HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HECT-domain (ubiquitin-transferase), putative

Species:

Leishmania major

UniProt:

Q4Q2E5_LEIMA

TriTrypDb:

LmjF.34.3960 , LMJLV39_340046200 , LMJSD75_340046600

Length:

1369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q2E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	2
GO:0006508	proteolysis	4	10
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0010498	proteasomal protein catabolic process	5	2
GO:0016567	protein ubiquitination	7	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004842	ubiquitin-protein transferase activity	4	10
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	2
GO:0016740	transferase activity	2	10
GO:0016874	ligase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	10
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.537
CLV_C14_Caspase3-7	593	597	PF00656	0.510
CLV_NRD_NRD_1	1363	1365	PF00675	0.367
CLV_NRD_NRD_1	242	244	PF00675	0.649
CLV_NRD_NRD_1	245	247	PF00675	0.632
CLV_NRD_NRD_1	432	434	PF00675	0.497
CLV_NRD_NRD_1	515	517	PF00675	0.453
CLV_NRD_NRD_1	605	607	PF00675	0.564
CLV_NRD_NRD_1	622	624	PF00675	0.615
CLV_NRD_NRD_1	649	651	PF00675	0.572

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS0	Leptomonas seymouri	59%	99%
A0A1X0PAF7	Trypanosomatidae	30%	100%
A0A3Q8INT8	Leishmania donovani	93%	100%
A0A3R7KJ27	Trypanosoma rangeli	30%	100%
A4HBB9	Leishmania braziliensis	78%	100%
A4IAG7	Leishmania infantum	93%	100%
E9B5J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BLT4	Trypanosoma cruzi	30%	100%

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