Inositol-pentakisphosphate 2-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-pentakisphosphate 2-kinase, putative

Species:

Leishmania major

UniProt:

Q4Q2H4_LEIMA

TriTrypDb:

LmjF.34.3700 , LMJLV39_340043300 , LMJSD75_340043700

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4Q2H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2H4

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006020	inositol metabolic process	4	2
GO:0006066	alcohol metabolic process	3	2
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019637	organophosphate metabolic process	3	2
GO:0019751	polyol metabolic process	4	2
GO:0032958	inositol phosphate biosynthetic process	5	2
GO:0043647	inositol phosphate metabolic process	4	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046165	alcohol biosynthetic process	4	2
GO:0046173	polyol biosynthetic process	5	2
GO:0046835	carbohydrate phosphorylation	4	2
GO:0052746	obsolete inositol phosphorylation	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901617	organic hydroxy compound biosynthetic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035299	inositol pentakisphosphate 2-kinase activity	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.517
CLV_NRD_NRD_1	241	243	PF00675	0.388
CLV_NRD_NRD_1	413	415	PF00675	0.390
CLV_NRD_NRD_1	69	71	PF00675	0.332
CLV_PCSK_KEX2_1	344	346	PF00082	0.353
CLV_PCSK_KEX2_1	413	415	PF00082	0.382
CLV_PCSK_KEX2_1	68	70	PF00082	0.325
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.240
CLV_PCSK_SKI1_1	197	201	PF00082	0.243
CLV_PCSK_SKI1_1	213	217	PF00082	0.181
CLV_PCSK_SKI1_1	251	255	PF00082	0.320
CLV_PCSK_SKI1_1	42	46	PF00082	0.434
DEG_APCC_DBOX_1	218	226	PF00400	0.539
DEG_Nend_UBRbox_2	1	3	PF02207	0.530
DOC_MAPK_gen_1	68	74	PF00069	0.388
DOC_MAPK_MEF2A_6	13	22	PF00069	0.424
DOC_MAPK_MEF2A_6	374	382	PF00069	0.462
DOC_SPAK_OSR1_1	366	370	PF12202	0.480
DOC_USP7_MATH_1	192	196	PF00917	0.492
DOC_USP7_MATH_1	215	219	PF00917	0.532
DOC_USP7_MATH_1	450	454	PF00917	0.632
DOC_USP7_MATH_1	81	85	PF00917	0.517
DOC_USP7_MATH_2	291	297	PF00917	0.474
DOC_WW_Pin1_4	287	292	PF00397	0.586
DOC_WW_Pin1_4	347	352	PF00397	0.535
DOC_WW_Pin1_4	400	405	PF00397	0.462
LIG_14-3-3_CanoR_1	213	222	PF00244	0.522
LIG_14-3-3_CanoR_1	366	376	PF00244	0.479
LIG_14-3-3_CanoR_1	385	389	PF00244	0.378
LIG_Actin_WH2_2	218	236	PF00022	0.504
LIG_BIR_III_2	288	292	PF00653	0.491
LIG_BIR_III_4	122	126	PF00653	0.457
LIG_BRCT_BRCA1_1	208	212	PF00533	0.388
LIG_BRCT_BRCA1_1	4	8	PF00533	0.478
LIG_Clathr_ClatBox_1	113	117	PF01394	0.518
LIG_eIF4E_1	206	212	PF01652	0.448
LIG_FHA_1	129	135	PF00498	0.480
LIG_FHA_1	250	256	PF00498	0.544
LIG_FHA_2	252	258	PF00498	0.491
LIG_FHA_2	324	330	PF00498	0.457
LIG_FHA_2	336	342	PF00498	0.452
LIG_FHA_2	370	376	PF00498	0.442
LIG_LIR_Apic_2	138	143	PF02991	0.539
LIG_LIR_Apic_2	350	356	PF02991	0.466
LIG_LIR_Gen_1	318	328	PF02991	0.466
LIG_LIR_Gen_1	77	87	PF02991	0.510
LIG_LIR_Nem_3	318	324	PF02991	0.466
LIG_LIR_Nem_3	57	62	PF02991	0.484
LIG_LIR_Nem_3	77	82	PF02991	0.442
LIG_SH2_CRK	79	83	PF00017	0.474
LIG_SH2_CRK	90	94	PF00017	0.411
LIG_SH2_NCK_1	79	83	PF00017	0.539
LIG_SH2_PTP2	353	356	PF00017	0.539
LIG_SH2_STAP1	130	134	PF00017	0.509
LIG_SH2_STAP1	167	171	PF00017	0.491
