GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRIP domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2D2_LEIMA

TriTrypDb:

LmjF.34.4090 , LMJLV39_340047500 , LMJSD75_340047900

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.630
CLV_C14_Caspase3-7	320	324	PF00656	0.707
CLV_NRD_NRD_1	137	139	PF00675	0.587
CLV_NRD_NRD_1	345	347	PF00675	0.558
CLV_NRD_NRD_1	365	367	PF00675	0.428
CLV_NRD_NRD_1	372	374	PF00675	0.624
CLV_PCSK_KEX2_1	112	114	PF00082	0.595
CLV_PCSK_KEX2_1	136	138	PF00082	0.571
CLV_PCSK_KEX2_1	345	347	PF00082	0.613
CLV_PCSK_KEX2_1	365	367	PF00082	0.376
CLV_PCSK_KEX2_1	372	374	PF00082	0.553
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.590
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.512
CLV_PCSK_SKI1_1	112	116	PF00082	0.498
CLV_PCSK_SKI1_1	19	23	PF00082	0.646
CLV_PCSK_SKI1_1	28	32	PF00082	0.537
CLV_PCSK_SKI1_1	366	370	PF00082	0.618
CLV_PCSK_SKI1_1	372	376	PF00082	0.638
CLV_PCSK_SKI1_1	409	413	PF00082	0.369
CLV_PCSK_SKI1_1	431	435	PF00082	0.596
CLV_PCSK_SKI1_1	95	99	PF00082	0.630
DEG_APCC_DBOX_1	408	416	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.523
DOC_CYCLIN_RxL_1	16	25	PF00134	0.561
DOC_CYCLIN_RxL_1	406	416	PF00134	0.401
DOC_MAPK_DCC_7	28	37	PF00069	0.634
DOC_MAPK_DCC_7	409	417	PF00069	0.429
DOC_MAPK_gen_1	136	142	PF00069	0.377
DOC_MAPK_gen_1	406	414	PF00069	0.438
DOC_MAPK_MEF2A_6	28	37	PF00069	0.634
DOC_MAPK_MEF2A_6	409	417	PF00069	0.429
DOC_MIT_MIM_1	134	142	PF04212	0.554
DOC_PP1_RVXF_1	349	355	PF00149	0.551
DOC_USP7_MATH_1	224	228	PF00917	0.555
DOC_USP7_MATH_1	322	326	PF00917	0.624
DOC_USP7_MATH_1	61	65	PF00917	0.600
DOC_WW_Pin1_4	226	231	PF00397	0.678
DOC_WW_Pin1_4	75	80	PF00397	0.733
LIG_14-3-3_CanoR_1	28	33	PF00244	0.580
LIG_14-3-3_CanoR_1	351	355	PF00244	0.560
LIG_Actin_WH2_2	404	422	PF00022	0.444
LIG_Actin_WH2_2	89	107	PF00022	0.587
LIG_BRCT_BRCA1_1	39	43	PF00533	0.577
LIG_CaM_IQ_9	206	221	PF13499	0.521
LIG_CaM_IQ_9	90	105	PF13499	0.627
LIG_Clathr_ClatBox_1	139	143	PF01394	0.375
LIG_CSL_BTD_1	80	83	PF09270	0.511
LIG_FHA_1	113	119	PF00498	0.618
LIG_FHA_1	120	126	PF00498	0.551
LIG_FHA_1	27	33	PF00498	0.352
LIG_FHA_1	335	341	PF00498	0.712
LIG_FHA_1	7	13	PF00498	0.526
LIG_FHA_1	88	94	PF00498	0.505
LIG_FHA_2	129	135	PF00498	0.488
LIG_FHA_2	174	180	PF00498	0.580
LIG_FHA_2	253	259	PF00498	0.580
LIG_FHA_2	318	324	PF00498	0.749
LIG_FHA_2	420	426	PF00498	0.449
LIG_FHA_2	86	92	PF00498	0.655
LIG_GBD_Chelix_1	394	402	PF00786	0.485
LIG_LIR_Gen_1	257	267	PF02991	0.522
LIG_LIR_Gen_1	353	362	PF02991	0.550
LIG_LIR_Nem_3	257	263	PF02991	0.509
LIG_LIR_Nem_3	353	357	PF02991	0.620
LIG_NRBOX	294	300	PF00104	0.586
LIG_NRBOX	414	420	PF00104	0.344
LIG_RPA_C_Fungi	360	372	PF08784	0.589
