CST complex subunit CTC1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2C6_LEIMA

TriTrypDb:

LmjF.34.4150 , LMJLV39_340048100 , LMJSD75_340048500

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.500
CLV_C14_Caspase3-7	228	232	PF00656	0.439
CLV_C14_Caspase3-7	601	605	PF00656	0.415
CLV_NRD_NRD_1	209	211	PF00675	0.741
CLV_NRD_NRD_1	403	405	PF00675	0.502
CLV_PCSK_KEX2_1	209	211	PF00082	0.745
CLV_PCSK_KEX2_1	342	344	PF00082	0.535
CLV_PCSK_KEX2_1	614	616	PF00082	0.528
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.560
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.528
CLV_PCSK_SKI1_1	167	171	PF00082	0.357
CLV_PCSK_SKI1_1	218	222	PF00082	0.410
CLV_PCSK_SKI1_1	390	394	PF00082	0.433
CLV_PCSK_SKI1_1	491	495	PF00082	0.432
DEG_APCC_DBOX_1	403	411	PF00400	0.529
DEG_APCC_DBOX_1	490	498	PF00400	0.460
DEG_Nend_UBRbox_2	1	3	PF02207	0.559
DOC_CDC14_PxL_1	585	593	PF14671	0.387
DOC_CYCLIN_RxL_1	218	228	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.403
DOC_MAPK_gen_1	345	353	PF00069	0.465
DOC_MAPK_gen_1	464	471	PF00069	0.649
DOC_MAPK_MEF2A_6	27	36	PF00069	0.442
DOC_MAPK_MEF2A_6	464	473	PF00069	0.564
DOC_MAPK_MEF2A_6	584	592	PF00069	0.400
DOC_MAPK_NFAT4_5	464	472	PF00069	0.544
DOC_PP1_RVXF_1	183	189	PF00149	0.341
DOC_PP2B_LxvP_1	68	71	PF13499	0.354
DOC_USP7_MATH_1	194	198	PF00917	0.651
DOC_USP7_MATH_1	208	212	PF00917	0.687
DOC_USP7_MATH_1	357	361	PF00917	0.583
DOC_USP7_MATH_1	46	50	PF00917	0.650
DOC_USP7_MATH_1	523	527	PF00917	0.536
DOC_USP7_MATH_1	555	559	PF00917	0.507
DOC_USP7_MATH_1	644	648	PF00917	0.722
DOC_WW_Pin1_4	147	152	PF00397	0.663
DOC_WW_Pin1_4	213	218	PF00397	0.640
DOC_WW_Pin1_4	431	436	PF00397	0.708
DOC_WW_Pin1_4	456	461	PF00397	0.656
DOC_WW_Pin1_4	474	479	PF00397	0.477
DOC_WW_Pin1_4	560	565	PF00397	0.501
LIG_14-3-3_CanoR_1	209	219	PF00244	0.681
LIG_14-3-3_CanoR_1	345	351	PF00244	0.488
LIG_14-3-3_CanoR_1	404	414	PF00244	0.396
LIG_14-3-3_CanoR_1	430	437	PF00244	0.632
LIG_14-3-3_CanoR_1	503	509	PF00244	0.528
LIG_14-3-3_CanoR_1	573	578	PF00244	0.480
LIG_APCC_ABBA_1	490	495	PF00400	0.448
LIG_BIR_III_2	445	449	PF00653	0.724
LIG_BRCT_BRCA1_1	215	219	PF00533	0.649
LIG_BRCT_BRCA1_1	366	370	PF00533	0.585
LIG_BRCT_BRCA1_1	4	8	PF00533	0.491
LIG_BRCT_BRCA1_1	540	544	PF00533	0.307
LIG_deltaCOP1_diTrp_1	23	29	PF00928	0.488
LIG_deltaCOP1_diTrp_1	389	393	PF00928	0.368
LIG_eIF4E_1	238	244	PF01652	0.574
LIG_FHA_1	117	123	PF00498	0.586
LIG_FHA_1	181	187	PF00498	0.473
LIG_FHA_1	31	37	PF00498	0.451
LIG_FHA_1	315	321	PF00498	0.500
LIG_FHA_1	411	417	PF00498	0.517
LIG_FHA_1	477	483	PF00498	0.423
LIG_FHA_1	525	531	PF00498	0.521
LIG_FHA_2	574	580	PF00498	0.385
LIG_FHA_2	72	78	PF00498	0.489
LIG_LIR_Gen_1	367	375	PF02991	0.499
LIG_LIR_Gen_1	53	63	PF02991	0.399
LIG_LIR_Gen_1	579	590	PF02991	0.449
LIG_LIR_Gen_1	630	639	PF02991	0.577
LIG_LIR_Gen_1	64	75	PF02991	0.352
LIG_LIR_Nem_3	367	373	PF02991	0.497
LIG_LIR_Nem_3	374	379	PF02991	0.393
LIG_LIR_Nem_3	53	59	PF02991	0.401
LIG_LIR_Nem_3	579	585	PF02991	0.460
LIG_LIR_Nem_3	630	635	PF02991	0.571
LIG_LIR_Nem_3	64	70	PF02991	0.326
LIG_LYPXL_yS_3	42	45	PF13949	0.568
LIG_PDZ_Class_3	653	658	PF00595	0.607
LIG_Rb_pABgroove_1	576	584	PF01858	0.327
LIG_SH2_CRK	56	60	PF00017	0.374
LIG_SH2_GRB2like	115	118	PF00017	0.573
LIG_SH2_PTP2	323	326	PF00017	0.481
LIG_SH2_STAT5	323	326	PF00017	0.515
LIG_SH2_STAT5	570	573	PF00017	0.395
LIG_SH2_STAT5	618	621	PF00017	0.595
LIG_SH3_3	104	110	PF00018	0.391
LIG_SH3_3	389	395	PF00018	0.482
LIG_SH3_3	40	46	PF00018	0.560
LIG_SH3_3	416	422	PF00018	0.486
LIG_SH3_3	454	460	PF00018	0.729
LIG_SH3_3	475	481	PF00018	0.481
LIG_SH3_3	486	492	PF00018	0.343
LIG_SH3_3	583	589	PF00018	0.424
LIG_SH3_3	66	72	PF00018	0.403
LIG_SUMO_SIM_anti_2	310	317	PF11976	0.410
LIG_SUMO_SIM_par_1	310	317	PF11976	0.545
LIG_SUMO_SIM_par_1	469	475	PF11976	0.461
LIG_TRAF2_1	279	282	PF00917	0.528
LIG_WRC_WIRS_1	629	634	PF05994	0.610
MOD_CDK_SPK_2	213	218	PF00069	0.640
MOD_CK1_1	116	122	PF00069	0.546
MOD_CK1_1	136	142	PF00069	0.265
MOD_CK1_1	197	203	PF00069	0.662
MOD_CK1_1	213	219	PF00069	0.442
MOD_CK1_1	286	292	PF00069	0.588
MOD_CK1_1	349	355	PF00069	0.500
MOD_CK1_1	360	366	PF00069	0.563
MOD_CK1_1	409	415	PF00069	0.452
MOD_CK1_1	507	513	PF00069	0.622
MOD_CK1_1	647	653	PF00069	0.503
MOD_CK2_1	124	130	PF00069	0.469
MOD_CK2_1	276	282	PF00069	0.551
MOD_CK2_1	555	561	PF00069	0.463
MOD_CK2_1	57	63	PF00069	0.465
MOD_CK2_1	631	637	PF00069	0.595
MOD_CK2_1	71	77	PF00069	0.313
MOD_GlcNHglycan	135	138	PF01048	0.523
MOD_GlcNHglycan	212	215	PF01048	0.504
MOD_GlcNHglycan	266	269	PF01048	0.594
MOD_GlcNHglycan	285	288	PF01048	0.634
MOD_GlcNHglycan	297	300	PF01048	0.420
MOD_GlcNHglycan	358	362	PF01048	0.628
MOD_GlcNHglycan	366	369	PF01048	0.552
MOD_GlcNHglycan	423	426	PF01048	0.635
MOD_GlcNHglycan	438	441	PF01048	0.689
