AP-1 complex subunit gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

AP-1 adapter complex gamma subunit, putative

Species:

Leishmania major

UniProt:

Q4Q2E4_LEIMA

TriTrypDb:

LmjF.34.3970 , LMJLV39_340046300 , LMJSD75_340046700

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030119	AP-type membrane coat adaptor complex	3	12
GO:0030121	AP-1 adaptor complex	5	12
GO:0030131	clathrin adaptor complex	4	12
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12

Expansion

Sequence features

Q4Q2E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2E4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006892	post-Golgi vesicle-mediated transport	6	2
GO:0006896	Golgi to vacuole transport	5	2
GO:0006897	endocytosis	5	2
GO:0006898	receptor-mediated endocytosis	6	2
GO:0007034	vacuolar transport	4	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030276	clathrin binding	3	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0035615	clathrin adaptor activity	4	2
GO:0060090	molecular adaptor activity	1	2
GO:0140312	cargo adaptor activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.443
CLV_C14_Caspase3-7	2	6	PF00656	0.609
CLV_C14_Caspase3-7	288	292	PF00656	0.308
CLV_C14_Caspase3-7	331	335	PF00656	0.326
CLV_C14_Caspase3-7	655	659	PF00656	0.490
CLV_NRD_NRD_1	119	121	PF00675	0.377
CLV_NRD_NRD_1	176	178	PF00675	0.428
CLV_NRD_NRD_1	224	226	PF00675	0.430
CLV_NRD_NRD_1	349	351	PF00675	0.221
CLV_NRD_NRD_1	36	38	PF00675	0.469
CLV_NRD_NRD_1	376	378	PF00675	0.295
CLV_NRD_NRD_1	487	489	PF00675	0.323
CLV_PCSK_KEX2_1	119	121	PF00082	0.440
CLV_PCSK_KEX2_1	375	377	PF00082	0.308
CLV_PCSK_SKI1_1	147	151	PF00082	0.308
CLV_PCSK_SKI1_1	167	171	PF00082	0.124
CLV_PCSK_SKI1_1	226	230	PF00082	0.314
CLV_PCSK_SKI1_1	233	237	PF00082	0.304
CLV_PCSK_SKI1_1	376	380	PF00082	0.333
CLV_PCSK_SKI1_1	437	441	PF00082	0.333
CLV_PCSK_SKI1_1	452	456	PF00082	0.299
CLV_PCSK_SKI1_1	488	492	PF00082	0.324
CLV_PCSK_SKI1_1	50	54	PF00082	0.318
CLV_PCSK_SKI1_1	511	515	PF00082	0.349
CLV_PCSK_SKI1_1	544	548	PF00082	0.381
DEG_APCC_DBOX_1	146	154	PF00400	0.323
DEG_APCC_DBOX_1	451	459	PF00400	0.338
DEG_APCC_DBOX_1	49	57	PF00400	0.323
DEG_ODPH_VHL_1	763	775	PF01847	0.377
DOC_CYCLIN_RxL_1	233	242	PF00134	0.308
DOC_CYCLIN_RxL_1	374	384	PF00134	0.342
DOC_CYCLIN_RxL_1	449	459	PF00134	0.260
DOC_CYCLIN_yClb1_LxF_4	334	340	PF00134	0.365
DOC_MAPK_gen_1	165	172	PF00069	0.182
DOC_MAPK_gen_1	375	383	PF00069	0.294
DOC_MAPK_gen_1	440	450	PF00069	0.323
DOC_MAPK_gen_1	48	56	PF00069	0.323
DOC_MAPK_gen_1	488	496	PF00069	0.428
DOC_MAPK_MEF2A_6	375	383	PF00069	0.308
DOC_MAPK_MEF2A_6	488	496	PF00069	0.428
DOC_MAPK_MEF2A_6	50	58	PF00069	0.427
DOC_MAPK_MEF2A_6	785	793	PF00069	0.305
DOC_MAPK_MEF2A_6	85	93	PF00069	0.311
DOC_MAPK_NFAT4_5	376	384	PF00069	0.323
DOC_MAPK_RevD_3	362	376	PF00069	0.365
DOC_PP1_RVXF_1	258	265	PF00149	0.308
DOC_PP2B_LxvP_1	393	396	PF13499	0.323
DOC_PP2B_PxIxI_1	44	50	PF00149	0.455
DOC_USP7_MATH_1	310	314	PF00917	0.342
DOC_USP7_MATH_1	400	404	PF00917	0.441
DOC_USP7_MATH_1	668	672	PF00917	0.704
DOC_USP7_MATH_1	675	679	PF00917	0.701
DOC_USP7_MATH_1	684	688	PF00917	0.674
DOC_USP7_MATH_1	705	709	PF00917	0.498
DOC_USP7_MATH_1	758	762	PF00917	0.360
DOC_USP7_MATH_2	608	614	PF00917	0.641
DOC_USP7_UBL2_3	544	548	PF12436	0.393
DOC_WW_Pin1_4	157	162	PF00397	0.428
DOC_WW_Pin1_4	691	696	PF00397	0.761
LIG_14-3-3_CanoR_1	119	125	PF00244	0.416
LIG_14-3-3_CanoR_1	225	235	PF00244	0.301
LIG_14-3-3_CanoR_1	243	249	PF00244	0.311
LIG_14-3-3_CanoR_1	327	333	PF00244	0.365
LIG_14-3-3_CanoR_1	415	421	PF00244	0.421
LIG_14-3-3_CanoR_1	750	755	PF00244	0.424
LIG_14-3-3_CanoR_1	790	796	PF00244	0.374
LIG_Actin_WH2_2	142	160	PF00022	0.221
LIG_Actin_WH2_2	322	340	PF00022	0.365
LIG_Actin_WH2_2	425	442	PF00022	0.455
LIG_AP2alpha_2	254	256	PF02296	0.323
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_2	42	46	PF00653	0.416
LIG_BIR_III_2	551	555	PF00653	0.416
LIG_BRCT_BRCA1_1	434	438	PF00533	0.454
LIG_BRCT_BRCA1_1	477	481	PF00533	0.342
LIG_BRCT_BRCA1_1	658	662	PF00533	0.657
LIG_BRCT_BRCA1_1	722	726	PF00533	0.441
LIG_BRCT_BRCA1_2	434	440	PF00533	0.455
LIG_Clathr_ClatBox_1	630	634	PF01394	0.650
LIG_deltaCOP1_diTrp_1	471	481	PF00928	0.455
LIG_DLG_GKlike_1	120	127	PF00625	0.377
LIG_eIF4E_1	124	130	PF01652	0.428
LIG_eIF4E_1	537	543	PF01652	0.308
LIG_eIF4E_1	88	94	PF01652	0.428
LIG_FHA_1	10	16	PF00498	0.460
LIG_FHA_1	196	202	PF00498	0.386
LIG_FHA_1	204	210	PF00498	0.403
LIG_FHA_1	227	233	PF00498	0.316
LIG_FHA_1	291	297	PF00498	0.365
LIG_FHA_1	317	323	PF00498	0.365
LIG_FHA_1	380	386	PF00498	0.301
LIG_FHA_1	460	466	PF00498	0.393
LIG_FHA_1	577	583	PF00498	0.319
LIG_FHA_1	622	628	PF00498	0.640
LIG_FHA_1	644	650	PF00498	0.713
LIG_FHA_1	751	757	PF00498	0.322
LIG_FHA_2	101	107	PF00498	0.308
LIG_FHA_2	19	25	PF00498	0.411
LIG_FHA_2	243	249	PF00498	0.308
LIG_FHA_2	286	292	PF00498	0.330
LIG_FHA_2	512	518	PF00498	0.455
LIG_FHA_2	563	569	PF00498	0.333
LIG_FHA_2	624	630	PF00498	0.641
LIG_FXI_DFP_1	582	586	PF00024	0.516
LIG_LIR_Gen_1	123	132	PF02991	0.427
LIG_LIR_Gen_1	253	264	PF02991	0.285
LIG_LIR_Gen_1	352	361	PF02991	0.398
LIG_LIR_Gen_1	435	446	PF02991	0.461
LIG_LIR_Gen_1	501	510	PF02991	0.333
LIG_LIR_Gen_1	529	539	PF02991	0.342
LIG_LIR_Gen_1	577	586	PF02991	0.308
LIG_LIR_Gen_1	592	601	PF02991	0.463
LIG_LIR_Gen_1	65	75	PF02991	0.455
