J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2F5_LEIMA

TriTrypDb:

LmjF.34.3870 , LMJLV39_340045200 , LMJSD75_340045600

Length:

781

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2F5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2F5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	629	635	PF00089	0.648
CLV_NRD_NRD_1	174	176	PF00675	0.766
CLV_NRD_NRD_1	277	279	PF00675	0.649
CLV_NRD_NRD_1	400	402	PF00675	0.622
CLV_NRD_NRD_1	646	648	PF00675	0.614
CLV_NRD_NRD_1	687	689	PF00675	0.792
CLV_NRD_NRD_1	725	727	PF00675	0.601
CLV_NRD_NRD_1	728	730	PF00675	0.611
CLV_NRD_NRD_1	747	749	PF00675	0.448
CLV_PCSK_FUR_1	644	648	PF00082	0.555
CLV_PCSK_FUR_1	726	730	PF00082	0.524
CLV_PCSK_KEX2_1	276	278	PF00082	0.643
CLV_PCSK_KEX2_1	400	402	PF00082	0.594
CLV_PCSK_KEX2_1	646	648	PF00082	0.634
CLV_PCSK_KEX2_1	657	659	PF00082	0.718
CLV_PCSK_KEX2_1	687	689	PF00082	0.797
CLV_PCSK_KEX2_1	724	726	PF00082	0.604
CLV_PCSK_KEX2_1	728	730	PF00082	0.610
CLV_PCSK_KEX2_1	747	749	PF00082	0.448
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.525
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.740
CLV_PCSK_PC7_1	724	730	PF00082	0.524
CLV_PCSK_SKI1_1	17	21	PF00082	0.580
CLV_PCSK_SKI1_1	442	446	PF00082	0.605
CLV_PCSK_SKI1_1	728	732	PF00082	0.552
CLV_PCSK_SKI1_1	748	752	PF00082	0.588
CLV_Separin_Metazoa	553	557	PF03568	0.462
DEG_APCC_DBOX_1	564	572	PF00400	0.407
DEG_Nend_Nbox_1	1	3	PF02207	0.500
DEG_SPOP_SBC_1	480	484	PF00917	0.421
DOC_CKS1_1	205	210	PF01111	0.454
DOC_CKS1_1	420	425	PF01111	0.389
DOC_CYCLIN_RxL_1	504	514	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.190
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.462
DOC_MAPK_DCC_7	79	87	PF00069	0.287
DOC_MAPK_gen_1	175	183	PF00069	0.534
DOC_MAPK_gen_1	400	408	PF00069	0.290
DOC_MAPK_gen_1	562	570	PF00069	0.427
DOC_MAPK_gen_1	724	734	PF00069	0.356
DOC_MAPK_MEF2A_6	131	139	PF00069	0.523
DOC_MAPK_MEF2A_6	247	255	PF00069	0.419
DOC_MAPK_MEF2A_6	725	734	PF00069	0.351
DOC_MAPK_MEF2A_6	79	87	PF00069	0.280
DOC_PP1_RVXF_1	177	184	PF00149	0.533
DOC_PP2B_LxvP_1	142	145	PF13499	0.559
DOC_PP2B_LxvP_1	31	34	PF13499	0.190
DOC_PP2B_LxvP_1	444	447	PF13499	0.468
DOC_PP2B_LxvP_1	555	558	PF13499	0.426
DOC_PP4_FxxP_1	132	135	PF00568	0.509
DOC_USP7_MATH_1	154	158	PF00917	0.535
DOC_USP7_MATH_1	198	202	PF00917	0.585
DOC_USP7_MATH_1	487	491	PF00917	0.334
DOC_USP7_MATH_1	537	541	PF00917	0.426
DOC_USP7_MATH_1	611	615	PF00917	0.428
DOC_USP7_MATH_1	663	667	PF00917	0.513
DOC_USP7_MATH_1	668	672	PF00917	0.542
DOC_USP7_MATH_1	673	677	PF00917	0.563
DOC_USP7_MATH_1	678	682	PF00917	0.601
DOC_USP7_MATH_1	693	697	PF00917	0.547
DOC_USP7_MATH_1	742	746	PF00917	0.351
DOC_USP7_MATH_1	9	13	PF00917	0.403
DOC_WW_Pin1_4	131	136	PF00397	0.573
