Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2D7_LEIMA

TriTrypDb:

LmjF.34.4040 , LMJLV39_340047000 , LMJSD75_340047400

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.636
CLV_NRD_NRD_1	21	23	PF00675	0.577
CLV_NRD_NRD_1	210	212	PF00675	0.410
CLV_NRD_NRD_1	275	277	PF00675	0.565
CLV_NRD_NRD_1	63	65	PF00675	0.755
CLV_PCSK_KEX2_1	160	162	PF00082	0.385
CLV_PCSK_KEX2_1	21	23	PF00082	0.599
CLV_PCSK_KEX2_1	210	212	PF00082	0.390
CLV_PCSK_KEX2_1	275	277	PF00082	0.554
CLV_PCSK_KEX2_1	63	65	PF00082	0.755
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.385
CLV_PCSK_SKI1_1	110	114	PF00082	0.518
CLV_PCSK_SKI1_1	211	215	PF00082	0.470
CLV_PCSK_SKI1_1	289	293	PF00082	0.400
CLV_PCSK_SKI1_1	312	316	PF00082	0.402
DEG_APCC_DBOX_1	183	191	PF00400	0.369
DEG_APCC_DBOX_1	25	33	PF00400	0.521
DEG_APCC_DBOX_1	288	296	PF00400	0.399
DEG_Nend_UBRbox_2	1	3	PF02207	0.683
DOC_MAPK_DCC_7	286	296	PF00069	0.509
DOC_MAPK_gen_1	160	166	PF00069	0.398
DOC_MAPK_gen_1	286	296	PF00069	0.473
DOC_MAPK_gen_1	319	329	PF00069	0.504
DOC_MAPK_MEF2A_6	171	179	PF00069	0.267
DOC_MAPK_MEF2A_6	289	296	PF00069	0.461
DOC_MAPK_NFAT4_5	289	297	PF00069	0.502
DOC_PP2B_LxvP_1	16	19	PF13499	0.470
DOC_PP2B_LxvP_1	164	167	PF13499	0.474
DOC_PP4_FxxP_1	82	85	PF00568	0.547
DOC_USP7_MATH_1	12	16	PF00917	0.580
DOC_USP7_MATH_1	206	210	PF00917	0.530
DOC_WW_Pin1_4	254	259	PF00397	0.516
DOC_WW_Pin1_4	330	335	PF00397	0.450
DOC_WW_Pin1_4	76	81	PF00397	0.482
LIG_14-3-3_CanoR_1	141	151	PF00244	0.474
LIG_14-3-3_CanoR_1	210	219	PF00244	0.461
LIG_14-3-3_CanoR_1	275	281	PF00244	0.624
LIG_14-3-3_CanoR_1	324	328	PF00244	0.513
LIG_Actin_WH2_2	114	130	PF00022	0.517
LIG_BRCT_BRCA1_1	325	329	PF00533	0.433
LIG_BRCT_BRCA1_1	78	82	PF00533	0.444
LIG_CaM_NSCaTE_8	28	35	PF13499	0.479
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.524
LIG_EVH1_1	164	168	PF00568	0.521
LIG_FHA_1	11	17	PF00498	0.569
LIG_FHA_1	297	303	PF00498	0.465
LIG_FHA_1	84	90	PF00498	0.488
LIG_FHA_2	102	108	PF00498	0.560
LIG_FHA_2	133	139	PF00498	0.416
LIG_FHA_2	142	148	PF00498	0.475
LIG_LIR_Apic_2	79	85	PF02991	0.469
LIG_LIR_Gen_1	326	336	PF02991	0.461
LIG_LIR_LC3C_4	185	189	PF02991	0.454
LIG_LIR_Nem_3	326	332	PF02991	0.456
LIG_LIR_Nem_3	79	84	PF02991	0.496
LIG_MLH1_MIPbox_1	78	82	PF16413	0.444
LIG_NRBOX	108	114	PF00104	0.496
LIG_SH2_PTP2	267	270	PF00017	0.456
LIG_SH2_STAT5	267	270	PF00017	0.367
LIG_SH2_STAT5	38	41	PF00017	0.564
LIG_SH2_STAT5	81	84	PF00017	0.460
