Putative expression site-associated protein 5 (ESAG5)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression site-associated protein 5 (ESAG5), putative

Species:

Leishmania major

UniProt:

Q4Q2E9_LEIMA

TriTrypDb:

LmjF.34.3930 , LMJLV39_340045800 , LMJSD75_340046200

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q2E9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2E9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0008289	lipid binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	47	51	PF00656	0.650
CLV_NRD_NRD_1	21	23	PF00675	0.629
CLV_NRD_NRD_1	424	426	PF00675	0.637
CLV_NRD_NRD_1	433	435	PF00675	0.616
CLV_PCSK_FUR_1	424	428	PF00082	0.594
CLV_PCSK_KEX2_1	13	15	PF00082	0.684
CLV_PCSK_KEX2_1	23	25	PF00082	0.612
CLV_PCSK_KEX2_1	236	238	PF00082	0.553
CLV_PCSK_KEX2_1	423	425	PF00082	0.608
CLV_PCSK_KEX2_1	426	428	PF00082	0.641
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.718
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.503
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.526
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.604
CLV_PCSK_PC7_1	420	426	PF00082	0.394
CLV_PCSK_SKI1_1	122	126	PF00082	0.498
CLV_PCSK_SKI1_1	151	155	PF00082	0.564
CLV_PCSK_SKI1_1	170	174	PF00082	0.269
CLV_PCSK_SKI1_1	236	240	PF00082	0.530
CLV_PCSK_SKI1_1	261	265	PF00082	0.543
CLV_PCSK_SKI1_1	434	438	PF00082	0.459
CLV_PCSK_SKI1_1	49	53	PF00082	0.566
CLV_PCSK_SKI1_1	490	494	PF00082	0.513
CLV_PCSK_SKI1_1	542	546	PF00082	0.575
DEG_APCC_DBOX_1	48	56	PF00400	0.491
DEG_COP1_1	125	133	PF00400	0.456
DEG_COP1_1	288	298	PF00400	0.511
DEG_SPOP_SBC_1	74	78	PF00917	0.534
DOC_CYCLIN_yClb1_LxF_4	509	514	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.490
DOC_MAPK_gen_1	22	31	PF00069	0.639
DOC_MAPK_gen_1	434	442	PF00069	0.508
DOC_MAPK_MEF2A_6	139	147	PF00069	0.561
DOC_MAPK_MEF2A_6	24	33	PF00069	0.550
DOC_MAPK_MEF2A_6	434	442	PF00069	0.516
DOC_PP1_RVXF_1	15	21	PF00149	0.552
DOC_PP2B_LxvP_1	510	513	PF13499	0.552
DOC_PP2B_PxIxI_1	365	371	PF00149	0.425
DOC_PP4_FxxP_1	499	502	PF00568	0.571
DOC_SPAK_OSR1_1	257	261	PF12202	0.474
DOC_USP7_MATH_1	290	294	PF00917	0.635
DOC_USP7_MATH_1	399	403	PF00917	0.443
DOC_USP7_MATH_1	69	73	PF00917	0.444
DOC_USP7_MATH_1	7	11	PF00917	0.622
DOC_USP7_MATH_1	74	78	PF00917	0.460
DOC_USP7_UBL2_3	242	246	PF12436	0.525
DOC_USP7_UBL2_3	486	490	PF12436	0.563
DOC_USP7_UBL2_3	9	13	PF12436	0.650
DOC_WW_Pin1_4	261	266	PF00397	0.425
DOC_WW_Pin1_4	286	291	PF00397	0.553
DOC_WW_Pin1_4	505	510	PF00397	0.505
LIG_14-3-3_CanoR_1	122	127	PF00244	0.326
LIG_14-3-3_CanoR_1	179	183	PF00244	0.500
LIG_14-3-3_CanoR_1	187	193	PF00244	0.483
LIG_14-3-3_CanoR_1	22	27	PF00244	0.532
LIG_14-3-3_CanoR_1	306	316	PF00244	0.555
