Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2F3_LEIMA

TriTrypDb:

LmjF.34.3890 , LMJLV39_340045400 , LMJSD75_340045800

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0020022	acidocalcisome	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q2F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.595
CLV_NRD_NRD_1	21	23	PF00675	0.344
CLV_NRD_NRD_1	84	86	PF00675	0.560
CLV_PCSK_KEX2_1	122	124	PF00082	0.595
CLV_PCSK_KEX2_1	21	23	PF00082	0.344
CLV_PCSK_KEX2_1	83	85	PF00082	0.554
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.567
CLV_PCSK_SKI1_1	134	138	PF00082	0.575
CLV_PCSK_SKI1_1	14	18	PF00082	0.339
CLV_PCSK_SKI1_1	256	260	PF00082	0.479
DEG_APCC_DBOX_1	277	285	PF00400	0.312
DOC_MAPK_gen_1	21	29	PF00069	0.460
DOC_MAPK_gen_1	82	90	PF00069	0.403
DOC_MAPK_MEF2A_6	278	286	PF00069	0.251
DOC_MAPK_MEF2A_6	294	303	PF00069	0.249
DOC_WW_Pin1_4	231	236	PF00397	0.368
DOC_WW_Pin1_4	248	253	PF00397	0.354
LIG_14-3-3_CanoR_1	122	129	PF00244	0.416
LIG_14-3-3_CanoR_1	159	163	PF00244	0.354
LIG_14-3-3_CanoR_1	189	194	PF00244	0.296
LIG_14-3-3_CanoR_1	212	217	PF00244	0.344
LIG_14-3-3_CanoR_1	256	265	PF00244	0.285
LIG_CaM_IQ_9	270	285	PF13499	0.310
LIG_Clathr_ClatBox_1	281	285	PF01394	0.261
LIG_FHA_1	107	113	PF00498	0.412
LIG_FHA_1	159	165	PF00498	0.385
LIG_FHA_1	208	214	PF00498	0.386
LIG_FHA_1	23	29	PF00498	0.318
LIG_FHA_1	259	265	PF00498	0.347
LIG_GBD_Chelix_1	73	81	PF00786	0.512
LIG_LIR_Gen_1	156	164	PF02991	0.360
LIG_LIR_Gen_1	24	34	PF02991	0.275
LIG_LIR_Gen_1	40	49	PF02991	0.419
LIG_LIR_Gen_1	57	64	PF02991	0.408
LIG_LIR_Nem_3	143	147	PF02991	0.386
LIG_LIR_Nem_3	156	160	PF02991	0.292
LIG_LIR_Nem_3	198	203	PF02991	0.318
LIG_LIR_Nem_3	24	29	PF02991	0.275
LIG_LIR_Nem_3	251	257	PF02991	0.319
LIG_LIR_Nem_3	40	44	PF02991	0.380
LIG_LYPXL_yS_3	144	147	PF13949	0.413
LIG_PCNA_yPIPBox_3	123	137	PF02747	0.331
LIG_PCNA_yPIPBox_3	14	27	PF02747	0.547
LIG_Pex14_2	26	30	PF04695	0.279
LIG_PTB_Apo_2	151	158	PF02174	0.325
LIG_PTB_Phospho_1	151	157	PF10480	0.331
LIG_SH2_GRB2like	230	233	PF00017	0.406
LIG_SH2_NCK_1	157	161	PF00017	0.349
LIG_SH2_STAP1	131	135	PF00017	0.274
LIG_SH2_STAT5	10	13	PF00017	0.603
LIG_SH2_STAT5	163	166	PF00017	0.405
LIG_SH2_STAT5	176	179	PF00017	0.377
LIG_SH2_STAT5	221	224	PF00017	0.384
LIG_SH2_STAT5	230	233	PF00017	0.406
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.376
