Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2D6_LEIMA

TriTrypDb:

LmjF.34.4050 , LMJLV39_340047100 , LMJSD75_340047500

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D6

Function

Biological processes
Term	Name	Level	Count
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.671
CLV_C14_Caspase3-7	393	397	PF00656	0.639
CLV_NRD_NRD_1	130	132	PF00675	0.656
CLV_NRD_NRD_1	352	354	PF00675	0.587
CLV_NRD_NRD_1	36	38	PF00675	0.623
CLV_NRD_NRD_1	369	371	PF00675	0.577
CLV_NRD_NRD_1	433	435	PF00675	0.627
CLV_NRD_NRD_1	628	630	PF00675	0.798
CLV_PCSK_FUR_1	27	31	PF00082	0.625
CLV_PCSK_KEX2_1	29	31	PF00082	0.598
CLV_PCSK_KEX2_1	352	354	PF00082	0.550
CLV_PCSK_KEX2_1	36	38	PF00082	0.611
CLV_PCSK_KEX2_1	369	371	PF00082	0.505
CLV_PCSK_KEX2_1	432	434	PF00082	0.673
CLV_PCSK_KEX2_1	598	600	PF00082	0.575
CLV_PCSK_KEX2_1	628	630	PF00082	0.780
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.598
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.611
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.600
CLV_PCSK_SKI1_1	176	180	PF00082	0.483
CLV_PCSK_SKI1_1	30	34	PF00082	0.585
CLV_PCSK_SKI1_1	370	374	PF00082	0.634
CLV_PCSK_SKI1_1	454	458	PF00082	0.626
CLV_PCSK_SKI1_1	485	489	PF00082	0.495
CLV_PCSK_SKI1_1	629	633	PF00082	0.762
CLV_PCSK_SKI1_1	661	665	PF00082	0.689
CLV_Separin_Metazoa	197	201	PF03568	0.383
DEG_APCC_DBOX_1	432	440	PF00400	0.724
DEG_APCC_DBOX_1	484	492	PF00400	0.495
DEG_Nend_UBRbox_2	1	3	PF02207	0.687
DEG_SPOP_SBC_1	273	277	PF00917	0.705
DOC_CKS1_1	83	88	PF01111	0.601
DOC_MAPK_gen_1	102	110	PF00069	0.636
DOC_MAPK_gen_1	352	360	PF00069	0.504
DOC_MAPK_gen_1	36	44	PF00069	0.563
DOC_MAPK_gen_1	432	438	PF00069	0.632
DOC_MAPK_gen_1	598	604	PF00069	0.612
DOC_MAPK_gen_1	613	621	PF00069	0.671
DOC_MAPK_MEF2A_6	286	293	PF00069	0.468
DOC_MAPK_MEF2A_6	352	360	PF00069	0.446
DOC_MAPK_MEF2A_6	36	44	PF00069	0.512
DOC_MAPK_MEF2A_6	613	621	PF00069	0.634
DOC_MAPK_NFAT4_5	286	294	PF00069	0.469
DOC_PP2B_LxvP_1	289	292	PF13499	0.535
DOC_PP2B_LxvP_1	535	538	PF13499	0.655
DOC_PP4_FxxP_1	582	585	PF00568	0.747
DOC_PP4_FxxP_1	659	662	PF00568	0.692
DOC_USP7_MATH_1	138	142	PF00917	0.688
DOC_USP7_MATH_1	144	148	PF00917	0.711
DOC_USP7_MATH_1	225	229	PF00917	0.573
DOC_USP7_MATH_1	445	449	PF00917	0.669
DOC_USP7_MATH_1	49	53	PF00917	0.710
DOC_USP7_MATH_1	631	635	PF00917	0.691
DOC_USP7_MATH_1	8	12	PF00917	0.685
DOC_USP7_UBL2_3	649	653	PF12436	0.750
DOC_WW_Pin1_4	140	145	PF00397	0.733
DOC_WW_Pin1_4	162	167	PF00397	0.775
DOC_WW_Pin1_4	292	297	PF00397	0.576
DOC_WW_Pin1_4	406	411	PF00397	0.686
DOC_WW_Pin1_4	51	56	PF00397	0.476
DOC_WW_Pin1_4	573	578	PF00397	0.624
DOC_WW_Pin1_4	637	642	PF00397	0.644
DOC_WW_Pin1_4	82	87	PF00397	0.603
LIG_14-3-3_CanoR_1	589	595	PF00244	0.661
LIG_14-3-3_CanoR_1	64	69	PF00244	0.597
