ER membrane protein complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1620), putative

Species:

Leishmania major

UniProt:

Q4Q2C8_LEIMA

TriTrypDb:

LmjF.34.4130 , LMJLV39_340047900 , LMJSD75_340048300

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0072546	EMC complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Expansion

Sequence features

Q4Q2C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.431
CLV_MEL_PAP_1	361	367	PF00089	0.544
CLV_NRD_NRD_1	330	332	PF00675	0.569
CLV_NRD_NRD_1	405	407	PF00675	0.610
CLV_NRD_NRD_1	435	437	PF00675	0.647
CLV_NRD_NRD_1	516	518	PF00675	0.599
CLV_NRD_NRD_1	540	542	PF00675	0.507
CLV_NRD_NRD_1	684	686	PF00675	0.442
CLV_NRD_NRD_1	741	743	PF00675	0.478
CLV_NRD_NRD_1	806	808	PF00675	0.266
CLV_PCSK_KEX2_1	152	154	PF00082	0.572
CLV_PCSK_KEX2_1	207	209	PF00082	0.467
CLV_PCSK_KEX2_1	330	332	PF00082	0.569
CLV_PCSK_KEX2_1	405	407	PF00082	0.452
CLV_PCSK_KEX2_1	516	518	PF00082	0.599
CLV_PCSK_KEX2_1	540	542	PF00082	0.507
CLV_PCSK_KEX2_1	646	648	PF00082	0.459
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.572
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.467
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.460
CLV_PCSK_SKI1_1	357	361	PF00082	0.458
CLV_PCSK_SKI1_1	436	440	PF00082	0.589
CLV_PCSK_SKI1_1	703	707	PF00082	0.535
CLV_PCSK_SKI1_1	737	741	PF00082	0.496
CLV_PCSK_SKI1_1	742	746	PF00082	0.485
CLV_PCSK_SKI1_1	784	788	PF00082	0.474
CLV_PCSK_SKI1_1	807	811	PF00082	0.274
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DEG_SCF_FBW7_2	448	455	PF00400	0.397
DEG_SPOP_SBC_1	767	771	PF00917	0.274
DOC_CDC14_PxL_1	292	300	PF14671	0.299
DOC_CDC14_PxL_1	368	376	PF14671	0.364
DOC_CKS1_1	449	454	PF01111	0.351
DOC_CYCLIN_RxL_1	683	694	PF00134	0.325
DOC_CYCLIN_RxL_1	781	789	PF00134	0.242
DOC_MAPK_DCC_7	652	661	PF00069	0.256
DOC_MAPK_gen_1	652	661	PF00069	0.256
DOC_MAPK_gen_1	717	726	PF00069	0.335
DOC_MAPK_MEF2A_6	302	311	PF00069	0.398
DOC_MAPK_MEF2A_6	652	661	PF00069	0.242
DOC_MAPK_RevD_3	632	647	PF00069	0.335
DOC_PP1_RVXF_1	273	279	PF00149	0.289
DOC_PP1_RVXF_1	735	741	PF00149	0.278
DOC_PP4_FxxP_1	667	670	PF00568	0.329
DOC_PP4_FxxP_1	782	785	PF00568	0.335
DOC_USP7_MATH_1	132	136	PF00917	0.309
DOC_USP7_MATH_1	169	173	PF00917	0.380
DOC_USP7_MATH_1	510	514	PF00917	0.373
DOC_USP7_MATH_1	624	628	PF00917	0.306
DOC_USP7_MATH_1	684	688	PF00917	0.256
DOC_USP7_MATH_1	809	813	PF00917	0.431
DOC_WW_Pin1_4	107	112	PF00397	0.395
DOC_WW_Pin1_4	448	453	PF00397	0.305
DOC_WW_Pin1_4	620	625	PF00397	0.298
DOC_WW_Pin1_4	83	88	PF00397	0.422
LIG_14-3-3_CanoR_1	275	279	PF00244	0.366
