Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2D4_LEIMA

TriTrypDb:

LmjF.34.4070 , LMJLV39_340047300 , LMJSD75_340047700

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0048487	beta-tubulin binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.477
CLV_NRD_NRD_1	167	169	PF00675	0.277
CLV_NRD_NRD_1	325	327	PF00675	0.513
CLV_NRD_NRD_1	436	438	PF00675	0.343
CLV_NRD_NRD_1	523	525	PF00675	0.438
CLV_NRD_NRD_1	673	675	PF00675	0.356
CLV_PCSK_KEX2_1	125	127	PF00082	0.314
CLV_PCSK_KEX2_1	166	168	PF00082	0.293
CLV_PCSK_KEX2_1	325	327	PF00082	0.513
CLV_PCSK_KEX2_1	436	438	PF00082	0.361
CLV_PCSK_KEX2_1	591	593	PF00082	0.442
CLV_PCSK_KEX2_1	673	675	PF00082	0.307
CLV_PCSK_KEX2_1	72	74	PF00082	0.391
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.334
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.329
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.442
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.267
CLV_PCSK_SKI1_1	15	19	PF00082	0.556
CLV_PCSK_SKI1_1	152	156	PF00082	0.318
CLV_PCSK_SKI1_1	167	171	PF00082	0.210
CLV_PCSK_SKI1_1	268	272	PF00082	0.552
CLV_PCSK_SKI1_1	436	440	PF00082	0.358
CLV_PCSK_SKI1_1	491	495	PF00082	0.455
CLV_PCSK_SKI1_1	524	528	PF00082	0.448
CLV_PCSK_SKI1_1	674	678	PF00082	0.357
CLV_PCSK_SKI1_1	684	688	PF00082	0.312
DEG_APCC_DBOX_1	673	681	PF00400	0.359
DEG_APCC_KENBOX_2	303	307	PF00400	0.384
DOC_CKS1_1	357	362	PF01111	0.411
DOC_CKS1_1	651	656	PF01111	0.404
DOC_CYCLIN_RxL_1	295	305	PF00134	0.418
DOC_MAPK_gen_1	11	20	PF00069	0.550
DOC_MAPK_gen_1	50	58	PF00069	0.535
DOC_MAPK_gen_1	673	679	PF00069	0.513
DOC_MAPK_MEF2A_6	378	386	PF00069	0.487
DOC_PP1_RVXF_1	150	156	PF00149	0.501
DOC_PP1_RVXF_1	383	389	PF00149	0.334
DOC_PP1_RVXF_1	682	689	PF00149	0.311
DOC_PP2B_PxIxI_1	279	285	PF00149	0.387
DOC_PP4_FxxP_1	388	391	PF00568	0.325
DOC_PP4_FxxP_1	603	606	PF00568	0.518
DOC_USP7_MATH_1	209	213	PF00917	0.440
DOC_USP7_MATH_1	347	351	PF00917	0.377
DOC_USP7_UBL2_3	11	15	PF12436	0.651
DOC_USP7_UBL2_3	29	33	PF12436	0.425
DOC_USP7_UBL2_3	68	72	PF12436	0.545
DOC_WW_Pin1_4	356	361	PF00397	0.462
DOC_WW_Pin1_4	500	505	PF00397	0.431
DOC_WW_Pin1_4	515	520	PF00397	0.421
DOC_WW_Pin1_4	650	655	PF00397	0.398
LIG_14-3-3_CanoR_1	222	226	PF00244	0.513
LIG_14-3-3_CanoR_1	250	259	PF00244	0.535
LIG_14-3-3_CanoR_1	272	278	PF00244	0.380
