LeishMANIAdb
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Transmembrane 9 superfamily member

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane 9 superfamily member
Gene product:
transmembrane/endomembrane-like protein
Species:
Leishmania major
UniProt:
Q4Q2H8_LEIMA
TriTrypDb:
LmjF.34.3660 , LMJLV39_340042900 * , LMJSD75_340043300
Length:
637

Annotations

LeishMANIAdb annotations

A compact protein with N-terminal signal peptide and 9 TM segments at the C-terminus. related to other Eukaryotic proteins of the same superfamily, sugguested to regulate vesicular pH. Localization: Endosomal (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 8, no: 1
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4Q2H8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2H8

Function

Biological processes
Term Name Level Count
GO:0008104 protein localization 4 2
GO:0009987 cellular process 1 2
GO:0033036 macromolecule localization 2 2
GO:0051179 localization 1 2
GO:0051641 cellular localization 2 2
GO:0051668 localization within membrane 3 2
GO:0070727 cellular macromolecule localization 3 2
GO:0072657 protein localization to membrane 4 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 236 240 PF00656 0.331
CLV_C14_Caspase3-7 488 492 PF00656 0.484
CLV_MEL_PAP_1 475 481 PF00089 0.312
CLV_NRD_NRD_1 126 128 PF00675 0.538
CLV_NRD_NRD_1 272 274 PF00675 0.541
CLV_NRD_NRD_1 301 303 PF00675 0.267
CLV_NRD_NRD_1 58 60 PF00675 0.591
CLV_NRD_NRD_1 82 84 PF00675 0.500
CLV_PCSK_FUR_1 56 60 PF00082 0.585
CLV_PCSK_KEX2_1 126 128 PF00082 0.545
CLV_PCSK_KEX2_1 272 274 PF00082 0.467
CLV_PCSK_KEX2_1 58 60 PF00082 0.591
CLV_PCSK_KEX2_1 586 588 PF00082 0.538
CLV_PCSK_KEX2_1 82 84 PF00082 0.547
CLV_PCSK_PC1ET2_1 586 588 PF00082 0.538
CLV_PCSK_SKI1_1 139 143 PF00082 0.538
CLV_PCSK_SKI1_1 241 245 PF00082 0.498
CLV_PCSK_SKI1_1 276 280 PF00082 0.376
CLV_PCSK_SKI1_1 396 400 PF00082 0.267
DEG_APCC_DBOX_1 57 65 PF00400 0.399
DEG_Nend_UBRbox_1 1 4 PF02207 0.670
DOC_CYCLIN_yCln2_LP_2 161 167 PF00134 0.327
DOC_MAPK_gen_1 15 24 PF00069 0.575
DOC_MAPK_gen_1 238 247 PF00069 0.312
DOC_MAPK_gen_1 299 309 PF00069 0.507
DOC_MAPK_HePTP_8 589 601 PF00069 0.350
DOC_MAPK_MEF2A_6 15 24 PF00069 0.603
DOC_MAPK_MEF2A_6 302 309 PF00069 0.538
DOC_MAPK_MEF2A_6 592 601 PF00069 0.327
DOC_PP4_FxxP_1 332 335 PF00568 0.467
DOC_USP7_MATH_1 146 150 PF00917 0.338
DOC_USP7_MATH_1 167 171 PF00917 0.215
DOC_USP7_MATH_1 433 437 PF00917 0.351
DOC_USP7_MATH_1 477 481 PF00917 0.527
DOC_USP7_MATH_1 54 58 PF00917 0.366
DOC_USP7_MATH_1 593 597 PF00917 0.353
