Small nuclear ribonucleoprotein Sm D3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein sm d3

Species:

Leishmania major

UniProt:

Q4Q2F6_LEIMA

TriTrypDb:

LmjF.34.3860 , LMJLV39_340045100 , LMJSD75_340045500

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000243	commitment complex	5	2
GO:0005681	spliceosomal complex	3	10
GO:0005682	U5 snRNP	5	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005685	U1 snRNP	5	2
GO:0005686	U2 snRNP	5	2
GO:0005687	U4 snRNP	5	2
GO:0005689	U12-type spliceosomal complex	4	2
GO:0005730	nucleolus	5	2
GO:0005829	cytosol	2	10
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	11
GO:0034715	pICln-Sm protein complex	3	2
GO:0034719	SMN-Sm protein complex	3	2
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0071011	precatalytic spliceosome	4	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0071024	SL snRNP	5	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0110165	cellular anatomical entity	1	11
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	10
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4Q2F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2F6

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	10
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0022618	ribonucleoprotein complex assembly	6	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0071826	ribonucleoprotein complex subunit organization	5	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.560
CLV_C14_Caspase3-7	96	100	PF00656	0.618
CLV_NRD_NRD_1	106	108	PF00675	0.599
CLV_PCSK_KEX2_1	108	110	PF00082	0.604
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.607
CLV_PCSK_SKI1_1	44	48	PF00082	0.314
CLV_PCSK_SKI1_1	8	12	PF00082	0.378
DOC_CYCLIN_RxL_1	5	12	PF00134	0.368
DOC_MAPK_gen_1	54	63	PF00069	0.498
DOC_PP1_RVXF_1	6	12	PF00149	0.407
DOC_PP4_FxxP_1	71	74	PF00568	0.510
DOC_USP7_UBL2_3	44	48	PF12436	0.494
DOC_WW_Pin1_4	77	82	PF00397	0.440
LIG_14-3-3_CterR_2	109	113	PF00244	0.688
LIG_Actin_WH2_2	2	19	PF00022	0.504
LIG_Actin_WH2_2	28	46	PF00022	0.537
LIG_Actin_WH2_2	70	87	PF00022	0.593
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_FHA_1	22	28	PF00498	0.473
LIG_FHA_2	29	35	PF00498	0.456
LIG_FHA_2	54	60	PF00498	0.560
LIG_FHA_2	94	100	PF00498	0.642
LIG_Integrin_RGD_1	97	99	PF01839	0.609
LIG_Rb_pABgroove_1	5	13	PF01858	0.414
LIG_TRAF2_1	31	34	PF00917	0.505
LIG_UBA3_1	10	17	PF00899	0.416
MOD_CK2_1	28	34	PF00069	0.483
MOD_GSK3_1	53	60	PF00069	0.495
MOD_NEK2_1	1	6	PF00069	0.536
MOD_NEK2_1	103	108	PF00069	0.669
MOD_PK_1	57	63	PF00069	0.518
MOD_PKA_2	63	69	PF00069	0.488
MOD_Plk_4	57	63	PF00069	0.461
MOD_ProDKin_1	77	83	PF00069	0.444
MOD_SUMO_rev_2	95	103	PF00179	0.586
TRG_NLS_MonoExtC_3	106	111	PF00514	0.622
TRG_NLS_MonoExtN_4	107	112	PF00514	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK5	Leptomonas seymouri	87%	100%
A0A0S4KRF8	Bodo saltans	50%	90%
A0A1X0PAE8	Trypanosomatidae	65%	98%
A0A3Q8IKS2	Leishmania donovani	33%	97%
A0A3S7X8L1	Leishmania donovani	100%	100%
A0A3S7XAB5	Leishmania donovani	31%	80%
A0A422NSZ6	Trypanosoma rangeli	60%	98%
A4HBA7	Leishmania braziliensis	96%	100%
A4HK52	Leishmania braziliensis	32%	97%
A4HNR2	Leishmania braziliensis	34%	80%
A4IAF5	Leishmania infantum	99%	100%
A4ICT3	Leishmania infantum	31%	80%
C9ZLT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9B5H9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O44437	Drosophila melanogaster	36%	75%
P43321	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P62318	Homo sapiens	37%	90%
P62320	Mus musculus	37%	90%
P62323	Xenopus laevis	37%	90%
Q17348	Caenorhabditis elegans	37%	83%
Q969L4	Homo sapiens	25%	92%
Q9LM92	Arabidopsis thaliana	37%	86%
Q9QXA5	Mus musculus	25%	82%
Q9S7E6	Arabidopsis thaliana	36%	88%
Q9SSF1	Arabidopsis thaliana	33%	99%
Q9SY09	Arabidopsis thaliana	35%	97%
Q9UUC6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q9VU02	Drosophila melanogaster	31%	91%