TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania major

UniProt:

Q4Q2G0_LEIMA

TriTrypDb:

LmjF.34.3820 , LMJLV39_340044700 , LMJSD75_340045100

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2G0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.279
CLV_NRD_NRD_1	234	236	PF00675	0.401
CLV_NRD_NRD_1	98	100	PF00675	0.415
CLV_PCSK_KEX2_1	200	202	PF00082	0.279
CLV_PCSK_SKI1_1	99	103	PF00082	0.436
DOC_CKS1_1	123	128	PF01111	0.631
DOC_USP7_MATH_1	127	131	PF00917	0.538
DOC_USP7_MATH_1	132	136	PF00917	0.683
DOC_USP7_MATH_1	36	40	PF00917	0.737
DOC_USP7_UBL2_3	173	177	PF12436	0.401
DOC_USP7_UBL2_3	236	240	PF12436	0.382
DOC_WW_Pin1_4	122	127	PF00397	0.646
DOC_WW_Pin1_4	18	23	PF00397	0.598
DOC_WW_Pin1_4	31	36	PF00397	0.706
LIG_Actin_WH2_2	65	81	PF00022	0.529
LIG_BIR_III_4	229	233	PF00653	0.425
LIG_BIR_III_4	62	66	PF00653	0.541
LIG_BRCT_BRCA1_1	283	287	PF00533	0.387
LIG_Clathr_ClatBox_1	171	175	PF01394	0.442
LIG_EVH1_1	123	127	PF00568	0.490
LIG_FHA_1	158	164	PF00498	0.294
LIG_FHA_2	138	144	PF00498	0.751
LIG_LIR_Gen_1	219	228	PF02991	0.414
LIG_LIR_Nem_3	212	218	PF02991	0.348
LIG_LIR_Nem_3	219	224	PF02991	0.427
LIG_NRP_CendR_1	286	289	PF00754	0.473
LIG_Pex14_1	211	215	PF04695	0.323
LIG_PTB_Apo_2	163	170	PF02174	0.272
LIG_SH2_CRK	26	30	PF00017	0.592
LIG_SH2_STAP1	157	161	PF00017	0.383
LIG_SH2_STAP1	283	287	PF00017	0.387
LIG_SH2_STAT3	206	209	PF00017	0.434
LIG_SH2_STAT5	157	160	PF00017	0.315
LIG_SH2_STAT5	164	167	PF00017	0.268
LIG_SH2_STAT5	194	197	PF00017	0.343
LIG_SH2_STAT5	198	201	PF00017	0.307
LIG_SH3_2	106	111	PF14604	0.332
LIG_SH3_3	103	109	PF00018	0.360
LIG_SH3_3	121	127	PF00018	0.616
LIG_SUMO_SIM_par_1	67	74	PF11976	0.541
LIG_UBA3_1	171	177	PF00899	0.389
LIG_UBA3_1	250	255	PF00899	0.340
MOD_CDC14_SPxK_1	21	24	PF00782	0.521
MOD_CDK_SPxK_1	18	24	PF00069	0.517
MOD_CK1_1	135	141	PF00069	0.656
MOD_CK2_1	142	148	PF00069	0.667
MOD_CK2_1	36	42	PF00069	0.756
MOD_CK2_1	61	67	PF00069	0.536
MOD_GlcNHglycan	119	123	PF01048	0.667
MOD_GlcNHglycan	129	132	PF01048	0.589
MOD_GlcNHglycan	212	215	PF01048	0.440
MOD_GlcNHglycan	62	66	PF01048	0.553
MOD_GSK3_1	114	121	PF00069	0.617
MOD_GSK3_1	133	140	PF00069	0.677
MOD_GSK3_1	277	284	PF00069	0.388
MOD_GSK3_1	89	96	PF00069	0.408
MOD_N-GLC_1	127	132	PF02516	0.518
MOD_N-GLC_1	89	94	PF02516	0.270
MOD_NEK2_2	281	286	PF00069	0.384
MOD_PIKK_1	137	143	PF00454	0.503
MOD_Plk_1	155	161	PF00069	0.351
MOD_Plk_1	190	196	PF00069	0.447
MOD_Plk_1	73	79	PF00069	0.421
MOD_Plk_2-3	217	223	PF00069	0.345
MOD_Plk_4	190	196	PF00069	0.399
MOD_Plk_4	93	99	PF00069	0.445
MOD_ProDKin_1	122	128	PF00069	0.648
MOD_ProDKin_1	18	24	PF00069	0.601
MOD_ProDKin_1	31	37	PF00069	0.708
MOD_SUMO_for_1	176	179	PF00179	0.458
MOD_SUMO_rev_2	146	155	PF00179	0.652
TRG_DiLeu_BaEn_3	178	184	PF01217	0.444
TRG_DiLeu_BaEn_3	245	251	PF01217	0.349
TRG_DiLeu_BaEn_4	73	79	PF01217	0.565
TRG_ENDOCYTIC_2	205	208	PF00928	0.338
TRG_ENDOCYTIC_2	221	224	PF00928	0.379
TRG_ENDOCYTIC_2	26	29	PF00928	0.595
TRG_ER_diArg_1	199	201	PF00400	0.289
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM5	Leptomonas seymouri	56%	100%
A0A0S4KMF2	Bodo saltans	50%	100%
A0A1X0PA31	Trypanosomatidae	55%	100%
A0A3Q8IHU2	Leishmania donovani	91%	100%
A0A422NSX9	Trypanosoma rangeli	56%	100%
A4HBA3	Leishmania braziliensis	78%	100%
A4IAF1	Leishmania infantum	91%	100%
C9ZLU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B5H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q3ZBR5	Bos taurus	32%	99%
Q91Z38	Mus musculus	31%	99%
Q99614	Homo sapiens	31%	99%