DOC_WW_Pin1_4	174	179	PF00397	0.589
DOC_WW_Pin1_4	204	209	PF00397	0.547
DOC_WW_Pin1_4	373	378	PF00397	0.410
DOC_WW_Pin1_4	419	424	PF00397	0.447
DOC_WW_Pin1_4	509	514	PF00397	0.409
DOC_WW_Pin1_4	699	704	PF00397	0.568
LIG_14-3-3_CanoR_1	123	132	PF00244	0.525
LIG_14-3-3_CanoR_1	285	291	PF00244	0.356
LIG_14-3-3_CanoR_1	658	662	PF00244	0.501
LIG_14-3-3_CanoR_1	675	682	PF00244	0.376
LIG_14-3-3_CanoR_1	694	703	PF00244	0.535
LIG_14-3-3_CanoR_1	728	733	PF00244	0.390
LIG_14-3-3_CanoR_1	770	774	PF00244	0.391
LIG_Actin_WH2_2	497	512	PF00022	0.394
LIG_APCC_ABBA_1	732	737	PF00400	0.351
LIG_BRCT_BRCA1_1	202	206	PF00533	0.534
LIG_BRCT_BRCA1_1	367	371	PF00533	0.575
LIG_CtBP_PxDLS_1	217	221	PF00389	0.430
LIG_eIF4E_1	30	36	PF01652	0.190
LIG_eIF4E_1	515	521	PF01652	0.399
LIG_EVH1_1	452	456	PF00568	0.416
LIG_FHA_1	22	28	PF00498	0.279
LIG_FHA_1	236	242	PF00498	0.519
LIG_FHA_1	301	307	PF00498	0.369
LIG_FHA_1	461	467	PF00498	0.473
LIG_FHA_1	481	487	PF00498	0.421
LIG_FHA_1	559	565	PF00498	0.456
LIG_FHA_1	66	72	PF00498	0.190
LIG_FHA_1	729	735	PF00498	0.351
LIG_FHA_2	175	181	PF00498	0.555
LIG_FHA_2	360	366	PF00498	0.501
LIG_FHA_2	380	386	PF00498	0.422
LIG_FHA_2	695	701	PF00498	0.590
LIG_FHA_2	705	711	PF00498	0.372
LIG_GBD_Chelix_1	332	340	PF00786	0.633
LIG_LIR_Gen_1	289	295	PF02991	0.433
LIG_LIR_Gen_1	315	324	PF02991	0.384
LIG_LIR_Gen_1	457	466	PF02991	0.414
LIG_LIR_Gen_1	495	505	PF02991	0.363
LIG_LIR_Gen_1	608	616	PF02991	0.472
LIG_LIR_Gen_1	707	714	PF02991	0.338
LIG_LIR_Gen_1	752	761	PF02991	0.371
LIG_LIR_Nem_3	126	132	PF02991	0.546
LIG_LIR_Nem_3	289	293	PF02991	0.413
LIG_LIR_Nem_3	315	321	PF02991	0.387
LIG_LIR_Nem_3	368	374	PF02991	0.556
LIG_LIR_Nem_3	457	461	PF02991	0.459
LIG_LIR_Nem_3	495	500	PF02991	0.379
LIG_LIR_Nem_3	542	547	PF02991	0.349
LIG_LIR_Nem_3	707	712	PF02991	0.338
LIG_LIR_Nem_3	752	757	PF02991	0.327
LIG_LYPXL_yS_3	544	547	PF13949	0.345
LIG_PCNA_yPIPBox_3	331	341	PF02747	0.424
LIG_PCNA_yPIPBox_3	627	637	PF02747	0.452
LIG_Pex14_2	524	528	PF04695	0.387
LIG_Rb_pABgroove_1	631	639	PF01858	0.463
LIG_SH2_CRK	10	14	PF00017	0.435
LIG_SH2_CRK	290	294	PF00017	0.397
LIG_SH2_CRK	709	713	PF00017	0.303
LIG_SH2_CRK	727	731	PF00017	0.375
LIG_SH2_CRK	761	765	PF00017	0.317
LIG_SH2_GRB2like	497	500	PF00017	0.372
LIG_SH2_NCK_1	346	350	PF00017	0.376
LIG_SH2_PTP2	250	253	PF00017	0.449
LIG_SH2_SRC	250	253	PF00017	0.449
LIG_SH2_SRC	497	500	PF00017	0.372
LIG_SH2_SRC	515	518	PF00017	0.357
LIG_SH2_STAP1	346	350	PF00017	0.431
LIG_SH2_STAT5	10	13	PF00017	0.431
LIG_SH2_STAT5	250	253	PF00017	0.373
LIG_SH2_STAT5	254	257	PF00017	0.346
LIG_SH2_STAT5	30	33	PF00017	0.190
LIG_SH2_STAT5	448	451	PF00017	0.377
LIG_SH2_STAT5	479	482	PF00017	0.338
LIG_SH2_STAT5	497	500	PF00017	0.389
LIG_SH2_STAT5	569	572	PF00017	0.443