LIG_Actin_WH2_2	196	213	PF00022	0.466
LIG_Actin_WH2_2	474	491	PF00022	0.509
LIG_APCC_ABBA_1	58	63	PF00400	0.583
LIG_BRCT_BRCA1_1	447	451	PF00533	0.702
LIG_BRCT_BRCA1_1	578	582	PF00533	0.737
LIG_CaM_IQ_9	550	565	PF13499	0.580
LIG_EH1_1	481	489	PF00400	0.569
LIG_FHA_1	285	291	PF00498	0.458
LIG_FHA_1	322	328	PF00498	0.726
LIG_FHA_1	381	387	PF00498	0.624
LIG_FHA_1	407	413	PF00498	0.623
LIG_FHA_1	55	61	PF00498	0.554
LIG_FHA_1	63	69	PF00498	0.477
LIG_FHA_2	163	169	PF00498	0.719
LIG_FHA_2	331	337	PF00498	0.530
LIG_FHA_2	474	480	PF00498	0.636
LIG_GBD_Chelix_1	343	351	PF00786	0.531
LIG_LIR_Apic_2	579	585	PF02991	0.714
LIG_LIR_Apic_2	81	86	PF02991	0.577
LIG_LIR_Gen_1	116	123	PF02991	0.573
LIG_LIR_Gen_1	228	236	PF02991	0.635
LIG_LIR_Gen_1	67	76	PF02991	0.528
LIG_LIR_Nem_3	116	122	PF02991	0.558
LIG_LIR_Nem_3	228	233	PF02991	0.658
LIG_LIR_Nem_3	634	639	PF02991	0.591
LIG_LIR_Nem_3	67	72	PF02991	0.528
LIG_NRBOX	189	195	PF00104	0.490
LIG_NRBOX	71	77	PF00104	0.583
LIG_PDZ_Class_2	660	665	PF00595	0.700
LIG_Pex14_2	659	663	PF04695	0.689
LIG_Rb_LxCxE_1	238	259	PF01857	0.640
LIG_SH2_CRK	303	307	PF00017	0.490
LIG_SH2_STAP1	204	208	PF00017	0.553
LIG_SH2_STAT3	25	28	PF00017	0.611
LIG_SH2_STAT5	115	118	PF00017	0.680
LIG_SH2_STAT5	202	205	PF00017	0.404
LIG_SH2_STAT5	230	233	PF00017	0.616
LIG_SH2_STAT5	25	28	PF00017	0.638
LIG_SH2_STAT5	529	532	PF00017	0.607
LIG_SH2_STAT5	591	594	PF00017	0.687
LIG_SH3_3	149	155	PF00018	0.689
LIG_SH3_3	435	441	PF00018	0.644
LIG_SH3_3	614	620	PF00018	0.749
LIG_SUMO_SIM_anti_2	180	189	PF11976	0.517
LIG_SUMO_SIM_anti_2	228	235	PF11976	0.534
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.546
LIG_SUMO_SIM_par_1	378	383	PF11976	0.670
LIG_SUMO_SIM_par_1	531	541	PF11976	0.637
LIG_SUMO_SIM_par_1	56	63	PF11976	0.534
LIG_TRAF2_1	476	479	PF00917	0.571
MOD_CDK_SPxK_1	637	643	PF00069	0.546
MOD_CDK_SPxK_1	82	88	PF00069	0.603
MOD_CK1_1	143	149	PF00069	0.783
MOD_CK1_1	159	165	PF00069	0.680
MOD_CK1_1	171	177	PF00069	0.571
MOD_CK1_1	261	267	PF00069	0.644
MOD_CK1_1	3	9	PF00069	0.736
MOD_CK1_1	406	412	PF00069	0.723
MOD_CK1_1	54	60	PF00069	0.588
MOD_CK1_1	590	596	PF00069	0.702
MOD_CK1_1	62	68	PF00069	0.554
MOD_CK2_1	106	112	PF00069	0.555
MOD_CK2_1	114	120	PF00069	0.574
MOD_CK2_1	123	129	PF00069	0.636
MOD_CK2_1	171	177	PF00069	0.534
MOD_CK2_1	277	283	PF00069	0.674
MOD_CK2_1	444	450	PF00069	0.599
MOD_CK2_1	473	479	PF00069	0.642
MOD_Cter_Amidation	129	132	PF01082	0.606
MOD_Cter_Amidation	430	433	PF01082	0.719
MOD_Cter_Amidation	626	629	PF01082	0.713
MOD_GlcNHglycan	116	119	PF01048	0.537
MOD_GlcNHglycan	258	261	PF01048	0.720
MOD_GlcNHglycan	262	266	PF01048	0.737
MOD_GlcNHglycan	279	282	PF01048	0.446
MOD_GlcNHglycan	361	364	PF01048	0.519
MOD_GlcNHglycan	370	373	PF01048	0.629
