Phosphomannomutase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomannomutase-like protein

Species:

Leishmania major

UniProt:

Q4Q2G5_LEIMA

TriTrypDb:

LmjF.34.3780 , LMJLV39_340044200 , LMJSD75_340044600

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2G5

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006166	purine ribonucleoside salvage	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	2
GO:0009116	nucleoside metabolic process	4	2
GO:0009119	ribonucleoside metabolic process	5	2
GO:0009163	nucleoside biosynthetic process	5	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0042278	purine nucleoside metabolic process	5	2
GO:0042451	purine nucleoside biosynthetic process	6	2
GO:0042455	ribonucleoside biosynthetic process	6	2
GO:0043094	cellular metabolic compound salvage	3	2
GO:0043101	purine-containing compound salvage	4	2
GO:0043174	nucleoside salvage	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046128	purine ribonucleoside metabolic process	6	2
GO:0046129	purine ribonucleoside biosynthetic process	7	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072522	purine-containing compound biosynthetic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901657	glycosyl compound metabolic process	4	2
GO:1901659	glycosyl compound biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008973	phosphopentomutase activity	5	3
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0016868	intramolecular transferase activity, phosphotransferases	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0004614	phosphoglucomutase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.447
CLV_NRD_NRD_1	344	346	PF00675	0.307
CLV_NRD_NRD_1	38	40	PF00675	0.545
CLV_NRD_NRD_1	392	394	PF00675	0.312
CLV_NRD_NRD_1	436	438	PF00675	0.375
CLV_NRD_NRD_1	514	516	PF00675	0.525
CLV_PCSK_FUR_1	342	346	PF00082	0.305
CLV_PCSK_KEX2_1	344	346	PF00082	0.305
CLV_PCSK_KEX2_1	37	39	PF00082	0.570
CLV_PCSK_KEX2_1	514	516	PF00082	0.446
CLV_PCSK_SKI1_1	136	140	PF00082	0.466
CLV_PCSK_SKI1_1	247	251	PF00082	0.271
CLV_PCSK_SKI1_1	352	356	PF00082	0.284
CLV_PCSK_SKI1_1	495	499	PF00082	0.559
DEG_SCF_FBW7_1	184	189	PF00400	0.364
DEG_SCF_FBW7_1	518	525	PF00400	0.375
DOC_ANK_TNKS_1	88	95	PF00023	0.330
DOC_CKS1_1	126	131	PF01111	0.268
DOC_CYCLIN_RxL_1	349	358	PF00134	0.367
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.383
DOC_MAPK_gen_1	136	146	PF00069	0.271
DOC_MAPK_gen_1	342	350	PF00069	0.315
DOC_MAPK_gen_1	37	46	PF00069	0.422
DOC_MAPK_MEF2A_6	139	146	PF00069	0.394
DOC_MAPK_MEF2A_6	520	528	PF00069	0.434
DOC_PP1_RVXF_1	157	163	PF00149	0.268
DOC_PP1_RVXF_1	542	548	PF00149	0.334
DOC_PP2B_LxvP_1	250	253	PF13499	0.328
DOC_PP4_FxxP_1	275	278	PF00568	0.250
DOC_USP7_MATH_1	186	190	PF00917	0.357
DOC_USP7_MATH_1	510	514	PF00917	0.558
DOC_USP7_MATH_2	278	284	PF00917	0.383
DOC_WW_Pin1_4	125	130	PF00397	0.252
DOC_WW_Pin1_4	182	187	PF00397	0.357
DOC_WW_Pin1_4	508	513	PF00397	0.410
DOC_WW_Pin1_4	518	523	PF00397	0.354
LIG_14-3-3_CanoR_1	215	219	PF00244	0.448
LIG_14-3-3_CanoR_1	228	237	PF00244	0.241
LIG_14-3-3_CanoR_1	240	249	PF00244	0.263
LIG_14-3-3_CanoR_1	393	402	PF00244	0.271
LIG_14-3-3_CanoR_1	52	56	PF00244	0.374
LIG_14-3-3_CanoR_1	64	68	PF00244	0.440
LIG_AP2alpha_1	207	211	PF02296	0.356
LIG_APCC_ABBA_1	524	529	PF00400	0.417
