DNA polymerase delta subunit 3

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q2C0_LEIMA

TriTrypDb:

LmjF.34.4210 , LMJLV39_340048700 , LMJSD75_340049100

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2C0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	55	59	PF00656	0.579
CLV_NRD_NRD_1	183	185	PF00675	0.574
CLV_NRD_NRD_1	247	249	PF00675	0.800
CLV_NRD_NRD_1	438	440	PF00675	0.818
CLV_NRD_NRD_1	66	68	PF00675	0.784
CLV_PCSK_KEX2_1	209	211	PF00082	0.751
CLV_PCSK_KEX2_1	247	249	PF00082	0.800
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.742
CLV_PCSK_SKI1_1	12	16	PF00082	0.570
CLV_PCSK_SKI1_1	466	470	PF00082	0.640
CLV_Separin_Metazoa	169	173	PF03568	0.738
DEG_Nend_UBRbox_2	1	3	PF02207	0.511
DEG_SCF_FBW7_1	334	340	PF00400	0.708
DEG_SPOP_SBC_1	159	163	PF00917	0.583
DOC_CKS1_1	334	339	PF01111	0.817
DOC_CYCLIN_RxL_1	9	19	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.621
DOC_MAPK_gen_1	172	180	PF00069	0.598
DOC_USP7_MATH_1	194	198	PF00917	0.704
DOC_USP7_MATH_1	243	247	PF00917	0.665
DOC_USP7_MATH_1	355	359	PF00917	0.555
DOC_USP7_MATH_1	432	436	PF00917	0.690
DOC_USP7_MATH_1	442	446	PF00917	0.765
DOC_USP7_MATH_1	57	61	PF00917	0.641
DOC_USP7_UBL2_3	215	219	PF12436	0.733
DOC_WW_Pin1_4	153	158	PF00397	0.739
DOC_WW_Pin1_4	160	165	PF00397	0.623
DOC_WW_Pin1_4	190	195	PF00397	0.752
DOC_WW_Pin1_4	330	335	PF00397	0.740
DOC_WW_Pin1_4	433	438	PF00397	0.697
DOC_WW_Pin1_4	445	450	PF00397	0.636
LIG_14-3-3_CanoR_1	12	22	PF00244	0.606
LIG_14-3-3_CanoR_1	121	127	PF00244	0.699
LIG_14-3-3_CanoR_1	175	181	PF00244	0.598
LIG_14-3-3_CanoR_1	210	217	PF00244	0.588
LIG_14-3-3_CanoR_1	402	412	PF00244	0.617
LIG_14-3-3_CanoR_1	439	446	PF00244	0.690
LIG_BIR_III_2	319	323	PF00653	0.615
LIG_BRCT_BRCA1_1	264	268	PF00533	0.737
LIG_BRCT_BRCA1_1	365	369	PF00533	0.604
LIG_EVH1_2	321	325	PF00568	0.648
LIG_FHA_1	234	240	PF00498	0.658
LIG_FHA_1	406	412	PF00498	0.568
LIG_FHA_1	419	425	PF00498	0.580
LIG_FHA_1	48	54	PF00498	0.654
LIG_FHA_1	60	66	PF00498	0.643
LIG_FHA_2	138	144	PF00498	0.813
LIG_FHA_2	14	20	PF00498	0.594
LIG_FHA_2	38	44	PF00498	0.471
LIG_Integrin_RGD_1	115	117	PF01839	0.562
LIG_LIR_Gen_1	197	207	PF02991	0.693
LIG_LIR_Gen_1	43	53	PF02991	0.483
LIG_LIR_Gen_1	77	87	PF02991	0.662
LIG_LIR_Nem_3	43	49	PF02991	0.513
LIG_LIR_Nem_3	77	82	PF02991	0.651
LIG_LYPXL_yS_3	110	113	PF13949	0.700
LIG_MLH1_MIPbox_1	365	369	PF16413	0.604
LIG_PCNA_PIPBox_1	362	371	PF02747	0.615
LIG_PTB_Apo_2	389	396	PF02174	0.521
LIG_REV1ctd_RIR_1	482	488	PF16727	0.661
LIG_SH2_CRK	46	50	PF00017	0.520
LIG_SH2_CRK	79	83	PF00017	0.637
LIG_SH2_STAT5	380	383	PF00017	0.515
LIG_SH2_STAT5	46	49	PF00017	0.456
LIG_SH3_1	331	337	PF00018	0.619
LIG_SH3_2	217	222	PF14604	0.687
LIG_SH3_2	224	229	PF14604	0.657
LIG_SH3_3	154	160	PF00018	0.642
LIG_SH3_3	177	183	PF00018	0.752
LIG_SH3_3	214	220	PF00018	0.692
LIG_SH3_3	221	227	PF00018	0.681
LIG_SH3_3	302	308	PF00018	0.777
LIG_SH3_3	324	330	PF00018	0.724
LIG_SH3_3	331	337	PF00018	0.745
LIG_SH3_3	443	449	PF00018	0.781
LIG_SH3_4	219	226	PF00018	0.813
LIG_SUMO_SIM_par_1	176	181	PF11976	0.595
LIG_SUMO_SIM_par_1	2	11	PF11976	0.554
LIG_SUMO_SIM_par_1	47	52	PF11976	0.429
LIG_SUMO_SIM_par_1	80	85	PF11976	0.567
LIG_TRAF2_1	295	298	PF00917	0.668
LIG_TRAF2_1	52	55	PF00917	0.655
LIG_UBA3_1	198	203	PF00899	0.667
LIG_WRC_WIRS_1	365	370	PF05994	0.677
LIG_WRC_WIRS_1	481	486	PF05994	0.651
LIG_WW_3	169	173	PF00397	0.738
MOD_CDK_SPK_2	160	165	PF00069	0.590
MOD_CDK_SPK_2	190	195	PF00069	0.726
MOD_CDK_SPxK_1	335	341	PF00069	0.773
MOD_CDK_SPxK_1	433	439	PF00069	0.672
MOD_CDK_SPxxK_3	335	342	PF00069	0.774
MOD_CDK_SPxxK_3	433	440	PF00069	0.781
MOD_CK1_1	153	159	PF00069	0.749
MOD_CK1_1	254	260	PF00069	0.752
MOD_CK1_1	282	288	PF00069	0.752
MOD_CK1_1	333	339	PF00069	0.824
MOD_CK1_1	37	43	PF00069	0.392
MOD_CK1_1	445	451	PF00069	0.756
MOD_CK1_1	460	466	PF00069	0.713
MOD_CK1_1	88	94	PF00069	0.675
MOD_CK2_1	13	19	PF00069	0.577
MOD_CK2_1	137	143	PF00069	0.815
MOD_CK2_1	277	283	PF00069	0.691
MOD_CK2_1	286	292	PF00069	0.690
MOD_CK2_1	307	313	PF00069	0.690
MOD_CK2_1	37	43	PF00069	0.570
MOD_CK2_1	404	410	PF00069	0.559
MOD_CK2_1	49	55	PF00069	0.548
MOD_DYRK1A_RPxSP_1	190	194	PF00069	0.649
MOD_GlcNHglycan	152	155	PF01048	0.715
MOD_GlcNHglycan	253	256	PF01048	0.791
MOD_GlcNHglycan	357	360	PF01048	0.678
MOD_GlcNHglycan	440	443	PF01048	0.721
MOD_GlcNHglycan	58	62	PF01048	0.717
MOD_GlcNHglycan	73	79	PF01048	0.738
MOD_GlcNHglycan	90	93	PF01048	0.626
MOD_GSK3_1	190	197	PF00069	0.685
MOD_GSK3_1	230	237	PF00069	0.694
MOD_GSK3_1	250	257	PF00069	0.492
MOD_GSK3_1	258	265	PF00069	0.675
MOD_GSK3_1	273	280	PF00069	0.728
MOD_GSK3_1	282	289	PF00069	0.647
MOD_GSK3_1	333	340	PF00069	0.705
MOD_GSK3_1	34	41	PF00069	0.576
MOD_GSK3_1	438	445	PF00069	0.793
MOD_GSK3_1	460	467	PF00069	0.738
MOD_GSK3_1	480	487	PF00069	0.632
MOD_N-GLC_1	234	239	PF02516	0.655
MOD_N-GLC_1	88	93	PF02516	0.690
MOD_NEK2_1	24	29	PF00069	0.543
MOD_NEK2_1	424	429	PF00069	0.672
MOD_NEK2_1	8	13	PF00069	0.510
MOD_NEK2_1	82	87	PF00069	0.579
MOD_NEK2_2	194	199	PF00069	0.632
MOD_NEK2_2	477	482	PF00069	0.658
MOD_PIKK_1	466	472	PF00454	0.699
MOD_PKA_2	102	108	PF00069	0.571
MOD_PKA_2	171	177	PF00069	0.595
MOD_PKA_2	243	249	PF00069	0.723
MOD_PKA_2	438	444	PF00069	0.692
MOD_PKA_2	460	466	PF00069	0.731
MOD_Plk_1	103	109	PF00069	0.695
MOD_Plk_1	234	240	PF00069	0.653
MOD_Plk_1	74	80	PF00069	0.678
MOD_Plk_4	194	200	PF00069	0.663
MOD_Plk_4	364	370	PF00069	0.588
MOD_Plk_4	44	50	PF00069	0.503
MOD_Plk_4	480	486	PF00069	0.606
MOD_ProDKin_1	153	159	PF00069	0.739
MOD_ProDKin_1	160	166	PF00069	0.622
MOD_ProDKin_1	190	196	PF00069	0.750
MOD_ProDKin_1	330	336	PF00069	0.741
MOD_ProDKin_1	433	439	PF00069	0.700
MOD_ProDKin_1	445	451	PF00069	0.639
MOD_SUMO_for_1	295	298	PF00179	0.668
MOD_SUMO_for_1	388	391	PF00179	0.521
MOD_SUMO_rev_2	138	148	PF00179	0.692
MOD_SUMO_rev_2	383	390	PF00179	0.564
TRG_DiLeu_BaEn_2	390	396	PF01217	0.649
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.626
TRG_ENDOCYTIC_2	110	113	PF00928	0.611
TRG_ENDOCYTIC_2	46	49	PF00928	0.508
TRG_ENDOCYTIC_2	79	82	PF00928	0.567
TRG_NLS_MonoCore_2	208	213	PF00514	0.709
TRG_NLS_MonoExtC_3	208	214	PF00514	0.709
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.727

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYZ0	Leptomonas seymouri	45%	95%
A0A1X0PAH9	Trypanosomatidae	28%	93%
A0A3S7X8I7	Leishmania donovani	87%	100%
A4HBE4	Leishmania braziliensis	62%	98%
A4IAJ2	Leishmania infantum	86%	100%
E9B5L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%