Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Species:

Leishmania major

UniProt:

Q4Q2F2_LEIMA

TriTrypDb:

LmjF.34.3900 , LMJLV39_340045500 , LMJSD75_340045900

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005759	mitochondrial matrix	5	7
GO:0031974	membrane-enclosed lumen	2	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	7
GO:0070013	intracellular organelle lumen	4	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q2F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2F2

Function

Biological processes
Term	Name	Level	Count
GO:0006109	regulation of carbohydrate metabolic process	5	2
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	2
GO:0010906	regulation of glucose metabolic process	5	2
GO:0016310	phosphorylation	5	7
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0062012	regulation of small molecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	2
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.679
CLV_NRD_NRD_1	14	16	PF00675	0.536
CLV_NRD_NRD_1	79	81	PF00675	0.454
CLV_PCSK_KEX2_1	14	16	PF00082	0.541
CLV_PCSK_SKI1_1	326	330	PF00082	0.416
CLV_PCSK_SKI1_1	376	380	PF00082	0.340
DEG_APCC_DBOX_1	232	240	PF00400	0.472
DEG_SCF_FBW7_1	356	361	PF00400	0.549
DEG_SPOP_SBC_1	179	183	PF00917	0.742
DEG_SPOP_SBC_1	338	342	PF00917	0.559
DEG_SPOP_SBC_1	487	491	PF00917	0.588
DOC_CKS1_1	30	35	PF01111	0.411
DOC_CYCLIN_RxL_1	189	198	PF00134	0.666
DOC_CYCLIN_RxL_1	19	32	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.702
DOC_MAPK_gen_1	216	225	PF00069	0.574
DOC_MAPK_gen_1	231	239	PF00069	0.368
DOC_MAPK_gen_1	388	397	PF00069	0.335
DOC_MAPK_gen_1	476	486	PF00069	0.397
DOC_MAPK_MEF2A_6	216	225	PF00069	0.574
DOC_MAPK_MEF2A_6	233	241	PF00069	0.343
DOC_MAPK_MEF2A_6	388	397	PF00069	0.335
DOC_MAPK_MEF2A_6	479	486	PF00069	0.402
DOC_MAPK_NFAT4_5	218	226	PF00069	0.550
DOC_PP1_RVXF_1	190	197	PF00149	0.573
DOC_PP1_RVXF_1	260	266	PF00149	0.371
DOC_PP1_RVXF_1	472	478	PF00149	0.335
DOC_PP1_RVXF_1	84	90	PF00149	0.419
DOC_PP2B_LxvP_1	27	30	PF13499	0.427
DOC_PP2B_LxvP_1	34	37	PF13499	0.384
DOC_PP2B_PxIxI_1	390	396	PF00149	0.335
DOC_PP4_FxxP_1	70	73	PF00568	0.420
DOC_USP7_MATH_1	177	181	PF00917	0.629
DOC_USP7_MATH_1	232	236	PF00917	0.439
DOC_USP7_MATH_1	245	249	PF00917	0.568
DOC_USP7_MATH_1	358	362	PF00917	0.444
DOC_USP7_UBL2_3	423	427	PF12436	0.335
DOC_USP7_UBL2_3	77	81	PF12436	0.456
DOC_WW_Pin1_4	130	135	PF00397	0.620
DOC_WW_Pin1_4	29	34	PF00397	0.409
DOC_WW_Pin1_4	354	359	PF00397	0.479
LIG_14-3-3_CanoR_1	216	222	PF00244	0.531
LIG_14-3-3_CanoR_1	231	237	PF00244	0.346
LIG_14-3-3_CanoR_1	344	348	PF00244	0.638
LIG_14-3-3_CanoR_1	362	368	PF00244	0.349
LIG_14-3-3_CanoR_1	398	407	PF00244	0.453
LIG_14-3-3_CanoR_1	4	9	PF00244	0.538
LIG_14-3-3_CanoR_1	65	71	PF00244	0.517
LIG_Actin_WH2_2	364	382	PF00022	0.453
LIG_APCC_ABBA_1	318	323	PF00400	0.514
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_deltaCOP1_diTrp_1	402	410	PF00928	0.335
LIG_FHA_1	181	187	PF00498	0.599
LIG_FHA_1	218	224	PF00498	0.440
LIG_FHA_1	279	285	PF00498	0.440
LIG_FHA_1	287	293	PF00498	0.414
LIG_FHA_1	340	346	PF00498	0.576
LIG_FHA_1	384	390	PF00498	0.335
LIG_FHA_1	402	408	PF00498	0.354
LIG_FHA_1	447	453	PF00498	0.335
LIG_FHA_1	464	470	PF00498	0.453
LIG_FHA_2	141	147	PF00498	0.692
LIG_FHA_2	201	207	PF00498	0.545
LIG_FHA_2	30	36	PF00498	0.404
LIG_FHA_2	429	435	PF00498	0.335
LIG_GBD_Chelix_1	51	59	PF00786	0.384
LIG_LIR_Apic_2	69	73	PF02991	0.511
LIG_LIR_Gen_1	402	411	PF02991	0.335
LIG_LIR_Gen_1	462	469	PF02991	0.517
