Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2C7_LEIMA

TriTrypDb:

LmjF.34.4140 , LMJLV39_340048000 , LMJSD75_340048400

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	443	447	PF00656	0.730
CLV_NRD_NRD_1	159	161	PF00675	0.686
CLV_NRD_NRD_1	205	207	PF00675	0.604
CLV_NRD_NRD_1	370	372	PF00675	0.676
CLV_NRD_NRD_1	38	40	PF00675	0.576
CLV_NRD_NRD_1	99	101	PF00675	0.608
CLV_PCSK_FUR_1	36	40	PF00082	0.575
CLV_PCSK_KEX2_1	205	207	PF00082	0.542
CLV_PCSK_KEX2_1	370	372	PF00082	0.676
CLV_PCSK_KEX2_1	38	40	PF00082	0.576
CLV_PCSK_KEX2_1	456	458	PF00082	0.628
CLV_PCSK_KEX2_1	99	101	PF00082	0.608
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.628
CLV_PCSK_SKI1_1	109	113	PF00082	0.680
CLV_PCSK_SKI1_1	191	195	PF00082	0.570
CLV_PCSK_SKI1_1	25	29	PF00082	0.661
CLV_PCSK_SKI1_1	39	43	PF00082	0.534
CLV_Separin_Metazoa	110	114	PF03568	0.684
CLV_Separin_Metazoa	44	48	PF03568	0.664
DEG_APCC_DBOX_1	38	46	PF00400	0.666
DEG_COP1_1	425	433	PF00400	0.585
DOC_CYCLIN_RxL_1	33	44	PF00134	0.553
DOC_MAPK_gen_1	104	114	PF00069	0.628
DOC_MAPK_gen_1	33	42	PF00069	0.671
DOC_PP1_RVXF_1	336	342	PF00149	0.704
DOC_PP2B_LxvP_1	233	236	PF13499	0.610
DOC_PP2B_LxvP_1	333	336	PF13499	0.636
DOC_PP4_FxxP_1	448	451	PF00568	0.677
DOC_USP7_MATH_1	10	14	PF00917	0.749
DOC_USP7_MATH_1	169	173	PF00917	0.684
DOC_USP7_MATH_1	248	252	PF00917	0.709
DOC_USP7_MATH_1	259	263	PF00917	0.580
DOC_USP7_MATH_1	314	318	PF00917	0.717
DOC_USP7_MATH_1	352	356	PF00917	0.795
DOC_USP7_MATH_1	404	408	PF00917	0.795
DOC_USP7_MATH_1	56	60	PF00917	0.627
DOC_USP7_MATH_1	65	69	PF00917	0.687
DOC_USP7_MATH_1	74	78	PF00917	0.635
DOC_USP7_MATH_1	85	89	PF00917	0.691
DOC_USP7_MATH_2	175	181	PF00917	0.562
DOC_USP7_UBL2_3	133	137	PF12436	0.772
DOC_USP7_UBL2_3	78	82	PF12436	0.592
DOC_WW_Pin1_4	142	147	PF00397	0.704
DOC_WW_Pin1_4	154	159	PF00397	0.724
DOC_WW_Pin1_4	283	288	PF00397	0.672
DOC_WW_Pin1_4	289	294	PF00397	0.629
DOC_WW_Pin1_4	298	303	PF00397	0.537
DOC_WW_Pin1_4	308	313	PF00397	0.697
DOC_WW_Pin1_4	387	392	PF00397	0.713
DOC_WW_Pin1_4	409	414	PF00397	0.784
LIG_14-3-3_CanoR_1	20	28	PF00244	0.595
LIG_14-3-3_CanoR_1	232	236	PF00244	0.705
LIG_14-3-3_CanoR_1	294	298	PF00244	0.605
LIG_14-3-3_CanoR_1	351	357	PF00244	0.643
LIG_14-3-3_CanoR_1	370	380	PF00244	0.618
LIG_14-3-3_CanoR_1	405	415	PF00244	0.797
LIG_14-3-3_CanoR_1	90	96	PF00244	0.638
LIG_Actin_WH2_2	190	207	PF00022	0.554
LIG_BIR_II_1	1	5	PF00653	0.807
LIG_FHA_1	171	177	PF00498	0.693
LIG_FHA_1	244	250	PF00498	0.639
LIG_FHA_1	294	300	PF00498	0.697
LIG_FHA_1	321	327	PF00498	0.754
LIG_FHA_1	362	368	PF00498	0.681
LIG_FHA_2	391	397	PF00498	0.797
LIG_FHA_2	441	447	PF00498	0.677
LIG_FHA_2	92	98	PF00498	0.605
LIG_LIR_Apic_2	446	451	PF02991	0.642
LIG_LIR_Nem_3	105	111	PF02991	0.578
LIG_LIR_Nem_3	282	288	PF02991	0.709
LIG_LIR_Nem_3	353	359	PF02991	0.625
LIG_LIR_Nem_3	372	376	PF02991	0.593
LIG_LIR_Nem_3	393	397	PF02991	0.795
LIG_LIR_Nem_3	458	464	PF02991	0.657
LIG_PTAP_UEV_1	383	388	PF05743	0.794
LIG_SH2_CRK	240	244	PF00017	0.717
LIG_SH2_CRK	376	380	PF00017	0.666
LIG_SH2_GRB2like	117	120	PF00017	0.562
LIG_SH2_NCK_1	276	280	PF00017	0.540
LIG_SH2_STAP1	276	280	PF00017	0.657
LIG_SH2_STAT5	117	120	PF00017	0.665
LIG_SH2_STAT5	130	133	PF00017	0.673
LIG_SH2_STAT5	276	279	PF00017	0.660
LIG_SH2_STAT5	297	300	PF00017	0.713
LIG_SH3_1	141	147	PF00018	0.690
LIG_SH3_2	236	241	PF14604	0.605
LIG_SH3_3	141	147	PF00018	0.672
LIG_SH3_3	233	239	PF00018	0.766
LIG_SH3_3	336	342	PF00018	0.798
LIG_SH3_3	381	387	PF00018	0.733
LIG_SH3_3	425	431	PF00018	0.638
LIG_SH3_5	414	418	PF00018	0.703
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.751
LIG_SUMO_SIM_par_1	177	183	PF11976	0.751
LIG_TRAF2_1	27	30	PF00917	0.673
LIG_TRAF2_1	41	44	PF00917	0.476
LIG_UBA3_1	203	212	PF00899	0.578
LIG_WW_3	413	417	PF00397	0.816
MOD_CDC14_SPxK_1	157	160	PF00782	0.727
MOD_CDC14_SPxK_1	286	289	PF00782	0.658
MOD_CDC14_SPxK_1	301	304	PF00782	0.741
MOD_CDK_SPK_2	289	294	PF00069	0.663
MOD_CDK_SPxK_1	154	160	PF00069	0.732
MOD_CDK_SPxK_1	283	289	PF00069	0.661
MOD_CDK_SPxK_1	298	304	PF00069	0.743
MOD_CDK_SPxxK_3	154	161	PF00069	0.593
MOD_CDK_SPxxK_3	409	416	PF00069	0.745
MOD_CK1_1	372	378	PF00069	0.581
MOD_CK1_1	385	391	PF00069	0.717
MOD_CK1_1	429	435	PF00069	0.697
MOD_CK1_1	59	65	PF00069	0.724
MOD_CK1_1	68	74	PF00069	0.710
MOD_CK2_1	177	183	PF00069	0.679
MOD_CK2_1	31	37	PF00069	0.597
MOD_CK2_1	390	396	PF00069	0.753
MOD_CK2_1	91	97	PF00069	0.608
MOD_Cter_Amidation	368	371	PF01082	0.678
MOD_DYRK1A_RPxSP_1	308	312	PF00069	0.690
MOD_GlcNHglycan	148	151	PF01048	0.679
MOD_GlcNHglycan	191	194	PF01048	0.646
MOD_GlcNHglycan	233	236	PF01048	0.684
MOD_GlcNHglycan	261	264	PF01048	0.579
MOD_GlcNHglycan	344	347	PF01048	0.783
MOD_GlcNHglycan	360	364	PF01048	0.523
MOD_GlcNHglycan	384	387	PF01048	0.642
MOD_GlcNHglycan	70	73	PF01048	0.737
MOD_GSK3_1	142	149	PF00069	0.684
MOD_GSK3_1	183	190	PF00069	0.705
MOD_GSK3_1	279	286	PF00069	0.656
MOD_GSK3_1	289	296	PF00069	0.587
MOD_GSK3_1	310	317	PF00069	0.670
MOD_GSK3_1	337	344	PF00069	0.755
MOD_GSK3_1	395	402	PF00069	0.677
MOD_GSK3_1	61	68	PF00069	0.703
MOD_GSK3_1	70	77	PF00069	0.661
MOD_N-GLC_1	65	70	PF02516	0.709
MOD_NEK2_1	320	325	PF00069	0.677
MOD_NEK2_1	359	364	PF00069	0.669
MOD_NEK2_1	397	402	PF00069	0.688
MOD_PIKK_1	395	401	PF00454	0.757
MOD_PKA_2	163	169	PF00069	0.602
MOD_PKA_2	223	229	PF00069	0.794
MOD_PKA_2	231	237	PF00069	0.677
MOD_PKA_2	293	299	PF00069	0.665
MOD_PKA_2	350	356	PF00069	0.678
MOD_PKA_2	369	375	PF00069	0.589
MOD_PKA_2	404	410	PF00069	0.756
MOD_PKA_2	59	65	PF00069	0.689
MOD_Plk_1	272	278	PF00069	0.663
MOD_Plk_2-3	177	183	PF00069	0.664
MOD_Plk_2-3	31	37	PF00069	0.674
MOD_Plk_4	293	299	PF00069	0.718
MOD_Plk_4	316	322	PF00069	0.779
MOD_Plk_4	440	446	PF00069	0.679
MOD_Plk_4	450	456	PF00069	0.648
MOD_ProDKin_1	142	148	PF00069	0.707
MOD_ProDKin_1	154	160	PF00069	0.725
MOD_ProDKin_1	283	289	PF00069	0.672
MOD_ProDKin_1	298	304	PF00069	0.538
MOD_ProDKin_1	308	314	PF00069	0.697
MOD_ProDKin_1	387	393	PF00069	0.711
MOD_ProDKin_1	409	415	PF00069	0.782
MOD_SUMO_for_1	455	458	PF00179	0.733
MOD_SUMO_rev_2	208	215	PF00179	0.602
MOD_SUMO_rev_2	30	35	PF00179	0.639
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.756
TRG_ENDOCYTIC_2	108	111	PF00928	0.604
TRG_ENDOCYTIC_2	376	379	PF00928	0.692
TRG_ER_diArg_1	204	206	PF00400	0.636
TRG_ER_diArg_1	303	306	PF00400	0.666
TRG_ER_diArg_1	38	40	PF00400	0.588
TRG_ER_diArg_1	98	100	PF00400	0.614
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.785
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P706	Leptomonas seymouri	33%	89%
A0A3S7X8Q0	Leishmania donovani	85%	100%
A4HBD7	Leishmania braziliensis	58%	99%
A4IAI5	Leishmania infantum	85%	100%
E9B5K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%