H/ACA ribonucleoprotein complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein family a, putative

Species:

Leishmania major

UniProt:

Q4Q2B2_LEIMA

TriTrypDb:

LmjF.34.4290 , LMJLV39_340049500 , LMJSD75_340049900

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	2
GO:0005737	cytoplasm	2	2
GO:0031429	box H/ACA snoRNP complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0072588	box H/ACA RNP complex	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q2B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2B2

Function

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	2
GO:0000454	snoRNA guided rRNA pseudouridine synthesis	8	2
GO:0001522	pseudouridine synthesis	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0031118	rRNA pseudouridine synthesis	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0030515	snoRNA binding	5	2
GO:0034513	box H/ACA snoRNA binding	6	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	141	145	PF00082	0.762
DOC_CKS1_1	136	141	PF01111	0.506
DOC_PP4_FxxP_1	143	146	PF00568	0.762
DOC_PP4_FxxP_1	20	23	PF00568	0.811
DOC_WW_Pin1_4	113	118	PF00397	0.506
DOC_WW_Pin1_4	130	135	PF00397	0.209
LIG_14-3-3_CanoR_1	141	146	PF00244	0.763
LIG_APCC_ABBA_1	140	145	PF00400	0.763
LIG_BRCT_BRCA1_1	16	20	PF00533	0.815
LIG_FHA_1	104	110	PF00498	0.506
LIG_LIR_Apic_2	128	134	PF02991	0.506
LIG_LIR_Apic_2	17	23	PF02991	0.811
LIG_LIR_Nem_3	135	140	PF02991	0.506
LIG_SH2_PTP2	131	134	PF00017	0.506
LIG_SH2_STAT5	131	134	PF00017	0.506
LIG_SH2_STAT5	89	92	PF00017	0.506
LIG_SH3_3	143	149	PF00018	0.766
LIG_SH3_3	48	54	PF00018	0.792
LIG_WRC_WIRS_1	60	65	PF05994	0.506
MOD_CDK_SPxK_1	135	141	PF00069	0.506
MOD_CK1_1	195	201	PF00069	0.800
MOD_CK2_1	120	126	PF00069	0.506
MOD_GlcNHglycan	14	17	PF01048	0.812
MOD_GlcNHglycan	197	200	PF01048	0.796
MOD_GSK3_1	109	116	PF00069	0.506
MOD_N-GLC_1	104	109	PF02516	0.506
MOD_PIKK_1	132	138	PF00454	0.506
MOD_PKA_2	12	18	PF00069	0.813
MOD_PKA_2	182	188	PF00069	0.790
MOD_PKA_2	192	198	PF00069	0.618
MOD_PKA_2	200	206	PF00069	0.485
MOD_Plk_4	59	65	PF00069	0.506
MOD_ProDKin_1	113	119	PF00069	0.506
MOD_ProDKin_1	130	136	PF00069	0.209
TRG_DiLeu_BaEn_3	58	64	PF01217	0.506
TRG_ER_diArg_1	149	152	PF00400	0.794

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q8VZT0	Arabidopsis thaliana	43%	100%