LIG_14-3-3_CanoR_1	355	360	PF00244	0.520
LIG_14-3-3_CanoR_1	412	422	PF00244	0.667
LIG_Actin_WH2_2	231	248	PF00022	0.352
LIG_Actin_WH2_2	509	524	PF00022	0.402
LIG_Actin_WH2_2	529	544	PF00022	0.249
LIG_APCC_ABBA_1	534	539	PF00400	0.366
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BRCT_BRCA1_1	1	5	PF00533	0.719
LIG_BRCT_BRCA1_1	161	165	PF00533	0.443
LIG_BRCT_BRCA1_1	299	303	PF00533	0.389
LIG_deltaCOP1_diTrp_1	185	192	PF00928	0.548
LIG_DLG_GKlike_1	22	29	PF00625	0.455
LIG_FHA_1	262	268	PF00498	0.462
LIG_FHA_1	274	280	PF00498	0.412
LIG_FHA_1	335	341	PF00498	0.496
LIG_FHA_1	483	489	PF00498	0.534
LIG_FHA_1	96	102	PF00498	0.556
LIG_FHA_2	45	51	PF00498	0.640
LIG_FHA_2	55	61	PF00498	0.434
LIG_LIR_Apic_2	498	502	PF02991	0.540
LIG_LIR_Gen_1	164	174	PF02991	0.528
LIG_LIR_Gen_1	2	11	PF02991	0.617
LIG_LIR_Gen_1	253	263	PF02991	0.489
LIG_LIR_Gen_1	460	471	PF02991	0.557
LIG_LIR_Gen_1	493	504	PF02991	0.546
LIG_LIR_Nem_3	164	169	PF02991	0.477
LIG_LIR_Nem_3	191	195	PF02991	0.534
LIG_LIR_Nem_3	198	202	PF02991	0.516
LIG_LIR_Nem_3	253	258	PF02991	0.496
LIG_LIR_Nem_3	342	347	PF02991	0.469
LIG_LIR_Nem_3	37	41	PF02991	0.581
LIG_LIR_Nem_3	416	422	PF02991	0.579
LIG_LIR_Nem_3	460	466	PF02991	0.547
LIG_LIR_Nem_3	493	499	PF02991	0.546
LIG_PDZ_Class_1	543	548	PF00595	0.630
LIG_Pex14_1	188	192	PF04695	0.530
LIG_Pex14_2	79	83	PF04695	0.418
LIG_PTB_Apo_2	311	318	PF02174	0.478
LIG_PTB_Phospho_1	311	317	PF10480	0.512
LIG_RPA_C_Fungi	17	29	PF08784	0.435
LIG_SH2_CRK	156	160	PF00017	0.519
LIG_SH2_CRK	317	321	PF00017	0.480
LIG_SH2_CRK	419	423	PF00017	0.399
LIG_SH2_NCK_1	317	321	PF00017	0.557
LIG_SH2_NCK_1	357	361	PF00017	0.558
LIG_SH2_PTP2	388	391	PF00017	0.499
LIG_SH2_STAT5	35	38	PF00017	0.561
LIG_SH2_STAT5	357	360	PF00017	0.487
LIG_SH2_STAT5	388	391	PF00017	0.478
LIG_SH2_STAT5	40	43	PF00017	0.607
LIG_SH3_3	187	193	PF00018	0.544
LIG_SH3_3	96	102	PF00018	0.545
LIG_SUMO_SIM_par_1	95	103	PF11976	0.565
LIG_TRAF2_1	102	105	PF00917	0.602
LIG_TRFH_1	463	467	PF08558	0.556
LIG_TYR_ITIM	315	320	PF00017	0.435
LIG_TYR_ITIM	461	466	PF00017	0.512
LIG_WRC_WIRS_1	80	85	PF05994	0.528
MOD_CDC14_SPxK_1	508	511	PF00782	0.537
MOD_CDK_SPxK_1	505	511	PF00069	0.543
MOD_CK1_1	288	294	PF00069	0.550
MOD_CK1_1	398	404	PF00069	0.553
MOD_CK1_1	445	451	PF00069	0.513
MOD_CK1_1	454	460	PF00069	0.538
MOD_CK2_1	165	171	PF00069	0.502
MOD_CK2_1	291	297	PF00069	0.513
MOD_CK2_1	532	538	PF00069	0.531
MOD_Cter_Amidation	11	14	PF01082	0.726
MOD_DYRK1A_RPxSP_1	261	265	PF00069	0.543
MOD_GlcNHglycan	1	4	PF01048	0.674
MOD_GlcNHglycan	14	17	PF01048	0.623
MOD_GlcNHglycan	161	164	PF01048	0.443
MOD_GlcNHglycan	331	334	PF01048	0.622
MOD_GlcNHglycan	397	400	PF01048	0.542
MOD_GlcNHglycan	415	418	PF01048	0.397
