Geranylgeranyl transferase type-2 subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

geranylgeranyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q2D8_LEIMA

TriTrypDb:

LmjF.34.4030 , LMJLV39_340046900 , LMJSD75_340047300

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005968	Rab-protein geranylgeranyltransferase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

Q4Q2D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018342	protein prenylation	4	12
GO:0018344	protein geranylgeranylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0097354	prenylation	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	12
GO:0004661	protein geranylgeranyltransferase activity	4	12
GO:0004663	Rab geranylgeranyltransferase activity	5	12
GO:0005488	binding	1	12
GO:0008318	protein prenyltransferase activity	3	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.533
CLV_MEL_PAP_1	129	135	PF00089	0.333
CLV_NRD_NRD_1	325	327	PF00675	0.582
CLV_PCSK_KEX2_1	325	327	PF00082	0.547
CLV_PCSK_SKI1_1	248	252	PF00082	0.247
DEG_Nend_UBRbox_2	1	3	PF02207	0.527
DOC_MAPK_gen_1	106	116	PF00069	0.488
DOC_USP7_MATH_1	117	121	PF00917	0.447
DOC_WW_Pin1_4	169	174	PF00397	0.488
LIG_14-3-3_CanoR_1	109	115	PF00244	0.488
LIG_14-3-3_CanoR_1	132	136	PF00244	0.485
LIG_14-3-3_CanoR_1	242	246	PF00244	0.469
LIG_14-3-3_CterR_2	326	330	PF00244	0.719
LIG_deltaCOP1_diTrp_1	124	133	PF00928	0.447
LIG_FHA_1	241	247	PF00498	0.378
LIG_Integrin_isoDGR_2	218	220	PF01839	0.247
LIG_LIR_Gen_1	130	141	PF02991	0.449
LIG_LIR_Gen_1	249	256	PF02991	0.489
LIG_LIR_Gen_1	275	283	PF02991	0.447
LIG_LIR_Gen_1	306	315	PF02991	0.494
LIG_LIR_Nem_3	124	129	PF02991	0.445
LIG_LIR_Nem_3	130	136	PF02991	0.436
LIG_LIR_Nem_3	230	234	PF02991	0.448
LIG_LIR_Nem_3	249	255	PF02991	0.349
LIG_LIR_Nem_3	275	280	PF02991	0.443
LIG_LIR_Nem_3	306	310	PF02991	0.465
LIG_Pex14_1	165	169	PF04695	0.447
LIG_Rb_pABgroove_1	90	98	PF01858	0.487
LIG_SH2_PTP2	135	138	PF00017	0.488
LIG_SH2_STAP1	229	233	PF00017	0.447
LIG_SH2_STAP1	303	307	PF00017	0.449
LIG_SH2_STAT5	135	138	PF00017	0.444
LIG_SH2_STAT5	158	161	PF00017	0.519
LIG_SH2_STAT5	254	257	PF00017	0.492
LIG_SH3_1	295	301	PF00018	0.375
LIG_SH3_3	295	301	PF00018	0.429
LIG_SH3_3	4	10	PF00018	0.528
LIG_SH3_4	269	276	PF00018	0.508
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.468
LIG_TRFH_1	294	298	PF08558	0.466
LIG_TYR_ITIM	305	310	PF00017	0.426
LIG_UBA3_1	48	55	PF00899	0.382
LIG_WRC_WIRS_1	277	282	PF05994	0.300
MOD_CK1_1	235	241	PF00069	0.334
MOD_Cter_Amidation	323	326	PF01082	0.541
MOD_GlcNHglycan	2	6	PF01048	0.462
MOD_GlcNHglycan	213	216	PF01048	0.315
MOD_GlcNHglycan	237	240	PF01048	0.415
MOD_GlcNHglycan	87	90	PF01048	0.300
MOD_GSK3_1	254	261	PF00069	0.420
MOD_NEK2_1	1	6	PF00069	0.699
MOD_NEK2_1	240	245	PF00069	0.425
MOD_NEK2_1	62	67	PF00069	0.403
MOD_NEK2_1	83	88	PF00069	0.274
MOD_PIKK_1	24	30	PF00454	0.554
MOD_PIKK_1	258	264	PF00454	0.420
MOD_PIKK_1	318	324	PF00454	0.620
MOD_PKA_2	131	137	PF00069	0.376
MOD_PKA_2	241	247	PF00069	0.474
MOD_Plk_1	24	30	PF00069	0.616
MOD_Plk_4	227	233	PF00069	0.300
MOD_Plk_4	241	247	PF00069	0.366
MOD_Plk_4	276	282	PF00069	0.300
MOD_Plk_4	284	290	PF00069	0.300
MOD_Plk_4	42	48	PF00069	0.445
MOD_ProDKin_1	169	175	PF00069	0.357
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.447
TRG_ENDOCYTIC_2	135	138	PF00928	0.293
TRG_ENDOCYTIC_2	277	280	PF00928	0.293
TRG_ENDOCYTIC_2	307	310	PF00928	0.349
TRG_ENDOCYTIC_2	40	43	PF00928	0.393
TRG_ER_diArg_1	325	327	PF00400	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE23	Leptomonas seymouri	81%	99%
A0A0S4KIX8	Bodo saltans	60%	93%
A0A1X0NZ61	Trypanosomatidae	28%	77%
A0A1X0PB07	Trypanosomatidae	67%	100%
A0A3Q8IEQ7	Leishmania donovani	98%	100%
A0A3R7NPB5	Trypanosoma rangeli	66%	100%
A0A3S5ISJ3	Trypanosoma rangeli	30%	82%
A4HBC6	Leishmania braziliensis	90%	100%
A4IAH4	Leishmania infantum	98%	100%
B0G172	Dictyostelium discoideum	54%	97%
C9ZLR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9B5J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O13782	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	86%
O80642	Arabidopsis thaliana	35%	88%
O93830	Candida albicans	46%	97%
P18898	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	88%
P20133	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P22007	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	77%
P41992	Caenorhabditis elegans	47%	99%
P46960	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
P49355	Bos taurus	35%	76%
P49356	Homo sapiens	35%	76%
P53609	Homo sapiens	34%	88%
P53610	Rattus norvegicus	34%	88%
P53611	Homo sapiens	48%	100%
P53612	Mus musculus	48%	97%
Q02293	Rattus norvegicus	35%	76%
Q08603	Rattus norvegicus	48%	100%
Q5E9B3	Bos taurus	48%	100%
Q5EAD5	Bos taurus	34%	88%
Q84J75	Arabidopsis thaliana	52%	100%
Q8BUY9	Mus musculus	34%	88%
Q8K2I1	Mus musculus	35%	76%
Q9LHL5	Arabidopsis thaliana	53%	100%
V5BGA3	Trypanosoma cruzi	28%	88%
V5BLT0	Trypanosoma cruzi	69%	100%