Sjogren syndrome nuclear autoantigen 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

13 kDa deflagellation-inducible protein, putative

Species:

Leishmania major

UniProt:

Q4Q287_LEIMA

TriTrypDb:

LmjF.34.4540 , LMJLV39_340050300 , LMJSD75_340050800

Length:

108

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4Q287

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q287

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.533
CLV_NRD_NRD_1	24	26	PF00675	0.403
CLV_PCSK_SKI1_1	26	30	PF00082	0.425
CLV_PCSK_SKI1_1	83	87	PF00082	0.449
CLV_PCSK_SKI1_1	90	94	PF00082	0.394
DOC_CYCLIN_RxL_1	87	95	PF00134	0.471
DOC_USP7_MATH_1	3	7	PF00917	0.540
DOC_USP7_MATH_1	81	85	PF00917	0.540
LIG_14-3-3_CanoR_1	25	29	PF00244	0.511
LIG_14-3-3_CanoR_1	73	82	PF00244	0.505
LIG_Actin_WH2_2	43	60	PF00022	0.543
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_FHA_2	25	31	PF00498	0.521
LIG_FHA_2	72	78	PF00498	0.513
LIG_FHA_2	9	15	PF00498	0.420
LIG_FHA_2	93	99	PF00498	0.514
LIG_LIR_Gen_1	76	86	PF02991	0.476
LIG_LIR_Nem_3	37	43	PF02991	0.553
LIG_LIR_Nem_3	76	82	PF02991	0.396
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.438
LIG_SUMO_SIM_anti_2	52	60	PF11976	0.326
LIG_SUMO_SIM_par_1	14	20	PF11976	0.424
LIG_TRAF2_1	34	37	PF00917	0.526
LIG_TRAF2_1	49	52	PF00917	0.543
LIG_TRAF2_1	96	99	PF00917	0.520
MOD_CK2_1	24	30	PF00069	0.543
MOD_CK2_1	31	37	PF00069	0.513
MOD_CK2_1	71	77	PF00069	0.475
MOD_CK2_1	8	14	PF00069	0.422
MOD_CK2_1	92	98	PF00069	0.514
MOD_GlcNHglycan	33	36	PF01048	0.545
MOD_GlcNHglycan	79	82	PF01048	0.473
MOD_GSK3_1	71	78	PF00069	0.470
MOD_NEK2_1	57	62	PF00069	0.444
MOD_NEK2_1	71	76	PF00069	0.476
MOD_NEK2_1	86	91	PF00069	0.414
MOD_NEK2_1	92	97	PF00069	0.420
MOD_PKA_2	24	30	PF00069	0.511
MOD_Plk_1	71	77	PF00069	0.475
MOD_Plk_1	97	103	PF00069	0.482
MOD_Plk_2-3	14	20	PF00069	0.448
MOD_Plk_2-3	24	30	PF00069	0.519
MOD_Plk_4	14	20	PF00069	0.424
MOD_Plk_4	24	30	PF00069	0.571
MOD_Plk_4	81	87	PF00069	0.513
MOD_SUMO_for_1	96	99	PF00179	0.520
MOD_SUMO_rev_2	20	28	PF00179	0.523
TRG_DiLeu_BaEn_1	24	29	PF01217	0.518
TRG_DiLeu_BaEn_4	98	104	PF01217	0.485
TRG_ENDOCYTIC_2	40	43	PF00928	0.551
TRG_ENDOCYTIC_2	79	82	PF00928	0.543
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.442
TRG_PTS2	1	33	PF00400	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT9	Leptomonas seymouri	71%	100%
A0A0S4IPN0	Bodo saltans	52%	100%
A0A1X0P6Z2	Trypanosomatidae	52%	99%
A0A3S7X8K8	Leishmania donovani	94%	100%
A0A422NPR2	Trypanosoma rangeli	45%	99%
A4HBG0	Leishmania braziliensis	91%	100%
A4IAK6	Leishmania infantum	94%	100%
C9ZZY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	83%
E9B5N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O43805	Homo sapiens	40%	91%
Q5E9C3	Bos taurus	40%	91%
Q9JJ94	Mus musculus	40%	91%
Q9XF62	Chlamydomonas reinhardtii	32%	97%