CAP10 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1193), putative

Species:

Leishmania major

UniProt:

Q4Q2C3_LEIMA

TriTrypDb:

LmjF.34.4180 , LMJLV39_340048400 , LMJSD75_340048800

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4Q2C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	274	276	PF00675	0.557
CLV_NRD_NRD_1	384	386	PF00675	0.552
CLV_NRD_NRD_1	491	493	PF00675	0.480
CLV_NRD_NRD_1	532	534	PF00675	0.576
CLV_NRD_NRD_1	67	69	PF00675	0.696
CLV_NRD_NRD_1	8	10	PF00675	0.440
CLV_PCSK_FUR_1	489	493	PF00082	0.494
CLV_PCSK_KEX2_1	399	401	PF00082	0.595
CLV_PCSK_KEX2_1	491	493	PF00082	0.484
CLV_PCSK_KEX2_1	8	10	PF00082	0.452
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.595
CLV_PCSK_SKI1_1	172	176	PF00082	0.695
CLV_PCSK_SKI1_1	240	244	PF00082	0.550
CLV_PCSK_SKI1_1	253	257	PF00082	0.458
CLV_PCSK_SKI1_1	412	416	PF00082	0.456
DEG_APCC_DBOX_1	399	407	PF00400	0.330
DEG_SPOP_SBC_1	37	41	PF00917	0.363
DEG_SPOP_SBC_1	97	101	PF00917	0.517
DOC_CKS1_1	70	75	PF01111	0.566
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.296
DOC_MAPK_gen_1	533	539	PF00069	0.343
DOC_MAPK_gen_1	8	18	PF00069	0.448
DOC_MAPK_JIP1_4	12	18	PF00069	0.453
DOC_MAPK_MEF2A_6	298	307	PF00069	0.297
DOC_MAPK_MEF2A_6	9	18	PF00069	0.457
DOC_PP1_RVXF_1	290	297	PF00149	0.286
DOC_PP2B_LxvP_1	373	376	PF13499	0.290
DOC_PP4_FxxP_1	559	562	PF00568	0.288
DOC_PP4_FxxP_1	75	78	PF00568	0.476
DOC_SPAK_OSR1_1	328	332	PF12202	0.391
DOC_USP7_MATH_1	110	114	PF00917	0.549
DOC_USP7_MATH_1	120	124	PF00917	0.545
DOC_USP7_MATH_1	244	248	PF00917	0.304
DOC_USP7_MATH_1	37	41	PF00917	0.481
DOC_USP7_MATH_1	54	58	PF00917	0.536
DOC_USP7_MATH_2	131	137	PF00917	0.430
DOC_USP7_UBL2_3	453	457	PF12436	0.313
DOC_WW_Pin1_4	143	148	PF00397	0.504
DOC_WW_Pin1_4	316	321	PF00397	0.298
DOC_WW_Pin1_4	69	74	PF00397	0.557
LIG_14-3-3_CanoR_1	12	17	PF00244	0.491
LIG_14-3-3_CanoR_1	134	140	PF00244	0.504
LIG_14-3-3_CanoR_1	210	216	PF00244	0.405
LIG_14-3-3_CanoR_1	217	222	PF00244	0.435
LIG_14-3-3_CanoR_1	298	304	PF00244	0.263
LIG_14-3-3_CanoR_1	348	355	PF00244	0.369
LIG_14-3-3_CanoR_1	38	48	PF00244	0.548
LIG_14-3-3_CanoR_1	489	498	PF00244	0.284
LIG_14-3-3_CanoR_1	550	559	PF00244	0.404
LIG_14-3-3_CanoR_1	68	73	PF00244	0.439
LIG_Actin_WH2_2	252	269	PF00022	0.420
LIG_BRCT_BRCA1_1	318	322	PF00533	0.277
LIG_CtBP_PxDLS_1	13	17	PF00389	0.298
LIG_deltaCOP1_diTrp_1	284	290	PF00928	0.352
LIG_DLG_GKlike_1	12	19	PF00625	0.453
LIG_EH_1	475	479	PF12763	0.357
LIG_FHA_1	122	128	PF00498	0.593
LIG_FHA_1	31	37	PF00498	0.613
LIG_FHA_1	345	351	PF00498	0.364
LIG_FHA_1	355	361	PF00498	0.208
LIG_FHA_1	39	45	PF00498	0.518
LIG_FHA_2	210	216	PF00498	0.353
LIG_FHA_2	552	558	PF00498	0.378
LIG_FHA_2	573	579	PF00498	0.480
LIG_KLC1_Yacidic_2	201	206	PF13176	0.317
LIG_LIR_Apic_2	557	562	PF02991	0.301
LIG_LIR_Apic_2	72	78	PF02991	0.425
LIG_LIR_Gen_1	182	190	PF02991	0.352
LIG_LIR_Gen_1	295	304	PF02991	0.329
LIG_LIR_Gen_1	310	318	PF02991	0.337
LIG_LIR_Gen_1	323	333	PF02991	0.375
LIG_LIR_Gen_1	370	379	PF02991	0.303
LIG_LIR_Gen_1	413	419	PF02991	0.326
LIG_LIR_Gen_1	493	502	PF02991	0.280
LIG_LIR_Gen_1	563	570	PF02991	0.426
LIG_LIR_Nem_3	182	188	PF02991	0.346
LIG_LIR_Nem_3	283	288	PF02991	0.262
LIG_LIR_Nem_3	295	299	PF02991	0.306
LIG_LIR_Nem_3	301	307	PF02991	0.363
LIG_LIR_Nem_3	310	314	PF02991	0.287
LIG_LIR_Nem_3	323	329	PF02991	0.318
LIG_LIR_Nem_3	370	375	PF02991	0.269
LIG_LIR_Nem_3	413	418	PF02991	0.315
LIG_LIR_Nem_3	493	498	PF02991	0.282
LIG_LIR_Nem_3	563	567	PF02991	0.371
LIG_LIR_Nem_3	61	67	PF02991	0.495
LIG_LYPXL_yS_3	509	512	PF13949	0.340
LIG_MYND_1	128	132	PF01753	0.429
LIG_MYND_1	88	92	PF01753	0.572
LIG_Pex14_1	286	290	PF04695	0.357
LIG_Pex14_1	325	329	PF04695	0.271
LIG_Pex14_2	322	326	PF04695	0.294
LIG_PTB_Apo_2	334	341	PF02174	0.312
LIG_PTB_Apo_2	473	480	PF02174	0.407
LIG_SH2_CRK	159	163	PF00017	0.402
LIG_SH2_CRK	318	322	PF00017	0.305
LIG_SH2_CRK	564	568	PF00017	0.428
LIG_SH2_GRB2like	335	338	PF00017	0.312
LIG_SH2_GRB2like	50	53	PF00017	0.381
LIG_SH2_NCK_1	279	283	PF00017	0.355
LIG_SH2_NCK_1	50	54	PF00017	0.395
LIG_SH2_SRC	388	391	PF00017	0.341
LIG_SH2_SRC	458	461	PF00017	0.340
LIG_SH2_STAP1	159	163	PF00017	0.405
LIG_SH2_STAP1	346	350	PF00017	0.426
LIG_SH2_STAP1	50	54	PF00017	0.378
LIG_SH2_STAT3	346	349	PF00017	0.388
LIG_SH2_STAT5	204	207	PF00017	0.409
LIG_SH2_STAT5	232	235	PF00017	0.308
LIG_SH2_STAT5	311	314	PF00017	0.338
LIG_SH2_STAT5	335	338	PF00017	0.300
LIG_SH2_STAT5	346	349	PF00017	0.328
LIG_SH2_STAT5	35	38	PF00017	0.460
LIG_SH2_STAT5	388	391	PF00017	0.288
LIG_SH2_STAT5	460	463	PF00017	0.342
LIG_SH2_STAT5	50	53	PF00017	0.381
LIG_SH2_STAT5	553	556	PF00017	0.418
LIG_SH3_1	125	131	PF00018	0.432
LIG_SH3_1	175	181	PF00018	0.442
LIG_SH3_2	103	108	PF14604	0.577
LIG_SH3_2	178	183	PF14604	0.448
LIG_SH3_3	100	106	PF00018	0.581
LIG_SH3_3	125	131	PF00018	0.484
LIG_SH3_3	175	181	PF00018	0.363
LIG_SH3_3	193	199	PF00018	0.238
LIG_SH3_3	300	306	PF00018	0.258
LIG_SH3_3	42	48	PF00018	0.513
LIG_SH3_3	471	477	PF00018	0.259
LIG_SH3_3	564	570	PF00018	0.376
LIG_SH3_3	75	81	PF00018	0.570
LIG_SH3_3	85	91	PF00018	0.579
LIG_TYR_ITIM	309	314	PF00017	0.292
LIG_TYR_ITIM	316	321	PF00017	0.305
LIG_WRC_WIRS_1	369	374	PF05994	0.289
LIG_WW_3	105	109	PF00397	0.563
MOD_CK1_1	101	107	PF00069	0.513
MOD_CK1_1	141	147	PF00069	0.532
MOD_CK1_1	151	157	PF00069	0.381
MOD_CK1_1	351	357	PF00069	0.327
MOD_CK1_1	39	45	PF00069	0.498
MOD_CK1_1	438	444	PF00069	0.343
MOD_CK1_1	466	472	PF00069	0.319
MOD_CK1_1	527	533	PF00069	0.369
MOD_CK1_1	59	65	PF00069	0.489
MOD_CK2_1	466	472	PF00069	0.319
MOD_CK2_1	490	496	PF00069	0.317
MOD_CK2_1	551	557	PF00069	0.363
MOD_GlcNHglycan	100	103	PF01048	0.753
MOD_GlcNHglycan	143	146	PF01048	0.770
MOD_GlcNHglycan	206	210	PF01048	0.484
MOD_GlcNHglycan	437	440	PF01048	0.617
MOD_GSK3_1	111	118	PF00069	0.461
MOD_GSK3_1	139	146	PF00069	0.510
MOD_GSK3_1	147	154	PF00069	0.392
MOD_GSK3_1	205	212	PF00069	0.295
MOD_GSK3_1	316	323	PF00069	0.254
MOD_GSK3_1	344	351	PF00069	0.376
MOD_GSK3_1	36	43	PF00069	0.438
MOD_GSK3_1	419	426	PF00069	0.421
MOD_GSK3_1	462	469	PF00069	0.290
MOD_GSK3_1	69	76	PF00069	0.445
MOD_GSK3_1	97	104	PF00069	0.506
MOD_LATS_1	10	16	PF00433	0.453
MOD_N-GLC_1	217	222	PF02516	0.629
MOD_N-GLC_1	333	338	PF02516	0.523
MOD_N-GLC_2	547	549	PF02516	0.491
MOD_NEK2_1	257	262	PF00069	0.368
MOD_NEK2_1	395	400	PF00069	0.414
MOD_NEK2_1	410	415	PF00069	0.362
MOD_NEK2_1	490	495	PF00069	0.294
MOD_NEK2_2	30	35	PF00069	0.461
MOD_PIKK_1	270	276	PF00454	0.271
MOD_PIKK_1	320	326	PF00454	0.254
MOD_PKA_1	491	497	PF00069	0.289
MOD_PKA_1	68	74	PF00069	0.375
MOD_PKA_2	133	139	PF00069	0.596
MOD_PKA_2	209	215	PF00069	0.305
MOD_PKA_2	37	43	PF00069	0.466
MOD_PKA_2	423	429	PF00069	0.462
MOD_PKA_2	483	489	PF00069	0.307
MOD_PKA_2	490	496	PF00069	0.257
MOD_PKA_2	59	65	PF00069	0.428
MOD_PKB_1	489	497	PF00069	0.274
MOD_Plk_1	151	157	PF00069	0.364
MOD_Plk_1	217	223	PF00069	0.379
MOD_Plk_1	351	357	PF00069	0.290
MOD_Plk_1	379	385	PF00069	0.338
MOD_Plk_1	410	416	PF00069	0.322
MOD_Plk_1	515	521	PF00069	0.388
MOD_Plk_1	572	578	PF00069	0.441
MOD_Plk_2-3	557	563	PF00069	0.357
MOD_Plk_2-3	572	578	PF00069	0.431
MOD_Plk_4	299	305	PF00069	0.302
MOD_Plk_4	30	36	PF00069	0.548
MOD_Plk_4	368	374	PF00069	0.280
MOD_Plk_4	379	385	PF00069	0.283
MOD_Plk_4	463	469	PF00069	0.299
MOD_Plk_4	527	533	PF00069	0.317
MOD_Plk_4	59	65	PF00069	0.516
MOD_ProDKin_1	143	149	PF00069	0.493
MOD_ProDKin_1	316	322	PF00069	0.296
MOD_ProDKin_1	69	75	PF00069	0.559
TRG_DiLeu_BaEn_4	571	577	PF01217	0.442
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.430
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.365
TRG_ENDOCYTIC_2	159	162	PF00928	0.399
TRG_ENDOCYTIC_2	279	282	PF00928	0.326
TRG_ENDOCYTIC_2	311	314	PF00928	0.276
TRG_ENDOCYTIC_2	318	321	PF00928	0.288
TRG_ENDOCYTIC_2	458	461	PF00928	0.269
TRG_ENDOCYTIC_2	509	512	PF00928	0.315
TRG_ENDOCYTIC_2	564	567	PF00928	0.348
TRG_ER_diArg_1	400	403	PF00400	0.397
TRG_ER_diArg_1	490	492	PF00400	0.270
TRG_ER_diArg_1	548	551	PF00400	0.404
TRG_ER_diArg_1	7	9	PF00400	0.655
TRG_NES_CRM1_1	153	166	PF08389	0.368
TRG_NES_CRM1_1	408	423	PF08389	0.295
TRG_NLS_Bipartite_1	385	403	PF00514	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V7	Leptomonas seymouri	64%	100%
A0A0S4KMJ1	Bodo saltans	50%	100%
A0A1X0PB74	Trypanosomatidae	53%	100%
A0A3S5IRZ3	Trypanosoma rangeli	53%	100%
A0A3S7X8K5	Leishmania donovani	93%	99%
A4HBE1	Leishmania braziliensis	82%	100%
A4IAI9	Leishmania infantum	93%	100%
C9ZLP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZS63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	90%
E9B5L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
V5BRE4	Trypanosoma cruzi	51%	100%