Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2E2_LEIMA

TriTrypDb:

LmjF.34.3990 , LMJLV39_340046500 , LMJSD75_340046900

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0032045	guanyl-nucleotide exchange factor complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0034066	Ric1-Rgp1 guanyl-nucleotide exchange factor complex	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	2

Expansion

Sequence features

Q4Q2E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2E2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0016482	cytosolic transport	4	2
GO:0042147	retrograde transport, endosome to Golgi	5	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.570
CLV_MEL_PAP_1	22	28	PF00089	0.464
CLV_NRD_NRD_1	331	333	PF00675	0.578
CLV_NRD_NRD_1	383	385	PF00675	0.573
CLV_NRD_NRD_1	433	435	PF00675	0.539
CLV_PCSK_KEX2_1	134	136	PF00082	0.585
CLV_PCSK_KEX2_1	333	335	PF00082	0.599
CLV_PCSK_KEX2_1	383	385	PF00082	0.533
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.618
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.599
CLV_PCSK_SKI1_1	182	186	PF00082	0.550
DEG_APCC_DBOX_1	24	32	PF00400	0.503
DEG_APCC_DBOX_1	277	285	PF00400	0.578
DEG_Nend_UBRbox_3	1	3	PF02207	0.410
DEG_ODPH_VHL_1	452	464	PF01847	0.476
DEG_SIAH_1	453	461	PF03145	0.481
DOC_ANK_TNKS_1	438	445	PF00023	0.575
DOC_CKS1_1	236	241	PF01111	0.687
DOC_CKS1_1	394	399	PF01111	0.537
DOC_MAPK_DCC_7	190	198	PF00069	0.498
DOC_MAPK_DCC_7	334	344	PF00069	0.407
DOC_MAPK_gen_1	190	198	PF00069	0.511
DOC_MAPK_gen_1	69	77	PF00069	0.477
DOC_MAPK_MEF2A_6	190	198	PF00069	0.469
DOC_MAPK_MEF2A_6	278	285	PF00069	0.546
DOC_MAPK_MEF2A_6	69	77	PF00069	0.555
DOC_PP1_RVXF_1	87	94	PF00149	0.552
DOC_PP2B_LxvP_1	283	286	PF13499	0.541
DOC_PP2B_LxvP_1	451	454	PF13499	0.472
DOC_PP2B_LxvP_1	462	465	PF13499	0.360
DOC_PP4_FxxP_1	145	148	PF00568	0.397
DOC_PP4_FxxP_1	213	216	PF00568	0.521
DOC_PP4_FxxP_1	403	406	PF00568	0.447
DOC_USP7_MATH_1	174	178	PF00917	0.555
DOC_USP7_MATH_1	321	325	PF00917	0.628
DOC_USP7_MATH_1	95	99	PF00917	0.656
DOC_WW_Pin1_4	228	233	PF00397	0.524
DOC_WW_Pin1_4	235	240	PF00397	0.554
DOC_WW_Pin1_4	352	357	PF00397	0.518
DOC_WW_Pin1_4	393	398	PF00397	0.536
LIG_14-3-3_CanoR_1	110	119	PF00244	0.583
LIG_14-3-3_CanoR_1	176	186	PF00244	0.677
LIG_14-3-3_CanoR_1	25	35	PF00244	0.572
LIG_14-3-3_CanoR_1	257	263	PF00244	0.676
LIG_14-3-3_CanoR_1	278	284	PF00244	0.565
LIG_14-3-3_CanoR_1	434	438	PF00244	0.478
LIG_Actin_WH2_2	241	259	PF00022	0.694
LIG_Actin_WH2_2	411	428	PF00022	0.489
LIG_BIR_III_4	369	373	PF00653	0.459
LIG_BRCT_BRCA1_1	466	470	PF00533	0.532
LIG_Clathr_ClatBox_1	80	84	PF01394	0.493
LIG_EVH1_1	213	217	PF00568	0.535
LIG_FHA_1	343	349	PF00498	0.484
LIG_FHA_1	394	400	PF00498	0.497
LIG_FHA_1	417	423	PF00498	0.384
LIG_FHA_2	124	130	PF00498	0.563
LIG_FHA_2	36	42	PF00498	0.682
LIG_FHA_2	412	418	PF00498	0.484
LIG_LIR_Apic_2	142	148	PF02991	0.425
LIG_LIR_Apic_2	211	216	PF02991	0.538
LIG_LIR_Apic_2	402	406	PF02991	0.456
LIG_LIR_Gen_1	390	399	PF02991	0.424
LIG_LIR_Nem_3	169	175	PF02991	0.503
LIG_LIR_Nem_3	311	315	PF02991	0.475
LIG_LIR_Nem_3	390	394	PF02991	0.426
LIG_MYND_1	450	454	PF01753	0.567
LIG_PCNA_PIPBox_1	206	215	PF02747	0.541
LIG_SH2_NCK_1	136	140	PF00017	0.574
LIG_SH2_NCK_1	358	362	PF00017	0.383
LIG_SH2_SRC	16	19	PF00017	0.425
LIG_SH2_STAP1	136	140	PF00017	0.573
LIG_SH2_STAT5	117	120	PF00017	0.510