DOC_USP7_MATH_1 614 618 PF00917 0.462
DOC_USP7_UBL2_3 173 177 PF12436 0.367
DOC_WW_Pin1_4 148 153 PF00397 0.376
DOC_WW_Pin1_4 46 51 PF00397 0.416
DOC_WW_Pin1_4 59 64 PF00397 0.380
LIG_14-3-3_CanoR_1 276 281 PF00244 0.228
LIG_14-3-3_CanoR_1 478 486 PF00244 0.515
LIG_14-3-3_CanoR_1 56 62 PF00244 0.374
LIG_14-3-3_CanoR_1 592 601 PF00244 0.348
LIG_Actin_WH2_2 284 301 PF00022 0.420
LIG_APCC_ABBA_1 138 143 PF00400 0.327
LIG_APCC_ABBA_1 305 310 PF00400 0.507
LIG_BRCT_BRCA1_1 356 360 PF00533 0.345
LIG_BRCT_BRCA1_1 455 459 PF00533 0.374
LIG_BRCT_BRCA1_1 580 584 PF00533 0.420
LIG_BRCT_BRCA1_1 607 611 PF00533 0.360
LIG_BRCT_BRCA1_1 616 620 PF00533 0.310
LIG_BRCT_BRCA1_2 580 586 PF00533 0.420
LIG_deltaCOP1_diTrp_1 558 564 PF00928 0.469
LIG_EH1_1 41 49 PF00400 0.274
LIG_FHA_1 176 182 PF00498 0.311
LIG_FHA_1 186 192 PF00498 0.327
LIG_FHA_1 246 252 PF00498 0.285
LIG_FHA_1 287 293 PF00498 0.365
LIG_FHA_1 376 382 PF00498 0.316
LIG_FHA_1 392 398 PF00498 0.408
LIG_FHA_1 435 441 PF00498 0.329
LIG_FHA_1 470 476 PF00498 0.567
LIG_FHA_1 570 576 PF00498 0.423
LIG_FHA_2 198 204 PF00498 0.312
LIG_FHA_2 98 104 PF00498 0.326
LIG_GBD_Chelix_1 305 313 PF00786 0.312
LIG_GBD_Chelix_1 445 453 PF00786 0.384
LIG_Integrin_RGD_1 328 330 PF01839 0.284
LIG_IRF3_LxIS_1 449 456 PF10401 0.462
LIG_LIR_Apic_2 330 335 PF02991 0.467
LIG_LIR_Apic_2 65 70 PF02991 0.312
LIG_LIR_Gen_1 135 142 PF02991 0.374
LIG_LIR_Gen_1 248 254 PF02991 0.206
LIG_LIR_Gen_1 451 459 PF02991 0.419
LIG_LIR_Gen_1 566 575 PF02991 0.448
LIG_LIR_LC3C_4 536 541 PF02991 0.384
LIG_LIR_Nem_3 279 284 PF02991 0.364
LIG_LIR_Nem_3 321 327 PF02991 0.465
LIG_LIR_Nem_3 451 455 PF02991 0.423
LIG_LIR_Nem_3 456 462 PF02991 0.412
LIG_LIR_Nem_3 494 499 PF02991 0.334
LIG_LIR_Nem_3 533 537 PF02991 0.333
LIG_LIR_Nem_3 551 555 PF02991 0.480
LIG_LIR_Nem_3 566 570 PF02991 0.321
LIG_LIR_Nem_3 623 627 PF02991 0.395
LIG_LIR_Nem_3 65 69 PF02991 0.327
LIG_MLH1_MIPbox_1 580 584 PF16413 0.381
LIG_MYND_1 483 487 PF01753 0.538
LIG_NRBOX 449 455 PF00104 0.384
LIG_Pex14_1 563 567 PF04695 0.467
LIG_Pex14_2 462 466 PF04695 0.438
LIG_Pex14_2 531 535 PF04695 0.420
LIG_Pex14_2 620 624 PF04695 0.324
LIG_PTB_Apo_2 114 121 PF02174 0.309
LIG_PTB_Apo_2 130 137 PF02174 0.305
LIG_PTB_Phospho_1 130 136 PF10480 0.337
LIG_REV1ctd_RIR_1 581 591 PF16727 0.381
LIG_SH2_CRK 281 285 PF00017 0.420
LIG_SH2_CRK 529 533 PF00017 0.462
LIG_SH2_CRK 567 571 PF00017 0.433
LIG_SH2_CRK 631 635 PF00017 0.540
LIG_SH2_CRK 67 71 PF00017 0.338
LIG_SH2_PTP2 232 235 PF00017 0.312
LIG_SH2_SRC 527 530 PF00017 0.367
LIG_SH2_STAP1 249 253 PF00017 0.275
