Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2G8_LEIMA

TriTrypDb:

LmjF.34.3750 , LMJLV39_340043900 , LMJSD75_340044300

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.600
CLV_C14_Caspase3-7	424	428	PF00656	0.718
CLV_NRD_NRD_1	30	32	PF00675	0.783
CLV_NRD_NRD_1	334	336	PF00675	0.670
CLV_NRD_NRD_1	363	365	PF00675	0.728
CLV_NRD_NRD_1	402	404	PF00675	0.712
CLV_NRD_NRD_1	406	408	PF00675	0.682
CLV_PCSK_KEX2_1	149	151	PF00082	0.619
CLV_PCSK_KEX2_1	162	164	PF00082	0.377
CLV_PCSK_KEX2_1	30	32	PF00082	0.688
CLV_PCSK_KEX2_1	334	336	PF00082	0.666
CLV_PCSK_KEX2_1	365	367	PF00082	0.728
CLV_PCSK_KEX2_1	406	408	PF00082	0.616
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.625
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.350
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.728
CLV_PCSK_SKI1_1	24	28	PF00082	0.752
CLV_PCSK_SKI1_1	79	83	PF00082	0.796
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DEG_SPOP_SBC_1	10	14	PF00917	0.593
DEG_SPOP_SBC_1	312	316	PF00917	0.755
DEG_SPOP_SBC_1	80	84	PF00917	0.800
DEG_SPOP_SBC_1	93	97	PF00917	0.582
DOC_CKS1_1	25	30	PF01111	0.763
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.742
DOC_MAPK_JIP1_4	326	332	PF00069	0.708
DOC_PP2B_LxvP_1	252	255	PF13499	0.462
DOC_USP7_MATH_1	196	200	PF00917	0.738
DOC_USP7_MATH_1	217	221	PF00917	0.690
DOC_USP7_MATH_1	312	316	PF00917	0.693
DOC_USP7_MATH_1	408	412	PF00917	0.675
DOC_USP7_MATH_1	473	477	PF00917	0.522
DOC_USP7_MATH_1	80	84	PF00917	0.720
DOC_USP7_MATH_1	9	13	PF00917	0.652
DOC_USP7_UBL2_3	400	404	PF12436	0.706
DOC_WW_Pin1_4	139	144	PF00397	0.513
DOC_WW_Pin1_4	192	197	PF00397	0.803
DOC_WW_Pin1_4	24	29	PF00397	0.719
DOC_WW_Pin1_4	294	299	PF00397	0.694
DOC_WW_Pin1_4	313	318	PF00397	0.766
DOC_WW_Pin1_4	358	363	PF00397	0.756
DOC_WW_Pin1_4	367	372	PF00397	0.716
DOC_WW_Pin1_4	447	452	PF00397	0.595
DOC_WW_Pin1_4	469	474	PF00397	0.645
DOC_WW_Pin1_4	509	514	PF00397	0.511
LIG_14-3-3_CanoR_1	102	106	PF00244	0.674
LIG_14-3-3_CanoR_1	191	196	PF00244	0.761
LIG_14-3-3_CanoR_1	406	414	PF00244	0.618
LIG_14-3-3_CanoR_1	497	503	PF00244	0.506
LIG_14-3-3_CanoR_1	67	76	PF00244	0.563
LIG_14-3-3_CanoR_1	79	88	PF00244	0.776
LIG_BIR_III_4	425	429	PF00653	0.553
LIG_BRCT_BRCA1_1	174	178	PF00533	0.494
LIG_FHA_1	115	121	PF00498	0.699
LIG_FHA_1	180	186	PF00498	0.566
LIG_FHA_1	386	392	PF00498	0.691
LIG_FHA_1	484	490	PF00498	0.369
LIG_FHA_1	58	64	PF00498	0.697
LIG_FHA_1	94	100	PF00498	0.810
LIG_FHA_2	382	388	PF00498	0.696
LIG_FHA_2	451	457	PF00498	0.636
LIG_FHA_2	46	52	PF00498	0.577
LIG_FHA_2	491	497	PF00498	0.595
LIG_LIR_Nem_3	142	148	PF02991	0.451
LIG_LIR_Nem_3	316	322	PF02991	0.577
LIG_SH2_CRK	145	149	PF00017	0.483
LIG_SH2_CRK	319	323	PF00017	0.573
LIG_SH2_SRC	145	148	PF00017	0.573
LIG_SH2_STAP1	445	449	PF00017	0.485
LIG_SH2_STAT5	105	108	PF00017	0.728
LIG_SH2_STAT5	484	487	PF00017	0.468
LIG_SH3_3	22	28	PF00018	0.762
LIG_SH3_3	306	312	PF00018	0.724
LIG_SH3_3	321	327	PF00018	0.594
LIG_SH3_3	340	346	PF00018	0.463
LIG_SH3_3	413	419	PF00018	0.706
LIG_SH3_3	467	473	PF00018	0.571
LIG_SH3_3	49	55	PF00018	0.571
LIG_TRAF2_1	419	422	PF00917	0.758
LIG_TRAF2_1	453	456	PF00917	0.545
LIG_TRAF2_2	419	424	PF00917	0.636
MOD_CDK_SPK_2	294	299	PF00069	0.574
MOD_CDK_SPK_2	313	318	PF00069	0.729
MOD_CDK_SPK_2	447	452	PF00069	0.595
MOD_CDK_SPxK_1	24	30	PF00069	0.609
