FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q2B7_LEIMA

TriTrypDb:

LmjF.34.4240 , LMJLV39_340049000 , LMJSD75_340049400

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q2B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.534
CLV_NRD_NRD_1	131	133	PF00675	0.722
CLV_NRD_NRD_1	195	197	PF00675	0.802
CLV_NRD_NRD_1	198	200	PF00675	0.767
CLV_NRD_NRD_1	310	312	PF00675	0.614
CLV_NRD_NRD_1	341	343	PF00675	0.478
CLV_PCSK_FUR_1	196	200	PF00082	0.692
CLV_PCSK_KEX2_1	195	197	PF00082	0.824
CLV_PCSK_KEX2_1	198	200	PF00082	0.795
CLV_PCSK_KEX2_1	209	211	PF00082	0.535
CLV_PCSK_KEX2_1	260	262	PF00082	0.340
CLV_PCSK_KEX2_1	310	312	PF00082	0.614
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.682
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.340
CLV_PCSK_SKI1_1	209	213	PF00082	0.663
CLV_PCSK_SKI1_1	263	267	PF00082	0.362
CLV_PCSK_SKI1_1	97	101	PF00082	0.358
DOC_CKS1_1	114	119	PF01111	0.766
DOC_CKS1_1	281	286	PF01111	0.536
DOC_CYCLIN_yClb5_NLxxxL_5	34	43	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.447
DOC_MAPK_gen_1	129	139	PF00069	0.736
DOC_MAPK_MEF2A_6	297	304	PF00069	0.577
DOC_PP1_RVXF_1	95	101	PF00149	0.420
DOC_PP1_SILK_1	399	404	PF00149	0.497
DOC_USP7_MATH_1	162	166	PF00917	0.749
DOC_USP7_MATH_1	180	184	PF00917	0.488
DOC_USP7_MATH_1	216	220	PF00917	0.711
DOC_USP7_MATH_1	300	304	PF00917	0.586
DOC_USP7_MATH_1	358	362	PF00917	0.481
DOC_USP7_MATH_2	30	36	PF00917	0.480
DOC_WW_Pin1_4	113	118	PF00397	0.651
DOC_WW_Pin1_4	148	153	PF00397	0.699
DOC_WW_Pin1_4	190	195	PF00397	0.799
DOC_WW_Pin1_4	202	207	PF00397	0.690
DOC_WW_Pin1_4	231	236	PF00397	0.616
DOC_WW_Pin1_4	280	285	PF00397	0.474
DOC_WW_Pin1_4	343	348	PF00397	0.515
DOC_WW_Pin1_4	38	43	PF00397	0.373
DOC_WW_Pin1_4	74	79	PF00397	0.473
DOC_WW_Pin1_4	90	95	PF00397	0.434
LIG_14-3-3_CanoR_1	132	140	PF00244	0.683
LIG_14-3-3_CanoR_1	26	30	PF00244	0.408
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_2	344	348	PF00653	0.550
LIG_FHA_1	132	138	PF00498	0.731
LIG_FHA_1	257	263	PF00498	0.519
LIG_FHA_1	281	287	PF00498	0.508
LIG_FHA_1	361	367	PF00498	0.520
LIG_FHA_2	107	113	PF00498	0.568
LIG_FHA_2	246	252	PF00498	0.591
LIG_FHA_2	330	336	PF00498	0.480
LIG_LIR_Gen_1	106	115	PF02991	0.580
LIG_LIR_Gen_1	219	228	PF02991	0.511
LIG_LIR_Gen_1	3	10	PF02991	0.496
LIG_LIR_Gen_1	35	44	PF02991	0.357
LIG_LIR_Gen_1	395	406	PF02991	0.413
LIG_LIR_Gen_1	72	80	PF02991	0.368
LIG_LIR_Nem_3	106	110	PF02991	0.509
LIG_LIR_Nem_3	219	224	PF02991	0.508
LIG_LIR_Nem_3	3	9	PF02991	0.466
LIG_LIR_Nem_3	35	39	PF02991	0.357
LIG_LIR_Nem_3	395	401	PF02991	0.386
LIG_LIR_Nem_3	72	76	PF02991	0.374
LIG_PDZ_Class_3	405	410	PF00595	0.558
LIG_PTAP_UEV_1	200	205	PF05743	0.741
LIG_Rb_pABgroove_1	392	400	PF01858	0.510
LIG_SH2_CRK	398	402	PF00017	0.391
LIG_SH2_CRK	6	10	PF00017	0.448
LIG_SH2_NCK_1	331	335	PF00017	0.460
LIG_SH2_NCK_1	6	10	PF00017	0.517
LIG_SH2_STAP1	398	402	PF00017	0.391
LIG_SH2_STAP1	6	10	PF00017	0.484
LIG_SH2_STAT3	15	18	PF00017	0.526
LIG_SH2_STAT5	169	172	PF00017	0.647
LIG_SH2_STAT5	306	309	PF00017	0.537
LIG_SH2_STAT5	331	334	PF00017	0.485
LIG_SH3_1	198	204	PF00018	0.790
LIG_SH3_2	204	209	PF14604	0.767
LIG_SH3_3	111	117	PF00018	0.737
LIG_SH3_3	198	204	PF00018	0.725
LIG_SH3_3	278	284	PF00018	0.476
LIG_SUMO_SIM_par_1	277	283	PF11976	0.469
LIG_SUMO_SIM_par_1	300	305	PF11976	0.586
LIG_TRFH_1	90	94	PF08558	0.378
LIG_TYR_ITSM	2	9	PF00017	0.560
LIG_WRC_WIRS_1	104	109	PF05994	0.480
MOD_CDK_SPK_2	190	195	PF00069	0.568
MOD_CDK_SPK_2	285	290	PF00069	0.482
MOD_CDK_SPxK_1	148	154	PF00069	0.784
MOD_CDK_SPxK_1	190	196	PF00069	0.608
MOD_CDK_SPxK_1	231	237	PF00069	0.659
MOD_CDK_SPxxK_3	202	209	PF00069	0.725
MOD_CDK_SPxxK_3	280	287	PF00069	0.487
MOD_CDK_SPxxK_3	90	97	PF00069	0.447
MOD_CK1_1	128	134	PF00069	0.635
MOD_CK1_1	146	152	PF00069	0.620
MOD_CK1_1	183	189	PF00069	0.627
MOD_CK1_1	360	366	PF00069	0.501
MOD_CK2_1	106	112	PF00069	0.570
MOD_CK2_1	329	335	PF00069	0.485
MOD_CK2_1	371	377	PF00069	0.504
MOD_GlcNHglycan	171	175	PF01048	0.747
MOD_GlcNHglycan	214	217	PF01048	0.662
MOD_GlcNHglycan	373	376	PF01048	0.540
MOD_GSK3_1	143	150	PF00069	0.654
MOD_GSK3_1	183	190	PF00069	0.634
MOD_GSK3_1	212	219	PF00069	0.648
MOD_GSK3_1	226	233	PF00069	0.497
MOD_GSK3_1	245	252	PF00069	0.539
MOD_GSK3_1	323	330	PF00069	0.483
MOD_GSK3_1	358	365	PF00069	0.474
MOD_GSK3_1	61	68	PF00069	0.334
MOD_N-GLC_1	66	71	PF02516	0.329
MOD_NEK2_1	1	6	PF00069	0.530
MOD_NEK2_1	123	128	PF00069	0.635
MOD_NEK2_1	143	148	PF00069	0.739
MOD_NEK2_1	170	175	PF00069	0.664
MOD_NEK2_1	397	402	PF00069	0.482
MOD_PK_1	362	368	PF00069	0.552
MOD_PKA_2	128	134	PF00069	0.729
MOD_PKA_2	183	189	PF00069	0.754
MOD_PKA_2	25	31	PF00069	0.447
MOD_Plk_4	172	178	PF00069	0.536
MOD_Plk_4	217	223	PF00069	0.727
MOD_Plk_4	32	38	PF00069	0.347
MOD_Plk_4	397	403	PF00069	0.418
MOD_Plk_4	69	75	PF00069	0.355
MOD_ProDKin_1	113	119	PF00069	0.656
MOD_ProDKin_1	148	154	PF00069	0.704
MOD_ProDKin_1	190	196	PF00069	0.800
MOD_ProDKin_1	202	208	PF00069	0.690
MOD_ProDKin_1	231	237	PF00069	0.599
MOD_ProDKin_1	280	286	PF00069	0.474
MOD_ProDKin_1	343	349	PF00069	0.506
MOD_ProDKin_1	38	44	PF00069	0.373
MOD_ProDKin_1	74	80	PF00069	0.473
MOD_ProDKin_1	90	96	PF00069	0.434
MOD_SUMO_for_1	211	214	PF00179	0.657
TRG_DiLeu_BaEn_1	172	177	PF01217	0.533
TRG_DiLeu_BaEn_2	31	37	PF01217	0.447
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.509
TRG_ENDOCYTIC_2	398	401	PF00928	0.375
TRG_ENDOCYTIC_2	6	9	PF00928	0.398
TRG_ENDOCYTIC_2	89	92	PF00928	0.410
TRG_ER_diArg_1	194	196	PF00400	0.762
TRG_NLS_Bipartite_1	191	213	PF00514	0.763
TRG_NLS_MonoExtC_3	208	214	PF00514	0.669
TRG_NLS_MonoExtN_4	206	213	PF00514	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS6	Leptomonas seymouri	60%	96%
A0A0S4IL96	Bodo saltans	30%	86%
A0A3R7KTI0	Trypanosoma rangeli	36%	100%
A0A3S7X8R1	Leishmania donovani	92%	100%
A4HBE7	Leishmania braziliensis	80%	100%
A4IAJ5	Leishmania infantum	92%	100%
C9ZLP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	95%
E9B5L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BW13	Trypanosoma cruzi	37%	100%