LIG_SH2_STAP1 567 571 PF00017 0.418
LIG_SH2_STAP1 580 584 PF00017 0.256
LIG_SH2_STAT5 137 140 PF00017 0.327
LIG_SH2_STAT5 159 162 PF00017 0.312
LIG_SH2_STAT5 232 235 PF00017 0.362
LIG_SH2_STAT5 308 311 PF00017 0.527
LIG_SH2_STAT5 497 500 PF00017 0.332
LIG_SH2_STAT5 527 530 PF00017 0.318
LIG_SH2_STAT5 552 555 PF00017 0.467
LIG_SH3_3 328 334 PF00018 0.498
LIG_SH3_3 508 514 PF00018 0.384
LIG_SH3_3 68 74 PF00018 0.367
LIG_SUMO_SIM_anti_2 377 383 PF11976 0.345
LIG_SUMO_SIM_anti_2 536 541 PF11976 0.433
LIG_SUMO_SIM_par_1 471 476 PF11976 0.538
LIG_SUMO_SIM_par_1 538 543 PF11976 0.228
LIG_SxIP_EBH_1 475 484 PF03271 0.492
LIG_TRAF2_1 200 203 PF00917 0.338
LIG_TRAF2_1 256 259 PF00917 0.371
LIG_TYR_ITIM 550 555 PF00017 0.345
LIG_UBA3_1 400 407 PF00899 0.527
LIG_UBA3_1 425 434 PF00899 0.406
LIG_UBA3_1 582 586 PF00899 0.410
LIG_WRC_WIRS_1 531 536 PF05994 0.381
LIG_WRC_WIRS_1 621 626 PF05994 0.449
MOD_CK1_1 197 203 PF00069 0.367
MOD_CK1_1 43 49 PF00069 0.393
MOD_CK1_1 57 63 PF00069 0.262
MOD_CK2_1 148 154 PF00069 0.284
MOD_CK2_1 197 203 PF00069 0.334
MOD_CK2_1 210 216 PF00069 0.328
MOD_CK2_1 253 259 PF00069 0.331
MOD_CK2_1 97 103 PF00069 0.326
MOD_GlcNHglycan 148 151 PF01048 0.539
MOD_GlcNHglycan 320 324 PF01048 0.279
MOD_GlcNHglycan 35 38 PF01048 0.658
MOD_GlcNHglycan 389 392 PF01048 0.341
MOD_GlcNHglycan 542 545 PF01048 0.228
MOD_GlcNHglycan 567 570 PF01048 0.337
MOD_GlcNHglycan 9 12 PF01048 0.683
MOD_GSK3_1 167 174 PF00069 0.328
MOD_GSK3_1 216 223 PF00069 0.313
MOD_GSK3_1 29 36 PF00069 0.592
MOD_GSK3_1 351 358 PF00069 0.403
MOD_GSK3_1 367 374 PF00069 0.250
MOD_GSK3_1 387 394 PF00069 0.399
MOD_GSK3_1 469 476 PF00069 0.519
MOD_GSK3_1 565 572 PF00069 0.384
MOD_N-GLC_1 116 121 PF02516 0.440
MOD_N-GLC_2 114 116 PF02516 0.401
MOD_NEK2_1 185 190 PF00069 0.286
MOD_NEK2_1 225 230 PF00069 0.378
MOD_NEK2_1 247 252 PF00069 0.334
MOD_NEK2_1 283 288 PF00069 0.338
MOD_NEK2_1 29 34 PF00069 0.508
MOD_NEK2_1 297 302 PF00069 0.311
MOD_NEK2_1 355 360 PF00069 0.399
MOD_NEK2_1 375 380 PF00069 0.341
MOD_NEK2_1 392 397 PF00069 0.221
MOD_NEK2_1 453 458 PF00069 0.385
MOD_NEK2_1 473 478 PF00069 0.331
MOD_NEK2_1 499 504 PF00069 0.462
MOD_NEK2_1 570 575 PF00069 0.329
MOD_NEK2_1 578 583 PF00069 0.334
MOD_NEK2_1 585 590 PF00069 0.357
MOD_NEK2_1 605 610 PF00069 0.166
MOD_NEK2_1 620 625 PF00069 0.298
MOD_NEK2_1 630 635 PF00069 0.524
MOD_NEK2_2 118 123 PF00069 0.367
MOD_NEK2_2 530 535 PF00069 0.420
MOD_PIKK_1 171 177 PF00454 0.340
MOD_PIKK_1 194 200 PF00454 0.367
MOD_PK_1 478 484 PF00069 0.484
MOD_PKA_2 371 377 PF00069 0.367
MOD_PKA_2 477 483 PF00069 0.572