LIG_BIR_II_1	1	5	PF00653	0.390
LIG_BIR_III_4	555	559	PF00653	0.401
LIG_BRCT_BRCA1_1	100	104	PF00533	0.298
LIG_deltaCOP1_diTrp_1	188	194	PF00928	0.394
LIG_deltaCOP1_diTrp_1	9	14	PF00928	0.363
LIG_FHA_1	106	112	PF00498	0.383
LIG_FHA_1	126	132	PF00498	0.250
LIG_FHA_1	18	24	PF00498	0.393
LIG_FHA_1	241	247	PF00498	0.253
LIG_FHA_1	31	37	PF00498	0.320
LIG_FHA_1	422	428	PF00498	0.352
LIG_FHA_1	46	52	PF00498	0.197
LIG_FHA_1	471	477	PF00498	0.471
LIG_FHA_1	496	502	PF00498	0.450
LIG_FHA_1	519	525	PF00498	0.405
LIG_FHA_2	183	189	PF00498	0.445
LIG_FHA_2	193	199	PF00498	0.383
LIG_FHA_2	325	331	PF00498	0.328
LIG_FHA_2	464	470	PF00498	0.483
LIG_GBD_Chelix_1	176	184	PF00786	0.305
LIG_GBD_Chelix_1	428	436	PF00786	0.315
LIG_IRF3_LxIS_1	350	357	PF10401	0.205
LIG_LIR_Apic_2	272	278	PF02991	0.250
LIG_LIR_Gen_1	201	211	PF02991	0.313
LIG_LIR_Gen_1	230	237	PF02991	0.268
LIG_LIR_Gen_1	320	331	PF02991	0.400
LIG_LIR_Gen_1	463	470	PF02991	0.559
LIG_LIR_Gen_1	589	594	PF02991	0.516
LIG_LIR_Nem_3	101	107	PF02991	0.317
LIG_LIR_Nem_3	128	133	PF02991	0.325
LIG_LIR_Nem_3	154	158	PF02991	0.243
LIG_LIR_Nem_3	188	194	PF02991	0.402
LIG_LIR_Nem_3	201	206	PF02991	0.253
LIG_LIR_Nem_3	208	214	PF02991	0.314
LIG_LIR_Nem_3	269	273	PF02991	0.255
LIG_LIR_Nem_3	320	326	PF02991	0.388
LIG_LIR_Nem_3	450	455	PF02991	0.249
LIG_LIR_Nem_3	463	467	PF02991	0.416
LIG_LIR_Nem_3	589	594	PF02991	0.514
LIG_PCNA_PIPBox_1	114	123	PF02747	0.383
LIG_PCNA_PIPBox_1	441	450	PF02747	0.425
LIG_PCNA_yPIPBox_3	114	123	PF02747	0.305
LIG_PCNA_yPIPBox_3	554	566	PF02747	0.392
LIG_PDZ_Class_1	589	594	PF00595	0.526
LIG_Pex14_2	207	211	PF04695	0.324
LIG_Pex14_2	285	289	PF04695	0.227
LIG_PTB_Apo_2	264	271	PF02174	0.328
LIG_REV1ctd_RIR_1	135	143	PF16727	0.205
LIG_SH2_CRK	155	159	PF00017	0.315
LIG_SH2_CRK	203	207	PF00017	0.447
LIG_SH2_NCK_1	203	207	PF00017	0.423
LIG_SH2_NCK_1	218	222	PF00017	0.383
LIG_SH2_SRC	218	221	PF00017	0.458
LIG_SH2_SRC	405	408	PF00017	0.315
LIG_SH2_STAP1	203	207	PF00017	0.423
LIG_SH2_STAP1	376	380	PF00017	0.328
LIG_SH2_STAP1	405	409	PF00017	0.315
LIG_SH2_STAP1	548	552	PF00017	0.310
LIG_SH2_STAT3	488	491	PF00017	0.372
LIG_SH2_STAT3	77	80	PF00017	0.315
LIG_SH2_STAT5	120	123	PF00017	0.337
LIG_SH2_STAT5	210	213	PF00017	0.250
LIG_SH2_STAT5	435	438	PF00017	0.328
LIG_SH2_STAT5	77	80	PF00017	0.246
LIG_SH3_3	123	129	PF00018	0.281
LIG_SH3_3	265	271	PF00018	0.267
LIG_Sin3_3	138	145	PF02671	0.183
LIG_SUMO_SIM_anti_2	255	262	PF11976	0.330
LIG_SUMO_SIM_par_1	170	175	PF11976	0.183
LIG_TRAF2_1	317	320	PF00917	0.476
LIG_TRAF2_1	404	407	PF00917	0.250
LIG_UBA3_1	23	31	PF00899	0.293
MOD_CDK_SPxK_1	508	514	PF00069	0.300
MOD_CDK_SPxxK_3	508	515	PF00069	0.303
MOD_CK1_1	222	228	PF00069	0.315
MOD_CK1_1	255	261	PF00069	0.335
MOD_CK1_1	288	294	PF00069	0.357
MOD_CK1_1	463	469	PF00069	0.393
MOD_CK1_1	479	485	PF00069	0.487
MOD_CK2_1	182	188	PF00069	0.376
MOD_CK2_1	324	330	PF00069	0.348
MOD_CK2_1	440	446	PF00069	0.358
MOD_CK2_1	468	474	PF00069	0.329
MOD_CK2_1	536	542	PF00069	0.365
MOD_CMANNOS	11	14	PF00535	0.331
MOD_GlcNHglycan	223	227	PF01048	0.302
MOD_GlcNHglycan	282	285	PF01048	0.396
MOD_GlcNHglycan	484	487	PF01048	0.541
MOD_GlcNHglycan	538	541	PF01048	0.399
MOD_GlcNHglycan	58	61	PF01048	0.320
MOD_GSK3_1	172	179	PF00069	0.271
MOD_GSK3_1	182	189	PF00069	0.376