LIG_14-3-3_CanoR_1	325	332	PF00244	0.443
LIG_14-3-3_CanoR_1	346	355	PF00244	0.454
LIG_14-3-3_CanoR_1	385	389	PF00244	0.384
LIG_14-3-3_CanoR_1	436	441	PF00244	0.386
LIG_14-3-3_CanoR_1	472	478	PF00244	0.388
LIG_14-3-3_CanoR_1	513	521	PF00244	0.465
LIG_14-3-3_CanoR_1	616	624	PF00244	0.350
LIG_14-3-3_CanoR_1	684	689	PF00244	0.304
LIG_Actin_WH2_2	582	597	PF00022	0.379
LIG_BRCT_BRCA1_1	275	279	PF00533	0.366
LIG_BRCT_BRCA1_1	564	568	PF00533	0.380
LIG_Clathr_ClatBox_1	354	358	PF01394	0.597
LIG_Clathr_ClatBox_1	474	478	PF01394	0.340
LIG_deltaCOP1_diTrp_1	461	468	PF00928	0.334
LIG_eIF4E_1	646	652	PF01652	0.467
LIG_FHA_1	135	141	PF00498	0.478
LIG_FHA_1	228	234	PF00498	0.511
LIG_FHA_1	265	271	PF00498	0.522
LIG_FHA_1	333	339	PF00498	0.376
LIG_FHA_1	426	432	PF00498	0.581
LIG_FHA_1	548	554	PF00498	0.390
LIG_FHA_1	606	612	PF00498	0.555
LIG_FHA_1	666	672	PF00498	0.455
LIG_FHA_2	340	346	PF00498	0.505
LIG_FHA_2	41	47	PF00498	0.547
LIG_FHA_2	452	458	PF00498	0.454
LIG_FHA_2	484	490	PF00498	0.450
LIG_FHA_2	605	611	PF00498	0.550
LIG_FHA_2	626	632	PF00498	0.506
LIG_FHA_2	651	657	PF00498	0.406
LIG_Integrin_RGD_1	482	484	PF01839	0.524
LIG_IRF3_LxIS_1	382	387	PF10401	0.426
LIG_LIR_Apic_2	387	391	PF02991	0.342
LIG_LIR_Apic_2	590	596	PF02991	0.512
LIG_LIR_Apic_2	600	606	PF02991	0.494
LIG_LIR_Gen_1	193	203	PF02991	0.446
LIG_LIR_Gen_1	216	225	PF02991	0.451
LIG_LIR_Gen_1	271	282	PF02991	0.374
LIG_LIR_Gen_1	453	460	PF02991	0.341
LIG_LIR_Gen_1	529	535	PF02991	0.390
LIG_LIR_Gen_1	54	63	PF02991	0.573
LIG_LIR_Gen_1	555	564	PF02991	0.355
LIG_LIR_Gen_1	610	617	PF02991	0.347
LIG_LIR_Gen_1	678	686	PF02991	0.441
LIG_LIR_Gen_1	96	104	PF02991	0.501
LIG_LIR_Nem_3	193	198	PF02991	0.446
LIG_LIR_Nem_3	216	221	PF02991	0.472
LIG_LIR_Nem_3	224	228	PF02991	0.433
LIG_LIR_Nem_3	271	277	PF02991	0.391
LIG_LIR_Nem_3	317	322	PF02991	0.364
LIG_LIR_Nem_3	327	332	PF02991	0.264
LIG_LIR_Nem_3	453	459	PF02991	0.349
LIG_LIR_Nem_3	487	493	PF02991	0.351
LIG_LIR_Nem_3	529	534	PF02991	0.390
LIG_LIR_Nem_3	54	58	PF02991	0.573
LIG_LIR_Nem_3	610	615	PF02991	0.342
LIG_LIR_Nem_3	643	649	PF02991	0.415
LIG_LIR_Nem_3	678	682	PF02991	0.448
LIG_LIR_Nem_3	96	101	PF02991	0.501
LIG_NRBOX	647	653	PF00104	0.341
LIG_PDZ_Wminus1_1	687	689	PF00595	0.306
LIG_Pex14_2	119	123	PF04695	0.431
LIG_Pex14_2	402	406	PF04695	0.466
LIG_PTB_Apo_2	664	671	PF02174	0.490