LIG_SH2_STAP1	360	364	PF00017	0.491
LIG_SH2_STAP1	79	83	PF00017	0.491
LIG_SH2_STAT5	130	133	PF00017	0.539
LIG_SH2_STAT5	164	167	PF00017	0.415
LIG_SH2_STAT5	206	209	PF00017	0.437
LIG_SH2_STAT5	210	213	PF00017	0.437
LIG_SH2_STAT5	353	356	PF00017	0.512
LIG_SH2_STAT5	368	371	PF00017	0.398
LIG_SH3_3	15	21	PF00018	0.454
LIG_SH3_3	202	208	PF00018	0.490
LIG_SH3_3	267	273	PF00018	0.541
LIG_SH3_3	386	392	PF00018	0.521
LIG_SH3_3	69	75	PF00018	0.562
LIG_SH3_5	356	360	PF00018	0.491
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.450
LIG_SUMO_SIM_par_1	251	257	PF11976	0.491
LIG_SUMO_SIM_par_1	377	383	PF11976	0.463
LIG_SUMO_SIM_par_1	422	427	PF11976	0.462
LIG_TRAF2_1	254	257	PF00917	0.491
LIG_TRAF2_1	290	293	PF00917	0.457
LIG_TYR_ITIM	171	176	PF00017	0.491
MOD_CDK_SPK_2	347	352	PF00069	0.457
MOD_CK1_1	186	192	PF00069	0.537
MOD_CK1_1	195	201	PF00069	0.550
MOD_CK1_1	27	33	PF00069	0.581
MOD_CK1_1	333	339	PF00069	0.578
MOD_CK1_1	347	353	PF00069	0.367
MOD_CK1_1	383	389	PF00069	0.487
MOD_CK1_1	98	104	PF00069	0.491
MOD_CK2_1	214	220	PF00069	0.518
MOD_CK2_1	251	257	PF00069	0.537
MOD_CK2_1	287	293	PF00069	0.480
MOD_Cter_Amidation	66	69	PF01082	0.278
MOD_GlcNHglycan	137	140	PF01048	0.361
MOD_GlcNHglycan	188	191	PF01048	0.274
MOD_GlcNHglycan	197	200	PF01048	0.208
MOD_GlcNHglycan	285	288	PF01048	0.348
MOD_GlcNHglycan	29	32	PF01048	0.712
MOD_GSK3_1	234	241	PF00069	0.507
MOD_GSK3_1	283	290	PF00069	0.522
MOD_GSK3_1	291	298	PF00069	0.545
MOD_GSK3_1	33	40	PF00069	0.629
MOD_GSK3_1	380	387	PF00069	0.495
MOD_GSK3_1	94	101	PF00069	0.522
MOD_N-GLC_1	104	109	PF02516	0.319
MOD_N-GLC_1	95	100	PF02516	0.358
MOD_NEK2_1	1	6	PF00069	0.515
MOD_NEK2_1	367	372	PF00069	0.440
MOD_NEK2_2	192	197	PF00069	0.440
MOD_PIKK_1	291	297	PF00454	0.405
MOD_PIKK_1	37	43	PF00454	0.567
MOD_PIKK_1	384	390	PF00454	0.457
MOD_PKA_1	242	248	PF00069	0.457
MOD_PKA_1	344	350	PF00069	0.440
MOD_PKA_2	344	350	PF00069	0.493
MOD_PKA_2	384	390	PF00069	0.533
MOD_PKA_2	450	456	PF00069	0.492
MOD_Plk_1	1	7	PF00069	0.441
MOD_Plk_1	128	134	PF00069	0.553
MOD_Plk_1	265	271	PF00069	0.559
MOD_Plk_1	374	380	PF00069	0.437
MOD_Plk_1	98	104	PF00069	0.539
MOD_Plk_4	2	8	PF00069	0.561
MOD_Plk_4	206	212	PF00069	0.458
MOD_Plk_4	374	380	PF00069	0.443
MOD_Plk_4	81	87	PF00069	0.578
MOD_Plk_4	98	104	PF00069	0.527
MOD_ProDKin_1	287	293	PF00069	0.586
MOD_ProDKin_1	347	353	PF00069	0.535
MOD_ProDKin_1	400	406	PF00069	0.462
MOD_SUMO_rev_2	129	136	PF00179	0.467
MOD_SUMO_rev_2	425	430	PF00179	0.504
TRG_ENDOCYTIC_2	167	170	PF00928	0.504
TRG_ENDOCYTIC_2	173	176	PF00928	0.504
TRG_ENDOCYTIC_2	59	62	PF00928	0.513
TRG_ENDOCYTIC_2	79	82	PF00928	0.345
TRG_ENDOCYTIC_2	90	93	PF00928	0.484
TRG_ER_diArg_1	412	414	PF00400	0.573
TRG_ER_diArg_1	45	48	PF00400	0.509
TRG_ER_diArg_1	68	70	PF00400	0.512
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW9	Leptomonas seymouri	54%	100%
A0A0S4KLU4	Bodo saltans	27%	92%
A0A1X0PAD2	Trypanosomatidae	30%	100%
A0A3Q8IEN4	Leishmania donovani	91%	100%
A0A3R7K0N1	Trypanosoma rangeli	31%	99%
A4HB89	Leishmania braziliensis	75%	100%
A4IAD7	Leishmania infantum	91%	100%
C9ZLV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
E9B5G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B6A7	Trypanosoma cruzi	31%	90%