LIG_LIR_Gen_1	711	720	PF02991	0.399
LIG_LIR_Gen_1	723	731	PF02991	0.443
LIG_LIR_LC3C_4	728	731	PF02991	0.338
LIG_LIR_Nem_3	123	127	PF02991	0.427
LIG_LIR_Nem_3	253	259	PF02991	0.285
LIG_LIR_Nem_3	352	356	PF02991	0.398
LIG_LIR_Nem_3	435	441	PF02991	0.461
LIG_LIR_Nem_3	501	505	PF02991	0.333
LIG_LIR_Nem_3	529	534	PF02991	0.323
LIG_LIR_Nem_3	577	581	PF02991	0.362
LIG_LIR_Nem_3	664	670	PF02991	0.603
LIG_LIR_Nem_3	711	715	PF02991	0.409
LIG_LIR_Nem_3	723	729	PF02991	0.426
LIG_LIR_Nem_3	80	84	PF02991	0.392
LIG_LYPXL_SIV_4	45	53	PF13949	0.428
LIG_LYPXL_SIV_4	765	773	PF13949	0.416
LIG_MLH1_MIPbox_1	658	662	PF16413	0.491
LIG_NRBOX	341	347	PF00104	0.308
LIG_PCNA_yPIPBox_3	258	266	PF02747	0.308
LIG_PCNA_yPIPBox_3	280	294	PF02747	0.320
LIG_PCNA_yPIPBox_3	535	543	PF02747	0.393
LIG_Pex14_1	430	434	PF04695	0.365
LIG_SH2_CRK	401	405	PF00017	0.401
LIG_SH2_CRK	578	582	PF00017	0.342
LIG_SH2_PTP2	46	49	PF00017	0.455
LIG_SH2_PTP2	502	505	PF00017	0.365
LIG_SH2_STAP1	434	438	PF00017	0.365
LIG_SH2_STAP1	578	582	PF00017	0.365
LIG_SH2_STAT5	185	188	PF00017	0.428
LIG_SH2_STAT5	189	192	PF00017	0.428
LIG_SH2_STAT5	46	49	PF00017	0.359
LIG_SH2_STAT5	502	505	PF00017	0.365
LIG_SH2_STAT5	57	60	PF00017	0.248
LIG_SH2_STAT5	578	581	PF00017	0.319
LIG_SH2_STAT5	795	798	PF00017	0.320
LIG_SH2_STAT5	88	91	PF00017	0.308
LIG_SH3_3	580	586	PF00018	0.541
LIG_SH3_3	595	601	PF00018	0.603
LIG_SH3_3	636	642	PF00018	0.710
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.308
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.365
LIG_SUMO_SIM_anti_2	745	750	PF11976	0.454
LIG_SUMO_SIM_anti_2	96	106	PF11976	0.439
LIG_SUMO_SIM_par_1	205	210	PF11976	0.455
LIG_SUMO_SIM_par_1	318	324	PF11976	0.455
LIG_SUMO_SIM_par_1	380	387	PF11976	0.342
LIG_SUMO_SIM_par_1	453	460	PF11976	0.349
LIG_SUMO_SIM_par_1	579	584	PF11976	0.467
LIG_SUMO_SIM_par_1	607	613	PF11976	0.693
LIG_SUMO_SIM_par_1	96	106	PF11976	0.319
LIG_TRAF2_1	21	24	PF00917	0.423
LIG_TYR_ITIM	122	127	PF00017	0.416
LIG_TYR_ITIM	300	305	PF00017	0.308
LIG_TYR_ITIM	399	404	PF00017	0.317
LIG_TYR_ITIM	86	91	PF00017	0.323
LIG_UBA3_1	149	158	PF00899	0.416
LIG_UBA3_1	454	463	PF00899	0.420
LIG_UBA3_1	725	734	PF00899	0.377
LIG_WRC_WIRS_1	557	562	PF05994	0.423
LIG_WRC_WIRS_1	590	595	PF05994	0.497
MOD_CK1_1	242	248	PF00069	0.308
MOD_CK1_1	250	256	PF00069	0.308
MOD_CK1_1	272	278	PF00069	0.342
MOD_CK1_1	3	9	PF00069	0.536
MOD_CK1_1	403	409	PF00069	0.377
MOD_CK1_1	459	465	PF00069	0.344
MOD_CK1_1	523	529	PF00069	0.385
MOD_CK1_1	562	568	PF00069	0.356
MOD_CK1_1	643	649	PF00069	0.719
MOD_CK1_1	678	684	PF00069	0.661
MOD_CK1_1	687	693	PF00069	0.761
MOD_CK1_1	733	739	PF00069	0.390
MOD_CK2_1	100	106	PF00069	0.308