LIG_SH2_STAT5	16	19	PF00017	0.516
LIG_SH2_STAT5	307	310	PF00017	0.544
LIG_SH2_STAT5	53	56	PF00017	0.604
LIG_SH3_2	466	471	PF14604	0.587
LIG_SH3_3	188	194	PF00018	0.464
LIG_SH3_3	211	217	PF00018	0.462
LIG_SH3_3	233	239	PF00018	0.572
LIG_SH3_3	245	251	PF00018	0.659
LIG_SH3_3	394	400	PF00018	0.559
LIG_SH3_3	460	466	PF00018	0.401
LIG_SH3_3	55	61	PF00018	0.716
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.488
LIG_SUMO_SIM_anti_2	74	79	PF11976	0.444
LIG_SUMO_SIM_par_1	340	345	PF11976	0.555
LIG_SUMO_SIM_par_1	346	352	PF11976	0.421
LIG_SUMO_SIM_par_1	71	76	PF11976	0.521
LIG_SUMO_SIM_par_1	79	86	PF11976	0.435
LIG_TRAF2_1	126	129	PF00917	0.510
LIG_TRFH_1	213	217	PF08558	0.535
LIG_WRC_WIRS_1	418	423	PF05994	0.448
MOD_CK1_1	105	111	PF00069	0.616
MOD_CK1_1	177	183	PF00069	0.689
MOD_CK1_1	200	206	PF00069	0.559
MOD_CK1_1	363	369	PF00069	0.649
MOD_CK1_1	413	419	PF00069	0.404
MOD_CK1_1	63	69	PF00069	0.631
MOD_CK2_1	123	129	PF00069	0.530
MOD_CK2_1	35	41	PF00069	0.669
MOD_CK2_1	95	101	PF00069	0.639
MOD_Cter_Amidation	122	125	PF01082	0.520
MOD_GlcNHglycan	107	110	PF01048	0.678
MOD_GlcNHglycan	112	115	PF01048	0.577
MOD_GlcNHglycan	168	171	PF01048	0.447
MOD_GlcNHglycan	177	180	PF01048	0.601
MOD_GlcNHglycan	218	221	PF01048	0.599
MOD_GlcNHglycan	323	326	PF01048	0.725
MOD_GlcNHglycan	7	10	PF01048	0.485
MOD_GSK3_1	115	122	PF00069	0.479
MOD_GSK3_1	266	273	PF00069	0.617
MOD_GSK3_1	310	317	PF00069	0.574
MOD_GSK3_1	340	347	PF00069	0.564
MOD_GSK3_1	359	366	PF00069	0.414
MOD_GSK3_1	413	420	PF00069	0.480
MOD_GSK3_1	433	440	PF00069	0.546
MOD_GSK3_1	52	59	PF00069	0.714
MOD_NEK2_1	119	124	PF00069	0.508
MOD_NEK2_1	256	261	PF00069	0.694
MOD_NEK2_1	270	275	PF00069	0.526
MOD_NEK2_1	297	302	PF00069	0.413
MOD_NEK2_1	3	8	PF00069	0.475
MOD_NEK2_1	308	313	PF00069	0.397
MOD_NEK2_1	378	383	PF00069	0.532
MOD_NEK2_1	401	406	PF00069	0.418
MOD_NEK2_1	437	442	PF00069	0.540
MOD_NEK2_1	83	88	PF00069	0.505
MOD_NEK2_2	208	213	PF00069	0.542
MOD_PKA_2	157	163	PF00069	0.443
MOD_PKA_2	175	181	PF00069	0.634
MOD_PKA_2	24	30	PF00069	0.519
MOD_PKA_2	256	262	PF00069	0.673
MOD_PKA_2	433	439	PF00069	0.490
MOD_PKA_2	63	69	PF00069	0.560
MOD_Plk_1	401	407	PF00069	0.490
MOD_Plk_1	416	422	PF00069	0.511
MOD_Plk_1	83	89	PF00069	0.511
MOD_Plk_4	115	121	PF00069	0.515
MOD_Plk_4	168	174	PF00069	0.489
MOD_Plk_4	208	214	PF00069	0.502
MOD_Plk_4	279	285	PF00069	0.516
MOD_Plk_4	363	369	PF00069	0.644
MOD_Plk_4	417	423	PF00069	0.422
MOD_Plk_4	83	89	PF00069	0.504
MOD_ProDKin_1	228	234	PF00069	0.533
MOD_ProDKin_1	235	241	PF00069	0.557
MOD_ProDKin_1	352	358	PF00069	0.518
MOD_ProDKin_1	393	399	PF00069	0.528
MOD_SUMO_rev_2	259	269	PF00179	0.639
TRG_DiLeu_BaEn_1	76	81	PF01217	0.485
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.424
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.542
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.394
TRG_ENDOCYTIC_2	53	56	PF00928	0.650
TRG_ER_diArg_1	383	385	PF00400	0.571
TRG_ER_diArg_1	68	71	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I798	Leptomonas seymouri	58%	100%
A0A1X0PA91	Trypanosomatidae	22%	100%
A0A3Q8ILJ7	Leishmania donovani	93%	100%
A0A422NVD8	Trypanosoma rangeli	25%	100%
A4HBC2	Leishmania braziliensis	74%	100%
A4IAH0	Leishmania infantum	93%	100%
C9ZLS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B5J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BRG2	Trypanosoma cruzi	25%	100%