MOD_PKA_2 57 63 PF00069 0.397
MOD_Plk_1 116 122 PF00069 0.373
MOD_Plk_1 171 177 PF00069 0.362
MOD_Plk_1 185 191 PF00069 0.255
MOD_Plk_1 522 528 PF00069 0.256
MOD_Plk_4 247 253 PF00069 0.251
MOD_Plk_4 276 282 PF00069 0.350
MOD_Plk_4 283 289 PF00069 0.351
MOD_Plk_4 29 35 PF00069 0.553
MOD_Plk_4 351 357 PF00069 0.402
MOD_Plk_4 371 377 PF00069 0.131
MOD_Plk_4 43 49 PF00069 0.415
MOD_Plk_4 441 447 PF00069 0.250
MOD_Plk_4 448 454 PF00069 0.297
MOD_Plk_4 491 497 PF00069 0.512
MOD_Plk_4 499 505 PF00069 0.371
MOD_Plk_4 522 528 PF00069 0.254
MOD_Plk_4 530 536 PF00069 0.389
MOD_Plk_4 548 554 PF00069 0.351
MOD_Plk_4 578 584 PF00069 0.387
MOD_Plk_4 593 599 PF00069 0.271
MOD_Plk_4 605 611 PF00069 0.321
MOD_Plk_4 620 626 PF00069 0.317
MOD_Plk_4 97 103 PF00069 0.292
MOD_ProDKin_1 148 154 PF00069 0.376
MOD_ProDKin_1 46 52 PF00069 0.414
MOD_ProDKin_1 59 65 PF00069 0.383
MOD_SUMO_for_1 634 637 PF00179 0.691
MOD_SUMO_rev_2 103 113 PF00179 0.352
MOD_SUMO_rev_2 236 246 PF00179 0.306
TRG_DiLeu_BaEn_4 523 529 PF01217 0.367
TRG_DiLeu_BaLyEn_6 393 398 PF01217 0.383
TRG_DiLeu_BaLyEn_6 481 486 PF01217 0.521
TRG_ENDOCYTIC_2 137 140 PF00928 0.338
TRG_ENDOCYTIC_2 249 252 PF00928 0.208
TRG_ENDOCYTIC_2 281 284 PF00928 0.399
TRG_ENDOCYTIC_2 465 468 PF00928 0.567
TRG_ENDOCYTIC_2 496 499 PF00928 0.420
TRG_ENDOCYTIC_2 529 532 PF00928 0.385
TRG_ENDOCYTIC_2 552 555 PF00928 0.467
TRG_ENDOCYTIC_2 567 570 PF00928 0.301
TRG_ENDOCYTIC_2 580 583 PF00928 0.242
TRG_ENDOCYTIC_2 631 634 PF00928 0.527
TRG_ENDOCYTIC_2 66 69 PF00928 0.338
TRG_ER_diArg_1 125 127 PF00400 0.339
TRG_ER_diArg_1 55 58 PF00400 0.396
TRG_Pf-PMV_PEXEL_1 194 198 PF00026 0.512
TRG_Pf-PMV_PEXEL_1 212 216 PF00026 0.484
TRG_Pf-PMV_PEXEL_1 316 320 PF00026 0.371
TRG_Pf-PMV_PEXEL_1 484 488 PF00026 0.338

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P948 Leptomonas seymouri 27% 96%
A0A0N1I2B1 Leptomonas seymouri 28% 100%
A0A0N1I6Y7 Leptomonas seymouri 57% 100%
A0A0N1IME8 Leptomonas seymouri 20% 100%
A0A0S4IV41 Bodo saltans 29% 100%
A0A0S4J9X2 Bodo saltans 27% 98%
A0A0S4JBB1 Bodo saltans 31% 100%
A0A0S4JCH7 Bodo saltans 26% 93%
A0A0S4JEU5 Bodo saltans 27% 99%
A0A0S4JIF4 Bodo saltans 33% 100%
A0A0S4JWZ9 Bodo saltans 25% 100%
A0A0S4JZ31 Bodo saltans 28% 100%
A0A1X0NJN3 Trypanosomatidae 26% 100%
A0A1X0NK64 Trypanosomatidae 28% 100%
A0A1X0NLM6 Trypanosomatidae 23% 100%
A0A1X0NZX5 Trypanosomatidae 30% 98%
A0A1X0P2G3 Trypanosomatidae 28% 100%
A0A1X0P6M4 Trypanosomatidae 25% 84%
A0A1X0PA12 Trypanosomatidae 34% 100%
A0A3Q8IBT4 Leishmania donovani 22% 100%
A0A3Q8IFM1 Leishmania donovani 28% 99%