MOD_GlcNHglycan	451	454	PF01048	0.732
MOD_GlcNHglycan	619	622	PF01048	0.593
MOD_GlcNHglycan	626	629	PF01048	0.549
MOD_GlcNHglycan	645	649	PF01048	0.523
MOD_GSK3_1	264	271	PF00069	0.619
MOD_GSK3_1	322	329	PF00069	0.430
MOD_GSK3_1	334	341	PF00069	0.411
MOD_GSK3_1	360	367	PF00069	0.554
MOD_GSK3_1	405	412	PF00069	0.392
MOD_GSK3_1	46	53	PF00069	0.538
MOD_GSK3_1	513	520	PF00069	0.542
MOD_GSK3_1	57	64	PF00069	0.329
MOD_GSK3_1	617	624	PF00069	0.564
MOD_GSK3_1	647	654	PF00069	0.608
MOD_N-GLC_1	116	121	PF02516	0.631
MOD_N-GLC_2	179	181	PF02516	0.506
MOD_NEK2_1	13	18	PF00069	0.524
MOD_NEK2_1	295	300	PF00069	0.490
MOD_NEK2_1	410	415	PF00069	0.473
MOD_NEK2_1	76	81	PF00069	0.472
MOD_PIKK_1	286	292	PF00454	0.473
MOD_PIKK_1	334	340	PF00454	0.557
MOD_PIKK_1	501	507	PF00454	0.549
MOD_PKA_2	208	214	PF00069	0.622
MOD_PKA_2	364	370	PF00069	0.635
MOD_PKA_2	403	409	PF00069	0.400
MOD_PKA_2	429	435	PF00069	0.700
MOD_PKA_2	572	578	PF00069	0.464
MOD_Plk_1	116	122	PF00069	0.539
MOD_Plk_1	276	282	PF00069	0.470
MOD_Plk_1	371	377	PF00069	0.378
MOD_Plk_1	76	82	PF00069	0.516
MOD_Plk_4	136	142	PF00069	0.500
MOD_Plk_4	322	328	PF00069	0.407
MOD_Plk_4	371	377	PF00069	0.413
MOD_Plk_4	504	510	PF00069	0.638
MOD_Plk_4	555	561	PF00069	0.394
MOD_Plk_4	573	579	PF00069	0.371
MOD_Plk_4	621	627	PF00069	0.497
MOD_Plk_4	89	95	PF00069	0.358
MOD_ProDKin_1	147	153	PF00069	0.664
MOD_ProDKin_1	213	219	PF00069	0.624
MOD_ProDKin_1	431	437	PF00069	0.709
MOD_ProDKin_1	456	462	PF00069	0.656
MOD_ProDKin_1	474	480	PF00069	0.477
MOD_ProDKin_1	560	566	PF00069	0.505
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.543
TRG_ENDOCYTIC_2	323	326	PF00928	0.465
TRG_ENDOCYTIC_2	42	45	PF00928	0.522
TRG_ENDOCYTIC_2	56	59	PF00928	0.311
TRG_ER_diArg_1	208	210	PF00400	0.751
TRG_ER_diArg_1	246	249	PF00400	0.482
TRG_ER_diArg_1	343	346	PF00400	0.532
TRG_ER_diArg_1	534	537	PF00400	0.388
TRG_NES_CRM1_1	529	542	PF08389	0.489
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E9	Leptomonas seymouri	54%	100%
A0A0S4KIT9	Bodo saltans	28%	96%
A0A1X0PA76	Trypanosomatidae	32%	100%
A0A3Q8IHL1	Leishmania donovani	91%	100%
A0A422NVA9	Trypanosoma rangeli	35%	100%
A4HBD8	Leishmania braziliensis	76%	100%
A4IAI6	Leishmania infantum	91%	100%
C9ZLQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B5L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5DMS9	Trypanosoma cruzi	34%	100%