MOD_CDK_SPxK_1	358	364	PF00069	0.653
MOD_CDK_SPxxK_3	24	31	PF00069	0.766
MOD_CDK_SPxxK_3	313	320	PF00069	0.733
MOD_CDK_SPxxK_3	358	365	PF00069	0.588
MOD_CDK_SPxxK_3	509	516	PF00069	0.480
MOD_CK1_1	12	18	PF00069	0.717
MOD_CK1_1	194	200	PF00069	0.645
MOD_CK1_1	20	26	PF00069	0.696
MOD_CK1_1	297	303	PF00069	0.676
MOD_CK1_1	381	387	PF00069	0.620
MOD_CK1_1	395	401	PF00069	0.723
MOD_CK1_1	45	51	PF00069	0.737
MOD_CK1_1	97	103	PF00069	0.689
MOD_CK2_1	123	129	PF00069	0.615
MOD_CK2_1	280	286	PF00069	0.534
MOD_CK2_1	45	51	PF00069	0.578
MOD_CK2_1	450	456	PF00069	0.527
MOD_DYRK1A_RPxSP_1	24	28	PF00069	0.765
MOD_GlcNHglycan	121	124	PF01048	0.713
MOD_GlcNHglycan	125	128	PF01048	0.717
MOD_GlcNHglycan	196	199	PF01048	0.709
MOD_GlcNHglycan	215	218	PF01048	0.688
MOD_GlcNHglycan	231	234	PF01048	0.376
MOD_GlcNHglycan	380	383	PF01048	0.656
MOD_GlcNHglycan	408	411	PF01048	0.733
MOD_GlcNHglycan	88	91	PF01048	0.700
MOD_GlcNHglycan	96	99	PF01048	0.691
MOD_GSK3_1	10	17	PF00069	0.681
MOD_GSK3_1	119	126	PF00069	0.564
MOD_GSK3_1	190	197	PF00069	0.741
MOD_GSK3_1	20	27	PF00069	0.640
MOD_GSK3_1	209	216	PF00069	0.758
MOD_GSK3_1	293	300	PF00069	0.662
MOD_GSK3_1	378	385	PF00069	0.755
MOD_GSK3_1	469	476	PF00069	0.636
MOD_GSK3_1	59	66	PF00069	0.719
MOD_GSK3_1	67	74	PF00069	0.737
MOD_GSK3_1	75	82	PF00069	0.592
MOD_GSK3_1	93	100	PF00069	0.673
MOD_N-GLC_1	229	234	PF02516	0.451
MOD_N-GLC_1	358	363	PF02516	0.586
MOD_N-GLC_1	385	390	PF02516	0.797
MOD_NEK2_1	106	111	PF00069	0.693
MOD_NEK2_1	477	482	PF00069	0.532
MOD_NEK2_1	483	488	PF00069	0.444
MOD_NEK2_1	507	512	PF00069	0.421
MOD_NEK2_1	65	70	PF00069	0.724
MOD_NEK2_2	71	76	PF00069	0.581
MOD_PIKK_1	114	120	PF00454	0.723
MOD_PIKK_1	302	308	PF00454	0.731
MOD_PKA_1	406	412	PF00069	0.618
MOD_PKA_2	101	107	PF00069	0.625
MOD_PKA_2	17	23	PF00069	0.728
MOD_PKA_2	190	196	PF00069	0.705
MOD_PKA_2	280	286	PF00069	0.619
MOD_PKA_2	392	398	PF00069	0.568
MOD_PKA_2	406	412	PF00069	0.550
MOD_PKA_2	496	502	PF00069	0.516
MOD_PKA_2	66	72	PF00069	0.704
MOD_Plk_1	277	283	PF00069	0.635
MOD_Plk_2-3	245	251	PF00069	0.614
MOD_Plk_4	101	107	PF00069	0.629
MOD_Plk_4	71	77	PF00069	0.581
MOD_ProDKin_1	139	145	PF00069	0.506
MOD_ProDKin_1	192	198	PF00069	0.804
MOD_ProDKin_1	24	30	PF00069	0.719
MOD_ProDKin_1	294	300	PF00069	0.692
MOD_ProDKin_1	313	319	PF00069	0.768
MOD_ProDKin_1	358	364	PF00069	0.759
MOD_ProDKin_1	367	373	PF00069	0.716
MOD_ProDKin_1	447	453	PF00069	0.602
MOD_ProDKin_1	469	475	PF00069	0.640
MOD_ProDKin_1	509	515	PF00069	0.518
MOD_SUMO_for_1	419	422	PF00179	0.758
MOD_SUMO_rev_2	206	210	PF00179	0.688
TRG_DiLeu_BaEn_4	115	121	PF01217	0.801
TRG_DiLeu_LyEn_5	129	134	PF01217	0.580
TRG_ENDOCYTIC_2	145	148	PF00928	0.453
TRG_ENDOCYTIC_2	168	171	PF00928	0.553
TRG_ENDOCYTIC_2	319	322	PF00928	0.580
TRG_ER_diArg_1	334	336	PF00400	0.670
TRG_ER_diArg_1	405	407	PF00400	0.733
TRG_NLS_MonoCore_2	363	368	PF00514	0.831
TRG_NLS_MonoExtC_3	363	368	PF00514	0.831
TRG_NLS_MonoExtC_3	402	407	PF00514	0.723
TRG_NLS_MonoExtN_4	362	369	PF00514	0.724
TRG_NLS_MonoExtN_4	400	407	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K2	Leptomonas seymouri	38%	89%
A0A3Q8INS4	Leishmania donovani	83%	100%
A4HB95	Leishmania braziliensis	60%	90%
A4IAE3	Leishmania infantum	84%	100%
E9B5G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	96%