Putative 60S ribosomal protein L21

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L21, putative

Species:

Leishmania major

UniProt:

Q4Q2H9_LEIMA

TriTrypDb:

LmjF.34.3650 , LMJLV39_340042800 , LMJSD75_340043200

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	16
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0044391	ribosomal subunit	3	3
GO:0110165	cellular anatomical entity	1	14

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Expansion

Sequence features

Q4Q2H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2H9

PDB structure(s): 6az3_S

Function

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Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	17
GO:0006518	peptide metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009058	biosynthetic process	2	17
GO:0009059	macromolecule biosynthetic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	17

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Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.494
CLV_NRD_NRD_1	19	21	PF00675	0.312
CLV_NRD_NRD_1	85	87	PF00675	0.304
CLV_NRD_NRD_1	96	98	PF00675	0.304
CLV_PCSK_KEX2_1	148	150	PF00082	0.494
CLV_PCSK_KEX2_1	87	89	PF00082	0.304
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.304
CLV_PCSK_PC7_1	83	89	PF00082	0.304
CLV_PCSK_SKI1_1	12	16	PF00082	0.321
DOC_MAPK_gen_1	83	93	PF00069	0.504

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JD84	Bodo saltans	76%	100%
A0A0S4JRZ0	Bodo saltans	77%	100%
A0A1X0PA26	Trypanosomatidae	86%	100%
A0A3Q8ICH0	Leishmania donovani	98%	100%
A0A3R7NZ63	Trypanosoma rangeli	84%	100%
A0A3R7RE25	Trypanosoma rangeli	86%	100%
A0A422N2X9	Trypanosoma rangeli	86%	100%
A4H8H2	Leishmania braziliensis	97%	100%
A4HB84	Leishmania braziliensis	97%	100%
A4HWU4	Leishmania infantum	97%	100%

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