Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2H1_LEIMA

TriTrypDb:

LmjF.34.3730 , LMJLV39_340043600 , LMJSD75_340044000

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q2H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2H1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	122	128	PF00089	0.676
CLV_NRD_NRD_1	107	109	PF00675	0.560
CLV_NRD_NRD_1	112	114	PF00675	0.558
CLV_NRD_NRD_1	140	142	PF00675	0.626
CLV_NRD_NRD_1	208	210	PF00675	0.546
CLV_NRD_NRD_1	266	268	PF00675	0.585
CLV_NRD_NRD_1	299	301	PF00675	0.634
CLV_PCSK_FUR_1	292	296	PF00082	0.692
CLV_PCSK_KEX2_1	107	109	PF00082	0.560
CLV_PCSK_KEX2_1	112	114	PF00082	0.558
CLV_PCSK_KEX2_1	140	142	PF00082	0.587
CLV_PCSK_KEX2_1	208	210	PF00082	0.546
CLV_PCSK_KEX2_1	266	268	PF00082	0.585
CLV_PCSK_KEX2_1	294	296	PF00082	0.682
CLV_PCSK_KEX2_1	298	300	PF00082	0.625
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.563
CLV_PCSK_PC7_1	108	114	PF00082	0.623
CLV_PCSK_PC7_1	262	268	PF00082	0.681
CLV_PCSK_PC7_1	295	301	PF00082	0.613
CLV_PCSK_SKI1_1	108	112	PF00082	0.567
CLV_PCSK_SKI1_1	119	123	PF00082	0.602
CLV_PCSK_SKI1_1	144	148	PF00082	0.584
CLV_PCSK_SKI1_1	194	198	PF00082	0.652
CLV_PCSK_SKI1_1	266	270	PF00082	0.638
CLV_PCSK_SKI1_1	313	317	PF00082	0.632
CLV_PCSK_SKI1_1	75	79	PF00082	0.524
CLV_PCSK_SKI1_1	96	100	PF00082	0.602
DEG_APCC_DBOX_1	233	241	PF00400	0.686
DEG_APCC_DBOX_1	99	107	PF00400	0.586
DOC_ANK_TNKS_1	83	90	PF00023	0.464
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.611
DOC_MAPK_gen_1	181	189	PF00069	0.597
DOC_MAPK_gen_1	192	200	PF00069	0.542
DOC_MAPK_gen_1	211	221	PF00069	0.391
DOC_MAPK_gen_1	275	285	PF00069	0.579
DOC_PP1_RVXF_1	117	124	PF00149	0.573
DOC_PP1_RVXF_1	162	168	PF00149	0.574
DOC_PP1_RVXF_1	216	222	PF00149	0.677
DOC_PP1_RVXF_1	57	64	PF00149	0.718
DOC_USP7_MATH_1	223	227	PF00917	0.688
DOC_USP7_MATH_1	239	243	PF00917	0.418
DOC_WW_Pin1_4	3	8	PF00397	0.691
LIG_14-3-3_CanoR_1	211	217	PF00244	0.611
LIG_14-3-3_CanoR_1	220	227	PF00244	0.554
LIG_14-3-3_CanoR_1	229	233	PF00244	0.509
LIG_14-3-3_CanoR_1	29	38	PF00244	0.710
LIG_14-3-3_CanoR_1	317	324	PF00244	0.691
LIG_14-3-3_CterR_2	344	347	PF00244	0.710
LIG_Actin_WH2_2	294	309	PF00022	0.508
LIG_Actin_WH2_2	99	114	PF00022	0.680
LIG_APCC_ABBAyCdc20_2	144	150	PF00400	0.597
LIG_CaM_IQ_9	111	127	PF13499	0.571
LIG_deltaCOP1_diTrp_1	168	173	PF00928	0.662
LIG_deltaCOP1_diTrp_1	291	296	PF00928	0.649
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.621
LIG_FHA_1	16	22	PF00498	0.647
LIG_FHA_1	77	83	PF00498	0.644
LIG_LIR_Gen_1	241	250	PF02991	0.639
LIG_LIR_Nem_3	241	246	PF02991	0.640
LIG_LIR_Nem_3	332	336	PF02991	0.615
LIG_Pex14_1	173	177	PF04695	0.438
LIG_SH2_NCK_1	53	57	PF00017	0.608
LIG_SH2_SRC	53	56	PF00017	0.548
LIG_SH2_STAP1	333	337	PF00017	0.674
LIG_SH2_STAT3	177	180	PF00017	0.456
LIG_SH2_STAT5	243	246	PF00017	0.702
LIG_SH2_STAT5	336	339	PF00017	0.668
LIG_SH3_3	32	38	PF00018	0.625
LIG_WRC_WIRS_1	12	17	PF05994	0.553
MOD_CK1_1	19	25	PF00069	0.721
MOD_CK2_1	14	20	PF00069	0.716
MOD_CK2_1	22	28	PF00069	0.703
MOD_CMANNOS	167	170	PF00535	0.595
MOD_CMANNOS	293	296	PF00535	0.547
MOD_GlcNHglycan	221	224	PF01048	0.598
MOD_GlcNHglycan	31	34	PF01048	0.743
MOD_GSK3_1	11	18	PF00069	0.761
MOD_GSK3_1	219	226	PF00069	0.604
MOD_NEK2_1	21	26	PF00069	0.665
MOD_PIKK_1	317	323	PF00454	0.597
MOD_PKA_2	219	225	PF00069	0.580
MOD_PKA_2	228	234	PF00069	0.549
MOD_PKA_2	28	34	PF00069	0.825
MOD_Plk_1	223	229	PF00069	0.619
MOD_Plk_4	11	17	PF00069	0.552
MOD_Plk_4	239	245	PF00069	0.570
MOD_Plk_4	88	94	PF00069	0.599
MOD_ProDKin_1	3	9	PF00069	0.691
TRG_DiLeu_BaEn_1	311	316	PF01217	0.617
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.630
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.650
TRG_ENDOCYTIC_2	243	246	PF00928	0.679
TRG_ER_diArg_1	106	108	PF00400	0.583
TRG_ER_diArg_1	111	113	PF00400	0.559
TRG_ER_diArg_1	117	120	PF00400	0.525
TRG_ER_diArg_1	140	142	PF00400	0.625
TRG_ER_diArg_1	207	209	PF00400	0.562
TRG_ER_diArg_1	297	300	PF00400	0.625
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILB8	Leptomonas seymouri	57%	100%
A0A1X0PA21	Trypanosomatidae	29%	100%
A0A3Q8IFU3	Leishmania donovani	89%	100%
A4HB92	Leishmania braziliensis	75%	100%
A4IAE0	Leishmania infantum	89%	100%
E9B5G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%