MOD_CK2_1	18	24	PF00069	0.421
MOD_CK2_1	416	422	PF00069	0.377
MOD_GlcNHglycan	215	218	PF01048	0.382
MOD_GlcNHglycan	229	232	PF01048	0.409
MOD_GlcNHglycan	246	252	PF01048	0.453
MOD_GlcNHglycan	32	35	PF01048	0.393
MOD_GlcNHglycan	664	667	PF01048	0.659
MOD_GlcNHglycan	677	680	PF01048	0.685
MOD_GlcNHglycan	689	692	PF01048	0.697
MOD_GlcNHglycan	716	719	PF01048	0.337
MOD_GlcNHglycan	80	84	PF01048	0.428
MOD_GSK3_1	111	118	PF00069	0.428
MOD_GSK3_1	238	245	PF00069	0.316
MOD_GSK3_1	269	276	PF00069	0.311
MOD_GSK3_1	323	330	PF00069	0.365
MOD_GSK3_1	416	423	PF00069	0.396
MOD_GSK3_1	517	524	PF00069	0.398
MOD_GSK3_1	559	566	PF00069	0.392
MOD_GSK3_1	640	647	PF00069	0.692
MOD_GSK3_1	652	659	PF00069	0.525
MOD_GSK3_1	662	669	PF00069	0.557
MOD_GSK3_1	687	694	PF00069	0.742
MOD_N-GLC_1	529	534	PF02516	0.374
MOD_N-GLC_1	562	567	PF02516	0.369
MOD_NEK2_1	149	154	PF00069	0.361
MOD_NEK2_1	238	243	PF00069	0.295
MOD_NEK2_1	328	333	PF00069	0.373
MOD_NEK2_1	346	351	PF00069	0.249
MOD_NEK2_1	379	384	PF00069	0.323
MOD_NEK2_1	591	596	PF00069	0.532
MOD_NEK2_1	650	655	PF00069	0.652
MOD_NEK2_1	720	725	PF00069	0.355
MOD_NEK2_1	742	747	PF00069	0.410
MOD_NEK2_1	806	811	PF00069	0.456
MOD_NEK2_1	9	14	PF00069	0.520
MOD_NEK2_2	684	689	PF00069	0.768
MOD_PIKK_1	457	463	PF00454	0.403
MOD_PIKK_1	591	597	PF00454	0.591
MOD_PIKK_1	612	618	PF00454	0.657
MOD_PIKK_1	652	658	PF00454	0.748
MOD_PIKK_1	668	674	PF00454	0.716
MOD_PIKK_1	74	80	PF00454	0.428
MOD_PIKK_1	775	781	PF00454	0.441
MOD_PIKK_1	806	812	PF00454	0.347
MOD_PKA_2	242	248	PF00069	0.323
MOD_PKA_2	367	373	PF00069	0.299
MOD_PKA_2	791	797	PF00069	0.455
MOD_Plk_1	370	376	PF00069	0.308
MOD_Plk_1	379	385	PF00069	0.308
MOD_Plk_1	432	438	PF00069	0.308
MOD_Plk_1	475	481	PF00069	0.297
MOD_Plk_1	529	535	PF00069	0.393
MOD_Plk_1	562	568	PF00069	0.410
MOD_Plk_1	576	582	PF00069	0.224
MOD_Plk_1	644	650	PF00069	0.737
MOD_Plk_1	684	690	PF00069	0.743
MOD_Plk_2-3	100	106	PF00069	0.308
MOD_Plk_4	100	106	PF00069	0.449
MOD_Plk_4	149	155	PF00069	0.398
MOD_Plk_4	197	203	PF00069	0.344
MOD_Plk_4	341	347	PF00069	0.322
MOD_Plk_4	381	387	PF00069	0.406
MOD_Plk_4	416	422	PF00069	0.377
MOD_Plk_4	577	583	PF00069	0.308
MOD_Plk_4	645	651	PF00069	0.775
MOD_Plk_4	656	662	PF00069	0.705
MOD_Plk_4	678	684	PF00069	0.661
MOD_Plk_4	720	726	PF00069	0.418
MOD_ProDKin_1	157	163	PF00069	0.428
MOD_ProDKin_1	691	697	PF00069	0.760
TRG_DiLeu_BaEn_1	100	105	PF01217	0.443
TRG_DiLeu_BaEn_1	125	130	PF01217	0.428
TRG_DiLeu_BaEn_1	501	506	PF01217	0.323
TRG_DiLeu_BaEn_1	577	582	PF01217	0.365
TRG_DiLeu_BaEn_1	71	76	PF01217	0.308
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.539
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.316
TRG_ENDOCYTIC_2	124	127	PF00928	0.428
TRG_ENDOCYTIC_2	302	305	PF00928	0.308
TRG_ENDOCYTIC_2	401	404	PF00928	0.311
TRG_ENDOCYTIC_2	46	49	PF00928	0.359
TRG_ENDOCYTIC_2	502	505	PF00928	0.323
TRG_ENDOCYTIC_2	51	54	PF00928	0.313
TRG_ENDOCYTIC_2	57	60	PF00928	0.248
TRG_ENDOCYTIC_2	578	581	PF00928	0.308
TRG_ENDOCYTIC_2	88	91	PF00928	0.308
TRG_ER_diArg_1	374	377	PF00400	0.308
TRG_ER_diArg_1	47	50	PF00400	0.323
TRG_ER_diArg_1	789	792	PF00400	0.455
TRG_NES_CRM1_1	199	210	PF08389	0.423
TRG_NES_CRM1_1	740	755	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	392	397	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P707	Leptomonas seymouri	71%	98%
A0A0N1I3J7	Leptomonas seymouri	20%	74%
A0A0N1PA13	Leptomonas seymouri	26%	84%
A0A0S4JAH1	Bodo saltans	25%	77%
A0A0S4JIE7	Bodo saltans	41%	93%
A0A1X0NLY4	Trypanosomatidae	25%	84%
A0A1X0P1U8	Trypanosomatidae	25%	79%
A0A1X0PA59	Trypanosomatidae	51%	100%
A0A3Q8IHK1	Leishmania donovani	93%	98%
A0A3S7WPR4	Leishmania donovani	26%	84%
A0A422NSY3	Trypanosoma rangeli	49%	100%
A0A422NT90	Trypanosoma rangeli	25%	84%
A0A422P3I9	Trypanosoma rangeli	25%	81%
A4H4U8	Leishmania braziliensis	26%	85%
A4HBC0	Leishmania braziliensis	82%	97%
A4HT27	Leishmania infantum	26%	84%
A4IAG8	Leishmania infantum	93%	98%
C9ZLS4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AL15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	84%
E9B5J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
O43747	Homo sapiens	30%	99%
O75843	Homo sapiens	35%	100%
O88512	Mus musculus	36%	100%
O94973	Homo sapiens	24%	86%
O95782	Homo sapiens	25%	83%
P17426	Mus musculus	25%	83%
P17427	Mus musculus	23%	87%
P18484	Rattus norvegicus	23%	87%
P22892	Mus musculus	30%	99%
P38065	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	79%
P91926	Drosophila melanogaster	25%	86%
Q0VCK5	Bos taurus	24%	87%
Q12028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	98%
Q29N38	Drosophila pseudoobscura pseudoobscura	24%	86%
Q4QIT9	Leishmania major	26%	84%
Q5R5M2	Pongo abelii	30%	99%
Q7QG73	Anopheles gambiae	25%	87%
Q84K16	Arabidopsis thaliana	35%	93%
Q86KI1	Dictyostelium discoideum	29%	82%
Q8I8U2	Dictyostelium discoideum	38%	91%
Q8L7A9	Arabidopsis thaliana	27%	87%
Q8LPK4	Arabidopsis thaliana	26%	80%
Q8LPL6	Arabidopsis thaliana	26%	80%
Q99128	Ustilago maydis (strain 521 / FGSC 9021)	39%	93%
Q9C0W7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	92%
Q9UTL8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	98%
Q9UU81	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	94%
Q9ZUI6	Arabidopsis thaliana	33%	94%
V5B8U2	Trypanosoma cruzi	25%	100%
V5BW37	Trypanosoma cruzi	51%	100%