Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2H3_LEIMA

TriTrypDb:

LmjF.34.3710 , LMJLV39_340043400 , LMJSD75_340043800

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2H3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.451
CLV_NRD_NRD_1	131	133	PF00675	0.364
CLV_NRD_NRD_1	77	79	PF00675	0.448
CLV_NRD_NRD_1	81	83	PF00675	0.449
CLV_PCSK_KEX2_1	119	121	PF00082	0.581
CLV_PCSK_KEX2_1	77	79	PF00082	0.454
CLV_PCSK_KEX2_1	81	83	PF00082	0.461
CLV_PCSK_PC7_1	77	83	PF00082	0.459
CLV_PCSK_SKI1_1	107	111	PF00082	0.598
CLV_PCSK_SKI1_1	148	152	PF00082	0.577
CLV_PCSK_SKI1_1	154	158	PF00082	0.504
CLV_PCSK_SKI1_1	38	42	PF00082	0.510
DEG_SCF_FBW7_2	16	23	PF00400	0.423
DOC_CKS1_1	17	22	PF01111	0.418
DOC_MAPK_gen_1	81	90	PF00069	0.577
DOC_MAPK_RevD_3	116	130	PF00069	0.480
DOC_PP2B_LxvP_1	10	13	PF13499	0.462
DOC_USP7_MATH_1	102	106	PF00917	0.510
DOC_USP7_MATH_1	150	154	PF00917	0.429
DOC_USP7_MATH_1	97	101	PF00917	0.524
DOC_USP7_UBL2_3	129	133	PF12436	0.545
DOC_WW_Pin1_4	16	21	PF00397	0.552
LIG_14-3-3_CanoR_1	29	36	PF00244	0.554
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_FHA_1	30	36	PF00498	0.494
LIG_FHA_2	108	114	PF00498	0.535
LIG_FHA_2	39	45	PF00498	0.458
LIG_LIR_Nem_3	46	52	PF02991	0.591
LIG_PDZ_Class_2	178	183	PF00595	0.524
LIG_Rb_pABgroove_1	116	124	PF01858	0.549
LIG_SH2_SRC	122	125	PF00017	0.437
LIG_SH2_STAP1	122	126	PF00017	0.399
LIG_SH2_STAP1	31	35	PF00017	0.529
LIG_SH2_STAT5	17	20	PF00017	0.556
LIG_SH2_STAT5	31	34	PF00017	0.534
LIG_TRAF2_1	110	113	PF00917	0.432
LIG_TRAF2_1	156	159	PF00917	0.544
LIG_TRAF2_1	20	23	PF00917	0.495
MOD_CK1_1	105	111	PF00069	0.609
MOD_CK1_1	59	65	PF00069	0.536
MOD_CK2_1	107	113	PF00069	0.455
MOD_CK2_1	38	44	PF00069	0.436
MOD_GlcNHglycan	148	151	PF01048	0.668
MOD_GlcNHglycan	97	100	PF01048	0.640
MOD_GSK3_1	107	114	PF00069	0.598
MOD_GSK3_1	146	153	PF00069	0.553
MOD_GSK3_1	50	57	PF00069	0.548
MOD_GSK3_1	59	66	PF00069	0.472
MOD_NEK2_1	157	162	PF00069	0.561
MOD_NEK2_1	63	68	PF00069	0.560
MOD_PIKK_1	29	35	PF00454	0.537
MOD_PIKK_1	52	58	PF00454	0.519
MOD_PKA_2	162	168	PF00069	0.564
MOD_Plk_1	114	120	PF00069	0.439
MOD_Plk_1	38	44	PF00069	0.431
MOD_Plk_4	31	37	PF00069	0.539
MOD_ProDKin_1	16	22	PF00069	0.548
MOD_SUMO_rev_2	145	150	PF00179	0.623
TRG_ENDOCYTIC_2	49	52	PF00928	0.525
TRG_ER_diArg_1	118	120	PF00400	0.545
TRG_NES_CRM1_1	61	76	PF08389	0.449
TRG_NLS_Bipartite_1	119	133	PF00514	0.620
TRG_NLS_MonoExtC_3	128	133	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P774	Leptomonas seymouri	62%	100%
A0A0S4J6R9	Bodo saltans	27%	98%
A0A0S4KRE5	Bodo saltans	28%	100%
A0A1X0PA28	Trypanosomatidae	38%	100%
A0A3Q8IIW0	Leishmania donovani	89%	100%
A0A3R7M5H7	Trypanosoma rangeli	38%	92%
A4HB90	Leishmania braziliensis	75%	100%
A4IAD8	Leishmania infantum	88%	100%
C9ZLV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B5G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%