AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4Q2C9_LEIMA

TriTrypDb:

LmjF.34.4120 , LMJLV39_340047800 , LMJSD75_340048200

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q2C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.579
CLV_NRD_NRD_1	175	177	PF00675	0.482
CLV_PCSK_KEX2_1	139	141	PF00082	0.442
CLV_PCSK_KEX2_1	175	177	PF00082	0.507
CLV_PCSK_SKI1_1	165	169	PF00082	0.491
CLV_Separin_Metazoa	136	140	PF03568	0.411
DEG_Nend_UBRbox_2	1	3	PF02207	0.550
DOC_MAPK_DCC_7	250	258	PF00069	0.375
DOC_MAPK_gen_1	228	236	PF00069	0.493
DOC_MAPK_gen_1	250	258	PF00069	0.319
DOC_MAPK_MEF2A_6	228	236	PF00069	0.496
DOC_MAPK_MEF2A_6	250	258	PF00069	0.375
DOC_PP2B_LxvP_1	105	108	PF13499	0.427
DOC_PP2B_LxvP_1	196	199	PF13499	0.477
DOC_PP4_FxxP_1	204	207	PF00568	0.470
DOC_USP7_MATH_1	110	114	PF00917	0.511
DOC_USP7_MATH_1	199	203	PF00917	0.526
DOC_USP7_MATH_1	61	65	PF00917	0.502
DOC_WW_Pin1_4	217	222	PF00397	0.506
DOC_WW_Pin1_4	245	250	PF00397	0.529
DOC_WW_Pin1_4	36	41	PF00397	0.418
LIG_EH1_1	131	139	PF00400	0.403
LIG_eIF4E_1	132	138	PF01652	0.450
LIG_FHA_1	113	119	PF00498	0.355
LIG_FHA_1	39	45	PF00498	0.430
LIG_FHA_2	239	245	PF00498	0.543
LIG_FHA_2	37	43	PF00498	0.422
LIG_LIR_Apic_2	202	207	PF02991	0.447
LIG_LIR_Gen_1	109	118	PF02991	0.381
LIG_LIR_LC3C_4	113	118	PF02991	0.233
LIG_LIR_Nem_3	109	114	PF02991	0.390
LIG_Rb_LxCxE_1	81	97	PF01857	0.254
LIG_SH2_NCK_1	190	194	PF00017	0.395
LIG_SH2_STAT5	15	18	PF00017	0.469
LIG_SH2_STAT5	154	157	PF00017	0.431
LIG_SH2_STAT5	190	193	PF00017	0.461
LIG_SH2_STAT5	211	214	PF00017	0.438
LIG_SH2_STAT5	47	50	PF00017	0.506
LIG_SH2_STAT5	68	71	PF00017	0.378
LIG_SH3_1	37	43	PF00018	0.539
LIG_SH3_3	156	162	PF00018	0.418
LIG_SH3_3	37	43	PF00018	0.416
LIG_SUMO_SIM_anti_2	112	120	PF11976	0.314
LIG_SUMO_SIM_par_1	112	120	PF11976	0.373
LIG_SUMO_SIM_par_1	7	14	PF11976	0.413
LIG_TRAF2_1	220	223	PF00917	0.496
LIG_UBA3_1	263	268	PF00899	0.329
MOD_CDK_SPK_2	245	250	PF00069	0.330
MOD_CDK_SPxxK_3	245	252	PF00069	0.410
MOD_CK1_1	112	118	PF00069	0.352
MOD_CK1_1	18	24	PF00069	0.409
MOD_CK1_1	36	42	PF00069	0.448
MOD_CK2_1	217	223	PF00069	0.547
MOD_CK2_1	238	244	PF00069	0.543
MOD_CK2_1	36	42	PF00069	0.498
MOD_GlcNHglycan	196	199	PF01048	0.377
MOD_GlcNHglycan	63	66	PF01048	0.503
MOD_GSK3_1	112	119	PF00069	0.363
MOD_GSK3_1	94	101	PF00069	0.437
MOD_N-GLC_1	26	31	PF02516	0.568
MOD_N-GLC_1	54	59	PF02516	0.373
MOD_NEK2_1	194	199	PF00069	0.517
MOD_NEK2_1	257	262	PF00069	0.450
MOD_NEK2_1	26	31	PF00069	0.491
MOD_NEK2_1	98	103	PF00069	0.390
MOD_PIKK_1	238	244	PF00454	0.533
MOD_PKA_2	181	187	PF00069	0.373
MOD_Plk_1	26	32	PF00069	0.528
MOD_Plk_4	112	118	PF00069	0.311
MOD_Plk_4	150	156	PF00069	0.491
MOD_Plk_4	205	211	PF00069	0.382
MOD_Plk_4	94	100	PF00069	0.434
MOD_ProDKin_1	217	223	PF00069	0.501
MOD_ProDKin_1	245	251	PF00069	0.524
MOD_ProDKin_1	36	42	PF00069	0.415
MOD_SUMO_rev_2	260	270	PF00179	0.337
TRG_DiLeu_BaEn_1	164	169	PF01217	0.449
TRG_ER_diArg_1	138	140	PF00400	0.418
TRG_ER_diArg_1	174	176	PF00400	0.482
TRG_ER_diArg_1	227	230	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A3	Leptomonas seymouri	62%	88%
A0A0S4KLY1	Bodo saltans	30%	79%
A0A1X0PB14	Trypanosomatidae	44%	87%
A0A3Q8INV4	Leishmania donovani	91%	100%
A0A422NVB8	Trypanosoma rangeli	43%	85%
A4HBD5	Leishmania braziliensis	83%	100%
A4IAI3	Leishmania infantum	91%	100%
C9ZLQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	86%
E9B5K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BLS2	Trypanosoma cruzi	41%	86%