LIG_LIR_Gen_1	64	75	PF02991	0.411
LIG_LIR_Nem_3	135	140	PF02991	0.633
LIG_LIR_Nem_3	188	194	PF02991	0.726
LIG_LIR_Nem_3	304	309	PF02991	0.410
LIG_LIR_Nem_3	372	378	PF02991	0.453
LIG_LIR_Nem_3	402	408	PF02991	0.335
LIG_LIR_Nem_3	462	467	PF02991	0.517
LIG_LIR_Nem_3	64	70	PF02991	0.392
LIG_MYND_1	134	138	PF01753	0.590
LIG_Pex14_1	254	258	PF04695	0.381
LIG_Pex14_1	89	93	PF04695	0.395
LIG_Pex14_2	422	426	PF04695	0.335
LIG_Pex14_2	8	12	PF04695	0.637
LIG_SH2_CRK	464	468	PF00017	0.313
LIG_SH2_NCK_1	150	154	PF00017	0.659
LIG_SH2_SRC	150	153	PF00017	0.588
LIG_SH2_STAP1	436	440	PF00017	0.351
LIG_SH2_STAT5	100	103	PF00017	0.298
LIG_SH2_STAT5	26	29	PF00017	0.410
LIG_SH2_STAT5	274	277	PF00017	0.395
LIG_SH2_STAT5	373	376	PF00017	0.335
LIG_SH2_STAT5	93	96	PF00017	0.483
LIG_SH3_3	27	33	PF00018	0.420
LIG_SH3_3	442	448	PF00018	0.389
LIG_SH3_3	472	478	PF00018	0.335
LIG_SH3_3	481	487	PF00018	0.419
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.446
LIG_SUMO_SIM_anti_2	286	296	PF11976	0.478
LIG_SUMO_SIM_par_1	301	307	PF11976	0.382
LIG_SUMO_SIM_par_1	314	319	PF11976	0.381
LIG_UBA3_1	223	228	PF00899	0.420
LIG_WRC_WIRS_1	5	10	PF05994	0.611
LIG_WRC_WIRS_1	67	72	PF05994	0.529
MOD_CK1_1	132	138	PF00069	0.551
MOD_CK1_1	158	164	PF00069	0.774
MOD_CK1_1	178	184	PF00069	0.725
MOD_CK1_1	286	292	PF00069	0.385
MOD_CK1_1	314	320	PF00069	0.402
MOD_CK1_1	339	345	PF00069	0.510
MOD_CK1_1	401	407	PF00069	0.488
MOD_CK2_1	200	206	PF00069	0.558
MOD_CK2_1	428	434	PF00069	0.314
MOD_GlcNHglycan	157	160	PF01048	0.704
MOD_GlcNHglycan	175	178	PF01048	0.653
MOD_GlcNHglycan	306	309	PF01048	0.331
MOD_GSK3_1	117	124	PF00069	0.469
MOD_GSK3_1	140	147	PF00069	0.651
MOD_GSK3_1	154	161	PF00069	0.539
MOD_GSK3_1	171	178	PF00069	0.642
MOD_GSK3_1	181	188	PF00069	0.646
MOD_GSK3_1	336	343	PF00069	0.502
MOD_GSK3_1	354	361	PF00069	0.607
MOD_GSK3_1	4	11	PF00069	0.666
MOD_N-GLC_1	311	316	PF02516	0.405
MOD_N-GLC_2	381	383	PF02516	0.453
MOD_N-GLC_2	99	101	PF02516	0.394
MOD_NEK2_1	186	191	PF00069	0.552
MOD_NEK2_1	273	278	PF00069	0.541
MOD_NEK2_1	336	341	PF00069	0.429
MOD_NEK2_1	428	433	PF00069	0.344
MOD_NEK2_1	8	13	PF00069	0.752
MOD_NEK2_2	187	192	PF00069	0.571
MOD_NEK2_2	383	388	PF00069	0.488
MOD_PIKK_1	278	284	PF00454	0.563
MOD_PKA_2	232	238	PF00069	0.478
MOD_PKA_2	343	349	PF00069	0.633
MOD_PKA_2	61	67	PF00069	0.374
MOD_Plk_1	121	127	PF00069	0.453
MOD_Plk_1	144	150	PF00069	0.626
MOD_Plk_1	401	407	PF00069	0.369
MOD_Plk_1	469	475	PF00069	0.493
MOD_Plk_4	132	138	PF00069	0.678
MOD_Plk_4	144	150	PF00069	0.529
MOD_Plk_4	232	238	PF00069	0.515
MOD_Plk_4	311	317	PF00069	0.483
MOD_Plk_4	369	375	PF00069	0.407
MOD_Plk_4	401	407	PF00069	0.421
MOD_Plk_4	89	95	PF00069	0.377
MOD_ProDKin_1	130	136	PF00069	0.616
MOD_ProDKin_1	29	35	PF00069	0.410
MOD_ProDKin_1	354	360	PF00069	0.474
MOD_SUMO_rev_2	319	328	PF00179	0.508
TRG_DiLeu_BaEn_3	323	329	PF01217	0.400
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.420
TRG_ENDOCYTIC_2	26	29	PF00928	0.410
TRG_ENDOCYTIC_2	453	456	PF00928	0.335
TRG_ENDOCYTIC_2	464	467	PF00928	0.517
TRG_ENDOCYTIC_2	67	70	PF00928	0.402
TRG_ER_diArg_1	14	16	PF00400	0.649
TRG_ER_diArg_1	230	233	PF00400	0.453
TRG_ER_diArg_1	260	263	PF00400	0.373
TRG_ER_diArg_1	473	476	PF00400	0.335
TRG_NLS_MonoExtC_3	76	81	PF00514	0.415
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P768	Leptomonas seymouri	57%	100%
A0A3Q8III9	Leishmania donovani	91%	100%
A4HBB1	Leishmania braziliensis	81%	100%
A4IAF9	Leishmania infantum	91%	100%
E9B5I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%