Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2D4_LEIMA

TriTrypDb:

LmjF.34.4070 , LMJLV39_340047300 , LMJSD75_340047700

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q2D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D4

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0048487	beta-tubulin binding	5	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.477
CLV_NRD_NRD_1	167	169	PF00675	0.277
CLV_NRD_NRD_1	325	327	PF00675	0.513
CLV_NRD_NRD_1	436	438	PF00675	0.343
CLV_NRD_NRD_1	523	525	PF00675	0.438
CLV_NRD_NRD_1	673	675	PF00675	0.356
CLV_PCSK_KEX2_1	125	127	PF00082	0.314
CLV_PCSK_KEX2_1	166	168	PF00082	0.293
CLV_PCSK_KEX2_1	325	327	PF00082	0.513
CLV_PCSK_KEX2_1	436	438	PF00082	0.361

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P710	Leptomonas seymouri	70%	98%
A0A0S4KLU8	Bodo saltans	39%	100%
A0A1X0PA51	Trypanosomatidae	46%	100%
A0A3Q8IFW2	Leishmania donovani	96%	100%
A0A3R7MX42	Trypanosoma rangeli	45%	98%
A4HBD0	Leishmania braziliensis	83%	100%
A4IAH8	Leishmania infantum	96%	100%
C9ZLR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B5K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BLS6	Trypanosoma cruzi	45%	98%

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