LeishMANIAdb
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Cell differentiation protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cell differentiation protein-like protein
Gene product:
cell differentiation protein-like protein
Species:
Leishmania major
UniProt:
Q4Q286_LEIMA
TriTrypDb:
LmjF.34.4550 , LMJLV39_340050400 * , LMJSD75_340050900 *
Length:
360

Annotations

LeishMANIAdb annotations

A conserved Eukaryotic protein. Certainly not TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000932 P-body 5 2
GO:0005737 cytoplasm 2 2
GO:0030015 CCR4-NOT core complex 3 2
GO:0032991 protein-containing complex 1 11
GO:0035770 ribonucleoprotein granule 3 2
GO:0036464 cytoplasmic ribonucleoprotein granule 4 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0099080 supramolecular complex 2 2
GO:0110165 cellular anatomical entity 1 4
GO:0140535 intracellular protein-containing complex 2 11
GO:0030014 CCR4-NOT complex 3 9
GO:0016020 membrane 2 2

Expansion

Sequence features

Q4Q286
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q286

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006401 RNA catabolic process 5 11
GO:0006402 mRNA catabolic process 6 11
GO:0006417 regulation of translation 6 2
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009056 catabolic process 2 11
GO:0009057 macromolecule catabolic process 4 11
GO:0009889 regulation of biosynthetic process 4 2
GO:0009890 negative regulation of biosynthetic process 5 2
GO:0009892 negative regulation of metabolic process 4 11
GO:0009987 cellular process 1 11
GO:0010468 regulation of gene expression 5 11
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0010558 negative regulation of macromolecule biosynthetic process 6 2
GO:0010605 negative regulation of macromolecule metabolic process 5 11
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0010629 negative regulation of gene expression 6 11
GO:0016070 RNA metabolic process 5 11
GO:0016071 mRNA metabolic process 6 11
GO:0017148 negative regulation of translation 7 2
GO:0019222 regulation of metabolic process 3 11
GO:0019439 aromatic compound catabolic process 4 11
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031324 negative regulation of cellular metabolic process 5 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0031327 negative regulation of cellular biosynthetic process 6 2
GO:0034248 regulation of amide metabolic process 5 2
GO:0034249 negative regulation of amide metabolic process 6 2
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034655 nucleobase-containing compound catabolic process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044248 cellular catabolic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0044265 obsolete cellular macromolecule catabolic process 4 11
GO:0044270 cellular nitrogen compound catabolic process 4 11
GO:0046483 heterocycle metabolic process 3 11
GO:0046700 heterocycle catabolic process 4 11
GO:0048519 negative regulation of biological process 3 11
GO:0048523 negative regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 11
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051172 negative regulation of nitrogen compound metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051248 negative regulation of protein metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 11
GO:0065007 biological regulation 1 11
GO:0071704 organic substance metabolic process 2 11
GO:0080090 regulation of primary metabolic process 4 2
GO:0090304 nucleic acid metabolic process 4 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901361 organic cyclic compound catabolic process 4 11
GO:1901575 organic substance catabolic process 3 11
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 2
GO:2000113 obsolete negative regulation of cellular macromolecule biosynthetic process 7 2
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 144 150 PF00089 0.523
CLV_NRD_NRD_1 165 167 PF00675 0.464
CLV_NRD_NRD_1 333 335 PF00675 0.537
CLV_NRD_NRD_1 350 352 PF00675 0.515
CLV_PCSK_KEX2_1 101 103 PF00082 0.348
CLV_PCSK_KEX2_1 165 167 PF00082 0.523
CLV_PCSK_KEX2_1 350 352 PF00082 0.650
CLV_PCSK_PC1ET2_1 101 103 PF00082 0.348
CLV_PCSK_SKI1_1 288 292 PF00082 0.530
CLV_PCSK_SKI1_1 307 311 PF00082 0.368
CLV_PCSK_SKI1_1 335 339 PF00082 0.493
CLV_PCSK_SKI1_1 76 80 PF00082 0.346
CLV_PCSK_SKI1_1 93 97 PF00082 0.226
CLV_Separin_Metazoa 190 194 PF03568 0.348
DEG_APCC_DBOX_1 306 314 PF00400 0.348
DEG_APCC_DBOX_1 333 341 PF00400 0.324
DEG_APCC_DBOX_1 75 83 PF00400 0.562
DEG_Nend_UBRbox_2 1 3 PF02207 0.785
DOC_CDC14_PxL_1 175 183 PF14671 0.273
DOC_CKS1_1 133 138 PF01111 0.303
DOC_MAPK_FxFP_2 176 179 PF00069 0.273
DOC_MAPK_gen_1 334 342 PF00069 0.273
DOC_MAPK_gen_1 91 98 PF00069 0.495
DOC_MAPK_MEF2A_6 334 342 PF00069 0.263
DOC_MAPK_NFAT4_5 335 343 PF00069 0.273
DOC_PP4_FxxP_1 176 179 PF00568 0.273
DOC_USP7_MATH_1 186 190 PF00917 0.347
DOC_USP7_MATH_2 9 15 PF00917 0.728
DOC_USP7_UBL2_3 100 104 PF12436 0.523
DOC_WW_Pin1_4 132 137 PF00397 0.287
DOC_WW_Pin1_4 181 186 PF00397 0.348
LIG_14-3-3_CanoR_1 147 152 PF00244 0.303
LIG_14-3-3_CanoR_1 193 198 PF00244 0.270
LIG_14-3-3_CanoR_1 262 270 PF00244 0.286
LIG_14-3-3_CanoR_1 319 324 PF00244 0.323
LIG_14-3-3_CanoR_1 93 99 PF00244 0.567
LIG_Actin_WH2_2 286 301 PF00022 0.262
LIG_CtBP_PxDLS_1 315 319 PF00389 0.323
LIG_EH1_1 240 248 PF00400 0.262
LIG_FHA_1 238 244 PF00498 0.262
LIG_FHA_2 182 188 PF00498 0.348
LIG_FHA_2 320 326 PF00498 0.367
LIG_LIR_Gen_1 103 112 PF02991 0.487
LIG_LIR_Gen_1 261 270 PF02991 0.303
LIG_LIR_Nem_3 103 108 PF02991 0.462
LIG_LIR_Nem_3 111 116 PF02991 0.314
LIG_LIR_Nem_3 128 133 PF02991 0.171
LIG_LIR_Nem_3 261 266 PF02991 0.273
LIG_LIR_Nem_3 322 326 PF02991 0.324
LIG_LIR_Nem_3 69 74 PF02991 0.641
LIG_LYPXL_S_1 129 133 PF13949 0.462
LIG_LYPXL_S_1 177 181 PF13949 0.462
LIG_LYPXL_yS_3 130 133 PF13949 0.262
LIG_LYPXL_yS_3 178 181 PF13949 0.262
LIG_LYPXL_yS_3 71 74 PF13949 0.629
LIG_NRBOX 336 342 PF00104 0.262
LIG_Pex14_2 176 180 PF04695 0.273
LIG_PTB_Apo_2 317 324 PF02174 0.273
LIG_SH2_STAT3 22 25 PF00017 0.788
LIG_SH2_STAT3 255 258 PF00017 0.303
LIG_SH2_STAT5 214 217 PF00017 0.262
LIG_SH2_STAT5 297 300 PF00017 0.283
LIG_SH2_STAT5 326 329 PF00017 0.348
LIG_SH3_3 137 143 PF00018 0.348
LIG_SH3_3 281 287 PF00018 0.367
LIG_SH3_3 34 40 PF00018 0.742
LIG_SH3_3 42 48 PF00018 0.747
LIG_SH3_3 49 55 PF00018 0.676
LIG_SUMO_SIM_anti_2 149 156 PF11976 0.274
LIG_SUMO_SIM_par_1 94 99 PF11976 0.544
LIG_TRAF2_1 322 325 PF00917 0.367
LIG_TRAF2_1 9 12 PF00917 0.788
LIG_TRAF2_2 68 73 PF00917 0.660
LIG_UBA3_1 220 226 PF00899 0.303
LIG_UBA3_1 95 101 PF00899 0.532
LIG_WRC_WIRS_1 238 243 PF05994 0.262
MOD_CDK_SPxxK_3 181 188 PF00069 0.348
MOD_CK1_1 150 156 PF00069 0.290
MOD_CK1_1 261 267 PF00069 0.367
MOD_CK2_1 181 187 PF00069 0.341
MOD_CK2_1 298 304 PF00069 0.348
MOD_CK2_1 319 325 PF00069 0.367
MOD_GlcNHglycan 137 140 PF01048 0.548
MOD_GSK3_1 108 115 PF00069 0.435
MOD_GSK3_1 146 153 PF00069 0.277
MOD_GSK3_1 232 239 PF00069 0.327
MOD_N-GLC_1 319 324 PF02516 0.487
MOD_N-GLC_2 172 174 PF02516 0.548
MOD_NEK2_1 112 117 PF00069 0.231
MOD_NEK2_1 168 173 PF00069 0.305
MOD_NEK2_1 192 197 PF00069 0.275
MOD_NEK2_1 96 101 PF00069 0.506
MOD_PIKK_1 66 72 PF00454 0.648
MOD_PK_1 147 153 PF00069 0.287
MOD_PKA_1 350 356 PF00069 0.429
MOD_PKA_2 146 152 PF00069 0.287
MOD_PKA_2 192 198 PF00069 0.278
MOD_PKA_2 261 267 PF00069 0.287
MOD_PKA_2 298 304 PF00069 0.262
MOD_PKA_2 350 356 PF00069 0.429
MOD_Plk_1 319 325 PF00069 0.303
MOD_Plk_4 108 114 PF00069 0.429
MOD_Plk_4 125 131 PF00069 0.330
MOD_Plk_4 147 153 PF00069 0.273
MOD_Plk_4 237 243 PF00069 0.256
MOD_ProDKin_1 132 138 PF00069 0.287
MOD_ProDKin_1 181 187 PF00069 0.348
TRG_DiLeu_BaEn_1 103 108 PF01217 0.548
TRG_DiLeu_BaEn_4 12 18 PF01217 0.612
TRG_DiLeu_BaLyEn_6 128 133 PF01217 0.262
TRG_DiLeu_BaLyEn_6 285 290 PF01217 0.262
TRG_ENDOCYTIC_2 130 133 PF00928 0.262
TRG_ENDOCYTIC_2 178 181 PF00928 0.262
TRG_ENDOCYTIC_2 297 300 PF00928 0.273
TRG_ENDOCYTIC_2 32 35 PF00928 0.766
TRG_ENDOCYTIC_2 71 74 PF00928 0.631
TRG_ER_diArg_1 165 167 PF00400 0.323
TRG_ER_diArg_1 350 352 PF00400 0.450
TRG_NES_CRM1_1 233 244 PF08389 0.287
TRG_Pf-PMV_PEXEL_1 312 316 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 350 354 PF00026 0.611

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1Y3 Leptomonas seymouri 92% 100%
A0A0S4ITM9 Bodo saltans 57% 100%
A0A1X0PA96 Trypanosomatidae 55% 100%
A0A3R7N5E2 Trypanosoma rangeli 52% 100%
A0A3S7X8L0 Leishmania donovani 98% 100%
A4HBG1 Leishmania braziliensis 94% 100%
A4IAK7 Leishmania infantum 98% 100%
A7MB47 Bos taurus 48% 100%
C9ZLN4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9B5N2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
P53829 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 97%
Q4R347 Macaca fascicularis 48% 100%
Q5PQL2 Rattus norvegicus 48% 100%
Q5R6Z6 Pongo abelii 48% 100%
Q6IP65 Xenopus laevis 48% 100%
Q6NWL4 Danio rerio 50% 100%
Q6P819 Xenopus tropicalis 48% 100%
Q92368 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 50% 100%
Q92600 Homo sapiens 48% 100%
Q9JKY0 Mus musculus 48% 100%
V5BLQ5 Trypanosoma cruzi 54% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS