FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q2F0_LEIMA

TriTrypDb:

LmjF.34.3920 , LMJLV39_340045700 , LMJSD75_340046100

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2F0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.630
CLV_C14_Caspase3-7	22	26	PF00656	0.694
CLV_C14_Caspase3-7	358	362	PF00656	0.671
CLV_C14_Caspase3-7	47	51	PF00656	0.597
CLV_NRD_NRD_1	138	140	PF00675	0.585
CLV_NRD_NRD_1	141	143	PF00675	0.569
CLV_NRD_NRD_1	145	147	PF00675	0.549
CLV_NRD_NRD_1	153	155	PF00675	0.461
CLV_NRD_NRD_1	175	177	PF00675	0.582
CLV_NRD_NRD_1	243	245	PF00675	0.333
CLV_NRD_NRD_1	84	86	PF00675	0.629
CLV_NRD_NRD_1	92	94	PF00675	0.639
CLV_PCSK_FUR_1	253	257	PF00082	0.333
CLV_PCSK_KEX2_1	138	140	PF00082	0.620
CLV_PCSK_KEX2_1	145	147	PF00082	0.530
CLV_PCSK_KEX2_1	153	155	PF00082	0.416
CLV_PCSK_KEX2_1	175	177	PF00082	0.582
CLV_PCSK_KEX2_1	243	245	PF00082	0.333
CLV_PCSK_KEX2_1	255	257	PF00082	0.333
CLV_PCSK_KEX2_1	84	86	PF00082	0.634
CLV_PCSK_KEX2_1	91	93	PF00082	0.646
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.320
CLV_PCSK_SKI1_1	315	319	PF00082	0.408
CLV_PCSK_SKI1_1	320	324	PF00082	0.340
CLV_PCSK_SKI1_1	360	364	PF00082	0.661
CLV_PCSK_SKI1_1	93	97	PF00082	0.635
CLV_Separin_Metazoa	207	211	PF03568	0.445
DEG_SPOP_SBC_1	112	116	PF00917	0.604
DEG_SPOP_SBC_1	329	333	PF00917	0.433
DOC_CYCLIN_RxL_1	312	319	PF00134	0.410
DOC_CYCLIN_RxL_1	415	425	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	156	159	PF00134	0.411
DOC_MAPK_DCC_7	366	375	PF00069	0.448
DOC_MAPK_gen_1	255	265	PF00069	0.270
DOC_MAPK_MEF2A_6	210	219	PF00069	0.333
DOC_MAPK_MEF2A_6	366	375	PF00069	0.455
DOC_PP2B_LxvP_1	156	159	PF13499	0.488
DOC_USP7_MATH_1	112	116	PF00917	0.607
DOC_USP7_MATH_1	147	151	PF00917	0.623
DOC_USP7_MATH_1	290	294	PF00917	0.445
DOC_USP7_MATH_1	307	311	PF00917	0.333
DOC_USP7_MATH_1	329	333	PF00917	0.579
DOC_USP7_MATH_1	369	373	PF00917	0.486
DOC_USP7_MATH_1	442	446	PF00917	0.584
DOC_USP7_MATH_1	450	454	PF00917	0.428
DOC_USP7_MATH_1	71	75	PF00917	0.543
DOC_USP7_MATH_1	95	99	PF00917	0.632
DOC_WW_Pin1_4	351	356	PF00397	0.716
DOC_WW_Pin1_4	422	427	PF00397	0.410
LIG_14-3-3_CanoR_1	109	119	PF00244	0.682
LIG_14-3-3_CanoR_1	356	360	PF00244	0.687
LIG_14-3-3_CanoR_1	366	373	PF00244	0.416
LIG_BIR_II_1	1	5	PF00653	0.459
LIG_Clathr_ClatBox_1	278	282	PF01394	0.445
LIG_EH1_1	387	395	PF00400	0.469
LIG_eIF4E_1	28	34	PF01652	0.454
LIG_FHA_1	11	17	PF00498	0.521
LIG_FHA_1	114	120	PF00498	0.585
LIG_FHA_1	365	371	PF00498	0.637
LIG_FHA_1	423	429	PF00498	0.516
LIG_FHA_1	438	444	PF00498	0.564
LIG_FHA_2	356	362	PF00498	0.690
LIG_GBD_Chelix_1	183	191	PF00786	0.333
LIG_LIR_Apic_2	152	158	PF02991	0.452
LIG_LIR_Apic_2	226	232	PF02991	0.445
LIG_LIR_Apic_2	299	304	PF02991	0.445
LIG_LIR_Gen_1	29	38	PF02991	0.441
LIG_LIR_Nem_3	25	31	PF02991	0.509
LIG_LIR_Nem_3	453	457	PF02991	0.479
LIG_MYND_1	426	430	PF01753	0.473
LIG_MYND_3	370	374	PF01753	0.501
LIG_NRBOX	293	299	PF00104	0.445
LIG_NRBOX	313	319	PF00104	0.375
LIG_PCNA_yPIPBox_3	404	418	PF02747	0.373
LIG_Pex14_2	181	185	PF04695	0.333
LIG_Pex14_2	61	65	PF04695	0.703
LIG_SH2_CRK	196	200	PF00017	0.320
LIG_SH2_CRK	31	35	PF00017	0.545
LIG_SH2_CRK	424	428	PF00017	0.516
LIG_SH2_CRK	454	458	PF00017	0.497
LIG_SH2_GRB2like	15	18	PF00017	0.587
LIG_SH2_GRB2like	229	232	PF00017	0.333
LIG_SH2_NCK_1	31	35	PF00017	0.545