MOD_GlcNHglycan	585	588	PF01048	0.704
MOD_GSK3_1	136	143	PF00069	0.711
MOD_GSK3_1	144	151	PF00069	0.708
MOD_GSK3_1	156	163	PF00069	0.706
MOD_GSK3_1	177	184	PF00069	0.473
MOD_GSK3_1	252	259	PF00069	0.654
MOD_GSK3_1	261	268	PF00069	0.717
MOD_GSK3_1	273	280	PF00069	0.687
MOD_GSK3_1	318	325	PF00069	0.717
MOD_GSK3_1	557	564	PF00069	0.661
MOD_GSK3_1	583	590	PF00069	0.677
MOD_GSK3_1	631	638	PF00069	0.737
MOD_N-GLC_1	466	471	PF02516	0.665
MOD_N-GLC_1	550	555	PF02516	0.644
MOD_NEK2_1	123	128	PF00069	0.621
MOD_NEK2_1	179	184	PF00069	0.445
MOD_NEK2_1	186	191	PF00069	0.396
MOD_NEK2_1	203	208	PF00069	0.420
MOD_NEK2_1	21	26	PF00069	0.561
MOD_NEK2_1	226	231	PF00069	0.591
MOD_NEK2_1	254	259	PF00069	0.678
MOD_NEK2_1	338	343	PF00069	0.495
MOD_NEK2_1	359	364	PF00069	0.507
MOD_NEK2_1	368	373	PF00069	0.516
MOD_NEK2_1	380	385	PF00069	0.564
MOD_NEK2_1	403	408	PF00069	0.716
MOD_NEK2_1	459	464	PF00069	0.590
MOD_PIKK_1	254	260	PF00454	0.601
MOD_PIKK_1	550	556	PF00454	0.673
MOD_PK_1	148	154	PF00069	0.776
MOD_PK_1	156	162	PF00069	0.719
MOD_PKA_2	123	129	PF00069	0.675
MOD_PKA_2	368	374	PF00069	0.603
MOD_PKA_2	557	563	PF00069	0.650
MOD_PKA_2	645	651	PF00069	0.734
MOD_Plk_1	466	472	PF00069	0.624
MOD_Plk_1	550	556	PF00069	0.634
MOD_Plk_2-3	106	112	PF00069	0.648
MOD_Plk_4	106	112	PF00069	0.591
MOD_Plk_4	226	232	PF00069	0.644
MOD_Plk_4	346	352	PF00069	0.566
MOD_Plk_4	64	70	PF00069	0.592
MOD_ProDKin_1	140	146	PF00069	0.734
MOD_ProDKin_1	162	168	PF00069	0.774
MOD_ProDKin_1	292	298	PF00069	0.587
MOD_ProDKin_1	406	412	PF00069	0.687
MOD_ProDKin_1	51	57	PF00069	0.477
MOD_ProDKin_1	573	579	PF00069	0.626
MOD_ProDKin_1	637	643	PF00069	0.646
MOD_ProDKin_1	82	88	PF00069	0.603
TRG_DiLeu_BaEn_1	181	186	PF01217	0.479
TRG_DiLeu_BaEn_1	71	76	PF01217	0.582
TRG_DiLeu_BaEn_2	105	111	PF01217	0.643
TRG_DiLeu_BaEn_2	505	511	PF01217	0.372
TRG_DiLeu_BaEn_2	599	605	PF01217	0.635
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.538
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.580
TRG_DiLeu_LyEn_5	71	76	PF01217	0.531
TRG_ENDOCYTIC_2	230	233	PF00928	0.661
TRG_ENDOCYTIC_2	303	306	PF00928	0.492
TRG_ER_diArg_1	218	221	PF00400	0.379
TRG_ER_diArg_1	351	353	PF00400	0.573
TRG_ER_diArg_1	368	370	PF00400	0.556
TRG_ER_diArg_1	432	434	PF00400	0.702
TRG_NES_CRM1_1	181	195	PF08389	0.472
TRG_NLS_MonoExtC_3	35	41	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	30	35	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E6	Leptomonas seymouri	47%	100%
A0A0S4KLZ0	Bodo saltans	27%	83%
A0A1X0PAG6	Trypanosomatidae	35%	100%
A0A3Q8IIY0	Leishmania donovani	90%	98%
A0A422NVB5	Trypanosoma rangeli	32%	100%
A4HBC8	Leishmania braziliensis	72%	99%
A4IAH6	Leishmania infantum	90%	98%
C9ZLR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
V5BRF7	Trypanosoma cruzi	33%	100%