Prohibitin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Prohibitin

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2D9_LEIMA

TriTrypDb:

LmjF.34.4020 , LMJLV39_340046800 , LMJSD75_340047200

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q2D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.414
CLV_NRD_NRD_1	181	183	PF00675	0.677
CLV_NRD_NRD_1	45	47	PF00675	0.473
CLV_PCSK_KEX2_1	45	47	PF00082	0.473
CLV_PCSK_SKI1_1	158	162	PF00082	0.671
CLV_PCSK_SKI1_1	182	186	PF00082	0.624
CLV_PCSK_SKI1_1	196	200	PF00082	0.558
CLV_PCSK_SKI1_1	45	49	PF00082	0.424
CLV_Separin_Metazoa	111	115	PF03568	0.505
DEG_SCF_FBW7_2	72	78	PF00400	0.614
DEG_SPOP_SBC_1	20	24	PF00917	0.712
DOC_CKS1_1	72	77	PF01111	0.610
DOC_CYCLIN_RxL_1	191	201	PF00134	0.454
DOC_CYCLIN_RxL_1	42	50	PF00134	0.665
DOC_MAPK_gen_1	157	163	PF00069	0.416
DOC_MAPK_gen_1	96	104	PF00069	0.479
DOC_USP7_MATH_1	138	142	PF00917	0.415
DOC_USP7_MATH_1	15	19	PF00917	0.756
DOC_USP7_MATH_1	202	206	PF00917	0.405
DOC_USP7_UBL2_3	196	200	PF12436	0.502
DOC_WW_Pin1_4	71	76	PF00397	0.604
LIG_14-3-3_CanoR_1	114	120	PF00244	0.503
LIG_14-3-3_CanoR_1	220	224	PF00244	0.472
LIG_14-3-3_CanoR_1	46	52	PF00244	0.652
LIG_Actin_WH2_2	187	202	PF00022	0.472
LIG_AP2alpha_2	166	168	PF02296	0.434
LIG_APCC_ABBAyCdc20_2	208	214	PF00400	0.523
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_EH1_1	220	228	PF00400	0.501
LIG_FHA_1	120	126	PF00498	0.457
LIG_FHA_1	150	156	PF00498	0.423
LIG_FHA_1	42	48	PF00498	0.667
LIG_FHA_1	7	13	PF00498	0.707
LIG_FHA_1	82	88	PF00498	0.443
LIG_GBD_Chelix_1	55	63	PF00786	0.401
LIG_PCNA_APIM_2	194	200	PF02747	0.500
LIG_PDZ_Wminus1_1	230	232	PF00595	0.367
LIG_Pex14_2	67	71	PF04695	0.444
LIG_SH2_CRK	73	77	PF00017	0.452
LIG_SH2_STAP1	151	155	PF00017	0.409
LIG_SH2_STAT5	151	154	PF00017	0.413
LIG_SH2_STAT5	73	76	PF00017	0.452
LIG_SH3_3	161	167	PF00018	0.455
LIG_SH3_3	31	37	PF00018	0.784
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.456
LIG_TRAF2_1	131	134	PF00917	0.501
LIG_UBA3_1	68	77	PF00899	0.557
MOD_CDK_SPxK_1	71	77	PF00069	0.607
MOD_CK1_1	222	228	PF00069	0.427
MOD_CK2_1	142	148	PF00069	0.465
MOD_GlcNHglycan	200	203	PF01048	0.595
MOD_GlcNHglycan	23	26	PF01048	0.571
MOD_GSK3_1	11	18	PF00069	0.745
MOD_GSK3_1	115	122	PF00069	0.502
MOD_GSK3_1	138	145	PF00069	0.429
MOD_GSK3_1	149	156	PF00069	0.388
MOD_GSK3_1	198	205	PF00069	0.408
MOD_GSK3_1	77	84	PF00069	0.444
MOD_NEK2_1	1	6	PF00069	0.785
MOD_NEK2_1	142	147	PF00069	0.439
MOD_NEK2_1	198	203	PF00069	0.377
MOD_NEK2_1	219	224	PF00069	0.488
MOD_NEK2_1	39	44	PF00069	0.644
MOD_NEK2_1	47	52	PF00069	0.585
MOD_PIKK_1	149	155	PF00454	0.431
MOD_PKA_2	219	225	PF00069	0.471
MOD_Plk_1	119	125	PF00069	0.536
MOD_Plk_1	77	83	PF00069	0.460
MOD_Plk_4	138	144	PF00069	0.446
MOD_Plk_4	222	228	PF00069	0.467
MOD_ProDKin_1	71	77	PF00069	0.607
MOD_SUMO_for_1	190	193	PF00179	0.501
MOD_SUMO_rev_2	128	138	PF00179	0.518
TRG_DiLeu_BaEn_2	192	198	PF01217	0.496
TRG_ENDOCYTIC_2	73	76	PF00928	0.427
TRG_ER_diArg_1	45	47	PF00400	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V1	Leptomonas seymouri	74%	75%
A0A0S4KPN7	Bodo saltans	44%	76%
A0A1X0PA58	Trypanosomatidae	54%	86%
A0A3S7X8H0	Leishmania donovani	96%	71%
A4HBC5	Leishmania braziliensis	86%	86%
A4IAH3	Leishmania infantum	96%	71%
C9ZLR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	93%
E9B5J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	75%