LIG_SH3_2	195	200	PF14604	0.523
LIG_SH3_2	205	210	PF14604	0.454
LIG_SH3_3	134	140	PF00018	0.514
LIG_SH3_3	15	21	PF00018	0.368
LIG_SH3_3	178	184	PF00018	0.555
LIG_SH3_3	187	193	PF00018	0.467
LIG_SH3_3	202	208	PF00018	0.486
LIG_SH3_3	450	456	PF00018	0.423
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.560
LIG_SUMO_SIM_anti_2	84	89	PF11976	0.307
LIG_SUMO_SIM_par_1	376	382	PF11976	0.346
LIG_SUMO_SIM_par_1	546	551	PF11976	0.336
LIG_SUMO_SIM_par_1	84	89	PF11976	0.307
LIG_TRFH_1	194	198	PF08558	0.538
LIG_TYR_ITIM	8	13	PF00017	0.403
LIG_WRC_WIRS_1	390	395	PF05994	0.444
LIG_WRC_WIRS_1	525	530	PF05994	0.391
MOD_CDK_SPK_2	174	179	PF00069	0.589
MOD_CDK_SPxK_1	204	210	PF00069	0.454
MOD_CDK_SPxxK_3	131	138	PF00069	0.466
MOD_CDK_SPxxK_3	699	706	PF00069	0.427
MOD_CK1_1	100	106	PF00069	0.534
MOD_CK1_1	161	167	PF00069	0.517
MOD_CK1_1	243	249	PF00069	0.456
MOD_CK1_1	259	265	PF00069	0.309
MOD_CK1_1	316	322	PF00069	0.523
MOD_CK1_1	389	395	PF00069	0.394
MOD_CK1_1	490	496	PF00069	0.435
MOD_CK1_1	57	63	PF00069	0.625
MOD_CK1_1	614	620	PF00069	0.352
MOD_CK1_1	666	672	PF00069	0.588
MOD_CK1_1	676	682	PF00069	0.503
MOD_CK1_1	696	702	PF00069	0.530
MOD_CK1_1	704	710	PF00069	0.380
MOD_CK1_1	716	722	PF00069	0.243
MOD_CK1_1	762	768	PF00069	0.322
MOD_CK2_1	174	180	PF00069	0.556
MOD_CK2_1	448	454	PF00069	0.467
MOD_CK2_1	587	593	PF00069	0.462
MOD_CK2_1	674	680	PF00069	0.525
MOD_CK2_1	694	700	PF00069	0.565
MOD_CK2_1	716	722	PF00069	0.310
MOD_GlcNHglycan	107	110	PF01048	0.740
MOD_GlcNHglycan	150	153	PF01048	0.786
MOD_GlcNHglycan	156	159	PF01048	0.763
MOD_GlcNHglycan	410	414	PF01048	0.590
MOD_GlcNHglycan	492	495	PF01048	0.623
MOD_GlcNHglycan	500	503	PF01048	0.595
MOD_GlcNHglycan	539	542	PF01048	0.644
MOD_GlcNHglycan	56	59	PF01048	0.399
MOD_GlcNHglycan	668	671	PF01048	0.744
MOD_GlcNHglycan	676	679	PF01048	0.710
MOD_GlcNHglycan	688	691	PF01048	0.817
MOD_GSK3_1	154	161	PF00069	0.477
MOD_GSK3_1	200	207	PF00069	0.616
MOD_GSK3_1	255	262	PF00069	0.462
MOD_GSK3_1	313	320	PF00069	0.457
MOD_GSK3_1	359	366	PF00069	0.550
MOD_GSK3_1	379	386	PF00069	0.365
MOD_GSK3_1	674	681	PF00069	0.503
MOD_GSK3_1	682	689	PF00069	0.505
MOD_GSK3_1	712	719	PF00069	0.382
MOD_GSK3_1	9	16	PF00069	0.357
MOD_GSK3_1	93	100	PF00069	0.539
MOD_LATS_1	121	127	PF00433	0.460
MOD_N-GLC_1	154	159	PF02516	0.678
MOD_N-GLC_1	473	478	PF02516	0.488
MOD_N-GLC_1	498	503	PF02516	0.650
MOD_N-GLC_1	716	721	PF02516	0.551
MOD_NEK2_1	13	18	PF00069	0.403
MOD_NEK2_1	167	172	PF00069	0.516
MOD_NEK2_1	199	204	PF00069	0.517
MOD_NEK2_1	235	240	PF00069	0.496
MOD_NEK2_1	255	260	PF00069	0.386
MOD_NEK2_1	352	357	PF00069	0.438
MOD_NEK2_1	379	384	PF00069	0.428
MOD_NEK2_1	481	486	PF00069	0.351
MOD_NEK2_1	492	497	PF00069	0.332
MOD_NEK2_1	498	503	PF00069	0.399
MOD_NEK2_1	54	59	PF00069	0.732
