Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase family C78, putative

Species:

Leishmania major

UniProt:

Q4Q2E1_LEIMA

TriTrypDb:

LmjF.34.4000 , LMJLV39_340046600 , LMJSD75_340047000

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2E1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.485
CLV_C14_Caspase3-7	265	269	PF00656	0.432
CLV_NRD_NRD_1	230	232	PF00675	0.431
CLV_NRD_NRD_1	261	263	PF00675	0.375
CLV_NRD_NRD_1	353	355	PF00675	0.276
CLV_PCSK_KEX2_1	229	231	PF00082	0.426
CLV_PCSK_KEX2_1	261	263	PF00082	0.375
CLV_PCSK_KEX2_1	353	355	PF00082	0.296
CLV_PCSK_KEX2_1	369	371	PF00082	0.296
CLV_PCSK_KEX2_1	400	402	PF00082	0.308
CLV_PCSK_KEX2_1	84	86	PF00082	0.407
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.259
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.240
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.407
CLV_PCSK_PC7_1	225	231	PF00082	0.448
CLV_PCSK_SKI1_1	176	180	PF00082	0.310
CLV_PCSK_SKI1_1	191	195	PF00082	0.354
CLV_PCSK_SKI1_1	56	60	PF00082	0.368
CLV_PCSK_SKI1_1	81	85	PF00082	0.460
CLV_PCSK_SKI1_1	91	95	PF00082	0.428
DEG_Nend_UBRbox_2	1	3	PF02207	0.532
DOC_ANK_TNKS_1	287	294	PF00023	0.345
DOC_CKS1_1	127	132	PF01111	0.499
DOC_CYCLIN_RxL_1	173	182	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.303
DOC_MAPK_gen_1	21	28	PF00069	0.383
DOC_MAPK_gen_1	81	90	PF00069	0.435
DOC_PP2B_LxvP_1	237	240	PF13499	0.348
DOC_PP2B_LxvP_1	426	429	PF13499	0.303
DOC_PP2B_LxvP_1	495	498	PF13499	0.270
DOC_PP4_FxxP_1	422	425	PF00568	0.325
DOC_USP7_MATH_1	161	165	PF00917	0.557
DOC_USP7_MATH_1	168	172	PF00917	0.510
DOC_USP7_MATH_1	328	332	PF00917	0.260
DOC_USP7_MATH_1	348	352	PF00917	0.139
DOC_USP7_MATH_1	40	44	PF00917	0.407
DOC_USP7_MATH_1	73	77	PF00917	0.319
DOC_USP7_UBL2_3	470	474	PF12436	0.269
DOC_USP7_UBL2_3	481	485	PF12436	0.251
DOC_WW_Pin1_4	126	131	PF00397	0.472
DOC_WW_Pin1_4	282	287	PF00397	0.402
DOC_WW_Pin1_4	421	426	PF00397	0.281
DOC_WW_Pin1_4	59	64	PF00397	0.451
LIG_14-3-3_CanoR_1	280	286	PF00244	0.426
LIG_14-3-3_CanoR_1	330	336	PF00244	0.319
LIG_14-3-3_CanoR_1	47	57	PF00244	0.363
LIG_14-3-3_CanoR_1	74	80	PF00244	0.353
LIG_BRCT_BRCA1_1	214	218	PF00533	0.347
LIG_BRCT_BRCA1_1	483	487	PF00533	0.319
LIG_deltaCOP1_diTrp_1	125	131	PF00928	0.406
LIG_deltaCOP1_diTrp_1	209	218	PF00928	0.390
LIG_deltaCOP1_diTrp_1	377	382	PF00928	0.260
LIG_FHA_1	134	140	PF00498	0.423
LIG_FHA_1	172	178	PF00498	0.387
LIG_FHA_1	23	29	PF00498	0.358
LIG_FHA_1	301	307	PF00498	0.356
LIG_FHA_1	43	49	PF00498	0.412
LIG_FHA_2	154	160	PF00498	0.543
LIG_FHA_2	198	204	PF00498	0.480
LIG_FHA_2	222	228	PF00498	0.558
LIG_FHA_2	254	260	PF00498	0.351
LIG_GBD_Chelix_1	149	157	PF00786	0.408
LIG_LIR_Apic_2	125	130	PF02991	0.458
LIG_LIR_Apic_2	420	425	PF02991	0.325
LIG_LIR_Gen_1	114	124	PF02991	0.555
LIG_LIR_Gen_1	381	388	PF02991	0.260
LIG_LIR_Gen_1	452	462	PF02991	0.325
LIG_LIR_Nem_3	114	120	PF02991	0.511
LIG_LIR_Nem_3	255	260	PF02991	0.416
LIG_LIR_Nem_3	307	313	PF02991	0.260
LIG_LIR_Nem_3	452	458	PF02991	0.325
LIG_LIR_Nem_3	459	465	PF02991	0.319
LIG_LIR_Nem_3	489	495	PF02991	0.328
LIG_MLH1_MIPbox_1	483	487	PF16413	0.319
LIG_MYND_3	392	396	PF01753	0.259
LIG_PCNA_PIPBox_1	385	394	PF02747	0.325
LIG_PCNA_PIPBox_1	415	424	PF02747	0.260
LIG_PCNA_yPIPBox_3	404	418	PF02747	0.193
LIG_Pex14_1	127	131	PF04695	0.421
LIG_Pex14_1	325	329	PF04695	0.260
LIG_Pex14_1	378	382	PF04695	0.260
LIG_SH2_CRK	241	245	PF00017	0.385
LIG_SH2_CRK	329	333	PF00017	0.260
