F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2F8_LEIMA

TriTrypDb:

LmjF.34.3840 , LMJLV39_340044900 , LMJSD75_340045300

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2F8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.489
CLV_PCSK_SKI1_1	104	108	PF00082	0.522
CLV_PCSK_SKI1_1	26	30	PF00082	0.481
CLV_PCSK_SKI1_1	93	97	PF00082	0.582
DOC_CYCLIN_RxL_1	90	99	PF00134	0.606
DOC_MAPK_gen_1	26	34	PF00069	0.467
DOC_PP2B_LxvP_1	185	188	PF13499	0.510
DOC_PP4_FxxP_1	152	155	PF00568	0.507
DOC_USP7_MATH_1	122	126	PF00917	0.690
DOC_USP7_MATH_1	131	135	PF00917	0.646
DOC_USP7_MATH_1	142	146	PF00917	0.592
DOC_USP7_MATH_1	188	192	PF00917	0.487
DOC_WW_Pin1_4	144	149	PF00397	0.618
DOC_WW_Pin1_4	4	9	PF00397	0.757
LIG_14-3-3_CanoR_1	135	141	PF00244	0.627
LIG_14-3-3_CanoR_1	179	185	PF00244	0.461
LIG_BIR_II_1	1	5	PF00653	0.701
LIG_BRCT_BRCA1_1	155	159	PF00533	0.532
LIG_BRCT_BRCA1_1	190	194	PF00533	0.401
LIG_FHA_1	41	47	PF00498	0.481
LIG_FHA_1	65	71	PF00498	0.475
LIG_FHA_2	211	217	PF00498	0.565
LIG_FHA_2	230	236	PF00498	0.562
LIG_FHA_2	58	64	PF00498	0.546
LIG_LIR_Gen_1	156	167	PF02991	0.537
LIG_LIR_Gen_1	183	190	PF02991	0.439
LIG_LIR_Gen_1	59	66	PF02991	0.582
LIG_LIR_Nem_3	156	162	PF02991	0.465
LIG_LIR_Nem_3	17	22	PF02991	0.507
LIG_LIR_Nem_3	183	187	PF02991	0.507
LIG_LIR_Nem_3	191	196	PF02991	0.469
LIG_LIR_Nem_3	221	226	PF02991	0.397
LIG_LIR_Nem_3	59	64	PF02991	0.581
LIG_MLH1_MIPbox_1	190	194	PF16413	0.487
LIG_NRBOX	108	114	PF00104	0.480
LIG_NRBOX	206	212	PF00104	0.478
LIG_SH2_STAT5	22	25	PF00017	0.390
LIG_SH2_STAT5	80	83	PF00017	0.639
LIG_SH3_3	10	16	PF00018	0.563
LIG_SH3_3	118	124	PF00018	0.650
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.563
LIG_TRAF2_1	166	169	PF00917	0.518
LIG_TRAF2_1	8	11	PF00917	0.736
LIG_WRC_WIRS_1	161	166	PF05994	0.337
MOD_CDK_SPK_2	4	9	PF00069	0.641
MOD_CK1_1	125	131	PF00069	0.699
MOD_CK1_1	134	140	PF00069	0.600
MOD_CK1_1	160	166	PF00069	0.529
MOD_CK1_1	2	8	PF00069	0.776
MOD_CK2_1	163	169	PF00069	0.433
MOD_CK2_1	229	235	PF00069	0.532
MOD_CK2_1	4	10	PF00069	0.754
MOD_CK2_1	57	63	PF00069	0.520
MOD_CMANNOS	181	184	PF00535	0.389
MOD_GlcNHglycan	165	168	PF01048	0.470
MOD_GlcNHglycan	4	7	PF01048	0.747
MOD_GlcNHglycan	74	77	PF01048	0.557
MOD_GSK3_1	122	129	PF00069	0.616
MOD_GSK3_1	131	138	PF00069	0.530
MOD_GSK3_1	153	160	PF00069	0.525
MOD_GSK3_1	218	225	PF00069	0.445
MOD_GSK3_1	74	81	PF00069	0.635
MOD_N-GLC_1	57	62	PF02516	0.560
MOD_N-GLC_2	176	178	PF02516	0.465
MOD_NEK2_1	105	110	PF00069	0.478
MOD_NEK2_1	157	162	PF00069	0.494
MOD_NEK2_1	210	215	PF00069	0.543
MOD_NEK2_1	57	62	PF00069	0.437
MOD_NEK2_1	78	83	PF00069	0.612
MOD_NEK2_1	87	92	PF00069	0.601
MOD_PIKK_1	150	156	PF00454	0.451
MOD_PKA_2	115	121	PF00069	0.672
MOD_PKA_2	134	140	PF00069	0.628
MOD_Plk_1	188	194	PF00069	0.547
MOD_Plk_1	57	63	PF00069	0.563
MOD_Plk_4	153	159	PF00069	0.422
MOD_Plk_4	160	166	PF00069	0.411
MOD_Plk_4	180	186	PF00069	0.523
MOD_Plk_4	57	63	PF00069	0.574
MOD_ProDKin_1	144	150	PF00069	0.601
MOD_ProDKin_1	4	10	PF00069	0.754
MOD_SUMO_rev_2	59	67	PF00179	0.570
TRG_ER_diArg_1	113	116	PF00400	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE51	Leptomonas seymouri	54%	98%
A0A0S4KKN8	Bodo saltans	28%	92%
A0A1X0ND66	Trypanosomatidae	34%	100%
A0A3Q8IEP6	Leishmania donovani	86%	100%
A0A422NSY2	Trypanosoma rangeli	36%	100%
A4HBA5	Leishmania braziliensis	66%	96%
A4IAF3	Leishmania infantum	86%	100%
C9ZLU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B5H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%