TetR family transcriptional regulator

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q2C1_LEIMA

TriTrypDb:

LmjF.34.4200 , LMJLV39_340048600 , LMJSD75_340049000

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.529
CLV_NRD_NRD_1	71	73	PF00675	0.643
CLV_PCSK_KEX2_1	71	73	PF00082	0.643
CLV_PCSK_SKI1_1	115	119	PF00082	0.413
CLV_PCSK_SKI1_1	193	197	PF00082	0.529
DEG_APCC_DBOX_1	113	121	PF00400	0.528
DEG_SCF_FBW7_1	211	217	PF00400	0.611
DOC_CKS1_1	211	216	PF01111	0.608
DOC_CYCLIN_RxL_1	111	122	PF00134	0.529
DOC_MAPK_gen_1	191	200	PF00069	0.546
DOC_MAPK_gen_1	71	77	PF00069	0.437
DOC_MAPK_MEF2A_6	193	202	PF00069	0.535
DOC_PP1_RVXF_1	113	120	PF00149	0.529
DOC_USP7_MATH_1	138	142	PF00917	0.543
DOC_USP7_MATH_1	214	218	PF00917	0.698
DOC_USP7_MATH_1	35	39	PF00917	0.605
DOC_USP7_MATH_1	46	50	PF00917	0.416
DOC_USP7_MATH_1	99	103	PF00917	0.561
DOC_USP7_MATH_2	164	170	PF00917	0.520
DOC_WW_Pin1_4	127	132	PF00397	0.435
DOC_WW_Pin1_4	160	165	PF00397	0.500
DOC_WW_Pin1_4	207	212	PF00397	0.637
LIG_14-3-3_CanoR_1	193	202	PF00244	0.519
LIG_BRCT_BRCA1_1	211	215	PF00533	0.475
LIG_deltaCOP1_diTrp_1	149	154	PF00928	0.542
LIG_FHA_2	183	189	PF00498	0.640
LIG_FHA_2	79	85	PF00498	0.360
LIG_LIR_Gen_1	165	176	PF02991	0.560
LIG_LIR_Nem_3	122	127	PF02991	0.541
LIG_LIR_Nem_3	165	171	PF02991	0.550
LIG_LIR_Nem_3	43	47	PF02991	0.404
LIG_PDZ_Class_2	216	221	PF00595	0.716
LIG_Pex14_1	150	154	PF04695	0.545
LIG_Pex14_2	146	150	PF04695	0.481
LIG_Pex14_2	154	158	PF04695	0.591
LIG_Pex14_2	40	44	PF04695	0.613
LIG_SH2_CRK	136	140	PF00017	0.546
LIG_SH2_STAT5	116	119	PF00017	0.531
LIG_SH2_STAT5	124	127	PF00017	0.428
LIG_SH2_STAT5	57	60	PF00017	0.492
LIG_SH3_3	128	134	PF00018	0.430
LIG_SH3_3	18	24	PF00018	0.630
LIG_SH3_3	208	214	PF00018	0.640
LIG_TRAF2_2	24	29	PF00917	0.556
MOD_CK1_1	210	216	PF00069	0.597
MOD_CK2_1	1	7	PF00069	0.630
MOD_CK2_1	160	166	PF00069	0.503
MOD_GlcNHglycan	101	104	PF01048	0.514
MOD_GSK3_1	166	173	PF00069	0.548
MOD_GSK3_1	178	185	PF00069	0.550
MOD_GSK3_1	205	212	PF00069	0.532
MOD_NEK2_1	139	144	PF00069	0.550
MOD_NEK2_1	170	175	PF00069	0.458
MOD_NEK2_1	205	210	PF00069	0.503
MOD_NEK2_1	40	45	PF00069	0.561
MOD_NEK2_1	47	52	PF00069	0.514
MOD_NEK2_2	35	40	PF00069	0.649
MOD_PKA_2	27	33	PF00069	0.528
MOD_PKA_2	58	64	PF00069	0.617
MOD_Plk_1	47	53	PF00069	0.476
MOD_Plk_1	78	84	PF00069	0.506
MOD_Plk_2-3	63	69	PF00069	0.608
MOD_Plk_4	35	41	PF00069	0.671
MOD_ProDKin_1	127	133	PF00069	0.432
MOD_ProDKin_1	160	166	PF00069	0.503
MOD_ProDKin_1	207	213	PF00069	0.638
MOD_SUMO_rev_2	188	192	PF00179	0.643
TRG_AP2beta_CARGO_1	165	174	PF09066	0.354
TRG_DiLeu_BaEn_1	166	171	PF01217	0.425
TRG_ENDOCYTIC_2	136	139	PF00928	0.540
TRG_NES_CRM1_1	137	149	PF08389	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KLZ9	Bodo saltans	28%	94%
A0A3S7X8J2	Leishmania donovani	90%	100%
A4HBE3	Leishmania braziliensis	76%	100%
A4IAJ1	Leishmania infantum	91%	100%
E9B5L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%