MOD_GSK3_1	210	217	PF00069	0.352
MOD_GSK3_1	236	243	PF00069	0.344
MOD_GSK3_1	354	361	PF00069	0.254
MOD_GSK3_1	374	381	PF00069	0.469
MOD_GSK3_1	506	513	PF00069	0.422
MOD_GSK3_1	514	521	PF00069	0.464
MOD_GSK3_1	532	539	PF00069	0.336
MOD_GSK3_1	63	70	PF00069	0.287
MOD_N-GLC_1	182	187	PF02516	0.354
MOD_NEK2_1	172	177	PF00069	0.371
MOD_NEK2_1	187	192	PF00069	0.388
MOD_NEK2_1	214	219	PF00069	0.364
MOD_NEK2_1	229	234	PF00069	0.183
MOD_NEK2_1	285	290	PF00069	0.383
MOD_NEK2_1	354	359	PF00069	0.260
MOD_NEK2_1	476	481	PF00069	0.462
MOD_NEK2_1	51	56	PF00069	0.322
MOD_NEK2_1	532	537	PF00069	0.371
MOD_NEK2_2	210	215	PF00069	0.293
MOD_NEK2_2	398	403	PF00069	0.315
MOD_NEK2_2	522	527	PF00069	0.302
MOD_PIKK_1	487	493	PF00454	0.530
MOD_PKA_1	30	36	PF00069	0.460
MOD_PKA_1	393	399	PF00069	0.271
MOD_PKA_1	514	520	PF00069	0.451
MOD_PKA_2	214	220	PF00069	0.448
MOD_PKA_2	227	233	PF00069	0.241
MOD_PKA_2	239	245	PF00069	0.280
MOD_PKA_2	51	57	PF00069	0.383
MOD_PKA_2	514	520	PF00069	0.472
MOD_PKA_2	536	542	PF00069	0.369
MOD_PKA_2	63	69	PF00069	0.440
MOD_PKB_1	37	45	PF00069	0.382
MOD_Plk_1	172	178	PF00069	0.315
MOD_Plk_1	187	193	PF00069	0.423
MOD_Plk_1	222	228	PF00069	0.386
MOD_Plk_4	107	113	PF00069	0.345
MOD_Plk_4	116	122	PF00069	0.302
MOD_Plk_4	255	261	PF00069	0.330
MOD_Plk_4	295	301	PF00069	0.448
MOD_Plk_4	355	361	PF00069	0.260
MOD_Plk_4	398	404	PF00069	0.386
MOD_Plk_4	440	446	PF00069	0.436
MOD_Plk_4	447	453	PF00069	0.365
MOD_Plk_4	460	466	PF00069	0.335
MOD_Plk_4	63	69	PF00069	0.250
MOD_ProDKin_1	125	131	PF00069	0.252
MOD_ProDKin_1	182	188	PF00069	0.361
MOD_ProDKin_1	508	514	PF00069	0.415
MOD_ProDKin_1	518	524	PF00069	0.345
MOD_SUMO_for_1	6	9	PF00179	0.348
MOD_SUMO_rev_2	2	8	PF00179	0.467
MOD_SUMO_rev_2	539	545	PF00179	0.373
TRG_DiLeu_BaEn_1	330	335	PF01217	0.268
TRG_DiLeu_BaEn_1	351	356	PF01217	0.271
TRG_DiLeu_BaEn_3	320	326	PF01217	0.387
TRG_DiLeu_BaEn_3	406	412	PF01217	0.328
TRG_ENDOCYTIC_2	155	158	PF00928	0.383
TRG_ENDOCYTIC_2	203	206	PF00928	0.398
TRG_ENDOCYTIC_2	464	467	PF00928	0.421
TRG_ENDOCYTIC_2	548	551	PF00928	0.304
TRG_ER_diArg_1	342	345	PF00400	0.386
TRG_ER_diArg_1	36	39	PF00400	0.557
TRG_ER_diArg_1	514	516	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	571	575	PF00026	0.278
TRG_PTS1	591	594	PF00515	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T5	Leptomonas seymouri	71%	100%
A0A0S4JIH0	Bodo saltans	50%	100%
A0A1X0PBG2	Trypanosomatidae	50%	100%
A0A3R7KJ42	Trypanosoma rangeli	50%	100%
A0A3S7X8H1	Leishmania donovani	95%	100%
A0K6C4	Burkholderia cenocepacia (strain HI2424)	25%	100%
A0QKT1	Mycobacterium avium (strain 104)	25%	100%
A3PAW2	Prochlorococcus marinus (strain MIT 9301)	22%	100%
A4HB98	Leishmania braziliensis	86%	100%
A4IAE6	Leishmania infantum	95%	100%
A4Z0D8	Bradyrhizobium sp. (strain ORS 278)	22%	100%
A5ECX6	Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)	23%	100%
A7HCU0	Anaeromyxobacter sp. (strain Fw109-5)	24%	100%
A7IIG5	Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)	25%	100%
A8HUR7	Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571)	25%	100%
A9ACL5	Burkholderia multivorans (strain ATCC 17616 / 249)	23%	100%
A9G862	Sorangium cellulosum (strain So ce56)	22%	100%
B0C132	Acaryochloris marina (strain MBIC 11017)	21%	100%
B0TQA7	Shewanella halifaxensis (strain HAW-EB4)	21%	100%
B1JZF2	Burkholderia cenocepacia (strain MC0-3)	25%	100%
B2IGB3	Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712)	23%	100%
B3E692	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	24%	100%
B4E5F6	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	25%	100%
B8CKG8	Shewanella piezotolerans (strain WP3 / JCM 13877)	22%	100%
B8GXK7	Caulobacter vibrioides (strain NA1000 / CB15N)	23%	100%
C4XU39	Solidesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)	25%	100%
E9B5H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O74478	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
P18159	Bacillus subtilis (strain 168)	33%	100%
P36871	Homo sapiens	23%	100%
P39671	Rhizobium radiobacter	23%	100%
P47299	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	26%	100%
P47723	Mycoplasma pirum	25%	100%
P75050	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	27%	100%
Q03262	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	95%
Q116W4	Trichodesmium erythraeum (strain IMS101)	22%	100%
Q11DI7	Chelativorans sp. (strain BNC1)	24%	100%
Q1BXC7	Burkholderia cenocepacia (strain AU 1054)	25%	100%
Q1GE79	Ruegeria sp. (strain TM1040)	25%	100%
Q1QP86	Nitrobacter hamburgensis (strain DSM 10229 / NCIMB 13809 / X14)	22%	100%
Q20YZ7	Rhodopseudomonas palustris (strain BisB18)	22%	100%
Q2FE11	Staphylococcus aureus (strain USA300)	32%	100%
Q2FVC1	Staphylococcus aureus (strain NCTC 8325 / PS 47)	32%	100%
Q2IHZ5	Anaeromyxobacter dehalogenans (strain 2CP-C)	25%	100%
Q2RVE4	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	25%	100%
Q2YW66	Staphylococcus aureus (strain bovine RF122 / ET3-1)	31%	100%
Q31LA7	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	24%	100%
Q3M6L2	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	22%	100%
Q49WH7	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	28%	100%
Q4L9R5	Staphylococcus haemolyticus (strain JCSC1435)	29%	100%
Q4R5E4	Macaca fascicularis	24%	100%
Q4WY53	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	100%
Q54UQ2	Dictyostelium discoideum	41%	99%
Q57290	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	36%	100%
Q5HD61	Staphylococcus aureus (strain COL)	32%	100%
Q5HLD2	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	31%	100%
Q5N0M0	Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1)	24%	100%
Q5R979	Pongo abelii	39%	95%
Q5RFI8	Pongo abelii	40%	97%
Q6AMQ5	Desulfotalea psychrophila (strain LSv54 / DSM 12343)	22%	100%
Q6G6I3	Staphylococcus aureus (strain MSSA476)	32%	100%
Q6GDU9	Staphylococcus aureus (strain MRSA252)	31%	100%
Q6MLS4	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	23%	100%
Q6PCE3	Homo sapiens	39%	95%
Q73S29	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	25%	100%
Q7A3K7	Staphylococcus aureus (strain N315)	32%	100%
Q7TSV4	Mus musculus	41%	96%
Q8CAA7	Mus musculus	39%	96%
Q8CN38	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	31%	100%
Q8NUV4	Staphylococcus aureus (strain MW2)	32%	100%
Q8YVS4	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	22%	100%
Q96G03	Homo sapiens	40%	97%
Q98F91	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	23%	100%
Q99RE2	Staphylococcus aureus (strain Mu50 / ATCC 700699)	32%	100%
Q9ABV3	Caulobacter vibrioides (strain ATCC 19089 / CB15)	23%	100%
V5B6A2	Trypanosoma cruzi	51%	100%