LIG_14-3-3_CanoR_1	516	524	PF00244	0.343
LIG_14-3-3_CanoR_1	540	544	PF00244	0.395
LIG_14-3-3_CanoR_1	685	689	PF00244	0.274
LIG_14-3-3_CanoR_1	719	727	PF00244	0.335
LIG_14-3-3_CanoR_1	742	748	PF00244	0.275
LIG_14-3-3_CanoR_1	768	775	PF00244	0.244
LIG_14-3-3_CanoR_1	80	90	PF00244	0.287
LIG_Actin_WH2_2	260	277	PF00022	0.360
LIG_BRCT_BRCA1_1	727	731	PF00533	0.335
LIG_Clathr_ClatBox_1	297	301	PF01394	0.303
LIG_CtBP_PxDLS_1	74	80	PF00389	0.307
LIG_FHA_1	111	117	PF00498	0.307
LIG_FHA_1	124	130	PF00498	0.318
LIG_FHA_1	260	266	PF00498	0.399
LIG_FHA_1	271	277	PF00498	0.318
LIG_FHA_1	449	455	PF00498	0.416
LIG_FHA_1	461	467	PF00498	0.301
LIG_FHA_1	495	501	PF00498	0.327
LIG_FHA_1	516	522	PF00498	0.358
LIG_FHA_1	571	577	PF00498	0.348
LIG_FHA_1	692	698	PF00498	0.315
LIG_FHA_2	156	162	PF00498	0.323
LIG_FHA_2	222	228	PF00498	0.426
LIG_FHA_2	267	273	PF00498	0.347
LIG_FHA_2	440	446	PF00498	0.405
LIG_FHA_2	48	54	PF00498	0.261
LIG_FHA_2	565	571	PF00498	0.270
LIG_FHA_2	643	649	PF00498	0.335
LIG_FHA_2	747	753	PF00498	0.232
LIG_GBD_Chelix_1	10	18	PF00786	0.559
LIG_LIR_Apic_2	367	372	PF02991	0.297
LIG_LIR_Apic_2	666	670	PF02991	0.231
LIG_LIR_Apic_2	780	785	PF02991	0.335
LIG_LIR_Gen_1	677	688	PF02991	0.348
LIG_LIR_LC3C_4	563	566	PF02991	0.262
LIG_LIR_Nem_3	293	298	PF02991	0.415
LIG_LIR_Nem_3	677	683	PF02991	0.246
LIG_LIR_Nem_3	78	82	PF02991	0.295
LIG_LRP6_Inhibitor_1	378	384	PF00058	0.429
LIG_LYPXL_S_1	526	530	PF13949	0.561
LIG_LYPXL_yS_3	295	298	PF13949	0.297
LIG_LYPXL_yS_3	527	530	PF13949	0.356
LIG_NRBOX	701	707	PF00104	0.256
LIG_PTB_Apo_2	776	783	PF02174	0.231
LIG_SH2_CRK	369	373	PF00017	0.269
LIG_SH2_CRK	472	476	PF00017	0.278
LIG_SH2_CRK	680	684	PF00017	0.282
LIG_SH2_CRK	72	76	PF00017	0.325
LIG_SH2_NCK_1	170	174	PF00017	0.371
LIG_SH2_NCK_1	680	684	PF00017	0.322
LIG_SH2_SRC	419	422	PF00017	0.245
LIG_SH2_SRC	554	557	PF00017	0.313
LIG_SH2_SRC	602	605	PF00017	0.278
LIG_SH2_STAP1	486	490	PF00017	0.353
LIG_SH2_STAT3	120	123	PF00017	0.395
LIG_SH2_STAT5	181	184	PF00017	0.381
LIG_SH2_STAT5	382	385	PF00017	0.399
LIG_SH2_STAT5	472	475	PF00017	0.302
LIG_SH2_STAT5	56	59	PF00017	0.290
LIG_SH2_STAT5	602	605	PF00017	0.301
LIG_SH2_STAT5	610	613	PF00017	0.303
LIG_SH2_STAT5	766	769	PF00017	0.231
LIG_SH2_STAT5	803	806	PF00017	0.457
LIG_SH3_3	280	286	PF00018	0.325
LIG_SH3_3	497	503	PF00018	0.290
LIG_SH3_3	735	741	PF00018	0.336
LIG_Sin3_3	4	11	PF02671	0.368
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.401
LIG_SUMO_SIM_anti_2	306	314	PF11976	0.343
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.324
LIG_SUMO_SIM_par_1	306	314	PF11976	0.296
LIG_SUMO_SIM_par_1	317	322	PF11976	0.235