LIG_PTB_Phospho_1	664	670	PF10480	0.495
LIG_SH2_CRK	195	199	PF00017	0.446
LIG_SH2_CRK	649	653	PF00017	0.339
LIG_SH2_NCK_1	182	186	PF00017	0.498
LIG_SH2_NCK_1	195	199	PF00017	0.498
LIG_SH2_STAP1	236	240	PF00017	0.453
LIG_SH2_STAP1	319	323	PF00017	0.482
LIG_SH2_STAP1	558	562	PF00017	0.323
LIG_SH2_STAT5	195	198	PF00017	0.384
LIG_SH2_STAT5	218	221	PF00017	0.487
LIG_SH2_STAT5	322	325	PF00017	0.463
LIG_SH2_STAT5	55	58	PF00017	0.537
LIG_SH2_STAT5	670	673	PF00017	0.473
LIG_SH2_STAT5	92	95	PF00017	0.583
LIG_SH3_3	291	297	PF00018	0.460
LIG_SH3_4	11	18	PF00018	0.614
LIG_SUMO_SIM_par_1	136	142	PF11976	0.557
LIG_SUMO_SIM_par_1	473	478	PF11976	0.325
LIG_TRAF2_1	596	599	PF00917	0.552
LIG_UBA3_1	299	304	PF00899	0.622
LIG_UBA3_1	522	527	PF00899	0.439
LIG_WRC_WIRS_1	340	345	PF05994	0.395
LIG_WW_3	370	374	PF00397	0.564
MOD_CK1_1	102	108	PF00069	0.540
MOD_CK1_1	197	203	PF00069	0.478
MOD_CK1_1	229	235	PF00069	0.464
MOD_CK1_1	273	279	PF00069	0.362
MOD_CK1_1	324	330	PF00069	0.512
MOD_CK1_1	417	423	PF00069	0.400
MOD_CK1_1	515	521	PF00069	0.386
MOD_CK1_1	650	656	PF00069	0.548
MOD_CK2_1	24	30	PF00069	0.474
MOD_CK2_1	339	345	PF00069	0.414
MOD_CK2_1	346	352	PF00069	0.452
MOD_CK2_1	48	54	PF00069	0.549
MOD_CK2_1	483	489	PF00069	0.424
MOD_CK2_1	650	656	PF00069	0.548
MOD_GlcNHglycan	241	244	PF01048	0.365
MOD_GlcNHglycan	252	255	PF01048	0.295
MOD_GlcNHglycan	349	352	PF01048	0.455
MOD_GlcNHglycan	416	419	PF01048	0.488
MOD_GlcNHglycan	528	531	PF01048	0.362
MOD_GSK3_1	193	200	PF00069	0.532
MOD_GSK3_1	244	251	PF00069	0.480
MOD_GSK3_1	264	271	PF00069	0.345
MOD_GSK3_1	317	324	PF00069	0.503
MOD_GSK3_1	417	424	PF00069	0.442
MOD_GSK3_1	436	443	PF00069	0.330
MOD_GSK3_1	511	518	PF00069	0.413
MOD_GSK3_1	562	569	PF00069	0.477
MOD_N-GLC_1	145	150	PF02516	0.300
MOD_NEK2_1	119	124	PF00069	0.509
MOD_NEK2_1	227	232	PF00069	0.586
MOD_NEK2_1	332	337	PF00069	0.414
MOD_NEK2_1	421	426	PF00069	0.591
MOD_NEK2_1	451	456	PF00069	0.452
MOD_NEK2_1	468	473	PF00069	0.478
MOD_NEK2_1	512	517	PF00069	0.521
MOD_NEK2_1	526	531	PF00069	0.377
MOD_NEK2_1	58	63	PF00069	0.497
MOD_NEK2_1	587	592	PF00069	0.355
MOD_NEK2_1	611	616	PF00069	0.487
MOD_NEK2_1	630	635	PF00069	0.322
MOD_NEK2_1	665	670	PF00069	0.431
MOD_NEK2_2	657	662	PF00069	0.414
MOD_PIKK_1	201	207	PF00454	0.445
MOD_PIKK_1	227	233	PF00454	0.570
