Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2F9_LEIMA

TriTrypDb:

LmjF.34.3830 , LMJLV39_340044800 , LMJSD75_340045200

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.629
CLV_NRD_NRD_1	147	149	PF00675	0.593
CLV_NRD_NRD_1	181	183	PF00675	0.614
CLV_NRD_NRD_1	40	42	PF00675	0.673
CLV_NRD_NRD_1	46	48	PF00675	0.568
CLV_NRD_NRD_1	75	77	PF00675	0.604
CLV_NRD_NRD_1	97	99	PF00675	0.657
CLV_PCSK_KEX2_1	147	149	PF00082	0.593
CLV_PCSK_KEX2_1	181	183	PF00082	0.653
CLV_PCSK_KEX2_1	40	42	PF00082	0.673
CLV_PCSK_KEX2_1	75	77	PF00082	0.534
CLV_PCSK_KEX2_1	96	98	PF00082	0.667
CLV_PCSK_PC7_1	71	77	PF00082	0.598
CLV_PCSK_PC7_1	93	99	PF00082	0.671
CLV_PCSK_SKI1_1	182	186	PF00082	0.596
CLV_PCSK_SKI1_1	26	30	PF00082	0.595
CLV_PCSK_SKI1_1	40	44	PF00082	0.446
CLV_PCSK_SKI1_1	56	60	PF00082	0.495
DEG_APCC_DBOX_1	25	33	PF00400	0.592
DEG_SCF_FBW7_2	158	165	PF00400	0.667
DOC_CKS1_1	159	164	PF01111	0.668
DOC_MAPK_gen_1	201	209	PF00069	0.649
DOC_MAPK_gen_1	47	55	PF00069	0.577
DOC_MAPK_MEF2A_6	48	57	PF00069	0.654
DOC_PP2B_PxIxI_1	130	136	PF00149	0.691
DOC_USP7_MATH_1	163	167	PF00917	0.635
DOC_USP7_MATH_1	86	90	PF00917	0.698
DOC_USP7_UBL2_3	219	223	PF12436	0.480
DOC_WW_Pin1_4	123	128	PF00397	0.812
DOC_WW_Pin1_4	141	146	PF00397	0.520
DOC_WW_Pin1_4	158	163	PF00397	0.672
LIG_14-3-3_CanoR_1	181	185	PF00244	0.686
LIG_14-3-3_CanoR_1	201	210	PF00244	0.557
LIG_14-3-3_CanoR_1	40	50	PF00244	0.496
LIG_Actin_WH2_2	103	119	PF00022	0.607
LIG_Actin_WH2_2	17	32	PF00022	0.600
LIG_Actin_WH2_2	189	206	PF00022	0.629
LIG_APCC_ABBA_1	150	155	PF00400	0.595
LIG_FHA_1	59	65	PF00498	0.467
LIG_FHA_1	86	92	PF00498	0.687
LIG_FHA_2	107	113	PF00498	0.638
LIG_Integrin_RGD_1	212	214	PF01839	0.711
LIG_LIR_Gen_1	49	58	PF02991	0.535
LIG_LIR_Nem_3	49	53	PF02991	0.533
LIG_SH2_SRC	102	105	PF00017	0.664
LIG_SH2_STAP1	102	106	PF00017	0.659
LIG_SH2_STAT5	221	224	PF00017	0.468
LIG_SH3_2	159	164	PF14604	0.668
LIG_SH3_3	153	159	PF00018	0.784
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.672
LIG_SUMO_SIM_par_1	138	144	PF11976	0.578
LIG_TRAF2_1	176	179	PF00917	0.616
MOD_CDC14_SPxK_1	144	147	PF00782	0.575
MOD_CDK_SPxK_1	141	147	PF00069	0.576
MOD_CDK_SPxK_1	158	164	PF00069	0.670
MOD_CDK_SPxxK_3	141	148	PF00069	0.577
MOD_CK1_1	126	132	PF00069	0.799
MOD_CK1_1	141	147	PF00069	0.581
MOD_Cter_Amidation	145	148	PF01082	0.576
MOD_GlcNHglycan	65	68	PF01048	0.559
MOD_GSK3_1	154	161	PF00069	0.608
MOD_GSK3_1	223	230	PF00069	0.638
MOD_NEK2_1	202	207	PF00069	0.490
MOD_NEK2_2	10	15	PF00069	0.478
MOD_PIKK_1	41	47	PF00454	0.551
MOD_PKA_2	120	126	PF00069	0.684
MOD_PKA_2	163	169	PF00069	0.761
MOD_PKA_2	180	186	PF00069	0.400
MOD_PKA_2	203	209	PF00069	0.555
MOD_PKA_2	86	92	PF00069	0.687
MOD_Plk_1	154	160	PF00069	0.685
MOD_Plk_1	213	219	PF00069	0.643
MOD_Plk_2-3	138	144	PF00069	0.578
MOD_ProDKin_1	123	129	PF00069	0.811
MOD_ProDKin_1	141	147	PF00069	0.524
MOD_ProDKin_1	158	164	PF00069	0.670
MOD_SUMO_rev_2	44	50	PF00179	0.554
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.687
TRG_ENDOCYTIC_2	221	224	PF00928	0.701
TRG_ER_diArg_1	96	98	PF00400	0.681
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IUX1	Leishmania donovani	90%	100%
A4HBA4	Leishmania braziliensis	67%	100%
A4IAF2	Leishmania infantum	90%	100%
E9B5H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%