LIG_SUMO_SIM_par_1	358	363	PF11976	0.309
LIG_SUMO_SIM_par_1	429	435	PF11976	0.344
LIG_SUMO_SIM_par_1	590	595	PF11976	0.265
LIG_SUMO_SIM_par_1	656	663	PF11976	0.292
LIG_SUMO_SIM_par_1	784	789	PF11976	0.240
LIG_TRAF2_1	159	162	PF00917	0.427
LIG_TRAF2_1	556	559	PF00917	0.379
LIG_TYR_ITIM	470	475	PF00017	0.342
LIG_TYR_ITIM	598	603	PF00017	0.325
LIG_TYR_ITSM	676	683	PF00017	0.302
LIG_UBA3_1	307	312	PF00899	0.230
LIG_UBA3_1	429	437	PF00899	0.303
LIG_WRC_WIRS_1	638	643	PF05994	0.322
LIG_WRC_WIRS_1	664	669	PF05994	0.265
LIG_WRC_WIRS_1	726	731	PF05994	0.331
MOD_CK1_1	110	116	PF00069	0.483
MOD_CK1_1	233	239	PF00069	0.545
MOD_CK1_1	281	287	PF00069	0.451
MOD_CK1_1	290	296	PF00069	0.424
MOD_CK1_1	422	428	PF00069	0.511
MOD_CK1_1	651	657	PF00069	0.341
MOD_CK1_1	83	89	PF00069	0.466
MOD_CK2_1	155	161	PF00069	0.366
MOD_CK2_1	266	272	PF00069	0.563
MOD_CK2_1	319	325	PF00069	0.454
MOD_CK2_1	439	445	PF00069	0.418
MOD_CK2_1	447	453	PF00069	0.425
MOD_CK2_1	47	53	PF00069	0.299
MOD_CK2_1	473	479	PF00069	0.372
MOD_CK2_1	528	534	PF00069	0.526
MOD_CK2_1	554	560	PF00069	0.450
MOD_CK2_1	642	648	PF00069	0.411
MOD_CK2_1	746	752	PF00069	0.267
MOD_GlcNHglycan	171	174	PF01048	0.469
MOD_GlcNHglycan	194	197	PF01048	0.391
MOD_GlcNHglycan	313	316	PF01048	0.421
MOD_GlcNHglycan	321	324	PF01048	0.354
MOD_GlcNHglycan	421	424	PF01048	0.533
MOD_GlcNHglycan	425	428	PF01048	0.498
MOD_GlcNHglycan	43	46	PF01048	0.533
MOD_GlcNHglycan	479	482	PF01048	0.445
MOD_GlcNHglycan	488	491	PF01048	0.469
MOD_GlcNHglycan	503	506	PF01048	0.384
MOD_GlcNHglycan	530	533	PF01048	0.550
MOD_GlcNHglycan	759	762	PF01048	0.300
MOD_GlcNHglycan	770	773	PF01048	0.304
MOD_GlcNHglycan	811	814	PF01048	0.309
MOD_GlcNHglycan	83	86	PF01048	0.488
MOD_GSK3_1	112	119	PF00069	0.434
MOD_GSK3_1	121	128	PF00069	0.404
MOD_GSK3_1	142	149	PF00069	0.483
MOD_GSK3_1	157	164	PF00069	0.456
MOD_GSK3_1	202	209	PF00069	0.398
MOD_GSK3_1	255	262	PF00069	0.472
MOD_GSK3_1	266	273	PF00069	0.402
MOD_GSK3_1	274	281	PF00069	0.438
MOD_GSK3_1	360	367	PF00069	0.366
MOD_GSK3_1	419	426	PF00069	0.467
MOD_GSK3_1	436	443	PF00069	0.382
MOD_GSK3_1	458	465	PF00069	0.459
MOD_GSK3_1	473	480	PF00069	0.293
MOD_GSK3_1	560	567	PF00069	0.344
MOD_GSK3_1	620	627	PF00069	0.353
MOD_GSK3_1	647	654	PF00069	0.313
MOD_GSK3_1	659	666	PF00069	0.300
MOD_GSK3_1	742	749	PF00069	0.337
MOD_N-GLC_1	439	444	PF02516	0.302
MOD_N-GLC_1	528	533	PF02516	0.424
MOD_N-GLC_1	75	80	PF02516	0.482
MOD_N-GLC_2	287	289	PF02516	0.371
MOD_NEK2_1	274	279	PF00069	0.444
MOD_NEK2_1	288	293	PF00069	0.510
MOD_NEK2_1	310	315	PF00069	0.413
MOD_NEK2_1	319	324	PF00069	0.351