LIG_SH3_3	162	168	PF00018	0.455
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.489
LIG_SUMO_SIM_anti_2	144	153	PF11976	0.517
LIG_SUMO_SIM_anti_2	185	192	PF11976	0.397
LIG_SUMO_SIM_par_1	12	17	PF11976	0.540
LIG_SUMO_SIM_par_1	185	192	PF11976	0.474
LIG_SUMO_SIM_par_1	292	297	PF11976	0.496
LIG_TRAF2_1	40	43	PF00917	0.546
LIG_WRC_WIRS_1	6	11	PF05994	0.606
MOD_CDK_SPK_2	254	259	PF00069	0.516
MOD_CK1_1	330	336	PF00069	0.452
MOD_CK1_1	58	64	PF00069	0.730
MOD_CK1_1	76	82	PF00069	0.493
MOD_CK1_1	83	89	PF00069	0.410
MOD_CK2_1	141	147	PF00069	0.487
MOD_CK2_1	179	185	PF00069	0.534
MOD_CK2_1	254	260	PF00069	0.483
MOD_GlcNHglycan	135	138	PF01048	0.360
MOD_GlcNHglycan	181	184	PF01048	0.529
MOD_GlcNHglycan	48	51	PF01048	0.653
MOD_GlcNHglycan	75	78	PF01048	0.551
MOD_GSK3_1	1	8	PF00069	0.581
MOD_GSK3_1	10	17	PF00069	0.522
MOD_GSK3_1	276	283	PF00069	0.617
MOD_GSK3_1	323	330	PF00069	0.427
MOD_GSK3_1	42	49	PF00069	0.624
MOD_GSK3_1	55	62	PF00069	0.737
MOD_GSK3_1	76	83	PF00069	0.482
MOD_NEK2_1	1	6	PF00069	0.635
MOD_NEK2_1	280	285	PF00069	0.484
MOD_NEK2_1	327	332	PF00069	0.557
MOD_NEK2_1	46	51	PF00069	0.600
MOD_PIKK_1	211	217	PF00454	0.467
MOD_PKA_2	142	148	PF00069	0.484
MOD_PKA_2	323	329	PF00069	0.533
MOD_PKA_2	55	61	PF00069	0.705
MOD_PKB_1	141	149	PF00069	0.484
MOD_PKB_1	64	72	PF00069	0.618
MOD_Plk_1	1	7	PF00069	0.638
MOD_Plk_1	42	48	PF00069	0.637
MOD_Plk_4	1	7	PF00069	0.658
MOD_Plk_4	323	329	PF00069	0.429
MOD_ProDKin_1	254	260	PF00069	0.513
MOD_ProDKin_1	330	336	PF00069	0.448
MOD_ProDKin_1	76	82	PF00069	0.471
MOD_SUMO_for_1	117	120	PF00179	0.503
TRG_DiLeu_BaEn_1	147	152	PF01217	0.494
TRG_DiLeu_BaEn_1	229	234	PF01217	0.402
TRG_DiLeu_BaEn_1	287	292	PF01217	0.383
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.458
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.455
TRG_ENDOCYTIC_2	267	270	PF00928	0.386
TRG_ENDOCYTIC_2	81	84	PF00928	0.568
TRG_ER_diArg_1	63	66	PF00400	0.746
TRG_NES_CRM1_1	107	123	PF08389	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P703	Leptomonas seymouri	59%	80%
A0A0S4KKR7	Bodo saltans	32%	66%
A0A1X0PA52	Trypanosomatidae	46%	84%
A0A3S7X8N4	Leishmania donovani	91%	100%
A0A422NVD0	Trypanosoma rangeli	43%	90%
A4HBC7	Leishmania braziliensis	82%	100%
A4IAH5	Leishmania infantum	91%	100%
C9ZLR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	89%
E9B5J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BW32	Trypanosoma cruzi	41%	89%