A0A3Q8IHT3 Leishmania donovani 94% 100%
A0A3R7MBZ3 Trypanosoma rangeli 37% 100%
A0A3S7X2L7 Leishmania donovani 30% 94%
A0A422NED2 Trypanosoma rangeli 31% 99%
A0A422NMS9 Trypanosoma rangeli 28% 97%
A0A422P482 Trypanosoma rangeli 24% 100%
A4H7C1 Leishmania braziliensis 22% 100%
A4HB85 Leishmania braziliensis 75% 100%
A4HHH4 Leishmania braziliensis 29% 94%
A4HHY3 Leishmania braziliensis 28% 99%
A4HVR6 Leishmania infantum 22% 100%
A4I4M3 Leishmania infantum 30% 94%
A4I563 Leishmania infantum 28% 99%
A4IAD3 Leishmania infantum 94% 100%
A4IFE9 Bos taurus 27% 100%
A5D7E2 Bos taurus 32% 99%
C9ZLB0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 87%
C9ZLW2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZUX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
D0A6H3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9AE21 Leishmania major 28% 99%
E9ALR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 94%
E9APG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 21% 100%
E9B0G0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 97%
E9B5F7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
F4HW17 Arabidopsis thaliana 26% 100%
F4JRE0 Arabidopsis thaliana 30% 98%
F4KIB2 Arabidopsis thaliana 31% 98%
O15321 Homo sapiens 27% 100%
P32802 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 96%
P40071 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 90%
P58021 Mus musculus 28% 96%
Q04562 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 95%
Q4KLL4 Rattus norvegicus 31% 99%
Q4Q7S3 Leishmania major 27% 100%
Q4QG16 Leishmania major 22% 100%
Q54ZW0 Dictyostelium discoideum 24% 100%
Q55FP0 Dictyostelium discoideum 29% 99%
Q5R8F1 Pongo abelii 27% 100%
Q5R8Y6 Pongo abelii 28% 96%
Q5RDY2 Pongo abelii 32% 99%
Q66HF2 Rattus norvegicus 27% 100%
Q66HG5 Rattus norvegicus 28% 96%
Q8BH24 Mus musculus 31% 99%
Q8RWW1 Arabidopsis thaliana 30% 100%
Q92544 Homo sapiens 32% 99%
Q940G0 Arabidopsis thaliana 28% 100%
Q940S0 Arabidopsis thaliana 24% 100%
Q99805 Homo sapiens 28% 96%
Q9C5N2 Arabidopsis thaliana 31% 99%
Q9C720 Arabidopsis thaliana 30% 100%
Q9DBU0 Mus musculus 27% 100%
Q9ET30 Mus musculus 27% 100%
Q9FHT4 Arabidopsis thaliana 26% 100%
Q9FYQ8 Arabidopsis thaliana 30% 97%
Q9HD45 Homo sapiens 27% 100%
Q9LIC2 Arabidopsis thaliana 30% 99%
Q9Y819 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q9ZPS7 Arabidopsis thaliana 24% 100%
V5BCD5 Trypanosoma cruzi 27% 100%
V5BHS7 Trypanosoma cruzi 27% 100%
V5D9U0 Trypanosoma cruzi 31% 98%
V5DII3 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS