RNA-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double RNA binding domain protein 7

Species:

Leishmania major

UniProt:

Q4Q285_LEIMA

TriTrypDb:

LmjF.34.4560 , LMJLV39_340050500 , LMJSD75_340051000

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4Q285

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q285

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	89	91	PF00675	0.232
CLV_PCSK_SKI1_1	149	153	PF00082	0.302
CLV_PCSK_SKI1_1	335	339	PF00082	0.438
CLV_PCSK_SKI1_1	361	365	PF00082	0.534
CLV_PCSK_SKI1_1	39	43	PF00082	0.587
CLV_PCSK_SKI1_1	77	81	PF00082	0.302
CLV_Separin_Metazoa	332	336	PF03568	0.444
DEG_Nend_UBRbox_3	1	3	PF02207	0.587
DEG_SCF_FBW7_1	278	283	PF00400	0.630
DEG_SCF_FBW7_1	40	46	PF00400	0.512
DOC_CKS1_1	106	111	PF01111	0.537
DOC_CKS1_1	40	45	PF01111	0.521
DOC_MAPK_gen_1	80	89	PF00069	0.418
DOC_MAPK_MEF2A_6	12	19	PF00069	0.542
DOC_PP4_FxxP_1	251	254	PF00568	0.583
DOC_PP4_FxxP_1	324	327	PF00568	0.498
DOC_USP7_MATH_1	191	195	PF00917	0.438
DOC_USP7_MATH_1	43	47	PF00917	0.466
DOC_WW_Pin1_4	105	110	PF00397	0.421
DOC_WW_Pin1_4	229	234	PF00397	0.543
DOC_WW_Pin1_4	237	242	PF00397	0.567
DOC_WW_Pin1_4	243	248	PF00397	0.602
DOC_WW_Pin1_4	249	254	PF00397	0.441
DOC_WW_Pin1_4	257	262	PF00397	0.393
DOC_WW_Pin1_4	274	279	PF00397	0.539
DOC_WW_Pin1_4	33	38	PF00397	0.569
DOC_WW_Pin1_4	39	44	PF00397	0.514
LIG_APCC_ABBA_1	119	124	PF00400	0.419
LIG_FHA_1	184	190	PF00498	0.444
LIG_FHA_1	285	291	PF00498	0.644
LIG_FHA_1	328	334	PF00498	0.536
LIG_FHA_1	378	384	PF00498	0.463
LIG_FHA_1	40	46	PF00498	0.492
LIG_FHA_1	74	80	PF00498	0.418
LIG_FHA_2	55	61	PF00498	0.486
LIG_GBD_Chelix_1	369	377	PF00786	0.457
LIG_LIR_Apic_2	321	327	PF02991	0.487
LIG_LIR_Nem_3	174	179	PF02991	0.448
LIG_LIR_Nem_3	246	251	PF02991	0.553
LIG_LIR_Nem_3	340	344	PF02991	0.475
LIG_LIR_Nem_3	65	70	PF02991	0.428
LIG_PDZ_Class_2	385	390	PF00595	0.436
LIG_PTB_Apo_2	78	85	PF02174	0.502
LIG_SH2_CRK	155	159	PF00017	0.502
LIG_SH2_CRK	296	300	PF00017	0.487
LIG_SH2_STAP1	208	212	PF00017	0.403
LIG_SH2_STAP1	303	307	PF00017	0.508
LIG_SH3_3	272	278	PF00018	0.620
LIG_SH3_3	305	311	PF00018	0.560
LIG_SH3_3	37	43	PF00018	0.641
LIG_TRAF2_1	181	184	PF00917	0.460
LIG_TRAF2_1	25	28	PF00917	0.788
LIG_UBA3_1	164	172	PF00899	0.276
LIG_WW_1	300	303	PF00397	0.595
MOD_CDC14_SPxK_1	36	39	PF00782	0.582
MOD_CDK_SPxK_1	33	39	PF00069	0.588
MOD_CDK_SPxxK_3	229	236	PF00069	0.554
MOD_CK1_1	243	249	PF00069	0.639
MOD_CK2_1	178	184	PF00069	0.254
MOD_CK2_1	337	343	PF00069	0.433
MOD_GlcNHglycan	173	176	PF01048	0.267
MOD_GlcNHglycan	20	23	PF01048	0.750
MOD_GlcNHglycan	210	213	PF01048	0.562
MOD_GlcNHglycan	303	306	PF01048	0.575
MOD_GlcNHglycan	324	327	PF01048	0.402
MOD_GlcNHglycan	93	96	PF01048	0.253
MOD_GSK3_1	239	246	PF00069	0.655
MOD_GSK3_1	249	256	PF00069	0.640
MOD_GSK3_1	270	277	PF00069	0.547
MOD_GSK3_1	280	287	PF00069	0.509
MOD_GSK3_1	373	380	PF00069	0.515
MOD_GSK3_1	39	46	PF00069	0.508
MOD_GSK3_1	7	14	PF00069	0.521
MOD_N-GLC_1	30	35	PF02516	0.633
MOD_N-GLC_1	351	356	PF02516	0.534
MOD_N-GLC_1	373	378	PF02516	0.416
MOD_N-GLC_1	99	104	PF02516	0.276
MOD_NEK2_1	115	120	PF00069	0.376
MOD_NEK2_1	322	327	PF00069	0.415
MOD_NEK2_1	337	342	PF00069	0.476
MOD_NEK2_1	373	378	PF00069	0.397
MOD_PIKK_1	102	108	PF00454	0.512
MOD_PIKK_1	178	184	PF00454	0.370
MOD_PIKK_1	284	290	PF00454	0.616
MOD_PKA_2	191	197	PF00069	0.276
MOD_PKB_1	359	367	PF00069	0.478
MOD_Plk_1	99	105	PF00069	0.276
MOD_Plk_2-3	193	199	PF00069	0.317
MOD_Plk_4	110	116	PF00069	0.527
MOD_Plk_4	253	259	PF00069	0.575
MOD_Plk_4	373	379	PF00069	0.426
MOD_ProDKin_1	105	111	PF00069	0.416
MOD_ProDKin_1	229	235	PF00069	0.544
MOD_ProDKin_1	237	243	PF00069	0.567
MOD_ProDKin_1	249	255	PF00069	0.442
MOD_ProDKin_1	257	263	PF00069	0.392
MOD_ProDKin_1	274	280	PF00069	0.536
MOD_ProDKin_1	33	39	PF00069	0.568
MOD_SUMO_for_1	25	28	PF00179	0.615
TRG_DiLeu_BaEn_1	160	165	PF01217	0.370
TRG_DiLeu_BaEn_1	332	337	PF01217	0.441
TRG_ENDOCYTIC_2	155	158	PF00928	0.370
TRG_ENDOCYTIC_2	248	251	PF00928	0.624
TRG_ENDOCYTIC_2	296	299	PF00928	0.540
TRG_ENDOCYTIC_2	341	344	PF00928	0.353
TRG_ENDOCYTIC_2	67	70	PF00928	0.318
TRG_ER_diArg_1	358	361	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHL9	Leptomonas seymouri	82%	100%
A0A1X0P4T3	Trypanosomatidae	23%	70%
A0A1X0PA83	Trypanosomatidae	57%	100%
A0A3S7X8L4	Leishmania donovani	97%	100%
A4HBG2	Leishmania braziliensis	88%	100%
A4IAK8	Leishmania infantum	97%	100%
C9ZLN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZYQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	70%
E9B5N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
F4HT49	Arabidopsis thaliana	26%	78%
Q6FKG4	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	67%
Q74ZS6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	67%
V5BW06	Trypanosoma cruzi	53%	97%
V5DUJ1	Trypanosoma cruzi	25%	71%