MOD_GlcNHglycan	444	447	PF01048	0.468
MOD_GlcNHglycan	453	456	PF01048	0.441
MOD_GlcNHglycan	505	508	PF01048	0.506
MOD_GlcNHglycan	67	70	PF01048	0.437
MOD_GSK3_1	120	127	PF00069	0.540
MOD_GSK3_1	161	168	PF00069	0.417
MOD_GSK3_1	286	293	PF00069	0.538
MOD_GSK3_1	304	311	PF00069	0.459
MOD_GSK3_1	390	397	PF00069	0.584
MOD_GSK3_1	398	405	PF00069	0.482
MOD_GSK3_1	453	460	PF00069	0.479
MOD_GSK3_1	50	57	PF00069	0.597
MOD_GSK3_1	65	72	PF00069	0.471
MOD_GSK3_1	75	82	PF00069	0.427
MOD_LATS_1	118	124	PF00433	0.563
MOD_N-GLC_1	147	152	PF02516	0.443
MOD_N-GLC_1	188	193	PF02516	0.522
MOD_N-GLC_1	335	340	PF02516	0.442
MOD_N-GLC_1	391	396	PF02516	0.501
MOD_N-GLC_1	451	456	PF02516	0.488
MOD_N-GLC_1	532	537	PF02516	0.546
MOD_N-GLC_1	69	74	PF02516	0.432
MOD_N-GLC_1	93	98	PF02516	0.636
MOD_NEK2_1	124	129	PF00069	0.444
MOD_NEK2_1	165	170	PF00069	0.455
MOD_NEK2_1	178	183	PF00069	0.390
MOD_NEK2_1	230	235	PF00069	0.522
MOD_NEK2_1	334	339	PF00069	0.453
MOD_NEK2_1	34	39	PF00069	0.546
MOD_NEK2_1	44	49	PF00069	0.599
MOD_NEK2_1	503	508	PF00069	0.601
MOD_NEK2_1	79	84	PF00069	0.446
MOD_PIKK_1	100	106	PF00454	0.325
MOD_PIKK_1	427	433	PF00454	0.586
MOD_PKA_1	22	28	PF00069	0.485
MOD_PKA_1	426	432	PF00069	0.665
MOD_PKA_2	138	144	PF00069	0.544
MOD_PKA_2	159	165	PF00069	0.425
MOD_PKA_2	178	184	PF00069	0.410
MOD_PKA_2	305	311	PF00069	0.555
MOD_PKA_2	426	432	PF00069	0.607
MOD_PKB_1	425	433	PF00069	0.433
MOD_Plk_1	147	153	PF00069	0.407
MOD_Plk_1	170	176	PF00069	0.424
MOD_Plk_1	188	194	PF00069	0.443
MOD_Plk_1	335	341	PF00069	0.399
MOD_Plk_1	374	380	PF00069	0.474
MOD_Plk_1	532	538	PF00069	0.544
MOD_Plk_1	69	75	PF00069	0.433
MOD_Plk_4	132	138	PF00069	0.502
MOD_Plk_4	161	167	PF00069	0.480
MOD_Plk_4	178	184	PF00069	0.342
MOD_Plk_4	335	341	PF00069	0.399
MOD_Plk_4	34	40	PF00069	0.549
MOD_Plk_4	399	405	PF00069	0.522
MOD_Plk_4	75	81	PF00069	0.423
MOD_Plk_4	95	101	PF00069	0.288
MOD_ProDKin_1	261	267	PF00069	0.431
MOD_ProDKin_1	286	292	PF00069	0.552
MOD_ProDKin_1	505	511	PF00069	0.511
TRG_DiLeu_BaEn_2	225	231	PF01217	0.502
TRG_ENDOCYTIC_2	156	159	PF00928	0.525
TRG_ENDOCYTIC_2	317	320	PF00928	0.471
TRG_ENDOCYTIC_2	419	422	PF00928	0.506
TRG_ENDOCYTIC_2	463	466	PF00928	0.454
TRG_ER_diArg_1	409	412	PF00400	0.661
TRG_ER_diArg_1	422	425	PF00400	0.540
TRG_NLS_MonoExtN_4	423	429	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I082	Leptomonas seymouri	41%	98%
A0A3S5H7X9	Leishmania donovani	87%	100%
A4HBB4	Leishmania braziliensis	57%	100%
A4IAG2	Leishmania infantum	88%	100%
C9ZLT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
C9ZNB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	100%
E9B5I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5DMU0	Trypanosoma cruzi	20%	100%