Quinonoid dihydropteridine reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

quinonoid dihydropteridine reductase

Species:

Leishmania major

UniProt:

Q4Q2A8_LEIMA

TriTrypDb:

LmjF.34.4330 , LMJLV39_340050000 , LMJSD75_340050300

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q2A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q2A8

PDB structure(s): 8b5t_A , 8b5t_B , 8b5t_C , 8b5u_A

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	3
GO:0006082	organic acid metabolic process	3	3
GO:0006520	amino acid metabolic process	3	3
GO:0006558	L-phenylalanine metabolic process	5	3
GO:0006559	L-phenylalanine catabolic process	5	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006729	tetrahydrobiopterin biosynthetic process	6	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009058	biosynthetic process	2	3
GO:0009063	amino acid catabolic process	4	3
GO:0009072	aromatic amino acid metabolic process	4	3
GO:0009074	aromatic amino acid family catabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016054	organic acid catabolic process	4	3
GO:0018130	heterocycle biosynthetic process	4	3
GO:0019438	aromatic compound biosynthetic process	4	3
GO:0019439	aromatic compound catabolic process	4	3
GO:0019751	polyol metabolic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0034311	diol metabolic process	5	3
GO:0034312	diol biosynthetic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0042558	pteridine-containing compound metabolic process	4	3
GO:0042559	pteridine-containing compound biosynthetic process	5	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044249	cellular biosynthetic process	3	3
GO:0044271	cellular nitrogen compound biosynthetic process	4	3
GO:0044281	small molecule metabolic process	2	3
GO:0044282	small molecule catabolic process	3	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046146	tetrahydrobiopterin metabolic process	5	3
GO:0046165	alcohol biosynthetic process	4	3
GO:0046173	polyol biosynthetic process	5	3
GO:0046395	carboxylic acid catabolic process	5	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901361	organic cyclic compound catabolic process	4	3
GO:1901362	organic cyclic compound biosynthetic process	4	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901565	organonitrogen compound catabolic process	4	3
GO:1901566	organonitrogen compound biosynthetic process	4	3
GO:1901575	organic substance catabolic process	3	3
GO:1901576	organic substance biosynthetic process	3	3
GO:1901605	alpha-amino acid metabolic process	4	3
GO:1901606	alpha-amino acid catabolic process	5	3
GO:1901615	organic hydroxy compound metabolic process	3	3
GO:1901617	organic hydroxy compound biosynthetic process	4	3
GO:1902221	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	5	3
GO:1902222	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process	6	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	7
GO:0004155	6,7-dihydropteridine reductase activity	5	6
GO:0005488	binding	1	3
GO:0016491	oxidoreductase activity	2	7
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	6
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	6
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0050661	NADP binding	4	3
GO:0051287	NAD binding	4	3
GO:0070402	NADPH binding	4	3
GO:0070404	NADH binding	4	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	208	210	PF00675	0.512
CLV_PCSK_KEX2_1	208	210	PF00082	0.473
CLV_PCSK_SKI1_1	10	14	PF00082	0.334
CLV_PCSK_SKI1_1	2	6	PF00082	0.334
CLV_PCSK_SKI1_1	217	221	PF00082	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.388
DEG_SPOP_SBC_1	84	88	PF00917	0.160
DOC_CKS1_1	173	178	PF01111	0.322
DOC_USP7_MATH_1	185	189	PF00917	0.483
DOC_USP7_MATH_1	211	215	PF00917	0.520
DOC_USP7_MATH_1	48	52	PF00917	0.334
DOC_USP7_MATH_1	58	62	PF00917	0.334
DOC_USP7_MATH_1	79	83	PF00917	0.334
DOC_USP7_MATH_1	84	88	PF00917	0.334
DOC_WW_Pin1_4	127	132	PF00397	0.342
DOC_WW_Pin1_4	172	177	PF00397	0.314
LIG_14-3-3_CanoR_1	187	196	PF00244	0.477
LIG_14-3-3_CanoR_1	97	101	PF00244	0.290
LIG_FHA_1	223	229	PF00498	0.433
LIG_FHA_2	110	116	PF00498	0.417
LIG_FHA_2	169	175	PF00498	0.378
LIG_FHA_2	189	195	PF00498	0.273
LIG_LIR_Gen_1	188	197	PF02991	0.539
LIG_LIR_Gen_1	99	109	PF02991	0.313
LIG_LIR_Nem_3	188	193	PF02991	0.417
LIG_LIR_Nem_3	99	104	PF02991	0.313
LIG_LYPXL_SIV_4	58	66	PF13949	0.438
LIG_PDZ_Class_2	224	229	PF00595	0.479
LIG_SUMO_SIM_anti_2	164	171	PF11976	0.459
LIG_SUMO_SIM_par_1	118	123	PF11976	0.387
LIG_SUMO_SIM_par_1	27	32	PF11976	0.459
LIG_TRAF2_1	51	54	PF00917	0.334
MOD_CDK_SPxxK_3	172	179	PF00069	0.322
MOD_CK1_1	188	194	PF00069	0.385
MOD_CK1_1	204	210	PF00069	0.398
MOD_CK1_1	27	33	PF00069	0.365
MOD_CK1_1	61	67	PF00069	0.420
MOD_CK1_1	99	105	PF00069	0.299
MOD_CK2_1	109	115	PF00069	0.417
MOD_CK2_1	148	154	PF00069	0.335
MOD_CK2_1	188	194	PF00069	0.430
MOD_CK2_1	47	53	PF00069	0.338
MOD_GlcNHglycan	142	145	PF01048	0.384
MOD_GlcNHglycan	179	182	PF01048	0.315
MOD_GlcNHglycan	211	214	PF01048	0.473
MOD_GlcNHglycan	60	63	PF01048	0.445
MOD_GSK3_1	154	161	PF00069	0.413
MOD_GSK3_1	168	175	PF00069	0.251
MOD_GSK3_1	185	192	PF00069	0.332
MOD_GSK3_1	79	86	PF00069	0.319
MOD_GSK3_1	96	103	PF00069	0.268
MOD_N-GLC_1	177	182	PF02516	0.378
MOD_N-GLC_1	204	209	PF02516	0.454
MOD_NEK2_1	120	125	PF00069	0.332
MOD_NEK2_1	148	153	PF00069	0.299
MOD_NEK2_1	96	101	PF00069	0.305
MOD_PIKK_1	109	115	PF00454	0.391
MOD_PKA_2	186	192	PF00069	0.490
MOD_PKA_2	96	102	PF00069	0.299
MOD_Plk_1	161	167	PF00069	0.456
MOD_Plk_1	177	183	PF00069	0.201
MOD_Plk_1	185	191	PF00069	0.383
MOD_Plk_4	154	160	PF00069	0.368
MOD_Plk_4	161	167	PF00069	0.290
MOD_Plk_4	168	174	PF00069	0.223
MOD_Plk_4	211	217	PF00069	0.479
MOD_Plk_4	96	102	PF00069	0.306
MOD_ProDKin_1	127	133	PF00069	0.342
MOD_ProDKin_1	172	178	PF00069	0.314
TRG_DiLeu_BaEn_1	115	120	PF01217	0.417
TRG_ER_diArg_1	208	210	PF00400	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZI9	Leptomonas seymouri	73%	100%
A0A0S4IVE4	Bodo saltans	49%	86%
A0A3S5H7Y1	Leishmania donovani	96%	100%
A0A422N4V6	Trypanosoma rangeli	52%	95%
A4HBF7	Leishmania braziliensis	83%	100%
A4IAL5	Leishmania infantum	96%	100%
E9B5M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P09417	Homo sapiens	42%	94%
P11348	Rattus norvegicus	42%	95%
Q3T0Z7	Bos taurus	43%	95%
Q4Q290	Leishmania major	100%	100%
Q86A17	Dictyostelium discoideum	37%	99%
Q8BVI4	Mus musculus	42%	95%
Q8MJ30	Sus scrofa	42%	94%