Zinc knuckle-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc knuckle, putative

Species:

Leishmania major

UniProt:

Q4Q2C4_LEIMA

TriTrypDb:

LmjF.34.4170 , LMJLV39_340048300 , LMJSD75_340048700

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.463
CLV_PCSK_KEX2_1	3	5	PF00082	0.463
CLV_PCSK_KEX2_1	87	89	PF00082	0.455
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.455
CLV_PCSK_SKI1_1	146	150	PF00082	0.542
CLV_PCSK_SKI1_1	157	161	PF00082	0.470
CLV_PCSK_SKI1_1	3	7	PF00082	0.450
DOC_CKS1_1	26	31	PF01111	0.484
DOC_PP4_FxxP_1	100	103	PF00568	0.429
DOC_PP4_FxxP_1	6	9	PF00568	0.472
DOC_USP7_MATH_1	112	116	PF00917	0.383
DOC_USP7_MATH_1	170	174	PF00917	0.576
DOC_USP7_MATH_1	175	179	PF00917	0.655
DOC_USP7_MATH_1	188	192	PF00917	0.767
DOC_USP7_MATH_1	199	203	PF00917	0.598
DOC_USP7_UBL2_3	70	74	PF12436	0.597
DOC_WW_Pin1_4	120	125	PF00397	0.377
DOC_WW_Pin1_4	22	27	PF00397	0.480
LIG_14-3-3_CanoR_1	88	96	PF00244	0.274
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_BRCT_BRCA1_1	135	139	PF00533	0.704
LIG_FHA_1	117	123	PF00498	0.353
LIG_FHA_1	159	165	PF00498	0.569
LIG_FHA_1	50	56	PF00498	0.501
LIG_FHA_2	142	148	PF00498	0.549
LIG_FHA_2	208	214	PF00498	0.744
LIG_LIR_Apic_2	99	103	PF02991	0.429
LIG_SH2_CRK	76	80	PF00017	0.576
LIG_SH3_3	137	143	PF00018	0.543
LIG_SH3_3	23	29	PF00018	0.476
LIG_SH3_3	6	12	PF00018	0.467
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.461
LIG_TRAF2_1	210	213	PF00917	0.567
MOD_CK1_1	115	121	PF00069	0.369
MOD_CK1_1	141	147	PF00069	0.648
MOD_CK1_1	158	164	PF00069	0.346
MOD_CK1_1	25	31	PF00069	0.476
MOD_CK2_1	141	147	PF00069	0.535
MOD_CK2_1	207	213	PF00069	0.590
MOD_GlcNHglycan	106	109	PF01048	0.384
MOD_GlcNHglycan	110	113	PF01048	0.354
MOD_GlcNHglycan	114	117	PF01048	0.441
MOD_GlcNHglycan	135	138	PF01048	0.618
MOD_GlcNHglycan	172	175	PF01048	0.605
MOD_GlcNHglycan	177	180	PF01048	0.693
MOD_GlcNHglycan	190	193	PF01048	0.514
MOD_GSK3_1	104	111	PF00069	0.297
MOD_GSK3_1	112	119	PF00069	0.335
MOD_GSK3_1	15	22	PF00069	0.448
MOD_GSK3_1	197	204	PF00069	0.597
MOD_GSK3_1	36	43	PF00069	0.474
MOD_GSK3_1	49	56	PF00069	0.453
MOD_GSK3_1	88	95	PF00069	0.362
MOD_N-GLC_1	83	88	PF02516	0.500
MOD_N-GLC_2	180	182	PF02516	0.652
MOD_NEK2_1	104	109	PF00069	0.471
MOD_NEK2_2	116	121	PF00069	0.500
MOD_NEK2_2	92	97	PF00069	0.274
MOD_PIKK_1	122	128	PF00454	0.376
MOD_PK_1	74	80	PF00069	0.633
MOD_PKA_2	7	13	PF00069	0.553
MOD_Plk_4	15	21	PF00069	0.502
MOD_Plk_4	28	34	PF00069	0.609
MOD_ProDKin_1	120	126	PF00069	0.377
MOD_ProDKin_1	22	28	PF00069	0.478
MOD_SUMO_for_1	194	197	PF00179	0.718
MOD_SUMO_for_1	205	208	PF00179	0.656
MOD_SUMO_rev_2	163	170	PF00179	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P713	Leptomonas seymouri	62%	100%
A0A1X0PAA9	Trypanosomatidae	39%	100%
A0A3Q8IHW3	Leishmania donovani	88%	100%
A4HBE0	Leishmania braziliensis	76%	100%
A4IAI8	Leishmania infantum	89%	100%
E9B5L2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	87%