LIG_SH2_STAT3	36	39	PF00017	0.650
LIG_SH2_STAT5	260	263	PF00017	0.597
LIG_SH2_STAT5	36	39	PF00017	0.616
LIG_SH2_STAT5	390	393	PF00017	0.344
LIG_SUMO_SIM_par_1	138	143	PF11976	0.375
LIG_SUMO_SIM_par_1	4	9	PF11976	0.529
LIG_TRAF2_1	165	168	PF00917	0.544
LIG_TRAF2_1	277	280	PF00917	0.616
LIG_UBA3_1	411	420	PF00899	0.444
MOD_CK1_1	182	188	PF00069	0.564
MOD_CK1_1	228	234	PF00069	0.569
MOD_CK1_1	325	331	PF00069	0.617
MOD_CK1_1	87	93	PF00069	0.623
MOD_CK2_1	173	179	PF00069	0.550
MOD_CK2_1	361	367	PF00069	0.614
MOD_CK2_1	85	91	PF00069	0.670
MOD_GlcNHglycan	306	309	PF01048	0.692
MOD_GlcNHglycan	383	386	PF01048	0.578
MOD_GlcNHglycan	63	66	PF01048	0.674
MOD_GSK3_1	22	29	PF00069	0.581
MOD_GSK3_1	224	231	PF00069	0.583
MOD_GSK3_1	313	320	PF00069	0.712
MOD_GSK3_1	330	337	PF00069	0.714
MOD_GSK3_1	71	78	PF00069	0.788
MOD_GSK3_1	81	88	PF00069	0.632
MOD_N-GLC_1	145	150	PF02516	0.580
MOD_NEK2_1	12	17	PF00069	0.507
MOD_NEK2_1	173	178	PF00069	0.580
MOD_NEK2_1	22	27	PF00069	0.553
MOD_NEK2_1	225	230	PF00069	0.508
MOD_NEK2_1	298	303	PF00069	0.612
MOD_NEK2_1	306	311	PF00069	0.745
MOD_NEK2_1	361	366	PF00069	0.505
MOD_NEK2_1	398	403	PF00069	0.406
MOD_NEK2_1	85	90	PF00069	0.629
MOD_NEK2_2	145	150	PF00069	0.544
MOD_PIKK_1	182	188	PF00454	0.620
MOD_PIKK_1	275	281	PF00454	0.501
MOD_PIKK_1	322	328	PF00454	0.749
MOD_PIKK_1	366	372	PF00454	0.425
MOD_PIKK_1	37	43	PF00454	0.552
MOD_PIKK_1	59	65	PF00454	0.663
MOD_PKA_1	112	118	PF00069	0.623
MOD_PKA_2	112	118	PF00069	0.615
MOD_PKA_2	182	188	PF00069	0.485
MOD_PKA_2	330	336	PF00069	0.594
MOD_PKA_2	350	356	PF00069	0.482
MOD_Plk_1	128	134	PF00069	0.610
MOD_Plk_1	145	151	PF00069	0.502
MOD_Plk_1	22	28	PF00069	0.628
MOD_Plk_1	366	372	PF00069	0.509
MOD_Plk_4	228	234	PF00069	0.686
MOD_Plk_4	350	356	PF00069	0.531
MOD_Plk_4	413	419	PF00069	0.372
MOD_ProDKin_1	226	232	PF00069	0.688
MOD_ProDKin_1	75	81	PF00069	0.731
MOD_SUMO_rev_2	160	165	PF00179	0.616
MOD_SUMO_rev_2	333	343	PF00179	0.470
TRG_DiLeu_BaEn_1	287	292	PF01217	0.615
TRG_DiLeu_BaEn_1	294	299	PF01217	0.642
TRG_ENDOCYTIC_2	260	263	PF00928	0.498
TRG_ENDOCYTIC_2	267	270	PF00928	0.473
TRG_ER_diArg_1	137	139	PF00400	0.547
TRG_ER_diArg_1	175	178	PF00400	0.585
TRG_ER_diArg_1	344	346	PF00400	0.611
TRG_ER_diArg_1	371	373	PF00400	0.625
TRG_NLS_MonoExtC_3	135	141	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF68	Leptomonas seymouri	42%	92%
A0A1X0PB65	Trypanosomatidae	27%	95%
A0A3S7X8J7	Leishmania donovani	84%	100%
A4HBD2	Leishmania braziliensis	64%	100%
A4IAI0	Leishmania infantum	85%	89%
C9ZLQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	94%
E9B5K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BW28	Trypanosoma cruzi	30%	92%