan	348	351	PF01048	0.567
MOD_GlcNHglycan	445	448	PF01048	0.373
MOD_GlcNHglycan	456	459	PF01048	0.362
MOD_GlcNHglycan	468	471	PF01048	0.425
MOD_GlcNHglycan	480	483	PF01048	0.480
MOD_GlcNHglycan	74	78	PF01048	0.520
MOD_GSK3_1	113	120	PF00069	0.294
MOD_GSK3_1	139	146	PF00069	0.268
MOD_GSK3_1	213	220	PF00069	0.328
MOD_GSK3_1	355	362	PF00069	0.304
MOD_GSK3_1	368	375	PF00069	0.302
MOD_GSK3_1	439	446	PF00069	0.462
MOD_GSK3_1	450	457	PF00069	0.373
MOD_GSK3_1	46	53	PF00069	0.303
MOD_GSK3_1	466	473	PF00069	0.629
MOD_GSK3_1	474	481	PF00069	0.528
MOD_GSK3_1	487	494	PF00069	0.604
MOD_GSK3_1	495	502	PF00069	0.701
MOD_N-GLC_1	113	118	PF02516	0.409
MOD_N-GLC_1	206	211	PF02516	0.494
MOD_N-GLC_1	322	327	PF02516	0.575
MOD_N-GLC_1	417	422	PF02516	0.572
MOD_N-GLC_1	427	432	PF02516	0.630
MOD_N-GLC_1	494	499	PF02516	0.543
MOD_N-GLC_1	95	100	PF02516	0.510
MOD_NEK2_1	143	148	PF00069	0.277
MOD_NEK2_1	18	23	PF00069	0.532
MOD_NEK2_1	285	290	PF00069	0.287
MOD_NEK2_1	39	44	PF00069	0.343
MOD_NEK2_1	454	459	PF00069	0.364
MOD_NEK2_1	46	51	PF00069	0.351
MOD_NEK2_1	466	471	PF00069	0.596
MOD_NEK2_1	474	479	PF00069	0.467
MOD_NEK2_1	67	72	PF00069	0.231
MOD_NEK2_1	94	99	PF00069	0.300
MOD_PIKK_1	433	439	PF00454	0.437
MOD_PKA_2	335	341	PF00069	0.391
MOD_PKB_1	111	119	PF00069	0.331
MOD_Plk_1	113	119	PF00069	0.242
MOD_Plk_1	168	174	PF00069	0.298
MOD_Plk_1	265	271	PF00069	0.350
MOD_Plk_1	375	381	PF00069	0.401
MOD_Plk_1	427	433	PF00069	0.422
MOD_Plk_1	61	67	PF00069	0.328
MOD_Plk_1	95	101	PF00069	0.277
MOD_Plk_4	168	174	PF00069	0.352
MOD_Plk_4	190	196	PF00069	0.248
MOD_Plk_4	268	274	PF00069	0.295
MOD_Plk_4	315	321	PF00069	0.252
MOD_Plk_4	375	381	PF00069	0.359
MOD_Plk_4	382	388	PF00069	0.310
MOD_Plk_4	410	416	PF00069	0.265
MOD_Plk_4	427	433	PF00069	0.278
MOD_Plk_4	439	445	PF00069	0.425
MOD_Plk_4	450	456	PF00069	0.309
MOD_Plk_4	484	490	PF00069	0.746
MOD_Plk_4	78	84	PF00069	0.299
MOD_ProDKin_1	307	313	PF00069	0.280
MOD_ProDKin_1	50	56	PF00069	0.264
MOD_ProDKin_1	76	82	PF00069	0.322
MOD_SUMO_rev_2	271	279	PF00179	0.335
TRG_DiLeu_BaEn_1	275	280	PF01217	0.339
TRG_ENDOCYTIC_2	140	143	PF00928	0.310
TRG_ENDOCYTIC_2	179	182	PF00928	0.250
TRG_ENDOCYTIC_2	245	248	PF00928	0.301
TRG_ENDOCYTIC_2	269	272	PF00928	0.259
TRG_ENDOCYTIC_2	276	279	PF00928	0.253
TRG_ENDOCYTIC_2	36	39	PF00928	0.268
TRG_ENDOCYTIC_2	408	411	PF00928	0.340
TRG_ENDOCYTIC_2	429	432	PF00928	0.446
TRG_NES_CRM1_1	107	118	PF08389	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ4	Leptomonas seymouri	54%	100%
A0A0S4JMD5	Bodo saltans	29%	100%
A0A0S4JQJ5	Bodo saltans	33%	91%
A0A1X0PA11	Trypanosomatidae	29%	100%
A0A1X0PAC3	Trypanosomatidae	37%	99%
A0A3Q8IHH9	Leishmania donovani	90%	100%
A0A3R7K6I9	Trypanosoma rangeli	34%	100%
A0A3R7KT12	Trypanosoma rangeli	27%	100%
A4HB81	Leishmania braziliensis	63%	100%
A4IAC9	Leishmania infantum	91%	100%
C9ZLW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZLW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AHU3	Leishmania infantum	37%	100%
E9B5F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P70158	Mus musculus	24%	100%
Q04519	Mus musculus	23%	82%
Q3ZC91	Bos taurus	22%	100%
Q54SR8	Dictyostelium discoideum	23%	100%
Q55C09	Dictyostelium discoideum	23%	88%
Q641Z7	Rattus norvegicus	22%	100%
Q92484	Homo sapiens	22%	100%
V5DMV6	Trypanosoma cruzi	28%	100%