LIG_SH2_SRC	391	394	PF00017	0.259
LIG_SH2_STAP1	437	441	PF00017	0.260
LIG_SH2_STAT3	465	468	PF00017	0.325
LIG_SH2_STAT5	391	394	PF00017	0.325
LIG_SH2_STAT5	455	458	PF00017	0.260
LIG_SH2_STAT5	477	480	PF00017	0.319
LIG_SH3_3	207	213	PF00018	0.321
LIG_SH3_3	293	299	PF00018	0.480
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.260
LIG_SUMO_SIM_par_1	302	307	PF11976	0.281
LIG_SxIP_EBH_1	342	354	PF03271	0.193
LIG_TYR_ITIM	239	244	PF00017	0.397
LIG_WRC_WIRS_1	379	384	PF05994	0.260
MOD_CDC14_SPxK_1	285	288	PF00782	0.368
MOD_CDK_SPxK_1	282	288	PF00069	0.368
MOD_CK1_1	108	114	PF00069	0.417
MOD_CK1_1	135	141	PF00069	0.442
MOD_CK1_1	171	177	PF00069	0.416
MOD_CK1_1	294	300	PF00069	0.461
MOD_CK1_1	331	337	PF00069	0.260
MOD_CK1_1	413	419	PF00069	0.218
MOD_CK2_1	108	114	PF00069	0.509
MOD_CK2_1	142	148	PF00069	0.446
MOD_CK2_1	179	185	PF00069	0.396
MOD_CK2_1	197	203	PF00069	0.306
MOD_CK2_1	48	54	PF00069	0.413
MOD_CMANNOS	254	257	PF00535	0.407
MOD_GlcNHglycan	121	125	PF01048	0.455
MOD_GlcNHglycan	163	166	PF01048	0.552
MOD_GlcNHglycan	181	184	PF01048	0.412
MOD_GlcNHglycan	293	296	PF01048	0.452
MOD_GlcNHglycan	306	309	PF01048	0.214
MOD_GlcNHglycan	346	349	PF01048	0.193
MOD_GlcNHglycan	462	465	PF01048	0.319
MOD_GlcNHglycan	50	53	PF01048	0.449
MOD_GlcNHglycan	99	102	PF01048	0.428
MOD_GSK3_1	105	112	PF00069	0.476
MOD_GSK3_1	129	136	PF00069	0.461
MOD_GSK3_1	168	175	PF00069	0.599
MOD_GSK3_1	197	204	PF00069	0.429
MOD_GSK3_1	267	274	PF00069	0.458
MOD_GSK3_1	300	307	PF00069	0.278
MOD_GSK3_1	344	351	PF00069	0.193
MOD_GSK3_1	433	440	PF00069	0.260
MOD_GSK3_1	460	467	PF00069	0.260
MOD_GSK3_1	73	80	PF00069	0.364
MOD_N-GLC_1	410	415	PF02516	0.193
MOD_N-GLC_2	494	496	PF02516	0.260
MOD_NEK2_1	172	177	PF00069	0.407
MOD_NEK2_1	179	184	PF00069	0.337
MOD_NEK2_1	304	309	PF00069	0.273
MOD_NEK2_1	344	349	PF00069	0.193
MOD_NEK2_1	48	53	PF00069	0.433
MOD_NEK2_1	486	491	PF00069	0.222
MOD_NEK2_1	79	84	PF00069	0.436
MOD_OFUCOSY	72	77	PF10250	0.317
MOD_PIKK_1	464	470	PF00454	0.319
MOD_PKA_2	73	79	PF00069	0.345
MOD_Plk_1	108	114	PF00069	0.561
MOD_Plk_1	168	174	PF00069	0.608
MOD_Plk_1	267	273	PF00069	0.432
MOD_Plk_1	410	416	PF00069	0.314
MOD_Plk_2-3	109	115	PF00069	0.428
MOD_Plk_4	112	118	PF00069	0.457
MOD_Plk_4	212	218	PF00069	0.545
MOD_Plk_4	267	273	PF00069	0.454
MOD_Plk_4	300	306	PF00069	0.319
MOD_Plk_4	331	337	PF00069	0.260
MOD_Plk_4	413	419	PF00069	0.193
MOD_Plk_4	437	443	PF00069	0.260
MOD_Plk_4	488	494	PF00069	0.210
MOD_ProDKin_1	126	132	PF00069	0.485
MOD_ProDKin_1	282	288	PF00069	0.412
MOD_ProDKin_1	421	427	PF00069	0.281
MOD_ProDKin_1	59	65	PF00069	0.458
MOD_SUMO_rev_2	51	58	PF00179	0.350
TRG_DiLeu_BaEn_1	452	457	PF01217	0.260
TRG_DiLeu_BaEn_2	53	59	PF01217	0.373
TRG_ENDOCYTIC_2	241	244	PF00928	0.396
TRG_ENDOCYTIC_2	329	332	PF00928	0.260
TRG_ENDOCYTIC_2	455	458	PF00928	0.325
TRG_ER_diArg_1	229	231	PF00400	0.388
TRG_ER_diArg_1	260	262	PF00400	0.358
TRG_ER_diArg_1	352	354	PF00400	0.296
TRG_NES_CRM1_1	377	390	PF08389	0.260
TRG_Pf-PMV_PEXEL_1	176	181	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	191	196	PF00026	0.280
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K1	Leptomonas seymouri	57%	99%
A0A1X0PB53	Trypanosomatidae	43%	100%
A0A3Q8IHV3	Leishmania donovani	91%	100%
A4HBC3	Leishmania braziliensis	78%	100%
A4IAH1	Leishmania infantum	91%	100%
E9B5J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q5XIB4	Rattus norvegicus	33%	100%
Q99K23	Mus musculus	32%	100%