DUF659 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF501), putative

Species:

Leishmania major

UniProt:

Q4Q2H2_LEIMA

TriTrypDb:

LmjF.34.3720 , LMJLV39_340043500 , LMJSD75_340043900

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2H2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	294	296	PF00675	0.530
CLV_PCSK_KEX2_1	204	206	PF00082	0.509
CLV_PCSK_KEX2_1	293	295	PF00082	0.619
CLV_PCSK_KEX2_1	5	7	PF00082	0.693
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.427
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.672
CLV_PCSK_SKI1_1	117	121	PF00082	0.310
CLV_PCSK_SKI1_1	204	208	PF00082	0.434
CLV_PCSK_SKI1_1	280	284	PF00082	0.451
CLV_PCSK_SKI1_1	5	9	PF00082	0.556
DOC_MAPK_gen_1	27	36	PF00069	0.466
DOC_MAPK_MEF2A_6	280	288	PF00069	0.433
DOC_PP4_FxxP_1	245	248	PF00568	0.461
DOC_USP7_MATH_1	146	150	PF00917	0.449
DOC_USP7_MATH_1	171	175	PF00917	0.388
DOC_WW_Pin1_4	118	123	PF00397	0.374
LIG_14-3-3_CanoR_1	216	225	PF00244	0.393
LIG_14-3-3_CanoR_1	280	285	PF00244	0.380
LIG_14-3-3_CanoR_1	6	12	PF00244	0.602
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_FHA_1	221	227	PF00498	0.555
LIG_FHA_1	281	287	PF00498	0.483
LIG_FHA_1	58	64	PF00498	0.366
LIG_FHA_2	35	41	PF00498	0.446
LIG_Integrin_isoDGR_2	54	56	PF01839	0.303
LIG_LIR_Apic_2	244	248	PF02991	0.439
LIG_LIR_Gen_1	215	226	PF02991	0.484
LIG_LIR_Gen_1	235	245	PF02991	0.367
LIG_LIR_Nem_3	13	19	PF02991	0.542
LIG_LIR_Nem_3	215	221	PF02991	0.483
LIG_LIR_Nem_3	235	240	PF02991	0.531
LIG_Pex14_2	128	132	PF04695	0.294
LIG_Pex14_2	221	225	PF04695	0.374
LIG_PTB_Apo_2	239	246	PF02174	0.450
LIG_SH2_NCK_1	19	23	PF00017	0.569
LIG_SH2_PTP2	179	182	PF00017	0.399
LIG_SH2_SRC	19	22	PF00017	0.584
LIG_SH2_STAP1	112	116	PF00017	0.294
LIG_SH2_STAP1	19	23	PF00017	0.568
LIG_SH2_STAT3	262	265	PF00017	0.334
LIG_SH2_STAT5	179	182	PF00017	0.305
LIG_SH3_3	165	171	PF00018	0.374
LIG_SH3_3	244	250	PF00018	0.477
LIG_TYR_ITIM	177	182	PF00017	0.398
MOD_CK1_1	149	155	PF00069	0.284
MOD_CK1_1	219	225	PF00069	0.466
MOD_CK1_1	57	63	PF00069	0.281
MOD_CK2_1	34	40	PF00069	0.452
MOD_Cter_Amidation	3	6	PF01082	0.500
MOD_GlcNHglycan	56	59	PF01048	0.297
MOD_GlcNHglycan	8	11	PF01048	0.588
MOD_GlcNHglycan	91	94	PF01048	0.328
MOD_GSK3_1	127	134	PF00069	0.338
MOD_GSK3_1	208	215	PF00069	0.413
MOD_GSK3_1	216	223	PF00069	0.308
MOD_N-GLC_1	212	217	PF02516	0.281
MOD_N-GLC_1	241	246	PF02516	0.420
MOD_NEK2_1	127	132	PF00069	0.274
MOD_NEK2_1	208	213	PF00069	0.417
MOD_NEK2_1	34	39	PF00069	0.444
MOD_NEK2_1	47	52	PF00069	0.223
MOD_NEK2_1	68	73	PF00069	0.294
MOD_PIKK_1	265	271	PF00454	0.520
MOD_PKA_1	5	11	PF00069	0.597
MOD_PKA_2	5	11	PF00069	0.657
MOD_Plk_1	212	218	PF00069	0.411
MOD_Plk_1	241	247	PF00069	0.410
MOD_Plk_4	171	177	PF00069	0.388
MOD_Plk_4	63	69	PF00069	0.322
MOD_ProDKin_1	118	124	PF00069	0.374
MOD_SUMO_rev_2	149	157	PF00179	0.298
MOD_SUMO_rev_2	197	206	PF00179	0.464
MOD_SUMO_rev_2	2	7	PF00179	0.598
TRG_DiLeu_BaEn_1	202	207	PF01217	0.510
TRG_DiLeu_LyEn_5	202	207	PF01217	0.372
TRG_ENDOCYTIC_2	179	182	PF00928	0.339
TRG_ER_diArg_1	293	295	PF00400	0.554
TRG_NLS_MonoExtN_4	294	301	PF00514	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T1	Leptomonas seymouri	58%	100%
A0A3Q8IIH7	Leishmania donovani	88%	100%
A0A422N2V1	Trypanosoma rangeli	40%	100%
A4HB91	Leishmania braziliensis	75%	100%
A4IAD9	Leishmania infantum	88%	100%
C9ZLV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B5G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%