J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2D3_LEIMA

TriTrypDb:

LmjF.34.4080 , LMJLV39_340047400 , LMJSD75_340047800

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q2D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.442
CLV_NRD_NRD_1	218	220	PF00675	0.621
CLV_NRD_NRD_1	3	5	PF00675	0.412
CLV_PCSK_KEX2_1	107	109	PF00082	0.442
CLV_PCSK_KEX2_1	211	213	PF00082	0.563
CLV_PCSK_KEX2_1	218	220	PF00082	0.562
CLV_PCSK_KEX2_1	3	5	PF00082	0.412
CLV_PCSK_KEX2_1	49	51	PF00082	0.235
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.570
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.556
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.235
CLV_PCSK_SKI1_1	211	215	PF00082	0.611
CLV_PCSK_SKI1_1	45	49	PF00082	0.276
CLV_PCSK_SKI1_1	53	57	PF00082	0.270
CLV_PCSK_SKI1_1	93	97	PF00082	0.446
DEG_Nend_Nbox_1	1	3	PF02207	0.705
DOC_CKS1_1	225	230	PF01111	0.399
DOC_CYCLIN_yCln2_LP_2	186	192	PF00134	0.411
DOC_MAPK_gen_1	197	205	PF00069	0.427
DOC_MAPK_gen_1	3	9	PF00069	0.664
DOC_MAPK_gen_1	48	58	PF00069	0.442
DOC_MAPK_MEF2A_6	49	58	PF00069	0.498
DOC_USP7_MATH_1	251	255	PF00917	0.480
DOC_USP7_UBL2_3	44	48	PF12436	0.482
DOC_USP7_UBL2_3	49	53	PF12436	0.447
DOC_WW_Pin1_4	224	229	PF00397	0.438
LIG_14-3-3_CanoR_1	120	126	PF00244	0.620
LIG_14-3-3_CanoR_1	163	169	PF00244	0.399
LIG_14-3-3_CanoR_1	237	241	PF00244	0.365
LIG_14-3-3_CterR_2	252	257	PF00244	0.388
LIG_CSL_BTD_1	186	189	PF09270	0.403
LIG_deltaCOP1_diTrp_1	184	190	PF00928	0.491
LIG_FHA_1	113	119	PF00498	0.581
LIG_FHA_2	41	47	PF00498	0.526
LIG_Integrin_RGD_1	174	176	PF01839	0.536
LIG_LIR_Gen_1	135	143	PF02991	0.300
LIG_LIR_Gen_1	66	75	PF02991	0.442
LIG_LIR_Nem_3	135	139	PF02991	0.309
LIG_LIR_Nem_3	66	72	PF02991	0.442
LIG_SH2_CRK	111	115	PF00017	0.633
LIG_SH2_GRB2like	111	114	PF00017	0.617
LIG_SH2_STAP1	11	15	PF00017	0.550
LIG_SH2_STAP1	155	159	PF00017	0.365
LIG_SH2_STAP1	168	172	PF00017	0.463
LIG_SH2_STAT5	150	153	PF00017	0.419
LIG_SH2_STAT5	155	158	PF00017	0.329
LIG_SH2_STAT5	177	180	PF00017	0.413
LIG_SH2_STAT5	226	229	PF00017	0.411
LIG_SH3_3	222	228	PF00018	0.387
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.429
LIG_WW_1	223	226	PF00397	0.478
MOD_CK1_1	164	170	PF00069	0.392
MOD_CK2_1	164	170	PF00069	0.391
MOD_CMANNOS	187	190	PF00535	0.592
MOD_GlcNHglycan	18	21	PF01048	0.399
MOD_GlcNHglycan	253	256	PF01048	0.713
MOD_GlcNHglycan	4	7	PF01048	0.451
MOD_GlcNHglycan	85	89	PF01048	0.381
MOD_N-GLC_1	112	117	PF02516	0.416
MOD_NEK2_1	114	119	PF00069	0.621
MOD_NEK2_1	2	7	PF00069	0.608
MOD_NEK2_1	206	211	PF00069	0.343
MOD_NEK2_1	78	83	PF00069	0.512
MOD_PKA_2	119	125	PF00069	0.592
MOD_PKA_2	164	170	PF00069	0.379
MOD_PKA_2	2	8	PF00069	0.608
MOD_PKA_2	236	242	PF00069	0.441
MOD_PKA_2	251	257	PF00069	0.432
MOD_Plk_4	29	35	PF00069	0.527
MOD_ProDKin_1	224	230	PF00069	0.435
MOD_SUMO_for_1	95	98	PF00179	0.673
TRG_DiLeu_BaEn_1	74	79	PF01217	0.482
TRG_ENDOCYTIC_2	11	14	PF00928	0.611
TRG_ENDOCYTIC_2	111	114	PF00928	0.591
TRG_ER_diArg_1	106	108	PF00400	0.650
TRG_ER_diArg_1	162	165	PF00400	0.382
TRG_ER_diArg_1	2	4	PF00400	0.622
TRG_NES_CRM1_1	46	57	PF08389	0.451
TRG_NLS_MonoExtN_4	45	52	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILG9	Leptomonas seymouri	73%	99%
A0A0S4KRJ1	Bodo saltans	45%	100%
A0A1X0PA98	Trypanosomatidae	53%	100%
A0A3S7X8J5	Leishmania donovani	93%	97%
A0A422NVC0	Trypanosoma rangeli	54%	100%
A4HBD1	Leishmania braziliensis	82%	100%
A4IAH9	Leishmania infantum	93%	97%
C9ZLR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B5K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%