ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania major

UniProt:

Q4Q2B3_LEIMA

TriTrypDb:

LmjF.34.4280 , LMJLV39_340049400 , LMJSD75_340049800

Length:

405

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4Q2B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	294	296	PF00675	0.526
CLV_NRD_NRD_1	332	334	PF00675	0.646
CLV_PCSK_KEX2_1	332	334	PF00082	0.595
CLV_PCSK_KEX2_1	96	98	PF00082	0.416
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.416
CLV_PCSK_SKI1_1	159	163	PF00082	0.460
CLV_PCSK_SKI1_1	25	29	PF00082	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.394
DOC_CKS1_1	109	114	PF01111	0.216
DOC_CYCLIN_yClb1_LxF_4	72	77	PF00134	0.315
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.352
DOC_MAPK_gen_1	363	371	PF00069	0.451
DOC_MAPK_gen_1	375	384	PF00069	0.245
DOC_MAPK_MEF2A_6	126	135	PF00069	0.197
DOC_PP1_RVXF_1	72	78	PF00149	0.304
DOC_PP2B_LxvP_1	316	319	PF13499	0.365
DOC_USP7_MATH_1	265	269	PF00917	0.264
DOC_USP7_MATH_1	312	316	PF00917	0.443
DOC_USP7_UBL2_3	336	340	PF12436	0.401
DOC_WW_Pin1_4	108	113	PF00397	0.260
DOC_WW_Pin1_4	141	146	PF00397	0.204
DOC_WW_Pin1_4	221	226	PF00397	0.456
LIG_14-3-3_CanoR_1	119	128	PF00244	0.260
LIG_14-3-3_CanoR_1	260	270	PF00244	0.301
LIG_14-3-3_CanoR_1	299	305	PF00244	0.448
LIG_14-3-3_CanoR_1	74	82	PF00244	0.277
LIG_FHA_1	142	148	PF00498	0.222
LIG_FHA_1	224	230	PF00498	0.301
LIG_FHA_1	265	271	PF00498	0.260
LIG_FHA_1	378	384	PF00498	0.349
LIG_LIR_Apic_2	194	198	PF02991	0.324
LIG_LIR_Gen_1	24	35	PF02991	0.290
LIG_LIR_Nem_3	108	113	PF02991	0.205
LIG_LIR_Nem_3	24	30	PF02991	0.295
LIG_LIR_Nem_3	256	262	PF02991	0.271
LIG_PTB_Apo_2	34	41	PF02174	0.326
LIG_PTB_Phospho_1	34	40	PF10480	0.329
LIG_SH2_CRK	259	263	PF00017	0.351
LIG_SH2_CRK	82	86	PF00017	0.244
LIG_SH2_NCK_1	82	86	PF00017	0.244
LIG_SH2_STAP1	181	185	PF00017	0.312
LIG_SH2_STAP1	82	86	PF00017	0.244
LIG_SH2_STAT3	160	163	PF00017	0.216
LIG_SH2_STAT5	160	163	PF00017	0.216
LIG_SH2_STAT5	228	231	PF00017	0.380
LIG_SH2_STAT5	392	395	PF00017	0.301
LIG_SH3_3	231	237	PF00018	0.366
LIG_SH3_3	320	326	PF00018	0.383
LIG_SH3_3	362	368	PF00018	0.415
LIG_SH3_4	336	343	PF00018	0.394
LIG_Sin3_3	281	288	PF02671	0.231
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.363
LIG_SUMO_SIM_anti_2	203	208	PF11976	0.237
LIG_SUMO_SIM_anti_2	380	385	PF11976	0.227
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.229
LIG_TYR_ITIM	257	262	PF00017	0.284
LIG_TYR_ITIM	80	85	PF00017	0.208
LIG_UBA3_1	287	296	PF00899	0.327
MOD_CDK_SPxK_1	221	227	PF00069	0.314
MOD_CK1_1	264	270	PF00069	0.236
MOD_CK2_1	11	17	PF00069	0.298
MOD_GlcNHglycan	121	124	PF01048	0.437
MOD_GlcNHglycan	13	16	PF01048	0.528
MOD_GlcNHglycan	263	266	PF01048	0.491
MOD_GlcNHglycan	347	350	PF01048	0.572
MOD_GSK3_1	137	144	PF00069	0.216
MOD_GSK3_1	261	268	PF00069	0.385
MOD_N-GLC_2	29	31	PF02516	0.482
MOD_NEK2_1	10	15	PF00069	0.291
MOD_NEK2_1	345	350	PF00069	0.365
MOD_NEK2_1	75	80	PF00069	0.309
MOD_NEK2_2	370	375	PF00069	0.352
MOD_PIKK_1	197	203	PF00454	0.307
MOD_PKA_1	295	301	PF00069	0.403
MOD_Plk_1	23	29	PF00069	0.301
MOD_Plk_4	23	29	PF00069	0.336
MOD_Plk_4	265	271	PF00069	0.273
MOD_Plk_4	377	383	PF00069	0.260
MOD_ProDKin_1	108	114	PF00069	0.260
MOD_ProDKin_1	141	147	PF00069	0.204
MOD_ProDKin_1	221	227	PF00069	0.461
MOD_SUMO_rev_2	17	27	PF00179	0.385
MOD_SUMO_rev_2	292	298	PF00179	0.353
TRG_DiLeu_BaEn_1	52	57	PF01217	0.230
TRG_DiLeu_BaEn_2	22	28	PF01217	0.291
TRG_ENDOCYTIC_2	259	262	PF00928	0.334
TRG_ENDOCYTIC_2	82	85	PF00928	0.304
TRG_ER_diArg_1	118	121	PF00400	0.216
TRG_ER_diArg_1	401	404	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P716	Leptomonas seymouri	54%	100%
A0A0S4IPR4	Bodo saltans	36%	89%
A0A1X0PAB7	Trypanosomatidae	31%	100%
A0A3Q8IUY8	Leishmania donovani	89%	100%
E9AHS2	Leishmania infantum	89%	100%
E9B5M3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%