LIG_SH2_NCK_1	325	329	PF00017	0.376
LIG_SH2_PTP2	229	232	PF00017	0.445
LIG_SH2_SRC	229	232	PF00017	0.333
LIG_SH2_STAP1	325	329	PF00017	0.481
LIG_SH2_STAT5	15	18	PF00017	0.484
LIG_SH2_STAT5	229	232	PF00017	0.337
LIG_SH2_STAT5	301	304	PF00017	0.353
LIG_SH2_STAT5	424	427	PF00017	0.505
LIG_SH3_1	424	430	PF00018	0.542
LIG_SH3_3	424	430	PF00018	0.466
LIG_SH3_3	456	462	PF00018	0.646
LIG_SUMO_SIM_anti_2	308	315	PF11976	0.442
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.506
LIG_SUMO_SIM_par_1	276	282	PF11976	0.333
LIG_TRAF2_1	341	344	PF00917	0.701
LIG_UBA3_1	311	315	PF00899	0.463
MOD_CDK_SPK_2	351	356	PF00069	0.716
MOD_CK1_1	100	106	PF00069	0.625
MOD_CK1_1	113	119	PF00069	0.623
MOD_CK1_1	161	167	PF00069	0.465
MOD_CK1_1	26	32	PF00069	0.486
MOD_CK1_1	332	338	PF00069	0.551
MOD_CK1_1	445	451	PF00069	0.521
MOD_CK1_1	45	51	PF00069	0.566
MOD_CK1_1	453	459	PF00069	0.499
MOD_CK1_1	6	12	PF00069	0.513
MOD_CK2_1	21	27	PF00069	0.580
MOD_CK2_1	339	345	PF00069	0.642
MOD_Cter_Amidation	173	176	PF01082	0.590
MOD_Cter_Amidation	241	244	PF01082	0.333
MOD_GlcNHglycan	149	152	PF01048	0.626
MOD_GlcNHglycan	160	163	PF01048	0.458
MOD_GlcNHglycan	19	24	PF01048	0.681
MOD_GlcNHglycan	286	289	PF01048	0.445
MOD_GlcNHglycan	332	335	PF01048	0.519
MOD_GSK3_1	1	8	PF00069	0.572
MOD_GSK3_1	108	115	PF00069	0.679
MOD_GSK3_1	117	124	PF00069	0.721
MOD_GSK3_1	161	168	PF00069	0.472
MOD_GSK3_1	19	26	PF00069	0.472
MOD_GSK3_1	328	335	PF00069	0.624
MOD_GSK3_1	351	358	PF00069	0.751
MOD_GSK3_1	360	367	PF00069	0.700
MOD_GSK3_1	42	49	PF00069	0.640
MOD_GSK3_1	95	102	PF00069	0.682
MOD_N-GLC_1	261	266	PF02516	0.253
MOD_NEK2_1	1	6	PF00069	0.526
MOD_NEK2_1	11	16	PF00069	0.405
MOD_NEK2_1	110	115	PF00069	0.585
MOD_NEK2_1	187	192	PF00069	0.333
MOD_NEK2_1	208	213	PF00069	0.445
MOD_NEK2_2	355	360	PF00069	0.685
MOD_NEK2_2	413	418	PF00069	0.489
MOD_PKA_1	138	144	PF00069	0.647
MOD_PKA_1	84	90	PF00069	0.620
MOD_PKA_2	108	114	PF00069	0.698
MOD_PKA_2	138	144	PF00069	0.676
MOD_PKA_2	258	264	PF00069	0.305
MOD_PKA_2	329	335	PF00069	0.577
MOD_PKA_2	349	355	PF00069	0.544
MOD_PKA_2	365	371	PF00069	0.666
MOD_PKA_2	83	89	PF00069	0.650
MOD_Plk_1	187	193	PF00069	0.333
MOD_Plk_1	261	267	PF00069	0.253
MOD_Plk_1	307	313	PF00069	0.333
MOD_Plk_2-3	339	345	PF00069	0.563
MOD_Plk_2-3	46	52	PF00069	0.685
MOD_Plk_4	114	120	PF00069	0.585
MOD_Plk_4	121	127	PF00069	0.543
MOD_Plk_4	187	193	PF00069	0.333
MOD_Plk_4	307	313	PF00069	0.501
MOD_Plk_4	6	12	PF00069	0.545
MOD_ProDKin_1	351	357	PF00069	0.717
MOD_ProDKin_1	422	428	PF00069	0.420
TRG_DiLeu_BaEn_1	152	157	PF01217	0.573
TRG_DiLeu_BaEn_1	406	411	PF01217	0.490
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.467
TRG_ENDOCYTIC_2	196	199	PF00928	0.320
TRG_ENDOCYTIC_2	31	34	PF00928	0.440
TRG_ENDOCYTIC_2	454	457	PF00928	0.482
TRG_ER_diArg_1	153	155	PF00400	0.475
TRG_ER_diArg_1	83	85	PF00400	0.642
TRG_ER_diArg_1	91	93	PF00400	0.656
TRG_NES_CRM1_1	177	189	PF08389	0.445
TRG_NES_CRM1_1	207	218	PF08389	0.333
TRG_NES_CRM1_1	270	282	PF08389	0.445
TRG_NLS_MonoExtC_3	141	146	PF00514	0.646
TRG_NLS_MonoExtN_4	139	146	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT0	Leptomonas seymouri	55%	91%
A0A3S7X8G2	Leishmania donovani	90%	87%
A4HBB3	Leishmania braziliensis	77%	100%
A4IAG1	Leishmania infantum	90%	87%
E9B5I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	79%