MOD_NEK2_1	570	575	PF00069	0.355
MOD_NEK2_1	65	70	PF00069	0.321
MOD_NEK2_1	674	679	PF00069	0.473
MOD_NEK2_1	682	687	PF00069	0.476
MOD_NEK2_1	712	717	PF00069	0.351
MOD_NEK2_1	764	769	PF00069	0.351
MOD_NEK2_1	86	91	PF00069	0.499
MOD_NEK2_1	99	104	PF00069	0.471
MOD_PIKK_1	200	206	PF00454	0.525
MOD_PIKK_1	570	576	PF00454	0.388
MOD_PIKK_1	764	770	PF00454	0.351
MOD_PK_1	546	552	PF00069	0.448
MOD_PK_1	657	663	PF00069	0.474
MOD_PKA_1	657	663	PF00069	0.557
MOD_PKA_1	728	734	PF00069	0.324
MOD_PKA_2	100	106	PF00069	0.512
MOD_PKA_2	54	60	PF00069	0.560
MOD_PKA_2	614	620	PF00069	0.420
MOD_PKA_2	657	663	PF00069	0.499
MOD_PKA_2	674	680	PF00069	0.372
MOD_PKA_2	686	692	PF00069	0.597
MOD_PKA_2	693	699	PF00069	0.484
MOD_PKA_2	728	734	PF00069	0.386
MOD_PKA_2	769	775	PF00069	0.386
MOD_PKA_2	93	99	PF00069	0.567
MOD_PKB_1	726	734	PF00069	0.379
MOD_Plk_1	161	167	PF00069	0.555
MOD_Plk_1	314	320	PF00069	0.472
MOD_Plk_1	558	564	PF00069	0.421
MOD_Plk_2-3	237	243	PF00069	0.348
MOD_Plk_2-3	454	460	PF00069	0.423
MOD_Plk_4	216	222	PF00069	0.595
MOD_Plk_4	240	246	PF00069	0.493
MOD_Plk_4	256	262	PF00069	0.316
MOD_Plk_4	481	487	PF00069	0.326
MOD_Plk_4	60	66	PF00069	0.583
MOD_Plk_4	759	765	PF00069	0.356
MOD_Plk_4	81	87	PF00069	0.390
MOD_ProDKin_1	131	137	PF00069	0.574
MOD_ProDKin_1	174	180	PF00069	0.589
MOD_ProDKin_1	204	210	PF00069	0.549
MOD_ProDKin_1	373	379	PF00069	0.408
MOD_ProDKin_1	419	425	PF00069	0.444
MOD_ProDKin_1	509	515	PF00069	0.407
MOD_ProDKin_1	699	705	PF00069	0.565
MOD_SUMO_rev_2	434	441	PF00179	0.453
TRG_DiLeu_BaEn_1	559	564	PF01217	0.457
TRG_DiLeu_BaEn_1	752	757	PF01217	0.407
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.190
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.428
TRG_ENDOCYTIC_2	10	13	PF00928	0.409
TRG_ENDOCYTIC_2	129	132	PF00928	0.541
TRG_ENDOCYTIC_2	250	253	PF00928	0.398
TRG_ENDOCYTIC_2	290	293	PF00928	0.393
TRG_ENDOCYTIC_2	30	33	PF00928	0.190
TRG_ENDOCYTIC_2	309	312	PF00928	0.245
TRG_ENDOCYTIC_2	497	500	PF00928	0.347
TRG_ENDOCYTIC_2	544	547	PF00928	0.345
TRG_ENDOCYTIC_2	709	712	PF00928	0.338
TRG_ENDOCYTIC_2	727	730	PF00928	0.317
TRG_ENDOCYTIC_2	761	764	PF00928	0.317
TRG_ER_diArg_1	277	279	PF00400	0.446
TRG_ER_diArg_1	400	402	PF00400	0.425
TRG_ER_diArg_1	603	606	PF00400	0.392
TRG_ER_diArg_1	644	647	PF00400	0.522
TRG_ER_diArg_1	72	75	PF00400	0.311
TRG_ER_diArg_1	723	726	PF00400	0.356
TRG_ER_diArg_1	727	729	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	728	733	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD42	Leptomonas seymouri	45%	100%
A0A0S4KK52	Bodo saltans	22%	78%
A0A3S7X8I0	Leishmania donovani	86%	100%
A4HBA8	Leishmania braziliensis	69%	100%
A4IAF6	Leishmania infantum	86%	100%
E9B5I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%