MOD_PIKK_1	289	295	PF00454	0.388
MOD_PIKK_1	324	330	PF00454	0.411
MOD_PIKK_1	48	54	PF00454	0.446
MOD_PIKK_1	562	568	PF00454	0.486
MOD_PKA_1	436	442	PF00069	0.420
MOD_PKA_2	191	197	PF00069	0.446
MOD_PKA_2	221	227	PF00069	0.513
MOD_PKA_2	324	330	PF00069	0.525
MOD_PKA_2	347	353	PF00069	0.517
MOD_PKA_2	384	390	PF00069	0.390
MOD_PKA_2	436	442	PF00069	0.472
MOD_PKA_2	512	518	PF00069	0.408
MOD_PKA_2	587	593	PF00069	0.347
MOD_Plk_1	102	108	PF00069	0.458
MOD_Plk_1	332	338	PF00069	0.417
MOD_Plk_1	58	64	PF00069	0.495
MOD_Plk_1	599	605	PF00069	0.495
MOD_Plk_1	657	663	PF00069	0.412
MOD_Plk_2-3	339	345	PF00069	0.431
MOD_Plk_2-3	599	605	PF00069	0.582
MOD_Plk_4	134	140	PF00069	0.577
MOD_Plk_4	209	215	PF00069	0.534
MOD_Plk_4	229	235	PF00069	0.390
MOD_Plk_4	244	250	PF00069	0.510
MOD_Plk_4	390	396	PF00069	0.355
MOD_Plk_4	397	403	PF00069	0.391
MOD_Plk_4	436	442	PF00069	0.404
MOD_Plk_4	451	457	PF00069	0.441
MOD_Plk_4	647	653	PF00069	0.320
MOD_Plk_4	88	94	PF00069	0.542
MOD_ProDKin_1	356	362	PF00069	0.456
MOD_ProDKin_1	500	506	PF00069	0.431
MOD_ProDKin_1	515	521	PF00069	0.416
MOD_ProDKin_1	650	656	PF00069	0.400
MOD_SUMO_for_1	67	70	PF00179	0.535
MOD_SUMO_rev_2	147	154	PF00179	0.529
TRG_DiLeu_BaEn_1	149	154	PF01217	0.522
TRG_DiLeu_BaEn_1	489	494	PF01217	0.362
TRG_DiLeu_BaEn_1	678	683	PF01217	0.482
TRG_DiLeu_BaEn_2	537	543	PF01217	0.362
TRG_DiLeu_BaEn_4	538	544	PF01217	0.486
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.395
TRG_ENDOCYTIC_2	195	198	PF00928	0.563
TRG_ENDOCYTIC_2	218	221	PF00928	0.468
TRG_ENDOCYTIC_2	236	239	PF00928	0.367
TRG_ENDOCYTIC_2	329	332	PF00928	0.351
TRG_ENDOCYTIC_2	55	58	PF00928	0.584
TRG_ENDOCYTIC_2	558	561	PF00928	0.311
TRG_ENDOCYTIC_2	649	652	PF00928	0.345
TRG_ER_diArg_1	435	437	PF00400	0.426
TRG_ER_diArg_1	672	674	PF00400	0.306
TRG_NLS_MonoExtN_4	163	170	PF00514	0.516
TRG_NLS_MonoExtN_4	71	76	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P710	Leptomonas seymouri	70%	98%
A0A0S4KLU8	Bodo saltans	39%	100%
A0A1X0PA51	Trypanosomatidae	46%	100%
A0A3Q8IFW2	Leishmania donovani	96%	100%
A0A3R7MX42	Trypanosoma rangeli	45%	98%
A4HBD0	Leishmania braziliensis	83%	100%
A4IAH8	Leishmania infantum	96%	100%
C9ZLR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B5K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BLS6	Trypanosoma cruzi	45%	98%