LIG_SUMO_SIM_par_1	269	276	PF11976	0.394
LIG_TYR_ITIM	155	160	PF00017	0.464
LIG_WRC_WIRS_1	23	28	PF05994	0.298
LIG_WRC_WIRS_1	38	43	PF05994	0.298
MOD_CK1_1	124	130	PF00069	0.552
MOD_CK1_1	181	187	PF00069	0.439
MOD_CK1_1	272	278	PF00069	0.481
MOD_CK1_1	66	72	PF00069	0.463
MOD_CK2_1	273	279	PF00069	0.479
MOD_CK2_1	65	71	PF00069	0.425
MOD_GlcNHglycan	217	220	PF01048	0.494
MOD_GlcNHglycan	291	294	PF01048	0.536
MOD_GSK3_1	165	172	PF00069	0.468
MOD_GSK3_1	177	184	PF00069	0.305
MOD_GSK3_1	191	198	PF00069	0.398
MOD_GSK3_1	207	214	PF00069	0.403
MOD_GSK3_1	215	222	PF00069	0.402
MOD_GSK3_1	244	251	PF00069	0.542
MOD_GSK3_1	269	276	PF00069	0.476
MOD_GSK3_1	72	79	PF00069	0.416
MOD_N-GLC_1	170	175	PF02516	0.554
MOD_N-GLC_1	231	236	PF02516	0.453
MOD_N-GLC_1	288	293	PF02516	0.557
MOD_NEK2_1	106	111	PF00069	0.334
MOD_NEK2_1	140	145	PF00069	0.431
MOD_NEK2_1	169	174	PF00069	0.490
MOD_NEK2_1	177	182	PF00069	0.362
MOD_NEK2_1	273	278	PF00069	0.406
MOD_NEK2_1	28	33	PF00069	0.257
MOD_NEK2_1	287	292	PF00069	0.486
MOD_NEK2_1	37	42	PF00069	0.257
MOD_PIKK_1	191	197	PF00454	0.397
MOD_PIKK_1	224	230	PF00454	0.365
MOD_PIKK_1	258	264	PF00454	0.455
MOD_PKA_2	121	127	PF00069	0.412
MOD_PKA_2	158	164	PF00069	0.413
MOD_PKA_2	188	194	PF00069	0.362
MOD_PKA_2	211	217	PF00069	0.514
MOD_Plk_1	14	20	PF00069	0.459
MOD_Plk_1	170	176	PF00069	0.517
MOD_Plk_4	14	20	PF00069	0.449
MOD_Plk_4	158	164	PF00069	0.346
MOD_Plk_4	165	171	PF00069	0.534
MOD_Plk_4	178	184	PF00069	0.318
MOD_Plk_4	195	201	PF00069	0.252
MOD_Plk_4	22	28	PF00069	0.231
MOD_Plk_4	76	82	PF00069	0.453
MOD_Plk_4	96	102	PF00069	0.502
MOD_ProDKin_1	231	237	PF00069	0.456
MOD_ProDKin_1	248	254	PF00069	0.424
TRG_DiLeu_BaEn_1	24	29	PF01217	0.392
TRG_ENDOCYTIC_2	144	147	PF00928	0.482
TRG_ENDOCYTIC_2	157	160	PF00928	0.338
TRG_ER_diArg_1	121	123	PF00400	0.446
TRG_ER_diArg_1	21	23	PF00400	0.467
TRG_NLS_MonoCore_2	81	86	PF00514	0.283
TRG_NLS_MonoExtN_4	82	87	PF00514	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I4	Leptomonas seymouri	61%	100%
A0A0S4JKH0	Bodo saltans	23%	100%
A0A1X0PA82	Trypanosomatidae	36%	100%
A0A3S7X8F5	Leishmania donovani	93%	100%
A0A422NSU6	Trypanosoma rangeli	30%	100%
A4HBB0	Leishmania braziliensis	76%	100%
A4IAF8	Leishmania infantum	93%	100%
C9ZLT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5B695	Trypanosoma cruzi	32%	100%