CUPID domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2E7_LEIMA

TriTrypDb:

LmjF.34.3950 , LMJLV39_340046000 , LMJSD75_340046400

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0020016	ciliary pocket	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2E7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2E7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.645
CLV_NRD_NRD_1	160	162	PF00675	0.529
CLV_NRD_NRD_1	206	208	PF00675	0.465
CLV_NRD_NRD_1	66	68	PF00675	0.483
CLV_NRD_NRD_1	73	75	PF00675	0.505
CLV_PCSK_FUR_1	204	208	PF00082	0.478
CLV_PCSK_KEX2_1	160	162	PF00082	0.540
CLV_PCSK_KEX2_1	206	208	PF00082	0.465
CLV_PCSK_KEX2_1	66	68	PF00082	0.482
CLV_PCSK_SKI1_1	161	165	PF00082	0.543
CLV_PCSK_SKI1_1	173	177	PF00082	0.458
CLV_PCSK_SKI1_1	209	213	PF00082	0.582
CLV_PCSK_SKI1_1	217	221	PF00082	0.521
CLV_PCSK_SKI1_1	75	79	PF00082	0.546
DOC_CYCLIN_RxL_1	69	79	PF00134	0.544
DOC_MAPK_MEF2A_6	165	172	PF00069	0.582
DOC_MAPK_RevD_3	51	67	PF00069	0.537
DOC_PP4_FxxP_1	114	117	PF00568	0.644
DOC_USP7_MATH_1	153	157	PF00917	0.591
DOC_USP7_MATH_1	18	22	PF00917	0.731
DOC_USP7_MATH_1	243	247	PF00917	0.725
DOC_WW_Pin1_4	14	19	PF00397	0.671
DOC_WW_Pin1_4	164	169	PF00397	0.586
DOC_WW_Pin1_4	247	252	PF00397	0.594
DOC_WW_Pin1_4	254	259	PF00397	0.552
LIG_14-3-3_CanoR_1	102	112	PF00244	0.689
LIG_14-3-3_CanoR_1	136	142	PF00244	0.553
LIG_14-3-3_CanoR_1	39	45	PF00244	0.699
LIG_14-3-3_CterR_2	265	270	PF00244	0.587
LIG_APCC_ABBA_1	49	54	PF00400	0.625
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_FHA_1	107	113	PF00498	0.718
LIG_FHA_1	165	171	PF00498	0.572
LIG_FHA_1	236	242	PF00498	0.619
LIG_FHA_1	88	94	PF00498	0.688
LIG_FHA_2	18	24	PF00498	0.643
LIG_LIR_Apic_2	10	16	PF02991	0.666
LIG_LIR_Apic_2	113	117	PF02991	0.645
LIG_LIR_Gen_1	257	267	PF02991	0.636
LIG_LIR_Nem_3	205	211	PF02991	0.467
LIG_LIR_Nem_3	257	263	PF02991	0.644
LIG_SH2_CRK	260	264	PF00017	0.589
LIG_SH2_STAT5	218	221	PF00017	0.435
LIG_SH2_STAT5	256	259	PF00017	0.572
LIG_SH3_3	12	18	PF00018	0.638
LIG_WRC_WIRS_1	188	193	PF05994	0.533
LIG_WW_3	25	29	PF00397	0.552
LIG_WW_3	265	269	PF00397	0.654
MOD_CDK_SPK_2	254	259	PF00069	0.589
MOD_CK1_1	106	112	PF00069	0.642
MOD_CK1_1	17	23	PF00069	0.709
MOD_CK1_1	237	243	PF00069	0.607
MOD_CK1_1	247	253	PF00069	0.578
MOD_CK1_1	261	267	PF00069	0.559
MOD_CK1_1	96	102	PF00069	0.676
MOD_CK2_1	116	122	PF00069	0.600
MOD_CK2_1	153	159	PF00069	0.486
MOD_GlcNHglycan	1	4	PF01048	0.678
MOD_GlcNHglycan	109	112	PF01048	0.517
MOD_GlcNHglycan	127	130	PF01048	0.476
MOD_GlcNHglycan	220	223	PF01048	0.536
MOD_GlcNHglycan	241	244	PF01048	0.703
MOD_GlcNHglycan	93	96	PF01048	0.653
MOD_GSK3_1	103	110	PF00069	0.616
MOD_GSK3_1	116	123	PF00069	0.593
MOD_GSK3_1	14	21	PF00069	0.700
MOD_GSK3_1	230	237	PF00069	0.684
MOD_GSK3_1	239	246	PF00069	0.595
MOD_GSK3_1	254	261	PF00069	0.614
MOD_GSK3_1	35	42	PF00069	0.637
MOD_GSK3_1	87	94	PF00069	0.630
MOD_N-GLC_1	230	235	PF02516	0.611
MOD_NEK2_1	163	168	PF00069	0.483
MOD_NEK2_1	187	192	PF00069	0.572
MOD_NEK2_1	230	235	PF00069	0.695
MOD_NEK2_1	244	249	PF00069	0.585
MOD_PIKK_1	103	109	PF00454	0.525
MOD_PIKK_1	21	27	PF00454	0.676
MOD_PIKK_1	245	251	PF00454	0.683
MOD_PKA_2	135	141	PF00069	0.651
MOD_PKA_2	142	148	PF00069	0.548
MOD_PKA_2	21	27	PF00069	0.716
MOD_PKA_2	258	264	PF00069	0.698
MOD_PKA_2	38	44	PF00069	0.624
MOD_Plk_1	182	188	PF00069	0.519
MOD_Plk_4	137	143	PF00069	0.663
MOD_Plk_4	182	188	PF00069	0.470
MOD_ProDKin_1	14	20	PF00069	0.672
MOD_ProDKin_1	164	170	PF00069	0.577
MOD_ProDKin_1	247	253	PF00069	0.600
MOD_ProDKin_1	254	260	PF00069	0.556
MOD_SUMO_for_1	45	48	PF00179	0.607
TRG_DiLeu_BaEn_1	159	164	PF01217	0.570
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.576
TRG_ENDOCYTIC_2	260	263	PF00928	0.594
TRG_ER_diArg_1	206	208	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P700	Leptomonas seymouri	47%	100%
A0A0S4JIE0	Bodo saltans	33%	100%
A0A1X0PA42	Trypanosomatidae	34%	100%
A0A3R7M3X3	Trypanosoma rangeli	38%	100%
A0A3S7X8G3	Leishmania donovani	90%	100%
A4HBB6	Leishmania braziliensis	68%	100%
A4IAG4	Leishmania infantum	90%	100%
E9B5I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%