MOD_NEK2_1	360	365	PF00069	0.340
MOD_NEK2_1	460	465	PF00069	0.355
MOD_NEK2_1	564	569	PF00069	0.350
MOD_NEK2_1	577	582	PF00069	0.512
MOD_NEK2_1	642	647	PF00069	0.303
MOD_NEK2_1	674	679	PF00069	0.346
MOD_NEK2_1	730	735	PF00069	0.321
MOD_NEK2_1	750	755	PF00069	0.204
MOD_NEK2_1	786	791	PF00069	0.275
MOD_PIKK_1	266	272	PF00454	0.516
MOD_PIKK_1	384	390	PF00454	0.531
MOD_PK_1	206	212	PF00069	0.427
MOD_PKA_1	206	212	PF00069	0.582
MOD_PKA_1	436	442	PF00069	0.475
MOD_PKA_1	742	748	PF00069	0.331
MOD_PKA_2	274	280	PF00069	0.456
MOD_PKA_2	494	500	PF00069	0.494
MOD_PKA_2	515	521	PF00069	0.444
MOD_PKA_2	539	545	PF00069	0.495
MOD_PKA_2	651	657	PF00069	0.300
MOD_PKA_2	684	690	PF00069	0.325
MOD_PKA_2	767	773	PF00069	0.266
MOD_Plk_1	116	122	PF00069	0.397
MOD_Plk_1	161	167	PF00069	0.604
MOD_Plk_1	458	464	PF00069	0.480
MOD_Plk_1	75	81	PF00069	0.483
MOD_Plk_2-3	479	485	PF00069	0.497
MOD_Plk_4	104	110	PF00069	0.380
MOD_Plk_4	132	138	PF00069	0.454
MOD_Plk_4	182	188	PF00069	0.407
MOD_Plk_4	278	284	PF00069	0.527
MOD_Plk_4	364	370	PF00069	0.418
MOD_Plk_4	462	468	PF00069	0.484
MOD_Plk_4	470	476	PF00069	0.468
MOD_Plk_4	494	500	PF00069	0.472
MOD_Plk_4	560	566	PF00069	0.334
MOD_Plk_4	572	578	PF00069	0.334
MOD_Plk_4	637	643	PF00069	0.306
MOD_Plk_4	684	690	PF00069	0.288
MOD_Plk_4	725	731	PF00069	0.339
MOD_Plk_4	746	752	PF00069	0.412
MOD_Plk_4	795	801	PF00069	0.334
MOD_ProDKin_1	107	113	PF00069	0.502
MOD_ProDKin_1	448	454	PF00069	0.365
MOD_ProDKin_1	620	626	PF00069	0.360
MOD_ProDKin_1	83	89	PF00069	0.527
MOD_SUMO_rev_2	432	439	PF00179	0.485
MOD_SUMO_rev_2	586	592	PF00179	0.479
TRG_DiLeu_BaEn_1	560	565	PF01217	0.354
TRG_DiLeu_BaEn_1	701	706	PF01217	0.349
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.353
TRG_DiLeu_BaLyEn_6	782	787	PF01217	0.411
TRG_ENDOCYTIC_2	295	298	PF00928	0.358
TRG_ENDOCYTIC_2	472	475	PF00928	0.460
TRG_ENDOCYTIC_2	527	530	PF00928	0.534
TRG_ENDOCYTIC_2	600	603	PF00928	0.266
TRG_ENDOCYTIC_2	680	683	PF00928	0.340
TRG_ENDOCYTIC_2	72	75	PF00928	0.420
TRG_ER_diArg_1	329	331	PF00400	0.457
TRG_ER_diArg_1	404	406	PF00400	0.336
TRG_ER_diArg_1	515	517	PF00400	0.530
TRG_ER_diArg_1	539	541	PF00400	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K5	Leptomonas seymouri	67%	93%
A0A0S4KM87	Bodo saltans	33%	95%
A0A1X0PA62	Trypanosomatidae	40%	99%
A0A3S7X8I3	Leishmania donovani	93%	100%
A0A422NVA5	Trypanosoma rangeli	44%	100%
A4HBD6	Leishmania braziliensis	82%	100%
A4IAI4	Leishmania infantum	93%	100%
C9ZLQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B5K8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BW22	Trypanosoma cruzi	43%	100%