LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q2I0_LEIMA
TriTrypDb:
LmjF.34.3640 , LMJLV39_340042600 * , LMJSD75_340043000 *
Length:
162

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 3, no: 7
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q2I0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2I0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.484
CLV_NRD_NRD_1 95 97 PF00675 0.476
CLV_PCSK_KEX2_1 102 104 PF00082 0.480
CLV_PCSK_KEX2_1 95 97 PF00082 0.479
DEG_SPOP_SBC_1 24 28 PF00917 0.674
DOC_MAPK_gen_1 65 73 PF00069 0.673
DOC_PP1_RVXF_1 73 79 PF00149 0.700
DOC_USP7_MATH_1 10 14 PF00917 0.443
DOC_USP7_MATH_1 138 142 PF00917 0.718
DOC_USP7_MATH_1 151 155 PF00917 0.703
DOC_USP7_MATH_1 2 6 PF00917 0.671
DOC_WW_Pin1_4 17 22 PF00397 0.326
LIG_eIF4E_1 57 63 PF01652 0.574
LIG_FHA_1 40 46 PF00498 0.382
LIG_FHA_2 9 15 PF00498 0.281
LIG_GBD_Chelix_1 51 59 PF00786 0.446
LIG_LIR_Gen_1 70 78 PF02991 0.694
LIG_LIR_Nem_3 58 63 PF02991 0.606
LIG_LIR_Nem_3 70 76 PF02991 0.662
LIG_SH2_STAT5 57 60 PF00017 0.568
LIG_SH3_3 154 160 PF00018 0.761
LIG_SUMO_SIM_anti_2 42 48 PF11976 0.414
LIG_UBA3_1 84 93 PF00899 0.612
MOD_CK1_1 141 147 PF00069 0.676
MOD_CK1_1 20 26 PF00069 0.281
MOD_CK2_1 71 77 PF00069 0.683
MOD_CK2_1 8 14 PF00069 0.281
MOD_GlcNHglycan 108 111 PF01048 0.616
MOD_GlcNHglycan 143 146 PF01048 0.478
MOD_GlcNHglycan 22 25 PF01048 0.273
MOD_GlcNHglycan 67 70 PF01048 0.571
MOD_GSK3_1 151 158 PF00069 0.779
MOD_GSK3_1 20 27 PF00069 0.398
MOD_GSK3_1 65 72 PF00069 0.769
MOD_NEK2_1 47 52 PF00069 0.443
MOD_NEK2_1 55 60 PF00069 0.461
MOD_NEK2_1 71 76 PF00069 0.735
MOD_PIKK_1 138 144 PF00454 0.695
MOD_Plk_1 151 157 PF00069 0.779
MOD_Plk_1 69 75 PF00069 0.687
MOD_Plk_4 47 53 PF00069 0.485
MOD_Plk_4 55 61 PF00069 0.517
MOD_ProDKin_1 17 23 PF00069 0.326
MOD_SUMO_for_1 89 92 PF00179 0.753
TRG_ENDOCYTIC_2 122 125 PF00928 0.717
TRG_ER_diArg_1 64 67 PF00400 0.678
TRG_ER_diArg_1 94 96 PF00400 0.627

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA23 Leptomonas seymouri 50% 88%
A0A3Q8ILG5 Leishmania donovani 60% 100%
A0A3S7X8E8 Leishmania donovani 87% 100%
A4HB82 Leishmania braziliensis 61% 70%
A4HB83 Leishmania braziliensis 55% 100%
A4IAD0 Leishmania infantum 86% 100%
A4IAD1 Leishmania infantum 56% 93%
E9B5F3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%
E9B5F5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS